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  • 1
    In: Head & Neck, Wiley, Vol. 44, No. 2 ( 2022-02), p. 325-331
    Abstract: Higher body mass index (BMI) may have a protective effect on survival in patients with head and neck cancer. The aim of this study was to determine the effect of BMI on overall survival (OS) in veterans with head and neck squamous cell carcinoma (HNSCC). Methods A cohort of 702 patients diagnosed with HNSCC between 1995 and 2019 were identified at the Washington DC Veterans Affairs Medical Center, and 342 patients were included for analysis. Records were queried for clinical‐demographic data, BMI, and outcomes. Results HNSCC patients categorized as overweight or obese at time of diagnosis had a lower 3‐year risk of death ( p  = 0.033) and improved OS ( p   〈  0.001) compared to patients who were underweight or normal weight. The majority of locoregional recurrences occurred in patients with low or normal pretreatment BMI. Conclusions Higher BMI at diagnosis may have a protective effect on OS in veterans with HNSCC.
    Type of Medium: Online Resource
    ISSN: 1043-3074 , 1097-0347
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2001440-5
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  • 2
    In: European Journal of Pain, Wiley, Vol. 23, No. 6 ( 2019-07), p. 1051-1070
    Abstract: To develop an evidence‐based guideline for the non‐pharmacological management of persistent headaches associated with neck pain (i.e., tension‐type or cervicogenic). Methods This guideline is based on systematic reviews of high‐quality studies. A multidisciplinary expert panel considered the evidence of clinical benefits, cost‐effectiveness, societal and ethical values, and patient experiences when formulating recommendations. Target audience includes clinicians; target population is adults with persistent headaches associated with neck pain. Results When managing patients with headaches associated with neck pain, clinicians should (a) rule out major structural or other pathologies, or migraine as the cause of headaches; (b) classify headaches associated with neck pain as tension‐type headache or cervicogenic headache once other sources of headache pathology has been ruled out; (c) provide care in partnership with the patient and involve the patient in care planning and decision making; (d) provide care in addition to structured patient education; (e) consider low‐load endurance craniocervical and cervicoscapular exercises for tension‐type headaches (episodic or chronic) or cervicogenic headaches 〉 3 months duration; (f) consider general exercise, multimodal care (spinal mobilization, craniocervical exercise and postural correction) or clinical massage for chronic tension‐type headaches; (g) do not offer manipulation of the cervical spine as the sole form of treatment for episodic or chronic tension‐type headaches; (h) consider manual therapy (manipulation with or without mobilization) to the cervical and thoracic spine for cervicogenic headaches 〉 3 months duration. However, there is no added benefit in combining spinal manipulation, spinal mobilization and exercises; and (i) reassess the patient at every visit to assess outcomes and determine whether a referral is indicated. Conclusions Our evidence‐based guideline provides recommendations for the conservative management of persistent headaches associated with neck pain. The impact of the guideline in clinical practice requires validation. Significance Neck pain and headaches are very common comorbidities in the population. Tension‐type and cervicogenic headaches can be treated effectively with specific exercises. Manual therapy can be considered as an adjunct therapy to exercise to treat patients with cervicogenic headaches. The management of tension‐type and cervicogenic headaches should be patient‐centred.
