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  • 1
    Online Resource
    Online Resource
    Aggravated MRSA pneumonia secondary to influenza A virus infection is derived from decreased expression of IL‐1β
    Wiley ; 2020
    In:  Journal of Medical Virology Vol. 92, No. 12 ( 2020-12), p. 3047-3056
    Details
    In: Journal of Medical Virology, Wiley, Vol. 92, No. 12 ( 2020-12), p. 3047-3056
    Abstract: MRSA pneumonia secondary to influenza A virus infection causes severe outcome. NLRP3 inflammasome plays a role in the pathogenesis of MRSA pneumonia secondary to IAV infection. The aggravated inflammatory pathology in MRSA pneumonia secondary to IAV infection was associated with decreased expression of IL‐1β. Immunotherapy targeting the NLRP3 inflammasome and IL‐1β signaling pathway could be possible therapeutic strategy for secondary MRSA pneumonia.
    Type of Medium: Online Resource
    ISSN: 0146-6615 , 1096-9071
    URL: Issue
    URL: Article
    DOI: 10.1002/jmv.v92.12
    DOI: 10.1002/jmv.26329
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 752392-0
    detail.hit.zdb_id: 1475090-9
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  • 2
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    Online Resource
    Atorvastatin ameliorates early brain injury after subarachnoid hemorrhage via inhibition of pyroptosis and neuroinflammation
    Wiley ; 2021
    In:  Journal of Cellular Physiology Vol. 236, No. 10 ( 2021-10), p. 6920-6931
    Details
    In: Journal of Cellular Physiology, Wiley, Vol. 236, No. 10 ( 2021-10), p. 6920-6931
    Abstract: Subarachnoid hemorrhage (SAH) is a subtype of stroke with high mortality and morbidity due to the lack of effective therapy. Atorvastatin has been reported to alleviate early brain injury (EBI) following subarachnoid hemorrhage (SAH) via reducing reactive oxygen species, antiapoptosis, regulated autophagy, and neuroinflammation. Which was the related to the pyroptosis? Pyroptosis can be defined as a highly specific inflammatory programmed cell death, distinct from classical apoptosis and necrosis. However, the precise role of pyroptosis in atorvastatin‐mediated neuroprotection following SAH has not been confirmed. The present study aimed to investigate the neuroprotection and potential molecular mechanisms of atorvastatin in the SAH‐induced EBI via regulating neural pyroptosis using the filament perforation model of SAH in male C57BL/6 mice, and the hemin‐induced neuron damage model in HT‐22. Atorvastatin or vehicle was administrated 2 h after SAH and hemin‐induced neuron damage. The mortality, neurological score, brain water content, and neuronal death were evaluated. The results show that the atorvastatin treatment markedly increased survival rate, neurological score, greater survival of neurons, downregulated the protein expression of NLRP1, cleaved caspase‐1, interleukin‐1β (IL‐1β), and IL‐18, which indicated that atorvastatin‐inhibited pyroptosis and neuroinflammation, ameliorated neuron death in vivo/vitro subjected to SAH. Taken together, this study demonstrates that atorvastatin improved the neurological outcome in rats and reduced the neuron death by against neural pyroptosis and neuroinflammation.
    Type of Medium: Online Resource
    ISSN: 0021-9541 , 1097-4652
    URL: Issue
    URL: Article
    DOI: 10.1002/jcp.v236.10
    DOI: 10.1002/jcp.30351
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1478143-8
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    Rapid screening and identification of the antioxidants in Hippocampus japonicus Kaup by HPLC‐ESI‐TOF/MS and on‐line ABTS free radical scavenging assay
    Wiley ; 2010
    In:  Journal of Separation Science Vol. 33, No. 4-5 ( 2010-03), p. 672-677
    Details
    In: Journal of Separation Science, Wiley, Vol. 33, No. 4-5 ( 2010-03), p. 672-677
    Abstract: In this paper, a method based on HPLC coupled with ESI‐TOF/MS and on‐line to a stable free radical scavenging detection system has been developed to rapidly screen and identify the major antioxidants in the water extract of Hippocampus japonicus Kaup, a kind of marine medicinal organism. The developed on‐line stable free radical scavenging detection method of water extract from H. japonicus Kaup revealed the presence of three radical scavenging compounds, which were simultaneously identified as hypoxanthine, phenylalanine and tryptophane by high‐resolution TOF‐MS. To the best of our knowledge, it is original to demonstrate the rapid and successful use of HPLC‐ESI‐TOF/MS and on‐line 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonate) diammonium salt free radical scavenging assay to directly and simultaneously screen and identify the antioxidants in the water extracts of H. japonicus Kaup without any purification. The present method provides a useful improvement on the reducing of workload and a powerful tool for rapid screening and identification of free radical scavenging compounds in complex natural products.
