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  • 1
    Online Resource
    Online Resource
    Influence of patient characteristics and immunosuppressant management on mortality in kidney transplant recipients hospitalized with coronavirus disease 2019 (COVID‐19)
    Wiley ; 2021
    In:  Clinical Transplantation Vol. 35, No. 4 ( 2021-04)
    Details
    In: Clinical Transplantation, Wiley, Vol. 35, No. 4 ( 2021-04)
    Abstract: The influence of patient characteristics and immunosuppression management on COVID‐19 outcomes in kidney transplant recipients (KTRs) remains uncertain. We performed a single‐center, retrospective review of all adult KTRs admitted to the hospital with confirmed COVID‐19 between 03/15/2020 and 05/15/2020. Patients were followed from the date of admission up to 1 month following hospital discharge or study conclusion (06/15/2020). Baseline characteristics, laboratory parameters, and immunosuppression were compared between survivors and patients who died to identify predictors of mortality. 38 KTRs with a mean baseline eGFR of 52.5 ml/min/1.73 m 2 were hospitalized during the review period. Maintenance immunosuppression included tacrolimus (84.2%), mycophenolate (89.5%), and corticosteroids (81.6%) in the majority of patients. Eleven patients (28.9%) died during the hospitalization. Older age (OR = 2.05; 1.04‐4.04), peak D‐dimer (OR = 1.20; 1.04‐1.39), and peak white blood cell count (OR = 1.11; 1.02‐1.21) were all associated with mortality among KTRs hospitalized for COVID‐19. Increased mortality was also observed among KTRs with concomitant HIV infection (87.5% vs. 36.1%; p   〈  .01). Conversely, immunosuppression intensity and degree of reduction following COVID‐19 diagnosis were not associated with either survival or acute allograft rejection. Our findings potentially support a strategy of individualization of immunosuppression targets based on patient‐specific risk factors, rather than universal immunosuppression reduction for KTRs at risk from COVID‐19.
    Type of Medium: Online Resource
    ISSN: 0902-0063 , 1399-0012
    URL: Issue
    URL: Article
    DOI: 10.1111/ctr.v35.4
    DOI: 10.1111/ctr.14221
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2739458-X
    detail.hit.zdb_id: 2004801-4
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  • 2
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    Near‐complete genome of SARS‐CoV‐2 Delta variant of concern identified in a symptomatic dog (Canis lupus familiaris) in Botswana
    Wiley ; 2023
    In:  Veterinary Medicine and Science Vol. 9, No. 4 ( 2023-07), p. 1465-1472
    Details
    In: Veterinary Medicine and Science, Wiley, Vol. 9, No. 4 ( 2023-07), p. 1465-1472
    Abstract: We sought to investigate whether SARS‐CoV‐2 was present, and to perform full‐length genomic sequencing, in a 5‐year‐old male crossbreed dog from Gaborone, Botswana that presented overt clinical signs (flu‐like symptoms, dry hacking cough and mild dyspnoea). It was only sampled a posteriori, because three adult owners were diagnosed with SARS‐CoV‐2 infection. Next‐generation sequencing based on Oxford Nanopore Technology (ONT) was performed on amplicons that were generated using a reverse transcriptase real‐time polymerase chain reaction (RT‐qPCR) of confirmed positive SARS‐CoV‐2 nasopharyngeal and buccal swabs, as well as a bronchoalveolar lavage with mean real cycle threshold (qCt) value of 36 based on the Nucleocapsid (N) gene. Descriptive comparisons to known sequences in Botswana and internationally were made using mutation profiling analysis and phylogenetic inferences. Human samples were not available. A near‐full length SARS‐CoV‐2 genome (∼90% coverage) was successfully genotyped and classified under clade 20 O and Pango‐Lineage AY.43 (Pango v.4.0.6 PLEARN‐v1.3; 2022‐04‐21), which is a sublineage of the Delta variant of concern (VOC) (formerly called B.1.617.2, first detected in India). We did not identify novel mutations that may be used to distinguish SARS‐CoV‐2 isolates from the dog and humans. In addition to Spike (S) region mutation profiling, we performed phylogenetic analysis including 30 Delta sequences publicly available reference also isolated from dogs. In addition, we performed another exploratory analysis to investigate the phylogenetic relatedness of sequence isolated from dog with those from humans in Botswana ( n = 1303) as of 31 March 2022 and of same sublineage. Expectedly, the sequence formed a cluster with Delta sublineages – AY.43, AY.116 and B.1.617.2 – circulating in same time frame. This is the first documented report of human‐associated SARS‐CoV‐2 infection in a dog in Botswana. Although the direction of transmission remains unknown, this study further affirms the need for monitoring pets during different COVID‐19 waves for possible clinically relevant SARS‐CoV‐2 transmissions between species.
