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  • Wiley  (324)
  • 1
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    Serum uric acid is associated with incidence of heart failure with preserved ejection fraction and cardiovascular events in patients with arterial hypertension
    Wiley ; 2018
    In:  The Journal of Clinical Hypertension Vol. 20, No. 3 ( 2018-03), p. 560-567
    Details
    In: The Journal of Clinical Hypertension, Wiley, Vol. 20, No. 3 ( 2018-03), p. 560-567
    Abstract: The objective of the present study was to evaluate clinical implications of serum uric acid ( UA ) on the progression of heart failure with preserved ejection fraction ( HF p EF ) in hypertensive patients. A total of 1009 adult patients with left ventricular hypertrophy and suspected left ventricular diastolic dysfunction were enrolled at our hospital from January 2008 to December 2011. With a median follow‐up of 7.2 years, 136 (13.2%) patients developed new‐onset HF p EF and 151 (15.0%) had major adverse cardiovascular events ( MACE s). Compared with the lowest UA tertile of UA ( 〈 302 μmol L −1 ), subjects in the highest tertile ( 〉 367 μmol L −1 ) had a higher risk of developing new‐onset HF p EF ( HR : 1.761, 95% CI : 1.119‐2.772, P  = .015) as well as MACE s ( HR : 1.664, 95% CI : 1.086‐2.547, P  = .019). Our findings indicate that hyperuricemia is associated with detrimental effects in terms of the incidence of new‐onset HF p EF as well as MACE s in hypertensive patient.
    Type of Medium: Online Resource
    ISSN: 1524-6175 , 1751-7176
    URL: Issue
    URL: Article
    DOI: 10.1111/jch.2018.20.issue-3
    DOI: 10.1111/jch.13210
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2058690-5
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  • 2
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    Characteristics and outcomes of transitions among heart failure categories: a prospective observational cohort study
    Wiley ; 2020
    In:  ESC Heart Failure Vol. 7, No. 2 ( 2020-04), p. 616-625
    Details
    In: ESC Heart Failure, Wiley, Vol. 7, No. 2 ( 2020-04), p. 616-625
    Abstract: Patients with heart failure (HF) are typically designated as having reduced, mid‐range, or preserved ejection fraction (EF) (HFrEF, HFmrEF, or HFpEF, respectively) because of the importance of left ventricular EF (LVEF) on therapeutic decisions and prognosis. However, such designations are not necessarily static, as there are many transitions among the three HF phenotypes during follow‐up. This prospective longitudinal cohort study sought to examine the HF transitions over time and their clinical characteristics, prognosis, and response to medical therapy. Methods and results We identified 1920 patients from a prospective cohort with a primary diagnosis of HF between 1 January 2007 and 31 December 2012. The enrolled HF patients were re‐classified into three groups on the basis of baseline and 1 year follow‐up echocardiography: HF with improved EF (HFiEF), HF with deteriorated EF (HFdEF), and HF with unchanged EF (HFuEF). The primary outcome was 5 year all‐cause mortality. According to 1 year follow‐up echocardiography, 490 (25.5%) were diagnosed as HFiEF, 179 (9.3%) as HFdEF, and 1251 (65.2%) as HFuEF. Ischaemic heart disease was an independent predictor of HFdEF, and beta‐blocker prescription was an independent predictor of HFiEF. During the 5 year follow‐up, patients with HFdEF had higher mortality, whereas patients with HFiEF had lower mortality. After adjustment, HFiEF, compared with HFuEF, was associated with a 62.1% decreased risk for mortality. Finally, the use of beta‐blockers was associated with improved prognosis of patients with HFiEF and HFuEF. Conclusions In this cohort of patients with HF, LVEF is a dynamic factor related to coexisting conditions and drug therapy. HFiEF and HFdEF are distinct HF phenotypes with different clinical outcomes than other phenotypes.
