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  • 1
    Online Resource
    Online Resource
    Risk of autism spectrum disorders after infantile spasms: A population‐based study nested in a cohort with seizures in the first year of life
    Wiley ; 2008
    In:  Epilepsia Vol. 49, No. 11 ( 2008-11), p. 1865-1870
    Details
    In: Epilepsia, Wiley, Vol. 49, No. 11 ( 2008-11), p. 1865-1870
    Abstract: Purpose:   No population‐based study has investigated the risk of autism spectrum disorders (ASDs) in children after unprovoked seizures with onset in the first year of life. Our objective was to determine whether infantile spasms were related to risk of ASD as compared to unprovoked seizures with onset in the first year of life after adjusting for symptomatic origin of seizures. Methods:   This is a population‐based case‐control study nested in a cohort of children with unprovoked seizures in the first year of life. The cohort comprised 95 children, 34 boys and 61 girls. Cases were defined as children with ASD, controls were without ASD, and exposure was a history of infantile spasms. The Mantel‐Haenszel test and logistic regression were used to calculate the odds ratio (OR) and 95% confidence intervals (CI). Results:   The crude OR for ASD associated with infantile spasms was 5.53 (95% CI 1.25–23.06). Stratification on age and gender did not change the OR. The OR for ASD associated with infantile spasms adjusted for symptomatic seizures was 1.55 (95% CI 0.33–7.37), while the OR for ASD associated with symptomatic seizures adjusted for infantile spasms was 8.73 (95% CI 1.88–40.54). Restriction to mental age 24 months or higher yielded higher ORs. Discussion:   Infantile spasms predicted high risk for ASD, but this was to a large extent explained by the association of ASD with symptomatic origin of seizures.
    Type of Medium: Online Resource
    ISSN: 0013-9580 , 1528-1167
    URL: Issue
    URL: Article
    DOI: 10.1111/epi.2008.49.issue-11
    DOI: 10.1111/j.1528-1167.2008.01688.x
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2008
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    detail.hit.zdb_id: 2002194-X
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  • 2
    Online Resource
    Online Resource
    Psychiatric disorders in an urban sample of preschool children
    Wiley ; 2013
    In:  Child and Adolescent Mental Health Vol. 18, No. 4 ( 2013-11), p. 210-217
    Details
    In: Child and Adolescent Mental Health, Wiley, Vol. 18, No. 4 ( 2013-11), p. 210-217
    Abstract: To increase limited epidemiological knowledge of early childhood psychopathology, a study of prevalence estimates and demographic correlates of psychiatric disorders was conducted in a sample of preschool children. Methods In a two‐stage study, parents of 339 children aged 4–6 years who came for a medical check‐up at three primary care centres in R eykjavik were invited to participate. First, the participants were screened with Brigance Screens and the Strengths and Difficulties Questionnaire ( SDQ ) for parents and teachers. Subsequently, the children were tested with a short version of W echsler Preschool and Primary Scales of Intelligence – Revised and their parents were interviewed with the Schedule for Affective Disorders and Schizophrenia for School Aged Children Present and Lifetime Version. Weighted prevalence estimates were calculated and logistic regression was used to analyse the association between risk factors and psychiatric disorders. Results Of those invited to participate, 317 (93.5%) were included in the screening and of those, 131 received a full diagnostic assessment. The final study sample included 151 girls (47.6%) and 166 boys (52.4%) who represented 11.6% of the total birth cohort in R eykjavik. Weighted prevalence of DSM ‐ IV psychiatric disorders was 10.1% (95% CI 6.7–13.5%) and 57/317 or 18.0% (95% CI 13.8–22.2%), including elimination disorders. Anxiety disorders (5.7%) and attention deficit hyperactivity disorder (3.8%) were the most common disorders in this preschool sample. Poor physical health of parents and higher education was associated with DSM ‐ IV psychiatric disorders of the children. SDQ Total Difficulties score was associated with male gender and poor physical health of parents. Conclusions This study indicates that psychiatric disorders in preschool children are common and may be correlated with parental health factors.
