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  • 1
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    Online Resource
    Psychiatric outcomes at age seven for very preterm children: rates and predictors
    Wiley ; 2013
    In:  Journal of Child Psychology and Psychiatry Vol. 54, No. 7 ( 2013-07), p. 772-779
    Details
    In: Journal of Child Psychology and Psychiatry, Wiley, Vol. 54, No. 7 ( 2013-07), p. 772-779
    Abstract: Background:  Uncertainty remains about the rate of specific psychiatric disorders and associated predictive factors for very preterm (VPT) children. The aims of this study were to document rates of psychiatric disorders in VPT children aged 7 years compared with term born children, and to examine potential predictive factors for psychiatric diagnoses in VPT children. Methods:  Participants were 177 VPT and 65 term born children. Perinatal medical data were collected, which included brain abnormalities detected using magnetic resonance imaging. The Infant‐Toddler Social‐Emotional Assessment (ITSEA) and Strengths and Difficulties Questionnaire (SDQ) were administered at 2 and 5 years respectively. At 7 years of age, the Developmental and Well‐being Assessment (DAWBA) was used to indicate psychiatric diagnoses. Results:  Compared with term born children, VPT children had three times the odds of meeting criteria for any psychiatric diagnosis at age 7 years (odds ratio 3.03; 95% confidence interval 1.23, 7.47, p  = .02). The most common diagnoses were anxiety disorders (11% VPT, 8% term), attention‐deficit/hyperactivity disorder (10% VPT, 3% term) and autism spectrum disorder (4.5% VPT, 0% term). For VPT children, those with severe global brain abnormalities ( p  = .02), those who displayed social‐emotional problems at age 5 ( p  = .000) and those with higher social risk at age 7 ( p  = .001) were more likely to meet criteria for a psychiatric illness at age 7. Conclusions:  Compared with term born children, VPT children have higher rates of psychiatric diagnoses at early school age, predicted by neonatal brain abnormalities, prior social‐emotional problems and social factors.
    Type of Medium: Online Resource
    ISSN: 0021-9630 , 1469-7610
    URL: Issue
    URL: Article
    DOI: 10.1111/jcpp.2013.54.issue-7
    DOI: 10.1111/jcpp.12040
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 1470297-6
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  • 2
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    Maternal and family factors differentiate profiles of psychiatric impairments in very preterm children at age 5‐years
    Wiley ; 2020
    In:  Journal of Child Psychology and Psychiatry Vol. 61, No. 2 ( 2020-02), p. 157-166
    Details
    In: Journal of Child Psychology and Psychiatry, Wiley, Vol. 61, No. 2 ( 2020-02), p. 157-166
    Abstract: Very preterm ( VPT ; 〈 30 weeks gestation) children are a heterogeneous group, yet the co‐occurrence of psychiatric and neurodevelopmental impairments remains unclear. Moreover, the clinical and socio‐environmental factors that promote resilient developmental outcomes among VPT children are poorly understood. Methods One hundred and twenty five children (85 VPT and 40 full‐term) underwent neurodevelopmental evaluation at age 5‐years. Parents and teachers completed measures of internalizing, externalizing, attention‐deficit/hyperactivity ( ADHD ), and autism symptoms. Psychiatric and neurodevelopmental measures were analyzed using Latent Profile Analysis. Multinomial regression examined the extent that infant, sociodemographic, and family factors, collected prospectively from birth to follow‐up, independently differentiated resilient and impaired children. Results Four latent profiles were identified, including a Typically Developing Group which represented 27.1% of the VPT group and 65.0% of the full‐term group, an At‐Risk Group with mild psychiatric and neurodevelopmental problems ( VPT 44.7%, full‐term 22.5%), a Psychiatric Group with moderate‐to‐severe psychiatric ratings ( VPT 12.9%, full‐term 10.0%), and a school‐based Inattentive/Hyperactive Group ( VPT 15.3%, full‐term 2.5%). Clinical diagnoses were highest among the Psychiatric Group (80%). Factors that differentiated resilient and impaired subgroups of VPT children included prolonged exposure to maternal psychosocial distress ( p  ≤   .04), current family dysfunction ( p  ≤   .05), and maternal ADHD symptoms ( p  ≤   .02), whereas social risk index scores differentiated resilient and impaired full‐term children ( p  〈   .03). Conclusions Lower levels of maternal distress, family dysfunction, and maternal ADHD symptoms were associated with resilience among VPT children. Maternal distress and family dysfunction are modifiable factors to be targeted as part of psychiatric interventions embedded in the long‐term care of VPT children.
