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  • 1
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    Online Resource
    Disruption of macrophage pro‐inflammatory cytokine release in C rohn's disease is associated with reduced optineurin expression in a subset of patients
    Wiley ; 2015
    In:  Immunology Vol. 144, No. 1 ( 2015-01), p. 45-55
    Details
    In: Immunology, Wiley, Vol. 144, No. 1 ( 2015-01), p. 45-55
    Abstract: Crohn's disease ( CD ) is a complex and highly heterogeneous chronic inflammatory disorder, primarily affecting the gastrointestinal tract. Genetic and functional studies have highlighted a key role for innate immunity in its pathogenesis. Profound systemic defects in innate immunity and acute inflammation are understood to result in markedly delayed clearance of bacteria from the tissues, leading to local chronic granulomatous inflammation and compensatory adaptive immunological changes. Macrophages, key orchestrators of acute inflammation, are likely to play an important role in the initial impaired innate immune response. Monocyte‐derived macrophages from CD patients stimulated with E scherichia coli were shown to release attenuated levels of tumour necrosis factor and interferon‐ γ with normal secretion of interleukin‐8 ( IL ‐8), IL ‐10 and IL ‐6. In controls, the secretion of these cytokines was strongly positively correlated, which was not seen with CD macrophages. The transcriptomes of CD and control macrophages were examined in an attempt to understand the molecular basis of this defect. There were no differentially expressed genes identified between the two groups, consistent with genetic heterogeneity; however, a number of molecules were found to be under‐expressed in subgroups of CD patients. The most common of these was optineurin ( OPTN ) which was under‐expressed in approximately 10% of the CD patients. Reduced OPTN expression coincided with lower intracellular protein levels and diminished cytokine secretion after bacterial stimulation both in the patients and with small interfering RNA knockdown in THP ‐1 cells. Identifying and studying subgroups of patients with shared defective gene expression could aid our understanding of the mechanisms underlying highly heterogeneous diseases such as CD .
    Type of Medium: Online Resource
    ISSN: 0019-2805 , 1365-2567
    URL: Issue
    URL: Article
    DOI: 10.1111/imm.2014.144.issue-1
    DOI: 10.1111/imm.12338
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2006481-0
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  • 2
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    Online Resource
    Dual‐site right ventricular pacing in patients undergoing cardiac resynchronization therapy: Results of a multicenter propensity‐matched analysis
    Wiley ; 2017
    In:  Pacing and Clinical Electrophysiology Vol. 40, No. 10 ( 2017-10), p. 1113-1120
    Details
    In: Pacing and Clinical Electrophysiology, Wiley, Vol. 40, No. 10 ( 2017-10), p. 1113-1120
    Abstract: Dual‐site right ventricular pacing (Dual RV) has been proposed as an alternative for patients with heart failure undergoing cardiac resynchronization therapy (CRT) with a failure to deliver a coronary sinus (CS) lead. Only short‐term hemodynamic and echocardiographic results of Dual RV are available. We aimed to assess the long‐term results of Dual RV and its impact on survival. Methods Multicenter retrospective assessment of all CRT implants during a 12‐year period. Patients with failed CS lead implantation, treated with Dual RV, were followed and assessed for the primary endpoint of all‐cause mortality and/or heart transplant. A control group was obtained from contemporary patients using propensity matching for all available baseline variables. Results Ninety‐three patients were implanted with Dual RV devices and compared with 93 matched controls. During a median of 1,273 days (interquartile range 557–2,218), intention‐to‐treat analysis showed that all‐cause mortality and/or heart transplant was higher in the Dual RV group (adjusted hazard ratio [HR] = 1.66, 95% confidence interval [CI] 1.12–2.47, P = 0.012). As‐treated analysis yielded similar results (HR = 1.97, 95% CI 1.31–2.96, P = 0.001). Cardiac device‐related infections occurred seven times more frequently in the Dual RV site group (HR = 7.60, 95% CI 1.51–38.33, P = 0.014). Among Dual RV nonresponders, four had their apical leads switched off, five required an epicardial LV lead insertion, a transseptal LV lead was implanted in two, and in nine patients, after reviewing the CS venogram, a new CS lead insertion was successfully attempted. Conclusion Dual RV pacing is associated with worse clinical outcomes and higher complication rates than conventional CRT.