    Type of Medium: Online Resource
    ISSN: 1615-9306 , 1615-9314
    URL: Issue
    URL: Article
    DOI: 10.1002/jssc.v33:4/5
    DOI: 10.1002/jssc.200900544
    RVK:
    VA 5450
    Language: English
    Publisher: Wiley
    Publication Date: 2010
    detail.hit.zdb_id: 2047990-6
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  • 4
    Online Resource
    Online Resource
    The cardioprotective effect of thymoquinone on ischemia‐reperfusion injury in isolated rat heart via regulation of apoptosis and autophagy
    Wiley ; 2018
    In:  Journal of Cellular Biochemistry Vol. 119, No. 9 ( 2018-09), p. 7212-7217
    Details
    In: Journal of Cellular Biochemistry, Wiley, Vol. 119, No. 9 ( 2018-09), p. 7212-7217
    Abstract: Thymoquinone (TQ), as the active constituents of black cumin (Nigella sativa) seed oil, has been reported to have potential protective effects on the cardiovascular system. This study aimed to investigate the effects and the underlying mechanisms of TQ on myocardial ischemia‐reperfusion (I/R) injury in Langendorff‐perfused rat hearts. Wister rat hearts were subjected to I/R and the experimental group were pretreated with TQ prior to I/R. Hemodynamic parameters, myocardial infarct size, cardiac marker enzymes, superoxide dismutase (SOD), malondialdehyde (MDA) content, and cardiomyocyte apoptosis were assayed. Compared with the untreated group, TQ preconditioning significantly improved cardiac function, reduced infarct size, decreased cardiac lactate dehydrogenase (LDH) and creatine kinase‐MB (CK‐MB) levels, suppressed enedoxidative stress, and apoptosis. In addition, TQ treatment promoted autophagy, which was partially reversed by chloroquine (CQ), a kind of autophagy blocker. Our study suggests that TQ can protect heart against I/R injury, which is associated with anti‐oxidative and anti‐apoptotic effects through activation of autophagy.
    Type of Medium: Online Resource
    ISSN: 0730-2312 , 1097-4644
    URL: Issue
    URL: Article
    DOI: 10.1002/jcb.v119.9
    DOI: 10.1002/jcb.26878
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 1479976-5
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    Long‐Duration and Non‐Invasive Photoacoustic Imaging of Multiple Anatomical Structures in a Live Mouse Using a Single Contrast Agent
    Wiley ; 2022
    In:  Advanced Science Vol. 9, No. 28 ( 2022-10)
    Details
    In: Advanced Science, Wiley, Vol. 9, No. 28 ( 2022-10)
    Abstract: Long‐duration in vivo simultaneous imaging of multiple anatomical structures is useful for understanding physiological aspects of diseases, informative for molecular optimization in preclinical models, and has potential applications in surgical settings to improve clinical outcomes. Previous studies involving simultaneous imaging of multiple anatomical structures, for example, blood and lymphatic vessels as well as peripheral nerves and sebaceous glands, have used genetically engineered mice, which require expensive and time‐consuming methods. Here, an IgG4 isotype control antibody is labeled with a near‐infrared dye and injected into a mouse ear to enable simultaneous visualization of blood and lymphatic vessels, peripheral nerves, and sebaceous glands for up to 3 h using photoacoustic microscopy. For multiple anatomical structure imaging, peripheral nerves and sebaceous glands are imaged inside the injected dye‐labeled antibody mass while the lymphatic vessels are visualized outside the mass. The efficacy of the contrast agent to label and localize deep medial lymphatic vessels and lymph nodes using photoacoustic computed tomography is demonstrated. The capability of a single injectable contrast agent to image multiple structures for several hours will potentially improve preclinical therapeutic optimization, shorten discovery timelines, and enable clinical treatments.