    Type of Medium: Online Resource
    ISSN: 0021-9630 , 1469-7610
    URL: Issue
    URL: Article
    DOI: 10.1111/jcpp.v61.2
    DOI: 10.1111/jcpp.13116
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 1470297-6
    SSG: 5,2
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  • 3
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    Online Resource
    An allometric scaling relationship in the brain of preterm infants
    Wiley ; 2014
    In:  Annals of Clinical and Translational Neurology Vol. 1, No. 11 ( 2014-11), p. 933-937
    Details
    In: Annals of Clinical and Translational Neurology, Wiley, Vol. 1, No. 11 ( 2014-11), p. 933-937
    Abstract: Allometry has been used to demonstrate a power–law scaling relationship in the brain of premature born infants. Forty‐nine preterm infants underwent neonatal MRI scans and neurodevelopmental testing at age 2 . Measures of cortical surface area and total cerebral volume demonstrated a power–law scaling relationship ( α  = 1.27). No associations were identified between these measures and investigated clinical variables. Term equivalent cortical surface area and total cerebral volume measures and scaling exponents were not related to outcome. These findings confirm a previously reported allometric scaling relationship in the preterm brain, and suggest that scaling is not a sensitive indicator of aberrant cortical maturation.
    Type of Medium: Online Resource
    ISSN: 2328-9503 , 2328-9503
    URL: Article
    DOI: 10.1002/acn3.130
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2740696-9
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  • 4
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    Less attention to emotional faces is associated with low empathy and prosociality in 12‐to 20‐month old infants
    Wiley ; 2024
    In:  Infancy
    Details
    In: Infancy, Wiley
    Abstract: The development of empathy and prosocial behavior begins in infancy and is likely supported by emotion processing skills. The current study explored whether early emerging deficits in emotion processing are associated with disruptions in the development of empathy and prosociality. We investigated this question in a large, diverse sample of 147, 11‐ to 20‐month‐old infants (42% female; 61% Black; 67% low socioeconomic status). Infants completed two observational tasks assessing prosocial helping and one task assessing empathy and prosocial comforting behavior. Infants also completed an eye‐tracking task assessing engagement and disengagement with negative emotional faces. Infants who attended less to angry, sad, and fearful faces (i.e., by being slower to look at and/or quicker to look away from negative compared to neutral faces) engaged in fewer helping behaviors, and effect sizes were larger when examining infants' attention toward the eye regions of faces. Additionally, infants who were quicker to look away from the eye regions of angry faces, but not the whole face, displayed less empathy and comforting behaviors. Results suggest that as early as 12 months of age, infants' decreased attention toward negative emotional faces, particularly the eye regions, is associated with less empathy and prosociality during a developmental period in which these abilities are rapidly maturing.
    Type of Medium: Online Resource
    ISSN: 1525-0008 , 1532-7078
    URL: Article
    DOI: 10.1111/infa.12569
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2020049-3
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  • 5
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    Online Resource
    Maternal intelligence quotient ( IQ ) predicts IQ and language in very preterm children at age 5 years
    Wiley ; 2018
    In:  Journal of Child Psychology and Psychiatry Vol. 59, No. 2 ( 2018-02), p. 150-159
    Details
    In: Journal of Child Psychology and Psychiatry, Wiley, Vol. 59, No. 2 ( 2018-02), p. 150-159
    Abstract: Sociodemographic factors are linked to cognitive outcomes in children born very preterm ( VPT ; ≤30 weeks gestation). The influence of maternal intellectual ability, a heritable trait, is unknown. Also undetermined is the extent to which associations between maternal and child intellectual ability vary according to parenting behaviors that target cognitive stimulation in the home. Methods At age 5 years, 84 VPT and 38 demographically matched full‐term ( FT ) children underwent neurodevelopmental assessment. Children's intellectual ability was assessed using The Wechsler Preschool Primary Scale of Intelligence‐ III , and language was assessed with the Clinical Evaluation of Language Fundamentals Preschool‐2. The Wechsler Test of Adult Reading estimated maternal intellectual ability. The StimQ‐Preschool questionnaire provided a measure of cognitive stimulation in the home. Linear mixed‐effects models examined independent effects and interactions between maternal intellectual ability and cognitive stimulation on children's outcomes. Results After covariate adjustment, maternal intellectual ability was associated with child intellectual ( p  〈   .001) and language ( p  = .002) abilities. Stronger associations were observed in FT mother–child dyads ( B  = .63, p  =   .04) than VPT dyads ( B  = .42, p  =   .01). Mothers of VPT children reported lower levels of Parental Involvement in Developmental Advance ( p  =   .007) and Parental Verbal Responsiveness ( p  =   .04). Group differences in Parental Involvement in Developmental Advance, but not Parental Verbal Responsivity, persisted after adjusting for social background ( p  =   .03). There was no evidence of an interaction between maternal intellectual ability and Parental Involvement in Developmental Advance ( p  =   .34). Instead, maternal intellectual ability ( p  〈   .001) and Parental Involvement in Developmental Advance ( p  =   .05) independently predicted VPT children's outcomes. Conclusions Maternal intellectual ability is an important trait linked to VPT and FT children's intellectual and language outcomes. Prematurity increases variation in the heritability of intellectual ability and shifts children from the expected range based on maternal ability. Parental involvement in activities that help children master new skills may promote cognitive development in VPT children born to mothers of lower intellectual ability.
