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  • 1
    Online Resource
    Online Resource
    Photoinduced Synthesis of Polycyclic γ ‐Sultines by a Radical‐Polar Crossover Cyclization
    Wiley ; 2023
    In:  Advanced Synthesis & Catalysis
    Details
    In: Advanced Synthesis & Catalysis, Wiley
    Abstract: Described herein is a visible light‐mediated radical addition/SO 2 insertion/anionic cyclization of benzo‐fused homoallylic tosylates, allowing access to a diverse array of otherwise challenging‐to‐access fluoromethylated polycyclic γ ‐sultines with two adjacent tetrasubstituted carbon stereocenters in 49–95% yields, which can be further readily functionalized towards bulky two adjacent tetrasubstituted carbon‐containing benzo‐fused γ ‐sultone and mercaptoalkanol. Sodium fluoroalkanesulfinates were utilized as bifunctionalization reagents for both fluoromethyl groups and SO 2 . The cyclization proceeds through a stepwise photoinduced radical addition followed by an intramolecular 5‐ exo‐tet anionic substitution cyclization after SO 2 insertion.
    Type of Medium: Online Resource
    ISSN: 1615-4150 , 1615-4169
    URL: Article
    DOI: 10.1002/adsc.202300616
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2041384-1
    detail.hit.zdb_id: 2033084-4
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  • 2
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    Online Resource
    Synthesis of Multifluoromethylated γ ‐Sultines by a Photoinduced Radical Addition–Polar Cyclization
    Wiley ; 2023
    In:  Angewandte Chemie Vol. 135, No. 15 ( 2023-04-03)
    Details
    In: Angewandte Chemie, Wiley, Vol. 135, No. 15 ( 2023-04-03)
    Abstract: Despite the significance of sultines in synthesis, medicine, and materials science, the chemistry of sultines has remained unexplored due to their inaccessibility. Herein, we demonstrate the development of a photoredox‐catalyzed multifluoromethyl radical addition/SO 2 incorporation/polar cyclization cascade approach to multifluoromethylated γ ‐sultines. The reactions proceed by single electron transfer induced multifluoromethyl radical addition to an alkene followed by SO 2 incorporation, and single‐electron reduction for polar 5‐ exo ‐ tet cyclization. Key to the success of the protocol is the use of easily oxidizable multifluoroalkanesulfinates as bifunctional reagents. The reactions proceed with excellent functional‐group tolerance to deliver γ ‐sultines in moderate to excellent yields.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v135.15
    DOI: 10.1002/ange.202300159
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 505868-5
    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
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  • 3
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    Green synthesis of fluorescent carbon dots using chloroplast dispersions as precursors and application for Fe 3+ ion sensing
    Wiley ; 2020
    In:  Luminescence Vol. 35, No. 6 ( 2020-09), p. 870-876
    Details
    In: Luminescence, Wiley, Vol. 35, No. 6 ( 2020-09), p. 870-876
    Abstract: Water‐soluble carbon dots (CDs) were synthesized using a one‐step hydrothermal treatment of chloroplast dispersions extracted from fresh leaves as a green carbon source. The CD solution showed an emission peak centred at 445 nm when excited at 300 nm. The synthesized CDs were uniform and monodispersed with an average size of 5.6 nm. When adding ferric(III) ions (Fe 3+ ) to the solution of the original CDs, the fluorescence intensity decreased significantly. Based on the linear relationship between fluorescence intensity and concentration of Fe 3+ ions, an effective method for rapid, sensitive and selective Fe 3+ sensing in aqueous solution could be established. Under optimum conditions, the extent of the fluorescence quenching of prepared CDs strongly depended on the Fe 3+ ions over a wide concentration range 1.0–100.0 μM with a detection limit (3σ/k) of 0.3 μM. Furthermore, the quantitative determination of Fe 3+ ions in environmental water samples was realized.
