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  • 1
    Online Resource
    Online Resource
    Spherization of red blood cells and platelet margination in COPD patients
    Wiley ; 2021
    In:  Annals of the New York Academy of Sciences Vol. 1485, No. 1 ( 2021-02), p. 71-82
    Details
    In: Annals of the New York Academy of Sciences, Wiley, Vol. 1485, No. 1 ( 2021-02), p. 71-82
    Abstract: Red blood cells (RBCs) in pathological situations undergo biochemical and conformational changes, leading to alterations in rheology involved in cardiovascular events. The shape of RBCs in volunteers and stable and exacerbated chronic obstructive pulmonary disease (COPD) patients was analyzed. The effects of RBC spherization on platelet transport (displacement in the flow field caused by their interaction with RBCs) were studied in vitro and by numerical simulations. RBC spherization was observed in COPD patients compared with volunteers. In in vitro experiments at a shear rate of 100 s −1 , treatment of RBCs with neuraminidase induced greater sphericity, which mainly affected platelet aggregates without changing aggregate size. At 400 s −1 , neuraminidase treatment changes both the size of the aggregates and the number of platelet aggregates. Numerical simulations indicated that RBC spherization induces an increase of the platelet mean square displacement, which is traditionally linked to the platelet diffusion coefficient. RBCs of COPD patients are more spherical than healthy volunteers. Experimentally, RBC spherization induces increased platelet transport to the wall. Additional studies are needed to understand the link between the effect of RBCs on platelet transport and the increased cardiovascular events observed in COPD patients.
    Type of Medium: Online Resource
    ISSN: 0077-8923 , 1749-6632
    URL: Issue
    URL: Article
    DOI: 10.1111/nyas.v1485.1
    DOI: 10.1111/nyas.14489
    RVK:
    TD 7650
    Language: English
    Publisher: Wiley
    Publication Date: 2021
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    detail.hit.zdb_id: 2071584-5
    SSG: 11
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  • 2
    Online Resource
    Online Resource
    Effects of red blood cell transfusion on global oxygenation in anemic critically ill patients
    Wiley ; 2021
    In:  Transfusion Vol. 61, No. 4 ( 2021-04), p. 1071-1079
    Details
    In: Transfusion, Wiley, Vol. 61, No. 4 ( 2021-04), p. 1071-1079
    Abstract: Consensus for transfusion in intensive care unit (ICU) patients recommends a restrictive strategy, based on a hemoglobin (Hb) concentration of 7 g/dL. Red blood cell (RBC) transfusion is used to prevent tissue hypoxia by improving oxygen transport (DO 2 ) and therefore oxygen consumption (VO 2 ). We studied the effects of RBC transfusion on systemic oxygenation parameters reflecting systemic oxygen extraction (EO 2 = DO 2 /VO 2 ): S(c)vO 2 , lactate level, venous‐to‐arterial carbon dioxide difference (Pv‐aCO 2 ), and cardiac index/EO 2 (CI/EO 2 ) and evaluated their usefulness in guiding transfusion decisions in ICU patients. Study Design and Methods Prospectively, all adult patients transfused were included except those with active bleeding or without a jugular or subclavian catheter. We measured O 2 parameters before and after transfusion. Patients were a priori grouped according to their initial S(c)vO 2 ( 〈 or ≥ 70%), treatment with vasopressors, cardiac function, and septic status. Results A total of 62 patients received 105 RBC transfusions. For all, mean arterial pressure (77 [69‐88] to 81 [73‐91] mm Hg), Hb concentration (7.4 [7.0‐7.8] to 8.4 [7.7‐8.9] g/dL) and S(c)vO 2 (65% [59%‐73%] to 69% [62%‐75%] ) increased after transfusion (all P 〈  .001). S(c)vO 2 improved after transfusion only when initial S(c)vO 2 was less than 70% (62% [56%‐65%] to 66% [61%‐71%] ; P 〈  .001). In this group, Pv‐aCO 2 , lactate concentrations, and CI/EO 2 did not change after transfusion. Cardiac function, sepsis, or vasopressor therapy did not affect these results. Conclusions Among systemic O 2 parameters, only a S(c)vO 2 〈  70% in anemic ICU patients improves after transfusion. As S(c)vO 2 can reflect a DO 2 /VO 2 imbalance, it could be helpful when combined with the Hb concentration to decide whether to transfuse. However, the benefit on outcome should be further studied.