    Type of Medium: Online Resource
    ISSN: 0021-9630 , 1469-7610
    URL: Issue
    URL: Article
    DOI: 10.1111/jcpp.2018.59.issue-2
    DOI: 10.1111/jcpp.12810
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 1470297-6
    SSG: 5,2
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  • 6
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    Sleep and circadian rhythms during pregnancy, social disadvantage, and alterations in brain development in neonates
    Wiley ; 2024
    In:  Developmental Science Vol. 27, No. 3 ( 2024-05)
    Details
    In: Developmental Science, Wiley, Vol. 27, No. 3 ( 2024-05)
    Abstract: Pregnant women in poverty may be especially likely to experience sleep and circadian rhythm disturbances, which may have downstream effects on fetal neurodevelopment. However, the associations between sleep and circadian rhythm disturbances, social disadvantage during pregnancy, and neonatal brain structure remains poorly understood. The current study explored the association between maternal sleep and circadian rhythm disturbances during pregnancy and neonatal brain outcomes, examining sleep and circadian rhythm disturbances as a mediator of the effect of social disadvantage during pregnancy on infant structural brain outcomes. The study included 148 mother‐infant dyads, recruited during early pregnancy, who had both actigraphy and neuroimaging data. Mothers’ sleep was assessed throughout their pregnancy using actigraphy, and neonates underwent brain magnetic resonance imaging in the first weeks of life. Neonatal structural brain outcomes included cortical gray matter, subcortical gray matter, and white matter volumes along with a measure of the total surface area of the cortex. Neonates of mothers who experienced greater inter‐daily deviations in sleep duration had smaller total cortical gray and white matter volumes and reduced cortical surface areas. Neonates of mothers who had higher levels of circadian misalignment and later sleep timing during pregnancy showed smaller subcortical gray matter volumes. Inter‐daily deviations in sleep duration during pregnancy mediated the association between maternal social disadvantage and neonatal structural brain outcomes. Findings highlight the importance of regularity and rhythmicity in sleep schedules during pregnancy and bring to light the role of chronodisruption as a potential mechanism underlying the deleterious neurodevelopmental effects of prenatal adversity. Research Highlights Social disadvantage was associated with sleep and circadian rhythm disturbances during pregnancy, including later sleep schedules, increased variability in sleep duration, circadian misalignment, and a higher proportion of the sleep period spent awake. Maternal sleep and circadian rhythm disturbances during pregnancy were associated with decreased brain volume and reduced cortical surface area in neonates. Maternal inter‐daily deviations in sleep duration during pregnancy mediated the association between social disadvantage and neonatal brain volume and cortical surface area.