    Type of Medium: Online Resource
    ISSN: 2198-3844 , 2198-3844
    URL: Issue
    URL: Article
    DOI: 10.1002/advs.v9.28
    DOI: 10.1002/advs.202202907
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2808093-2
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  • 6
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    Online Resource
    Substrate quality overrides soil salinity in mediating microbial respiration in coastal wetlands
    Wiley ; 2023
    In:  Land Degradation & Development Vol. 34, No. 15 ( 2023-09), p. 4546-4560
    Details
    In: Land Degradation & Development, Wiley, Vol. 34, No. 15 ( 2023-09), p. 4546-4560
    Abstract: As productive and essential ecosystems, coastal wetlands have experienced increased environmental impacts such as saltwater intrusion and eutrophication, resulting in significant shifts in microbially mediated ecosystem functions, such as carbon sequestration and nutrient transformations. The soil microbial respiration, a primary process in the transfer of carbon from soil to the atmosphere, is susceptible to environmental changes. However, studies on how salinity affects soil microbial respiration in coastal wetlands have not been fully explored. Soil samples were systematically collected from divergent sampling sites covering medium‐ and extremely‐saline wetlands along a river‐estuary‐coast continuum to investigate mechanisms controlling soil microbial respiration in coastal wetlands. According to the results, the microbial biomass and carbon‐related extracellular enzyme activities were significantly lower in extremely saline (ECe  〉 15 ds m −1 , ES) than medium and highly saline soils (ECe 〈 15 ds m −1 , MHS) ( p   〈  0.05), indicating a suppressive effect of salinity on soil microbiota. Meanwhile, high‐salinity soils had lower vector length and soil microbial respiration rates, suggesting that soils with low carbon limitation might cause less carbon loss under higher salinity environments. Moreover, it was showed that increased available phosphorus could alleviate microbial carbon limitations. Changes in the microbial functional community demonstrated that the microbial community in favor of metabolic mediates and secondary metabolites substrates (regarded as labile substrates) were more sensitive to salinity. The partial least square path modeling further confirmed that microbial nutrient limitation and microbial biomass contribute more directly to promoting soil microbial respiration. These results have substantial implications for elucidating carbon dynamics in coastal wetlands ecosystems under increased nutrient discharge and sea‐level rise.
    Type of Medium: Online Resource
    ISSN: 1085-3278 , 1099-145X
    URL: Issue
    URL: Article
    DOI: 10.1002/ldr.v34.15
    DOI: 10.1002/ldr.4792
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2021787-0
    detail.hit.zdb_id: 1319202-4
    SSG: 14
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  • 7
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    Characteristics of energy storage and dissipation of coal under one‐time cyclic load
    Wiley ; 2020
    In:  Energy Science & Engineering Vol. 8, No. 9 ( 2020-09), p. 3117-3135
    Details
    In: Energy Science & Engineering, Wiley, Vol. 8, No. 9 ( 2020-09), p. 3117-3135
    Abstract: Energy is an important research parameter in rock mechanics. To explore the law of energy evolution of coal, a one‐time loading and unloading test under uniaxial compression was conducted on coal taken from four different coal mines. By utilizing the area integral method, the total input, elastic, and dissipated energy densities in coal at different unloading levels were calculated. The correlation between various energy densities and the evolution law of energy density with different unloading levels was attained. The peak strengths of the coal slowly declined with an increasing unloading level, which conforms to the relation of a linearly decreasing function. The energy dissipation rate has nonlinear characteristics, and the shape of the dissipation rate fitting curve changed from an upper concave to a downward concave with increasing strength. In all the coal samples, the energy density grew nonlinearly with the unloading level. Moreover, the growth rate of the total energy density was the highest, followed by the growth rates of the elastic and dissipated energy densities. All ratios of the elastic and dissipated energy densities to the total input energy density and the ratio of the dissipated energy density to the elastic energy density were constant. As the strength increased, the input energy and the elastic energy density increased at a faster rate, and they observed the same law. There is an insignificant relationship between the degree of destruction of the coal and the level of unloading. Energy is a major factor that drives the failure of a test piece, but this is not the main factor that determines the degree of damage to the test piece.
    Type of Medium: Online Resource
    ISSN: 2050-0505 , 2050-0505
    URL: Issue
    URL: Article
    DOI: 10.1002/ese3.v8.9
    DOI: 10.1002/ese3.738
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2720339-6
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  • 8
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    Online Resource
    Superelongation of Liquid Metal
    Wiley ; 2022
    In:  Advanced Science Vol. 9, No. 11 ( 2022-04)
    Details
    In: Advanced Science, Wiley, Vol. 9, No. 11 ( 2022-04)
    Abstract: The ability to control interfacial tension electrochemically is uniquely available for liquid metals (LMs), in particular gallium‐based LM alloys. This imparts them with excellent locomotion and deformation capabilities and enables diverse applications. However, electrochemical oxidation of LM is a highly dynamic process, which often induces Marangoni instabilities that make it almost impossible to elongate LM and manipulate its morphology directly and precisely on a 2D plane without the assistance of other patterning methods. To overcome these limitations, this study investigates the use of an LM–iron (Fe) particle mixture that is capable of suppressing instabilities during the electrochemical oxidation process, thereby allowing for superelongation of the LM core of the mixture to form a thin wire that is tens of times of its original length. More importantly, the elongated LM core can be manipulated freely on a 2D plane to form complex patterns. Eliminating Marangoni instabilities also allows for the effective spreading and filling of the LM–Fe mixture into molds with complex structures and small features. Harnessing these excellent abilities, a channel‐less patterning method for fabricating elastomeric wearable sensors is demonstrated to detect motions. This study shows the potential for developing functional and flexible structures of LM with superior performance.