    Type of Medium: Online Resource
    ISSN: 1522-7235 , 1522-7243
    URL: Issue
    URL: Article
    DOI: 10.1002/bio.v35.6
    DOI: 10.1002/bio.3794
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2001819-8
    SSG: 12
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  • 4
    Online Resource
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    Synthesis of Multifluoromethylated γ ‐Sultines by a Photoinduced Radical Addition–Polar Cyclization
    Wiley ; 2023
    In:  Angewandte Chemie International Edition Vol. 62, No. 15 ( 2023-04-03)
    Details
    In: Angewandte Chemie International Edition, Wiley, Vol. 62, No. 15 ( 2023-04-03)
    Abstract: Despite the significance of sultines in synthesis, medicine, and materials science, the chemistry of sultines has remained unexplored due to their inaccessibility. Herein, we demonstrate the development of a photoredox‐catalyzed multifluoromethyl radical addition/SO 2 incorporation/polar cyclization cascade approach to multifluoromethylated γ ‐sultines. The reactions proceed by single electron transfer induced multifluoromethyl radical addition to an alkene followed by SO 2 incorporation, and single‐electron reduction for polar 5‐ exo ‐ tet cyclization. Key to the success of the protocol is the use of easily oxidizable multifluoroalkanesulfinates as bifunctional reagents. The reactions proceed with excellent functional‐group tolerance to deliver γ ‐sultines in moderate to excellent yields.
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    URL: Article
    DOI: 10.1002/anie.v62.15
    DOI: 10.1002/anie.202300159
    RVK:
    VA 2100
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2011836-3
    detail.hit.zdb_id: 123227-7
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  • 5
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    Carbon dots synthesized by the m ‐trihydroxybenzene as the carbon source and its application on the detection of pH value
    Wiley ; 2019
    In:  Luminescence Vol. 34, No. 3 ( 2019-05), p. 341-346
    Details
    In: Luminescence, Wiley, Vol. 34, No. 3 ( 2019-05), p. 341-346
    Abstract: New carbon dots (CDs) were prepared by a microwave method using m ‐trihydroxybenzene and dilute sulphuric acid as raw materials. The as‐prepared CDs exhibited excellent water solubility and photoluminesence properties. The optimum excitation and emission wavelengths of the new CDs were at 365 nm and 465 nm, respectively. The fluorescence of the new CDs experienced remarkable changes in the presence of Britton–Robinson (BR) buffer solution with different pH values under 4°C after reacting for 70 min. In addition, a linear relationship between the logarithm of the relative fluorescence intensity ratio [lg( I F /I Fo )] of CDs and the pH values of the sensing system ranging 1.81–5.72 was obtained, with a correlation coefficient of 0.9933. Thus, a sensitive and simple method to detect the pH value of solution was developed. Furthermore, the analytical application of detecting the concentration of acetic acid in vinegar was investigated. The detection values were found similar to the reference values, fully demonstrating a good linear relationship between the logarithm of the relative fluorescence intensity ratio of the CDs and the pH value of the system. Hence, the method could be used to detect the concentration of acetic acid in vinegar.
    Type of Medium: Online Resource
    ISSN: 1522-7235 , 1522-7243
    URL: Issue
    URL: Article
    DOI: 10.1002/bio.v34.3
    DOI: 10.1002/bio.3613
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2001819-8
    SSG: 12
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  • 6
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    Effect of matrix stiffness on osteoblast functionalization
    Wiley ; 2017
    In:  Cell Proliferation Vol. 50, No. 3 ( 2017-06)
    Details
    In: Cell Proliferation, Wiley, Vol. 50, No. 3 ( 2017-06)
    Abstract: Stiffness of bone tissue differs response to its physiological or pathological status, such as osteoporosis or osteosclerosis. Consequently, the function of cells residing in bone tissue including osteoblasts (OBs), osteoclasts and osteocytes will be affected. However, to the best of our knowledge, the detailed mechanism of how extracellular matrix stiffness affects OB function remains unclear. Materials and methods We conducted a study that exposed rat primary OBs to polydimethylsiloxane substrates with varied stiffness to investigate the alterations of cell morphology, osteoblastic differentiation and its potential mechanism in mechanotransduction. Results Distinctive differences of cell shapes and vinculin expression in rat osteoblasts were detected on different PDMS substrates. As representatives for OB function, expression of alkaline phosphatase, Runx2 and osteocalcin were identified and showed a decrease trend as substrates become soft, which is associated with the Rho/ ROCK signalling pathway. Conclusions Our results indicated substrate elasticity as a potent regulator in OBs functionalization, which may pave a way for further understanding of bone diseases as well as a potential therapeutic alternative in tissue regeneration.