    Type of Medium: Online Resource
    ISSN: 1090-3801 , 1532-2149
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2002493-9
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  • 3
    In: European Journal of Pain, Wiley, Vol. 25, No. 8 ( 2021-09), p. 1644-1667
    Abstract: Objective of this study is to develop an evidence‐based guideline for the noninvasive management of soft tissue disorders of the shoulder (shoulder pain), excluding major pathology. Methods This guideline is based on high‐quality evidence from seven systematic reviews. Multidisciplinary experts considered the evidence of effectiveness, safety, cost‐effectiveness, societal and ethical values, and patient experiences when formulating recommendations. Target audience is clinicians; target population is adults with shoulder pain. Results When managing patients with shoulder pain, clinicians should (a) rule out major structural or other pathologies as the cause of shoulder pain and reassure patients about the benign and self‐limited nature of most soft tissue shoulder pain; (b) develop a care plan in partnership with the patient; (c) for shoulder pain of any duration, consider low‐level laser therapy; multimodal care (heat/cold, joint mobilization, and range of motion exercise); cervicothoracic spine manipulation and mobilization for shoulder pain when associated pain or restricted movement of the cervicothoracic spine; or thoracic spine manipulation; (d) for shoulder pain 〉 3‐month duration, consider stretching and/or strengthening exercises; laser acupuncture; or general physician care (information, advice, and pharmacological pain management if necessary); (e) for shoulder pain with calcific tendinitis on imaging, consider shock‐wave therapy; (f) for shoulder pain of any duration, do not offer ultrasound; taping; interferential current therapy; diacutaneous fibrolysis; soft tissue massage; or cervicothoracic spine manipulation and mobilization as an adjunct to exercise (i.e., range of motion, strengthening and stretching exercise) for pain between the neck and the elbow at rest or during movement of the arm; (g) for shoulder pain 〉 3‐month duration, do not offer shock‐wave therapy; and (h) should reassess the patient's status at each visit for worsening of symptoms or new physical, mental, or psychological symptoms, or satisfactory recovery. Conclusions Our evidence‐based guideline provides recommendations for non‐invasive management of shoulder pain. The impact of the guideline in clinical practice requires further evaluation. Significance Shoulder pain of any duration can be effectively treated with laser therapy, multimodal care (i.e., heat/cold, joint mobilization, range of motion exercise), or cervicothoracic manipulation and mobilization. Shoulder pain ( 〉 3 months) can be effectively treated with exercises, laser acupuncture, or general physician care (information, advice, and pharmacological pain management if necessary).
    Type of Medium: Online Resource
    ISSN: 1090-3801 , 1532-2149
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2002493-9
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  • 4
    In: Clinical Case Reports, Wiley, Vol. 8, No. 12 ( 2020-12), p. 2776-2780
    Abstract: We describe the implementation of brief action planning in conjunction with evidence‐based clinical practice guideline recommendations to improve self‐efficacy in a patient with psychosocial barriers and persistent nonspecific low back pain.
    Type of Medium: Online Resource
    ISSN: 2050-0904 , 2050-0904
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2740234-4
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  • 5
    In: Alimentary Pharmacology & Therapeutics, Wiley, Vol. 55, No. 6 ( 2022-03), p. 645-657
    Abstract: Electronic health records (EHRs) collate longitudinal data that can be used to facilitate large‐scale research in patients with cirrhosis. However, there is no consensus code set to define the presence of cirrhosis in EHR. This systematic review aims to evaluate the validity of diagnostic coding in cirrhosis and to synthesise a comprehensive set of ICD‐10 codes for future EHR research. Method MEDLINE and EMBASE databases were searched for studies that used EHR to identify cirrhosis and cirrhosis‐related complications. Validated code sets were summarised, and the performance characteristics were extracted. Citation analysis was done to inform development of a consensus code set. This was then validated in a cohort of patients. Results One thousand six hundred twenty‐six records were screened, and 18 studies were identified. The positive predictive value (PPV) was the most frequently reported statistical estimate and was ≥80% in 17/18 studies. Citation analyses showed continued variation in those used in contemporary research practice. Nine codes were identified as those most frequently used in the literature and these formed the consensus code set. This was validated in diverse patient populations from Europe and North America and showed high PPV (83%–89%) and greater sensitivity for the identification of cirrhosis than the most often used code set in the recent literature. Conclusion There is variation in code sets used to identify cirrhosis in contemporary research practice. A consensus set has been developed and validated, showing improved performance, and is proposed to align EHR study designs in cirrhosis to facilitate international collaboration and comparisons.