    Type of Medium: Online Resource
    ISSN: 1363-755X , 1467-7687
    URL: Issue
    URL: Article
    DOI: 10.1111/desc.v27.3
    DOI: 10.1111/desc.13456
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2023952-X
    SSG: 5,2
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  • 7
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    Special Reviewers
    Wiley ; 2005
    In:  Journal of Marriage and Family Vol. 67, No. 5 ( 2005-12), p. 1355-1358
    Details
    In: Journal of Marriage and Family, Wiley, Vol. 67, No. 5 ( 2005-12), p. 1355-1358
    Type of Medium: Online Resource
    ISSN: 0022-2445 , 1741-3737
    URL: Issue
    URL: Article
    DOI: 10.1111/jomf.2005.67.issue-5
    DOI: 10.1111/j.1741-3737.2005.00226.x
    RVK:
    MN 1000
    Language: English
    Publisher: Wiley
    Publication Date: 2005
    detail.hit.zdb_id: 218322-5
    detail.hit.zdb_id: 2066605-6
    SSG: 3,4
    SSG: 5,2
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  • 8
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    Bone Research Society Abstracts
    Wiley ; 2018
    In:  JBMR Plus Vol. 2, No. S1 ( 2018-09)
    Details
    In: JBMR Plus, Wiley, Vol. 2, No. S1 ( 2018-09)
    Type of Medium: Online Resource
    ISSN: 2473-4039 , 2473-4039
    URL: Issue
    URL: Article
    DOI: 10.1002/jbm4.v2.S1
    DOI: 10.1002/jbm4.10073
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2905710-3
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  • 9
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    An investigation of indirect effects of personality features on anorexia nervosa severity through interoceptive dysfunction in individuals with lifetime anorexia nervosa diagnoses
    Wiley ; 2019
    In:  International Journal of Eating Disorders Vol. 52, No. 2 ( 2019-02), p. 200-205
    Details
    In: International Journal of Eating Disorders, Wiley, Vol. 52, No. 2 ( 2019-02), p. 200-205
    Abstract: This study examined a hypothesized pathway by which interoceptive dysfunction accounted for associations between personality features (harm avoidance, self‐directedness, and perfectionism) and anorexia nervosa (AN) severity (indicated by drive for thinness, eating disorder‐related preoccupations and rituals, and body mass index). Method The study sample ( n  = 270, mean age = 28.47, 95.2% female, 98% White/Caucasian) consisted of probands and biological relatives who met DSM‐IV criteria for lifetime diagnoses of AN (omitting criterion D, amenorrhea) drawn from the Price Foundation Anorexia Nervosa Affected Relative Pairs Study (AN‐ARP). Participants completed measures assessing personality, interoceptive dysfunction, and eating pathology. Results Associations between personality features of low self‐directedness and high perfectionism and indicators of AN severity (drive for thinness and eating disorder‐related preoccupations and rituals) were significant, as were the hypothesized indirect pathways through interoceptive dysfunction. Neither harm avoidance nor body mass index was significantly related to other study variables, and the proposed indirect pathways involving these variables were not significant. Discussion Findings suggest that certain personality features may relate to AN severity, in part, through their associations with interoceptive dysfunction. Future research should examine prospective associations and the value of interventions targeting interoceptive dysfunction for interrupting the link between personality and AN severity.
    Type of Medium: Online Resource
    ISSN: 0276-3478 , 1098-108X
    URL: Issue
    URL: Article
    DOI: 10.1002/eat.v52.2
    DOI: 10.1002/eat.23008
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 1492880-2
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  • 10
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    Effects of hydroxyurea treatment for patients with hemoglobin SC disease
    Wiley ; 2016
    In:  American Journal of Hematology Vol. 91, No. 2 ( 2016-02), p. 238-242
    Details
    In: American Journal of Hematology, Wiley, Vol. 91, No. 2 ( 2016-02), p. 238-242
    Abstract: Although hemoglobin SC (HbSC) disease is usually considered less severe than sickle cell anemia (SCA), which includes HbSS and HbS/β 0 ‐thalassemia genotypes, many patients with HbSC experience severe disease complications, including vaso‐occlusive pain, acute chest syndrome, avascular necrosis, retinopathy, and poor quality of life. Fully 20 years after the clinical and laboratory efficacy of hydroxyurea was proven in adult SCA patients, the safety and utility of hydroxyurea treatment for HbSC patients remain unclear. Recent NHLBI evidence‐based guidelines highlight this as a critical knowledge gap, noting HbSC accounts for ∼30% of sickle cell patients within the United States. To date, only 5 publications have reported short‐term, incomplete, or conflicting laboratory and clinical outcomes of hydroxyurea treatment in a total of 71 adults and children with HbSC. We now report on a cohort of 133 adult and pediatric HbSC patients who received hydroxyurea, typically for recurrent vaso‐occlusive pain. Hydroxyurea treatment was associated with a stable hemoglobin concentration; increased fetal hemoglobin (HbF) and mean corpuscular volume (MCV); and reduced white blood cell count (WBC), absolute neutrophil count (ANC), and absolute reticulocyte count (ARC). Reversible cytopenias occurred in 22% of patients, primarily neutropenia and thrombocytopenia. Painful events were reduced with hydroxyurea, more in patients 〉 15 years old. These multicenter data support the safety and potentially salutary effects of hydroxyurea treatment for HbSC disease; however, a multicenter, placebo‐controlled, Phase 3 clinical trial is needed to determine if hydroxyurea therapy has efficacy for patients with HbSC disease. Am. J. Hematol. 91:238–242, 2016. © 2015 Wiley Periodicals, Inc.
    Type of Medium: Online Resource
    ISSN: 0361-8609 , 1096-8652
    URL: Issue
    URL: Article
    DOI: 10.1002/ajh.v91.2
    DOI: 10.1002/ajh.24255
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 1492749-4
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