    Type of Medium: Online Resource
    ISSN: 1475-357X , 1475-3588
    URL: Issue
    URL: Article
    DOI: 10.1111/camh.2013.18.issue-4
    DOI: 10.1111/j.1475-3588.2012.00675.x
    Language: English
    Publisher: Wiley
    Publication Date: 2013
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    detail.hit.zdb_id: 2073663-0
    SSG: 2,1
    SSG: 5,2
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  • 3
    Online Resource
    Online Resource
    Autism Spectrum Disorders in Children with Seizures in the First Year of Life—A Population‐Based Study
    Wiley ; 2007
    In:  Epilepsia Vol. 48, No. 9 ( 2007-09), p. 1724-1730
    Details
    In: Epilepsia, Wiley, Vol. 48, No. 9 ( 2007-09), p. 1724-1730
    Abstract: Summary:  Purpose: To describe autistic spectrum disorders (ASDs) in a cohort of children with history of unprovoked seizures other than infantile spasms in the first year of life. Methods: The source of data was computer records from all the three pediatric departments in Iceland. Children diagnosed 1982–2000 with unprovoked seizures with onset between 28 days and 12 months of age (N = 102) were invited to participate in a study. Children with known developmental disorders and those whose parents had concerns regarding their child's development or behavior were investigated for possible ASD. Parents were asked to complete the Social Communication Questionnaire and children scoring 10 points or higher were further examined with the Autism Diagnostic Interview‐Revised and observational measures. Results: Eighty‐four children (82.4%), 28 boys and 56 girls, participated in the study and 36.9% (31/84) were investigated for possible ASD. Twenty‐four (28.6%) had at least one neurodevelopmental disorder, 14.3% had mental retardation (MR), and six (7.1%) were diagnosed with ASD, all of whom also had MR and three of whom had congenital brain abnormalities. Conclusion: These results suggest that the estimated prevalence of ASD is higher in children with history of seizure in the first year of life than it is in the general population. There are indications that support the view that children with ASD and history of seizure in the first year of life have higher prevalence of congenital brain abnormalities and are more often female, than other children with ASD.
    Type of Medium: Online Resource
    ISSN: 0013-9580 , 1528-1167
    URL: Issue
    URL: Article
    DOI: 10.1111/epi.2007.48.issue-9
    DOI: 10.1111/j.1528-1167.2007.01150.x
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2007
    detail.hit.zdb_id: 216382-2
    detail.hit.zdb_id: 2002194-X
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  • 4
    Online Resource
    Online Resource
    No association between a common single nucleotide polymorphism, rs4141463, in the MACROD2 gene and autism spectrum disorder
    Wiley ; 2011
    In:  American Journal of Medical Genetics Part B: Neuropsychiatric Genetics Vol. 156, No. 6 ( 2011-09), p. 633-639
    Details
    In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Wiley, Vol. 156, No. 6 ( 2011-09), p. 633-639
    Abstract: The Autism Genome Project (AGP) Consortium recently reported genome‐wide significant association between autism and an intronic single nucleotide polymorphism marker, rs4141463, within the MACROD2 gene. In the present study we attempted to replicate this finding using an independent case–control design of 1,170 cases with autism spectrum disorder (ASD) (874 of which fulfilled narrow criteria for Autism (A)) from five centers within Europe (UK, Germany, the Netherlands, Italy, and Iceland), and 35,307 controls. The combined sample size gave us a non‐centrality parameter (NCP) of 11.9, with 93% power to detect allelic association of rs4141463 at an alpha of 0.05 with odds ratio of 0.84 (the best odds ratio estimate of the AGP Consortium data), and for the narrow diagnosis of autism, an NCP of 8.9 and power of 85%. Our case–control data were analyzed for association, stratified by each center, and the summary statistics were combined using the meta‐analysis program, GWAMA. This resulted in an odds ratio (OR) of 1.03 (95% CI 0.944–1.133), with a P ‐value of 0.5 for ASD and OR of 0.99 (95% CI 0.88–1.11) with P ‐value = 0.85 for the Autism (A) sub‐group. Therefore, this study does not provide support for the reported association between rs4141463 and autism. © 2011 Wiley‐Liss, Inc.
    Type of Medium: Online Resource
    ISSN: 1552-4841 , 1552-485X
    URL: Issue
    URL: Article
    DOI: 10.1002/ajmg.b.v156.6
    DOI: 10.1002/ajmg.b.31201
    Language: English
    Publisher: Wiley
    Publication Date: 2011
    detail.hit.zdb_id: 2143866-3
    detail.hit.zdb_id: 2108616-3
    SSG: 12
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