    Type of Medium: Online Resource
    ISSN: 2053-1095 , 2053-1095
    URL: Issue
    URL: Article
    DOI: 10.1002/vms3.v9.4
    DOI: 10.1002/vms3.1152
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2819409-3
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  • 3
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    Symptoms and recovery among adult outpatients with and without COVID‐19 at 11 healthcare facilities—July 2020, United States
    Wiley ; 2021
    In:  Influenza and Other Respiratory Viruses Vol. 15, No. 3 ( 2021-05), p. 345-351
    Details
    In: Influenza and Other Respiratory Viruses, Wiley, Vol. 15, No. 3 ( 2021-05), p. 345-351
    Abstract: Symptoms of mild COVID‐19 illness are non‐specific and may persist for prolonged periods. Effects on quality of life of persistent poor physical or mental health associated with COVID‐19 are not well understood. Methods Adults aged ≥18 years with laboratory‐confirmed COVID‐19 and matched control patients who tested negative for SARS‐CoV‐2 infection at outpatient facilities associated with 11 medical centers in the United States were interviewed to assess symptoms, illness duration, and health‐related quality of life. Duration of symptoms, health‐related quality of life measures, and days of poor physical health by symptoms experienced during illness were compared between case patients and controls using Wilcoxon rank‐sum tests. Symptoms associated with COVID‐19 case status were evaluated by multivariable logistic regression. Results Among 320 participants included, 157 were COVID‐19 cases and 163 were SARS‐CoV‐2 negative controls. Loss of taste or smell was reported by 63% of cases and 6% of controls and was strongly associated with COVID‐19 in logistic regression models (adjusted odds ratio [aOR] = 32.4; 95% confidence interval [CI] , 12.6‐83.1). COVID‐19 cases were more likely than controls to have experienced fever, body aches, weakness, or fatigue during illness, and to report ≥1 persistent symptom more than 14 days after symptom onset (50% vs 32%, P   〈  .001). Cases reported significantly more days of poor physical health during the past 14 days than controls ( P   〈  .01). Conclusions Differentiating COVID‐19 from other acute illnesses will require widespread diagnostic testing, especially during influenza seasons. Persistent COVID‐19‐related symptoms may negatively affect quality of life, even among those initially presenting with mild illness.
    Type of Medium: Online Resource
    ISSN: 1750-2640 , 1750-2659
    URL: Issue
    URL: Article
    DOI: 10.1111/irv.v15.3
    DOI: 10.1111/irv.12832
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2272349-3
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  • 4
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    Online Resource
    Coalescing investments in school mental health in South Carolina
    Wiley ; 2020
    In:  Child and Adolescent Mental Health Vol. 25, No. 3 ( 2020-09), p. 150-156
    Details
    In: Child and Adolescent Mental Health, Wiley, Vol. 25, No. 3 ( 2020-09), p. 150-156
    Abstract: Improving child and adolescent mental health requires states and jurisdictions to invest in school mental health efforts. In recent years, there has been notable expansion and improvement in school mental health services in the state of South Carolina related to a number of investments that are cumulatively promoting capacity building. Methods This narrative overview examines the history of the school mental health movement in one southern state and details efforts by multiple key stakeholders that have coalesced to form a strong system for advancing school mental health. Results Resting on a strong university–community partnership, five separate initiatives are described that together provide enhanced workforce training and support and expansion of school mental health services. Themes of this work are identified with a goal of supporting and advancing the development of school mental health systems in the United States. Conclusion Strong collaborations and communication efforts both within the university setting and between partners in education and community settings, along with engaged funders keen to enhance well‐being of children, youth, and families statewide have set the stage for the growth and expansion of school mental health services.