    Type of Medium: Online Resource
    ISSN: 0147-8389 , 1540-8159
    URL: Issue
    URL: Article
    DOI: 10.1111/pace.2017.40.issue-10
    DOI: 10.1111/pace.13145
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2037547-5
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  • 3
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    Online Resource
    Subject factors influencing blood flow restriction in the arm at low cuff pressures
    Wiley ; 2022
    In:  Clinical Physiology and Functional Imaging Vol. 42, No. 4 ( 2022-07), p. 233-240
    Details
    In: Clinical Physiology and Functional Imaging, Wiley, Vol. 42, No. 4 ( 2022-07), p. 233-240
    Abstract: Limb circumference predicts the pressure needed for complete occlusion. However, that relationship is inconsistent at moderate pressures typical of effective blood flow restriction (BFR) training. The purpose of this study was to investigate the influence of subject factors on BFR at low restriction pressures in the arm. Methods Fifty subjects had arm anthropometrics assessed by peripheral quantitative computed tomography (pQCT), sum of skinfold thickness (sumSKF) and Gulick tape (Gulick tape circumference [Gulick Circ.]) at cuff level. Blood flow (BF) was measured with ultrasound at baseline and five restrictive pressures (20, 30, 40, 50 and 60 mmHg). Relationships between subject characteristics and BFR were assessed using Pearson's correlations and hierarchical regression. Results BF decreased ( p   〈  0.05) at each incremental pressure. Regression models including percent muscle composition (%Muscle), pQCT circumference and systolic blood pressure (SBP), were significant at all five pressures ( R 2  = 0.18–0.49). %Muscle explained the most variance at each pressure. Regression models including sumSKF, Gulick Circ. and SBP, were significant at 30–60 mmHg ( R 2  = 0.28–0.49). SumSKF explained the most variance at each pressure. Conclusions At low pressures (20–60 mmHg), there is considerable variability in the magnitude of BFR across individuals. Arm composition factors (muscle and fat) explained the greatest variance at each cuff pressure and may be the most important consideration when using BFR protocols.
    Type of Medium: Online Resource
    ISSN: 1475-0961 , 1475-097X
    URL: Issue
    URL: Article
    DOI: 10.1111/cpf.v42.4
    DOI: 10.1111/cpf.12752
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2004626-1
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  • 4
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    Online Resource
    Deficiency of p67 phox , p47 phox or gp91 phox in chronic granulomatous disease does not impair leucocyte chemotaxis or motility
    Wiley ; 1997
    In:  British Journal of Haematology Vol. 96, No. 3 ( 1997-03), p. 543-550
    Details
    In: British Journal of Haematology, Wiley, Vol. 96, No. 3 ( 1997-03), p. 543-550
    Abstract: Chronic granulomatous disease (CGD) is a syndrome characterized by failure of the NADPH oxidase of phagocytes that generates superoxide, which is central to the microbicidal process. Cytosolic components of this oxidase system include the proteins p67 phox and p47 phox , deficiencies of which cause the autosomal recessive form of CGD, whereas the X‐linked form of the disease is characterized by a deficiency in the plasma membrane component gp91 phox . Components of the oxidase system have been reported to be associated with the cytoskeleton and neutrophils from CGD patients have been reported to have a defective chemotactic response in Boyden chambers. Using a chamber that permits the direct observation of cell behaviour in a linear gradient of a chemoattractant, we have analysed the chemotactic response of neutrophils from a patient lacking p67 phox ; from another lacking p47 phox and from a third lacking gp91 phox . The results of measuring the speeds and directions of locomotion of the cells show that their speeds are undiminished relative to cells from healthy control subjects and that their directions of migration are at least as strongly biased in the direction of the gradient as those of the control cells. We conclude that these definitive aspects of the chemotactic response are not abnormal in either the autosomal recessive or the X‐linked forms of CGD and that they are therefore not factors in the predisposition to infection that characterizes the syndrome.