    Type of Medium: Online Resource
    ISSN: 0269-2813 , 1365-2036
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2003094-0
    SSG: 15,3
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  • 6
    In: Tropical Medicine & International Health, Wiley, Vol. 19, No. 7 ( 2014-07), p. 872-882
    Abstract: Reportar un análisis en profundidad de los cambios políticos para del Manejo Casos Comunitarios integrado ( MCC i) de enfermedades infantiles en seis países de África subsahariana. Hemos analizado como se desarrollaron las políticas de MCC i, así como las barreras para y los facilitadores del cambio político. Métodos Se realizaron estudios cualitativos retrospectivos de casos mediante la revisión de documentación, entrevistas semi‐estructuradas y talleres de validación dentro del país, en Burkina Faso, Kenia, Malawi, Mali, Mozambique y Níger. Estos países se seleccionaron para maximizar la variación en el estatus de las políticas de MCC i, el modelo de trabajadores sanitarios comunitarios ( TSC ) y las diferentes regiones Africanas. Resultados Las políticas nacionales de MCC i evolucionaron de una forma ad hoc , pero estaban sustancialmente influenciadas por la historia de los cuidados primarios y la naturaleza de los programas de TSC . Los técnicos dentro de los Ministerios de Salud lideraron los cambios de políticas de MCC i con el apoyo de los donantes internacionales, pero no se movilizaron ni las comunidades ni los líderes políticos. Las preocupaciones por alcanzar los Objetivos de Desarrollo del Milenio, conjuntamente con el reconocimiento de las carencias de los programas sanitarios infantiles existentes, llevaron a la adopción de las políticas de MCC i. La disponibilidad de financiación externa jugó un papel crítico, facilitando el cambio político. Conclusiones El cambio de política de MCC i ha estado promovido por agencias internacionales, pero los gobiernos nacionales han luchado por alinear el MCC i con los sistemas sanitarios nacionales. Se requieren mayores inversiones en el diseño de iniciativas de políticas globales que se ajusten a las necesidades nacionales. La propiedad de las políticas de MCC i a un alto nivel político, facilitarían el cambio en las políticas, al igual que lo harían tener una estrategia clara para asegurar su sostenibilidad a largo plazo.
    Type of Medium: Online Resource
    ISSN: 1360-2276 , 1365-3156
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2018112-7
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  • 7
    Online Resource
    Online Resource
    Wiley ; 2010
    In:  International Journal of Gynecology & Obstetrics Vol. 108, No. 2 ( 2010-02), p. 165-169
    In: International Journal of Gynecology & Obstetrics, Wiley, Vol. 108, No. 2 ( 2010-02), p. 165-169
    Abstract: To evaluate the quality of costing studies of post‐abortion care from low‐ and middle‐income countries and to describe costs in various settings. Methods A systematic review identified unit costs. Descriptive statistical analysis and univariate regression analysis identified drivers of unit costs of post‐abortion care. Results There are few cost studies from Asia or Eastern Europe. Data indicate that the cost (in 2007 international dollars) of post‐abortion care in Africa and Latin America is $392 and $430, respectively, per case. Conclusion Differences in post‐abortion care costs were associated with region, procedure, facility level, case severity, and whether the study was operations research. Methods varied between studies, and efforts should be made in future research to improve consistency. Additional data are needed from Asia and Eastern Europe, as well as the costs of medical methods of uterine evacuation. These data justify improved access to contraception and safe, legal abortion.