    Type of Medium: Online Resource
    ISSN: 0960-7722 , 1365-2184
    URL: Issue
    URL: Article
    DOI: 10.1111/cpr.2017.50.issue-3
    DOI: 10.1111/cpr.12338
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2019986-7
    SSG: 12
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  • 7
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    Targeting macrophage liver X receptors by hydrogel‐encapsulated T0901317 reduces atherosclerosis without effect on hepatic lipogenesis
    Wiley ; 2021
    In:  British Journal of Pharmacology Vol. 178, No. 7 ( 2021-04), p. 1620-1638
    Details
    In: British Journal of Pharmacology, Wiley, Vol. 178, No. 7 ( 2021-04), p. 1620-1638
    Abstract: Targeting macrophage but not hepatocyte liver X receptors (LXRs) can reduce atherosclerosis without effect on hepatic lipogenesis. In this study, we encapsulated LXR ligands with D‐Nap‐GFFY to form a nanofibre hydrogel (D‐Nap‐GFFY‐T0901317 or GFFY‐T0901317) and determined its effect on atherosclerosis, hepatic lipogenesis and the underlying mechanisms involved. Experimental Approach D‐Nap‐GFFY‐T0901317 was subcutaneously injected to proatherogenic diet‐fed apoE‐deficient ( Apoe −/− ) mice, followed by determination of the development of atherosclerosis, liver steatosis and the involved mechanisms, with comparison of T0901317 oral administration. Key Results Subcutaneous injection of D‐Nap‐GFFY‐T0901317 to Apoe −/− mice inhibited atherosclerosis at a comparable level as T0901317 oral administration without effect on hepatic lipogenesis. More importantly, D‐Nap‐GFFY‐T0901317 regressed the advanced lesions. In arterial wall, D‐Nap‐GFFY‐T0901317 reduced macrophage/foam cells, necrotic cores and calcification and increased collagen content. It activated expression of ABCA1/G1 and smooth muscle α‐actin, while inhibiting expression of intracellular adhesion molecule 1 (ICAM‐1) and vascular cell adhesion molecule 1 (VCAM‐1). D‐Nap‐GFFY‐T0901317 also reduced serum pro‐inflammatory cytokines and facilitated Kupffer cell M2 polarization. Mechanistically, D‐Nap‐GFFY‐T0901317 was selectively taken up by macrophages but not hepatocytes, resulting in activation of macrophage ABCA1/G1 expression, while having no effect on lipogenic genes in hepatocytes. Moreover, the selective uptake of D‐Nap‐GFFY‐T0901317 by macrophages was mainly completed in a scavenger receptor class A‐dependent manner. Conclusion and Implications Our study demonstrates that D‐Nap‐GFFY‐T0901317 reduces atherosclerosis without effect on hepatic lipogenesis by targeting macrophage LXRs selectively, indicating its potential application for atherosclerosis treatment.
    Type of Medium: Online Resource
    ISSN: 0007-1188 , 1476-5381
    URL: Issue
    URL: Article
    DOI: 10.1111/bph.v178.7
    DOI: 10.1111/bph.15387
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2029728-2
    SSG: 15,3
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  • 8
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    Climatic‐niche evolution with key morphological innovations across clades within Scutiger boulengeri (Anura: Megophryidae)
    Wiley ; 2021
    In:  Ecology and Evolution Vol. 11, No. 15 ( 2021-08), p. 10353-10368
    Details
    In: Ecology and Evolution, Wiley, Vol. 11, No. 15 ( 2021-08), p. 10353-10368
    Abstract: The studies of climatic‐niche shifts over evolutionary time accompanied by key morphological innovations have attracted the interest of many researchers recently. We applied ecological niche models (ENMs), ordination method (environment principal component analyses; PCA‐env), combined phylogenetic comparative methods (PCMs), and phylogenetic generalized least squares (PGLS) regression methods to analyze the realized niche dynamics and correspondingly key morphological innovations across clades within Scutiger boulengeri throughout their distributions in Qinghai–Tibet Plateau (QTP) margins of China. Our results show there are six clades in S. boulengeri and obvious niche divergences caused by niche expansion in three clades. Moreover, in our system, niche expansion is more popular than niche unfilling into novel environmental conditions. Annual mean temperature, annual precipitation, and precipitation of driest month may contribute to such a shift. In addition, we identified several key climatic factors and morphological traits that tend to be associated with niche expansion in S. boulengeri clades correspondingly. We found phenotypic plasticity [i.e., length of lower arm and hand (LAHL), hind‐limb length (HLL), and foot length (FL)] and evolutionary changes [i.e., snout–vent length (SVL)] may together contribute to niche expansion toward adapting novel niche, which provides us a potential pattern of how a colonizing toad might seed a novel habitat to begin the process of speciation and finally adaptive radiation. For these reasons, persistent phylogeographic divisions and accompanying divergences in niche occupancy and morphological adaption suggest that for future studies, distinct genetic structure and morphological changes corresponding to each genetic clade should be included in modeling niche evolution dynamics, but not just constructed at the species level.