    Type of Medium: Online Resource
    ISSN: 2198-3844 , 2198-3844
    URL: Issue
    URL: Article
    DOI: 10.1002/advs.v9.11
    DOI: 10.1002/advs.202105289
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2808093-2
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  • 9
    Online Resource
    Online Resource
    CD4 +  CD25 +  GARP + regulatory T cells display a compromised suppressive function in patients with dilated cardiomyopathy
    Wiley ; 2017
    In:  Immunology Vol. 151, No. 3 ( 2017-07), p. 291-303
    Details
    In: Immunology, Wiley, Vol. 151, No. 3 ( 2017-07), p. 291-303
    Abstract: Dilated cardiomyopathy (DCM) is a lethal inflammatory heart disease and closely connected with dysfunction of the immune system. Glycoprotein A repetitions predominant (GARP) expressed on activated CD4 + T cells with suppressive activity has been established. This study aimed to investigate the frequency and function of circulating CD4 +   CD25 +  GARP + regulatory T (Treg) cells in DCM. Forty‐five DCM patients and 46 controls were enrolled in this study. There was a significant increase in peripheral T helper type 1 (Th1) and Th17 number and their related cytokines [interferon‐ γ (IFN‐ γ ), interleukin (IL‐17)], and an obvious decrease in Treg number, transforming growth factor‐ β 1 (TGF‐ β 1 ) levels and the expression of forkhead box P3 (FOXP3) and GARP in patients with DCM compared with controls. In addition, the suppressive function of CD4 +  CD25 +  GARP + Treg cells was impaired in DCM patients upon T‐cell receptor stimulation detected using CFSE dye. Lower level of TGF‐ β 1 and higher levels of IFN‐ γ and IL‐17 detected using ELISA were found in supernatants of the cultured CD4 +  CD25 +  GARP + Treg cells in DCM patients compared with controls. Together, our results indicate that CD4 +  CD25 +  GARP + Treg cells are defective in DCM patients and GARP seems to be a better molecular definition of the regulatory phenotype. Therefore, it might be an attractive stategy to pay more attention to GARP in DCM patients.
    Type of Medium: Online Resource
    ISSN: 0019-2805 , 1365-2567
    URL: Issue
    URL: Article
    DOI: 10.1111/imm.2017.151.issue-3
    DOI: 10.1111/imm.12728
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2006481-0
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  • 10
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    Lattice‐Gradient Perovskite KTaO 3 Films for Ultra‐Stable and Low‐Dose X‐Ray Detector
    Wiley ; 2023
    In:  Advanced Materials
    Details
    In: Advanced Materials, Wiley
    Abstract: Conventional indirect X‐ray detectors employ scintillating phosphors to convert X‐ray photons into photodiode‐detectable visible photons, leading to low conversion efficiencies, low spatial resolutions, and optical crosstalk. Consequently, X‐ray detectors that directly convert photons into electric signals have long been desired for high‐performance medical imaging and industrial inspection. Although emerging hybrid inorganic–organic halide perovskites, such as MAPbI 3 and MAPbBr 3 , exhibit high sensitivity, they have salient drawbacks including structural instability, ion motion, and the use of toxic Pb. Here we report an ultrastable, low‐dose X‐ray detector comprising KTaO 3 perovskite films epitaxially grown on a Nb‐doped strontium titanate substrate using a low‐cost solution method. The detector exhibits a stable photocurrent under high‐dose‐irradiation, high‐temperature (200°C), and aqueous conditions. Moreover, the prototype KTaO 3 ‐film‐based detector exhibits a 150‐fold higher sensitivity (3150 μC Gy air −1 cm −2 ) and 150‐fold lower detection limit ( 〈 40 nGy air s −1 ) than those of commercial amorphous α‐Se‐based direct detectors. Systematic investigations revealed that the high stability of the detector originates from the strong covalent bonds within the KTaO 3 film, whereas the low detection limit is due to a lattice‐gradient‐driven built‐in electric field, yielding an extremely low dark current. This study unveils a new path toward the fabrication of green, stable, and low‐dose X‐ray detectors using oxide perovskite films, which have significant application potential in medical imaging and security operations. This article is protected by copyright. All rights reserved
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Article
    DOI: 10.1002/adma.202211026
    RVK:
    UA 1538
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1474949-X
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