    Type of Medium: Online Resource
    ISSN: 2055-5822 , 2055-5822
    URL: Issue
    URL: Article
    DOI: 10.1002/ehf2.v7.2
    DOI: 10.1002/ehf2.12619
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2814355-3
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  • 3
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    Optimal management of blood glucose, blood pressure and atrial fibrillation to reduce the risk of heart failure with preserved ejection fraction
    Wiley ; 2022
    In:  Internal Medicine Journal Vol. 52, No. 2 ( 2022-02), p. 301-309
    Details
    In: Internal Medicine Journal, Wiley, Vol. 52, No. 2 ( 2022-02), p. 301-309
    Abstract: Type 2 diabetes mellitus (T2DM), hypertension and atrial fibrillation (AF) are risk factors for heart failure with preserved ejection fraction (HFpEF). Aim To examine the effects of the simultaneous control of all three conditions on new‐onset HFpEF in this population. Methods This prospective cohort study enrolled 552 patients with T2DM, hypertension and AF, but without clinical signs or symptoms of heart failure. The participants were followed up for 5 years to examine the effects of glycaemic control (haemoglobin A1c: 〈 7.0%, 7.0%–8.0% and 〉 8.0%), blood pressure (BP) control (systolic BP: 〈 120, 120–140 and 〉 140 mmHg) or rhythm versus rate control for AF on new‐onset HFpEF. Results With a follow up of 5 years, the new‐onset HFpEF occurred in 62 of 552 enrolled participants. Among the different control level for diabetes, hypertension and AF, the intensive blood glucose (BG) control, poor BP control and rate control of AF had the highest risk of new‐onset HFpEF, and the conservative BG control, intensive BP control and rhythm control of AF had the lowest risk of new‐onset HFpEF. Multivariable Cox regression analysis showed that both poor BP control (hazard ratio (HR): 1.421, 95% confidence interval (CI): 1.013–1.992, P = 0.042) and rate control of AF (HR: 1.362, 95% CI: 1.006–1.821, P = 0.033) were independently associated with the development of new‐onset HFpEF. Conclusion This study demonstrated that, besides intensive BP control, conservative BG control and rhythm control of AF were crucial factors to delay the progression of HFpEF among patients with T2DM, hypertension and AF.
    Type of Medium: Online Resource
    ISSN: 1444-0903 , 1445-5994
    URL: Issue
    URL: Article
    DOI: 10.1111/imj.v52.2
    DOI: 10.1111/imj.15006
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2044081-9
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  • 4
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    Left ventricular geometry transition in hypertensive patients with heart failure with preserved ejection fraction
    Wiley ; 2021
    In:  ESC Heart Failure Vol. 8, No. 4 ( 2021-08), p. 2784-2790
    Details
    In: ESC Heart Failure, Wiley, Vol. 8, No. 4 ( 2021-08), p. 2784-2790
    Abstract: Heart failure with preserved ejection fraction (HFpEF) develops in response to hypertensive left ventricular (LV) hypertrophy and is associated with increased cardiovascular events. Although the progression to systolic heart failure is a known consequence of LV hypertrophy and HFpEF, few data are available on the LV geometry change and frequency of deterioration to systolic dysfunction in this population. Methods and results We evaluated the baseline and follow‐up characteristics in 680 patients with LV hypertrophy and HFpEF in this prospective cohort study. The primary endpoint was 5 year all‐cause mortality. The changes of LV geometry and heart failure transition were analysed. Systolic dysfunction [left ventricular ejection fraction (LVEF)  〈  50%] occurred in 182 patients (26.8%) during a 5 year follow‐up. Patients with LVEF deterioration were associated with a lower survival rate. Beta‐blocker prescription was a protective factor for preserved LVEF. And concentric LV geometry shifted to eccentric hypertrophy was uncommon (10.6%) during a 5 year follow‐up. Conclusions A quarter of patients with hypertensive LV hypertrophy and HFpEF progresses to systolic dysfunction during a 5 year follow‐up, which was accompanied by poor clinical outcomes. And beta‐blocker therapy might play a protective role for preserved LVEF in this population.
    Type of Medium: Online Resource
    ISSN: 2055-5822 , 2055-5822
    URL: Issue
    URL: Article
    DOI: 10.1002/ehf2.v8.4
    DOI: 10.1002/ehf2.13349
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2814355-3
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  • 5
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    Predicting potential distribution of Ziziphus spinosa (Bunge) H.H. Hu ex F.H. Chen in China under climate change scenarios
    Wiley ; 2022
    In:  Ecology and Evolution Vol. 12, No. 2 ( 2022-02)
    Details
    In: Ecology and Evolution, Wiley, Vol. 12, No. 2 ( 2022-02)
    Abstract: Ziziphus spinosa (Bunge) H.H. Hu ex F.H. Chen is a woody plant species of the family Rhamnaceae (order Rhamnales) that possesses high nutritional and medicinal value. Predicting the effects of climate change on the distribution of Z . spinosa is of great significance for the investigation, protection, and exploitation of this germplasm resource. For this study, optimized maximum entropy models were employed to predict the distribution patterns and changes of its present (1970–2000) and future (2050s, 2070s, and 2090s) potential suitable regions in China under multiple climate scenarios (SSP1‐2.6, SSP2‐4.5, SSP3‐7.0 & SSP5‐8.5). The results revealed that the total area of the present potential suitable region for Z . spinosa is 162.60 × 10 4  km 2 , which accounts for 16.94% of China's territory. Within this area, the regions having low, medium, and high suitability were 80.14 × 10 4  km 2 , 81.50 × 10 4  km 2 , and 0.96 × 10 4  km 2 , respectively, with the high suitability regions being distributed primarily in Shanxi, Hebei, and Beijing Provinces. Except for SSP‐1‐2.6‐2070s, SSP‐5‐8.5‐2070s, and SSP‐5‐8.5‐2090s, the suitable areas for Z . spinosa in the future increased to different degrees. Meanwhile, considering the distribution of Z . spinosa during different periods and under different climate scenarios, our study predicted that the low impact areas of Z . spinosa were mainly restricted to Shanxi, Shaanxi, Ningxia, Gansu, Liaoning, Inner Mongolia, and Jilin Provinces. The results of core distributional shifts showed that, except for SSP1‐2.6, the center of the potential suitable region of Z . spinosa exhibited a trend of gradually shifting to the northwest.