    Type of Medium: Online Resource
    ISSN: 0007-1048 , 1365-2141
    URL: Article
    DOI: 10.1046/j.1365-2141.1997.d01-2080.x
    RVK:
    XA 34100
    Language: English
    Publisher: Wiley
    Publication Date: 1997
    detail.hit.zdb_id: 1475751-5
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  • 5
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    Online Resource
    Lipid rafts determine efficiency of NADPH oxidase activation in neutrophils
    Wiley ; 2003
    In:  FEBS Letters Vol. 550, No. 1-3 ( 2003-08-28), p. 101-106
    Details
    In: FEBS Letters, Wiley, Vol. 550, No. 1-3 ( 2003-08-28), p. 101-106
    Abstract: We have investigated the contribution of lipid rafts to activation of the NADPH oxidase enzyme system in neutrophils. Membrane‐bound NADPH oxidase subunits are present in the lipid raft compartment of neutrophils. Cytosolic NADPH oxidase components are mainly absent from but are recruited to rafts upon Fcγ receptor activation. In parallel, protein kinase C isotypes are recruited to the rafts. Kinetic analysis of NADPH oxidase activation revealed that rafts determine the onset but not the maximal rate of enzyme activity. Thus lipid rafts serve to physically juxtapose the NADPH oxidase effector, protein kinase C and Fcγ receptor, resulting in efficient coupling.
    Type of Medium: Online Resource
    ISSN: 0014-5793 , 1873-3468
    URL: Article
    DOI: 10.1016/S0014-5793(03)00845-7
    RVK:
    WA 15000
    Language: English
    Publisher: Wiley
    Publication Date: 2003
    detail.hit.zdb_id: 1460391-3
    SSG: 12
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  • 6
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    Catalase negative Staphylococcus aureus retain virulence in mouse model of chronic granulomatous disease
    Wiley ; 2002
    In:  FEBS Letters Vol. 518, No. 1-3 ( 2002-05-08), p. 107-110
    Details
    In: FEBS Letters, Wiley, Vol. 518, No. 1-3 ( 2002-05-08), p. 107-110
    Abstract: Myeloperoxidase‐mediated chlorination is thought to be a necessary microbicidal mechanism. The H 2 O 2 required for this process is generated by the NADPH oxidase. Staphylococcus aureus can also produce H 2 O 2 , which is not broken down by catalase negative organisms. It has been thought that this bacterial H 2 O 2 can substitute for cellular H 2 O 2 in the halogenation reaction in chronic granulomatous disease (CGD) where neutrophils are lacking the NADPH oxidase. We have readdressed this issue in a mouse model of CGD using clinical isolates of catalase positive and negative strains of S. aureus . The results showed these organisms to be equally virulent and that the H 2 O 2 they produced is insufficient to cause significant iodination, a marker for chlorination, thereby contradicting the accepted views on this subject.
    Type of Medium: Online Resource
    ISSN: 0014-5793 , 1873-3468
    URL: Article
    DOI: 10.1016/S0014-5793(02)02658-3
    RVK:
    WA 15000
    Language: English
    Publisher: Wiley
    Publication Date: 2002
    detail.hit.zdb_id: 1460391-3
    SSG: 12
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  • 7
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    Online Resource
    Percutaneous left atrial appendage occlusion using different technologies in the United Kingdom: A multicenter registry
    Wiley ; 2017
    In:  Catheterization and Cardiovascular Interventions Vol. 89, No. 3 ( 2017-02-15), p. 484-492
    Details
    In: Catheterization and Cardiovascular Interventions, Wiley, Vol. 89, No. 3 ( 2017-02-15), p. 484-492
    Abstract: This study aimed at assessing the feasibility and long‐term efficacy of left atrial appendage occlusion (LAAO) in a “real world” setting. Background Although LAAO has recently emerged as an alternative to oral anticoagulants in patients with atrial fibrillation for the prevention of thromboembolic stroke, “real world” data about the procedure with different devices are lacking. Methods Eight centers in the United Kingdom contributed to a retrospective registry for LAAO procedures undertaken between July 2009 and November 2014. Results A total of 371 patients (72.9 ± 8.3 years old, 88.9% males) were enrolled. The overall procedure success was 92.5%, with major events in 3.5% of cases. The device choice was Watchman in 63% of cases, Amplatzer Cardiac Plug in 34.7%, Lariat in 1.7%, and Coherex WaveCrest in 0.6%. A significant improvement in procedure success (from 89.2% to 95.7%; P  = 0.018) and reduction of acute major complications (from 6.5% to 0.5%; P  = 0.001) were observed between procedures in the first and the second half of the recruitment time. An annual 90.1% relative risk reduction (RRR) for ischemic stroke, an 87.2% thromboembolic events RRR, and a 92.9% major bleeding RRR were observed, if compared with the predicted annual risks based on CHADS2, CHA2DS2‐Vasc, and HAS‐BLED scores, respectively, over a follow‐up period of 24.7 ± 16.07 months. Conclusions LAAO can be performed safely in a real world setting with good implant success rates and procedural outcomes. The long‐term benefits of the procedure are reassuring in terms of both ischemic events and avoidance of severe bleeding associated with anticoagulation in this patient group. © 2016 Wiley Periodicals, Inc.
