In:
FEBS Letters, Wiley, Vol. 591, No. 19 ( 2017-10), p. 2978-2991
Abstract:
The response of immune cells to pathogens is often associated with changes in the flux through basic metabolic pathways. Indeed, in many cases changes in metabolism appear to be necessary for a robust immune response. The Liver X receptors ( LXR s) are members of the nuclear hormone receptor superfamily that regulate gene networks controlling cholesterol and lipid metabolism. In immune cells, particularly in macrophages, LXR s also inhibit proinflammatory gene expression. This Review will highlight recent studies that connect LXR ‐dependent control of lipid metabolism to regulation of the immune response.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1002/feb2.2017.591.issue-19
DOI:
10.1002/1873-3468.12702
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
1460391-3
SSG:
12
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