    Type of Medium: Online Resource
    ISSN: 0020-7292 , 1879-3479
    Language: English
    Publisher: Wiley
    Publication Date: 2010
    detail.hit.zdb_id: 1500480-6
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  • 8
    In: International Journal of Dermatology, Wiley, Vol. 59, No. 8 ( 2020-08)
    Type of Medium: Online Resource
    ISSN: 0011-9059 , 1365-4632
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2020365-2
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  • 9
    In: Journal of Viral Hepatitis, Wiley
    Abstract: Hepatitis C virus infection (HCV) is prevalent in prisons. Therefore, effective prison HCV services are critical for HCV elimination programmes. We aimed to evaluate the efficacy of a regional HCV prison testing and treatment programme. Between July 2017 and June 2022, data were collected prospectively on HCV test offer and uptake rates, HCV Antibody (HCV‐Ab) and HCV‐RNA positivity, treatment starts and outcomes for new inmates incarcerated in three prisons. Rates of HCV‐Ab and RNA positivity at reception, incidence of new HCV infections and reinfection following treatment were determined. From a total of 39,652 receptions, 33,028 (83.3%) were offered HCV testing and 20,394 (61.7%) completed testing. Including all receptions, 24.5% of tests ( n  = 4995) were HCV‐Ab positive and 8.4% of tests ( n  = 1713) were HCV‐RNA positive. When considering the first test for each individual (median age 34 years; 88.1% male), 14.8% ( n  = 1869) and 7.2% ( n  = 905) were HCV‐Ab and HCV‐RNA positive, respectively. The incidence of new HCV‐Ab and RNA positivity was 5.1 and 3.3 per 100 person‐years, respectively. Of 1145 HCV viraemic individuals, 18 died within 6 months and 150 were rapidly transferred out of area, leaving 977 individuals with outcomes. Of these, 835 (85.5%) received antivirals and 47 spontaneously cleared the infection, leaving 95 (9.7%) untreated. 607 (72.7%) achieved SVR. 95 patients had reinfection post‐treatment (rate 10.1 cases per 100 person‐years). Testing for HCV has increased in our prisons and the majority with viraemia are initiated on antiviral treatment. Reassuringly, a significant fall in frequency of HCV‐RNA positivity at prison reception was observed suggesting progress towards HCV elimination.
    Type of Medium: Online Resource
    ISSN: 1352-0504 , 1365-2893
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2007924-2
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  • 10
    Online Resource
    Online Resource
    Wiley ; 2024
    In:  International Journal of Ceramic Engineering & Science
    In: International Journal of Ceramic Engineering & Science, Wiley
    Abstract: This article reviews promising studies on the design, manufacturing, microstructure, properties, and applications of glass‐ceramics containing ZrO 2 and relevant glass‐ceramic matrix composites. After the addition of ZrO 2 to a glass‐ceramic composition, it can persist in the residual glassy phase, facilitate nucleation, and/or precipitate as ZrO 2 or another zirconate crystalline phase. Also, ZrO 2 ‐reinforced or ZrO 2 ‐toughened glass‐ceramics can be designed as composites. In this article, the term “ZrO 2 ‐containing glass‐ceramics” encompasses all these scenarios in which ZrO 2 is present. Such glass‐ceramics offer a wide range of applications in modern industries, including but not limited to architecture, optics, dentistry, medicine, and energy. Since S. Donald Stookey's discovery of glass‐ceramics in the early 1950s, the most important scientific efforts reported in the literature are reviewed. ZrO 2 is commonly added to glass‐ceramics to promote nucleation. As a result, the role of ZrO 2 in structural modification of residual glass and stimulating the nucleation in glass‐ceramic is first discussed. ZrO 2 can also be designed into the main crystalline phase of glass‐ceramics, contributing achieving super high fracture toughness above 4 MPa·m 0.5 . Experimental and computational studies are reviewed in detail to elucidate how the transformation toughening and other mechanisms help to achieve such high values of fracture toughness. Sintered and glass‐ceramic matrix composites also show promise, where ZrO 2 contributes to improved stability and mechanical properties. Finally, we hope this article will provoke interest in glass‐ceramic materials in both the scientific and industrial communities so that their tremendous technological potential in developing, for example, tough, thermally stable, transparent, and biologically compatible materials can be realized more widely.
    Type of Medium: Online Resource
    ISSN: 2578-3270 , 2578-3270
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2947566-1
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