    Type of Medium: Online Resource
    ISSN: 1475-357X , 1475-3588
    URL: Issue
    URL: Article
    DOI: 10.1111/camh.v25.3
    DOI: 10.1111/camh.12382
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2073663-0
    SSG: 2,1
    SSG: 5,2
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  • 5
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    Increased transport of acetyl‐CoA into the endoplasmic reticulum causes a progeria‐like phenotype
    Wiley ; 2018
    In:  Aging Cell Vol. 17, No. 5 ( 2018-10)
    Details
    In: Aging Cell, Wiley, Vol. 17, No. 5 ( 2018-10)
    Abstract: The membrane transporter AT‐1/SLC33A1 translocates cytosolic acetyl‐CoA into the lumen of the endoplasmic reticulum (ER), participating in quality control mechanisms within the secretory pathway. Mutations and duplication events in AT‐1/SLC33A1 are highly pleiotropic and have been linked to diseases such as spastic paraplegia, developmental delay, autism spectrum disorder, intellectual disability, propensity to seizures, and dysmorphism. Despite these known associations, the biology of this key transporter is only beginning to be uncovered. Here, we show that systemic overexpression of AT‐1 in the mouse leads to a segmental form of progeria with dysmorphism and metabolic alterations. The phenotype includes delayed growth, short lifespan, alopecia, skin lesions, rectal prolapse, osteoporosis, cardiomegaly, muscle atrophy, reduced fertility, and anemia. In terms of homeostasis, the AT‐1 overexpressing mouse displays hypocholesterolemia, altered glycemia, and increased indices of systemic inflammation. Mechanistically, the phenotype is caused by a block in Atg9a‐Fam134b‐LC3β and Atg9a‐Sec62‐LC3β interactions, and defective reticulophagy, the autophagic recycling of the ER. Inhibition of ATase1/ATase2 acetyltransferase enzymes downstream of AT‐1 restores reticulophagy and rescues the phenotype of the animals. These data suggest that inappropriately elevated acetyl‐CoA flux into the ER directly induces defects in autophagy and recycling of subcellular structures and that this diversion of acetyl‐CoA from cytosol to ER is causal in the progeria phenotype. Collectively, these data establish the cytosol‐to‐ER flux of acetyl‐CoA as a novel event that dictates the pace of aging phenotypes and identify intracellular acetyl‐CoA‐dependent homeostatic mechanisms linked to metabolism and inflammation.
    Type of Medium: Online Resource
    ISSN: 1474-9718 , 1474-9726
    URL: Issue
    URL: Article
    DOI: 10.1111/acel.2018.17.issue-5
    DOI: 10.1111/acel.12820
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2099130-7
    SSG: 12
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  • 6
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    Ascertainment of vaccination status by self‐report versus source documentation: Impact on measuring COVID‐19 vaccine effectiveness
    Wiley ; 2022
    In:  Influenza and Other Respiratory Viruses Vol. 16, No. 6 ( 2022-11), p. 1101-1111
    Details
    In: Influenza and Other Respiratory Viruses, Wiley, Vol. 16, No. 6 ( 2022-11), p. 1101-1111
    Abstract: During the COVID‐19 pandemic, self‐reported COVID‐19 vaccination might facilitate rapid evaluations of vaccine effectiveness (VE) when source documentation (e.g., immunization information systems [IIS]) is not readily available. We evaluated the concordance of COVID‐19 vaccination status ascertained by self‐report versus source documentation and its impact on VE estimates. Methods Hospitalized adults (≥18 years) admitted to 18 U.S. medical centers March–June 2021 were enrolled, including COVID‐19 cases and SARS‐CoV‐2 negative controls. Patients were interviewed about COVID‐19 vaccination. Abstractors simultaneously searched IIS, medical records, and other sources for vaccination information. To compare vaccination status by self‐report and documentation, we estimated percent agreement and unweighted kappa with 95% confidence intervals (CIs). We then calculated VE in preventing COVID‐19 hospitalization of full vaccination (2 doses of mRNA product ≥14 days prior to illness onset) independently using data from self‐report or source documentation. Results Of 2520 patients, 594 (24%) did not have self‐reported vaccination information to assign vaccination group; these patients tended to be more severely ill. Among 1924 patients with both self‐report and source documentation information, 95.0% (95% CI: 93.9–95.9%) agreement was observed, with a kappa of 0.9127 (95% CI: 0.9109–0.9145). VE was 86% (95% CI: 81–90%) by self‐report data only and 85% (95% CI: 81‐89%) by source documentation data only. Conclusions Approximately one‐quarter of hospitalized patients could not provide self‐report COVID‐19 vaccination status. Among patients with self‐report information, there was high concordance with source documented status. Self‐report may be a reasonable source of COVID‐19 vaccination information for timely VE assessment for public health action.