    Type of Medium: Online Resource
    ISSN: 2045-7758 , 2045-7758
    URL: Issue
    URL: Article
    DOI: 10.1002/ece3.v11.15
    DOI: 10.1002/ece3.7838
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2635675-2
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  • 9
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    Irisin ameliorates angiotensin II‐induced cardiomyocyte apoptosis through autophagy
    Wiley ; 2019
    In:  Journal of Cellular Physiology Vol. 234, No. 10 ( 2019-10), p. 17578-17588
    Details
    In: Journal of Cellular Physiology, Wiley, Vol. 234, No. 10 ( 2019-10), p. 17578-17588
    Abstract: Cardiac hypertrophy is the main cause of heart failure and sudden death in patients. But the pathogenesis is unclear. Angiotensin II may contribute to cardiac hypertrophy in response to pressure overload. In angiotensin II‐treated cardiomyocytes, there is a larger cross‐sectional area, more apoptosis cells, and a reduction of irisin expression. An increase in P62, an autophagy flux index, as well as LC3II, were observed in cardiomyocytes after angiotensin II‐induced injury. Surprisely, irisin supplementation increased LC3II expression and decreased P62 expression, consisted of results of RFP‐GFP‐LC3B adenovirus transfection, and reduced cardiomyocyte apoptosis, meanwhile, the protection of irisin was reversed by the autophagy inhibitor 3‐methyladenine. In animal experiments, overexpression of irisin reduced cardiomyocyte apoptosis and alleviated myocardial hypertrophy caused by pressure overload. The above results indicate that irisin‐induced protective autophagy and alleviated the apoptosis signaling pathway in cardiomyocytes, consequently reducing cardiomyocyte apoptosis after angiotensin II‐induced injury. Hence, increasing irisin expression may be a new way to improve cardiac function and quality of life in patients with cardiac hypertrophy.
    Type of Medium: Online Resource
    ISSN: 0021-9541 , 1097-4652
    URL: Issue
    URL: Article
    DOI: 10.1002/jcp.v234.10
    DOI: 10.1002/jcp.28382
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 1478143-8
    SSG: 12
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  • 10
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    Regeneration of articular cartilage by adipose tissue derived mesenchymal stem cells: Perspectives from stem cell biology and molecular medicine
    Wiley ; 2013
    In:  Journal of Cellular Physiology Vol. 228, No. 5 ( 2013-05), p. 938-944
    Details
    In: Journal of Cellular Physiology, Wiley, Vol. 228, No. 5 ( 2013-05), p. 938-944
    Abstract: Adipose‐derived stem cells (ASCs) have been discovered for more than a decade. Due to the large numbers of cells that can be harvested with relatively little donor morbidity, they are considered to be an attractive alternative to bone marrow derived mesenchymal stem cells. Consequently, isolation and differentiation of ASCs draw great attention in the research of tissue engineering and regenerative medicine. Cartilage defects cause big therapeutic problems because of their low self‐repair capacity. Application of ASCs in cartilage regeneration gives hope to treat cartilage defects with autologous stem cells. In recent years, a lot of studies have been performed to test the possibility of using ASCs to re‐construct damaged cartilage tissue. In this article, we have reviewed the most up‐to‐date articles utilizing ASCs for cartilage regeneration in basic and translational research. Our topic covers differentiation of adipose tissue derived mesenchymal stem cells into chondrocytes, increased cartilage formation by co‐culture of ASCs with chondrocytes and enhancing chondrogenic differentiation of ASCs by gene manipulation. J. Cell. Physiol. © 2012 Wiley Periodicals, Inc.
    Type of Medium: Online Resource
    ISSN: 0021-9541 , 1097-4652
    URL: Issue
    URL: Article
    DOI: 10.1002/jcp.v228.5
    DOI: 10.1002/jcp.24255
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 1478143-8
    SSG: 12
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