    Type of Medium: Online Resource
    ISSN: 1522-1946 , 1522-726X
    URL: Issue
    URL: Article
    DOI: 10.1002/ccd.v89.3
    DOI: 10.1002/ccd.26782
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2001555-0
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  • 8
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    Online Resource
    Subproteome analysis of the neutrophil cytoskeleton
    Wiley ; 2009
    In:  PROTEOMICS Vol. 9, No. 7 ( 2009-04), p. 2037-2049
    Details
    In: PROTEOMICS, Wiley, Vol. 9, No. 7 ( 2009-04), p. 2037-2049
    Abstract: Neutrophils play a key role in the early host‐defense mechanisms due to their capacity to migrate into inflamed tissues and phagocytose microorganisms. The cytoskeleton has an essential role in these neutrophil functions, however, its composition is still poorly understood. We separately analyzed different cytoskeletal compartments: cytosolic skeleton, phagosome membrane skeleton, and plasma membrane skeleton. Using a proteomic approach, 138 nonredundant proteins were identified. Proteins not previously known to associate with the skeleton were: n ‐acetylglucosamine kinase, phosphoglycerate mutase 1, prohibitin, ficolin‐1, phosphogluconate dehydrogenase, glucosidase, transketolase, major vault protein, valosin‐containing protein, aldehyde dehydrogenase, and lung cancer‐related protein‐8 (LCRP8). The majority of these proteins can be classified as energy metabolism enzymes. Such a finding was interesting because neutrophil energy metabolism is unusual, mainly relying on glycolysis. The enrichment of phosphoglycerate mutase in cytosolic skeleton was additionally indicated by the use of Western blotting. This is the broadest subcellular investigation to date of the neutrophil cytoskeletal proteome and the first proteomic analysis in any cell type of the phagosome skeleton. The association of metabolic enzymes with cytoskeleton is suggestive of the importance of their localized enrichment and macromolecular organization in neutrophils.
    Type of Medium: Online Resource
    ISSN: 1615-9853 , 1615-9861
    URL: Issue
    URL: Article
    DOI: 10.1002/pmic.v9:7
    DOI: 10.1002/pmic.200800674
    Language: English
    Publisher: Wiley
    Publication Date: 2009
    detail.hit.zdb_id: 2037674-1
    SSG: 12
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  • 9
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    A variant form of X-linked chronic granulomatous disease with normal nitroblue tetrazolium slide test and cytochrome b
    Wiley ; 1983
    In:  European Journal of Clinical Investigation Vol. 13, No. 3 ( 1983-06), p. 243-247
    Details
    In: European Journal of Clinical Investigation, Wiley, Vol. 13, No. 3 ( 1983-06), p. 243-247
    Type of Medium: Online Resource
    ISSN: 0014-2972 , 1365-2362
    URL: Article
    DOI: 10.1111/j.1365-2362.1983.tb00095.x
    Language: English
    Publisher: Wiley
    Publication Date: 1983
    detail.hit.zdb_id: 2004971-7
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  • 10
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    Online Resource
    Investigations of host defence in patients with sickle cell disease
    Wiley ; 1985
    In:  British Journal of Haematology Vol. 59, No. 3 ( 1985-03), p. 523-531
    Details
    In: British Journal of Haematology, Wiley, Vol. 59, No. 3 ( 1985-03), p. 523-531
    Type of Medium: Online Resource
    ISSN: 0007-1048 , 1365-2141
    URL: Article
    DOI: 10.1111/j.1365-2141.1985.tb07339.x
    RVK:
    XA 34100
    Language: English
    Publisher: Wiley
    Publication Date: 1985
    detail.hit.zdb_id: 1475751-5
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