    Type of Medium: Online Resource
    ISSN: 1750-2640 , 1750-2659
    URL: Issue
    URL: Article
    DOI: 10.1111/irv.v16.6
    DOI: 10.1111/irv.13023
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2272349-3
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  • 7
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    Online Resource
    Altered Affect and Increased CLIP+ B cells in the Meningeal Lymphatics of 5xFAD mice are mitigated by antagonizing MHCII‐associated invariant chain (CLIP)
    Wiley ; 2022
    In:  Alzheimer's & Dementia Vol. 18, No. S3 ( 2022-12)
    Details
    In: Alzheimer's & Dementia, Wiley, Vol. 18, No. S3 ( 2022-12)
    Abstract: Depression often occurs prior to Alzheimer’s disease (AD) and both depression and AD have been linked to immune mechanisms. A key role for activated B cells in AD pathogenesis was recently identified. The study found that B cell depletion reduced Aβ plaque accumulation, neuroinflammation, and behavioral deficits in three AD transgenic mouse models. Our work has shown that treatment with a peptide antagonist for Major histocompatibility complex class II (MHCII) invariant peptide (CLIP), a key component in the transition between innate and adaptive immunity, results in selective depletion of pro‐inflammatory, CLIP+ve B cells and neuroprotection. We hypothesized that selective depletion of CLIP+ve B cells in the 5xFAD model of AD would reduce depression‐associated behavioral deficits. Method 11‐week‐old male WT and 5xFAD mice underwent social interaction and burrowing pre‐testing. 12‐week‐old mice were treated once with a competitive antagonist peptide (CAP) or vehicle, followed by social interaction and burrowing testing once a month for 5 months. 6 months post‐treatment, meningeal lymphatics were collected, stained, and analyzed flow cytometrically for markers of B cells (CD19), T cells (CD3), and CLIP. Result Affective alterations were observed in 5xFAD mice as early as 11 weeks of age and persisted up to 9 months of age. CAP treatment in 5xFAD mice protected against an age‐associated decline in social interaction. At 9 months of age 5xFAD mice were found to have significantly more B cells and CLIP+ve B cells in the meningeal lymphatics when compared to age‐matched WT, and CLIP+ve B cells were significantly decreased by a single CAP injection at 3 months of age. Conclusion A key function of B cells is their role as antigen presenting cells (APCs). CLIP occupies the MHCII antigen binding groove until it is displaced by antigen to be presented to CD4+ T cells, marking the transition between an innate and an adaptive immune response. Our findings suggest that 5xFAD mice exhibit depression‐associated behavior by 11 weeks of age, that CLIP+ve cells are elevated in 5xFAD mice, and that antagonizing CLIP depletes these B cells and functionally protects mice genetically predisposed to AD.
    Type of Medium: Online Resource
    ISSN: 1552-5260 , 1552-5279
    URL: Issue
    URL: Article
    DOI: 10.1002/alz.v18.S3
    DOI: 10.1002/alz.068349
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2201940-6
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  • 8
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    Online Resource
    Bacterial Transport Experiments in Fractured Crystalline Bedrock
    Wiley ; 2003
    In:  Ground Water Vol. 41, No. 5 ( 2003-09), p. 682-689
    Details
    In: Ground Water, Wiley, Vol. 41, No. 5 ( 2003-09), p. 682-689
    Type of Medium: Online Resource
    ISSN: 0017-467X , 1745-6584
    URL: Issue
    URL: Article
    DOI: 10.1111/gwat.2003.41.issue-5
    DOI: 10.1111/j.1745-6584.2003.tb02406.x
    Language: English
    Publisher: Wiley
    Publication Date: 2003
    detail.hit.zdb_id: 2066386-9
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