    Type of Medium: Online Resource
    ISSN: 2045-7758 , 2045-7758
    URL: Issue
    URL: Article
    DOI: 10.1002/ece3.v12.2
    DOI: 10.1002/ece3.8629
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2635675-2
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  • 6
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    Chemotherapeutic perfusion of portal vein after tumor thrombectomy and hepatectomy benefits patients with advanced hepatocellular carcinoma: A propensity score‐matched survival analysis
    Wiley ; 2019
    In:  Cancer Medicine Vol. 8, No. 16 ( 2019-11), p. 6933-6944
    Details
    In: Cancer Medicine, Wiley, Vol. 8, No. 16 ( 2019-11), p. 6933-6944
    Abstract: Portal vein tumor thrombus (PVTT) is a common complication in hepatocellular carcinoma (HCC), signaling dismal outcomes. This study was conducted to evaluate the survival benefit of postoperative portal vein perfusion chemotherapy (PVC) in patients with HCC and PVTT. Methods A retrospective review was conducted in 401 consecutive patients with HCC and PVTT who underwent hepatic resection between January 2009 and December 2015 and 67 patients received adjuvant postoperative PVC. A propensity score matching (PSM) was used to match patients with and without PVC at a ratio of 1:1. Results After PSM, the median time to recurrence (TTR) and overall survival (OS) were significantly longer in PVC group compared with control group (12.3 vs 5.8 months, P  = .001; 19.0 vs 13.4 months, P  = .037; respectively). At 1, 2, 3, and 5 years, the cumulative recurrence rates in PVC group were 48.1%, 86.5%, 92.3% ,96.2%, respectively, with OS rates of 63.8%, 37.9%, 24.4%, 18.3%, respectively; whereas cumulative recurrence rates of 76.6%, 91.5%, 94.3%, and 97.2%, respectively and OS rates of 55.4%, 23.0%, 12.4%, and 12.4%, respectively were recorded for the control group. In multivariate analysis, postoperative PVC emerged as a significant predictor for TTR (hazard ratio [HR], 0.523; P  = .001) and OS (HR, 0.591; P  = .010). PVC could reduce early recurrence (≤1 year) rate after surgical resection (40.3% vs 64.2%, P  = .006) and clinical outcomes were further enhanced by adding sorafenib to postoperative PVC. Conclusions Compared with surgical resection alone, postoperative adjuvant PVC treatment boosts survival and reduces early tumor recurrences in patients surgically treated for HCC and PVTT.
    Type of Medium: Online Resource
    ISSN: 2045-7634 , 2045-7634
    URL: Issue
    URL: Article
    DOI: 10.1002/cam4.v8.16
    DOI: 10.1002/cam4.2556
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2659751-2
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  • 7
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    Investigation on a Potential Targeting Drug Delivery System Consisting of Folate, Mitoxantrone and Human Serum Albumin
    Wiley ; 2008
    In:  Chinese Journal of Chemistry Vol. 26, No. 8 ( 2008-08), p. 1385-1389
    Details
    In: Chinese Journal of Chemistry, Wiley, Vol. 26, No. 8 ( 2008-08), p. 1385-1389
    Type of Medium: Online Resource
    ISSN: 1001-604X , 1614-7065
    URL: Issue
    URL: Article
    DOI: 10.1002/cjoc.v26:8
    DOI: 10.1002/cjoc.200890252
    Language: English
    Publisher: Wiley
    Publication Date: 2008
    detail.hit.zdb_id: 2144352-X
    SSG: 6,25
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  • 8
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    Mutation in the Non‐coding Sequence of Badh2 Gene Reduces its Transcription and Translation in Fragrant Rice ‘Nankai 138’
    Wiley ; 2016
    In:  Crop Science Vol. 56, No. 3 ( 2016-05), p. 1157-1162
    Details
    In: Crop Science, Wiley, Vol. 56, No. 3 ( 2016-05), p. 1157-1162
    Abstract: It has been previously demonstrated that loss‐of‐function mutations in the coding sequence of the betaine aldehyde dehydrogenase 2 (BADH2) gene result in the accumulation of 2‐acetyl‐1‐pyrroline (2‐AP), the key component of fragrance in most rice cultivars. In this work, a novel allele of the BADH2 gene, badh2‐p‐5′UTR , found in a new fragrant rice cultivar Nankai 138 was studied. In Nankai 138, mutations in the non‐coding sequence of the BADH2 gene result in downregulation of the mRNA. This makes the specific activity of the BADH2 protein in the Nankai 138 decline from 50 to 40% of the value observed in Nipponbare from 12 to 20 d after flowering, and subsequently leading an increase of 2‐AP content to 47.8 ng g –1 in brown rice. In conclusion, the mutations in non‐coding region of BADH2 gene in Nankai 138 weaken transcription of the gene thereby reducing the accumulation of the functional protein and conferring fragrance to rice. These results add to the current knowledge of molecular mechanism of fragrance in rice.
    Type of Medium: Online Resource
    ISSN: 0011-183X , 1435-0653
    URL: Article
    DOI: 10.2135/cropsci2014.03.0243
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 1480918-7
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  • 9
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    Microwave‐assisted fabrication of a mixed‐ligand [Cu 4 (μ 3 ‐OH) 2 ]‐cluster‐based metal–organic framework with coordinatively unsaturated metal sites for carboxylation of terminal alkynes with carbon dioxide
    Wiley ; 2021
    In:  Applied Organometallic Chemistry Vol. 35, No. 8 ( 2021-08)
    Details
    In: Applied Organometallic Chemistry, Wiley, Vol. 35, No. 8 ( 2021-08)
    Abstract: The development of efficient and stable metal–organic framework (MOF) catalysts with coordinatively unsaturated metal sites for modern organic synthesis is greatly important. Herein, a robust [Cu 4 (μ 3 ‐OH) 2 ]‐cluster‐based MOF (Cu‐MOF) with a mixed‐ligand system was successfully fabricated by a microwave‐assisted method under mild conditions. The as‐prepared Cu‐MOF catalyst possessing unsaturated Cu (II) sites exhibited excellent catalytic activity toward the direct carboxylation of 1‐ethynylbenzene with CO 2 , and various propiolic acid derivatives were synthesized in moderate to good yields under optimized reaction conditions. Furthermore, the catalyst remained stable and could be easily recycled for five sequential runs without incredible decrease in catalytic efficiency.
    Type of Medium: Online Resource
    ISSN: 0268-2605 , 1099-0739
    URL: Issue
    URL: Article
    DOI: 10.1002/aoc.v35.8
    DOI: 10.1002/aoc.6288
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1480791-9
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  • 10
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    Efficient adsorption separation of xylene isomers using a facilely fabricated cyclodextrin‐based metal–organic framework
    Wiley ; 2018
    In:  Journal of Chemical Technology & Biotechnology Vol. 93, No. 10 ( 2018-10), p. 2898-2905
    Details
    In: Journal of Chemical Technology & Biotechnology, Wiley, Vol. 93, No. 10 ( 2018-10), p. 2898-2905
    Abstract: Metal−organic frameworks (MOFs) are energy‐efficient adsorbents for separating industrial chemical feedstocks. A type of MOF containing an extended porous network of γ‐cyclodextrin (γ‐CD) and alkali metal salts, CD‐MOF, has potential applications in adsorption separation processes in the petrochemical industry. This study aims to present the adsorption efficiency of CD‐MOF‐1 in separating xylene regioisomers. Results The adsorption separation of xylene regioisomers on layered CD‐MOF‐1 microcrystals was studied using batch vapor‐phase adsorption and liquid‐phase breakthrough adsorption. CD‐MOF‐1 showed preferable adsorption of o ‐xylene over the other two isomers, with adsorption strength in the order o ‐xylene ( o X)  〉   m ‐xylene ( m X)  〉   p ‐xylene ( p X). With increased temperature, high adsorption capacities of o X and m X over p X were detected. However, this also resulted in a decrease of the separation factors of o X/ p X and m X/ p X. Conclusion The high resolution and large separation factors for o X/ p X and m X/ p X make CD‐MOF‐1 an efficient and reliable alternative adsorbent to the isolation protocols for xylene isomers currently used in the petrochemical industry. © 2018 Society of Chemical Industry
    Type of Medium: Online Resource
    ISSN: 0268-2575 , 1097-4660
    URL: Issue
    URL: Article
    DOI: 10.1002/jctb.2018.93.issue-10
    DOI: 10.1002/jctb.5644
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 1479465-2
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