    Type of Medium: Online Resource
    ISSN: 0041-1132 , 1537-2995
    URL: Issue
    URL: Article
    DOI: 10.1111/trf.v61.4
    DOI: 10.1111/trf.16284
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 208417-X
    detail.hit.zdb_id: 2018415-3
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  • 3
    Online Resource
    Online Resource
    Alterations of the Erythrocyte Membrane during Sepsis
    Wiley ; 2012
    In:  Critical Care Research and Practice Vol. 2012 ( 2012), p. 1-7
    Details
    In: Critical Care Research and Practice, Wiley, Vol. 2012 ( 2012), p. 1-7
    Abstract: Erythrocytes have been long considered as “dead” cells with transport of oxygen (O 2 ) as their only function. However, the ability of red blood cells (RBCs) to modulate the microcirculation is now recognized as an important additional function. This capacity is regulated by a key element in the rheologic process: the RBC membrane. This membrane is a complex unit with multiple interactions between the extracellular and intracellular compartments: blood stream, endothelium, and other blood cells on the one hand, and the intracytoplasmic compartment with possible rapid adaptation of erythrocyte metabolism on the other. In this paper, we review the alterations in the erythrocyte membrane observed in critically ill patients and the influence of these alterations on the microcirculatory abnormalities observed in such patients. An understanding of the mechanisms of RBC rheologic alterations in sepsis and their effects on blood flow and on oxygen transport may be important to help reduce morbidity and mortality from severe sepsis.
    Type of Medium: Online Resource
    ISSN: 2090-1305 , 2090-1313
    URL: Article
    DOI: 10.1155/2012/702956
    Language: English
    Publisher: Wiley
    Publication Date: 2012
    detail.hit.zdb_id: 2573849-5
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  • 4
    Online Resource
    Online Resource
    Microcirculation
    Wiley ; 2012
    In:  Critical Care Research and Practice Vol. 2012 ( 2012), p. 1-3
    Details
    In: Critical Care Research and Practice, Wiley, Vol. 2012 ( 2012), p. 1-3
    Type of Medium: Online Resource
    ISSN: 2090-1305 , 2090-1313
    URL: Article
    DOI: 10.1155/2012/867176
    Language: English
    Publisher: Wiley
    Publication Date: 2012
    detail.hit.zdb_id: 2573849-5
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  • 5
    Online Resource
    Online Resource
    Association between duration of storage of transfused red blood cells and morbidity and mortality in adult patients: myth or reality?
    Wiley ; 2009
    In:  Transfusion Vol. 49, No. 7 ( 2009-07), p. 1384-1394
    Details
    In: Transfusion, Wiley, Vol. 49, No. 7 ( 2009-07), p. 1384-1394
    Abstract: BACKGROUND: The duration of red blood cell (RBC) storage before transfusion may alter RBC function and, therefore, influence the incidence of complications. STUDY DESIGN AND METHODS: With a computerized literature search from 1983 to 2008, 27 studies reporting the relationship between age of transfused RBCs and physiologic variables or incidence of complications in adult patients were identified. RESULTS: Three studies (one abstract only, two foreign language) were excluded. The 24 remaining studies were grouped according to the patient population: cardiac surgery (eight studies), colorectal surgery (three), intensive care unit (ICU; seven), and trauma (six). The studies were too heterogeneous to allow a formal meta‐analysis. Twenty‐one of the 24 studies were single‐center, and 12 were retrospective. The number of patients was highly variable, ranging from 15 to 6002. In cardiac surgery, two studies reported an increased risk of mortality but had statistical limitations. In colorectal surgery, two studies that addressed the effect on postoperative infections in the same database but with different designs yielded conflicting results. In general ICU patients, two retrospective studies reported a significant correlation between length of RBC storage and microcirculatory alterations or mortality, but the results were not confirmed in subsequent prospective, double‐blinded studies. In trauma, five studies reported a correlation between RBC age and development of infection, multiple organ dysfunction, or mortality. CONCLUSIONS: From the currently available published data, it is difficult to determine whether there is a relationship between the age of transfused RBCs and outcome in adult patients, except possibly in trauma patients receiving massive transfusion.
    Type of Medium: Online Resource
    ISSN: 0041-1132 , 1537-2995
    URL: Issue
    URL: Article
    DOI: 10.1111/trf.2009.49.issue-7
    DOI: 10.1111/j.1537-2995.2009.02211.x
    Language: English
    Publisher: Wiley
    Publication Date: 2009
    detail.hit.zdb_id: 208417-X
    detail.hit.zdb_id: 2018415-3
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  • 6
    Online Resource
    Online Resource
    Anemia in sepsis: the importance of red blood cell membrane changes
    Wiley ; 2007
    In:  Transfusion Alternatives in Transfusion Medicine Vol. 9, No. 3 ( 2007-09), p. 143-149
    Details
    In: Transfusion Alternatives in Transfusion Medicine, Wiley, Vol. 9, No. 3 ( 2007-09), p. 143-149
    Abstract: Anemia is a common problem in acutely ill patients, especially in those who develop sepsis. There are many factors contributing to the development of anemia in these patients, including blood sampling and other losses, decreased red blood cell (RBC) synthesis, and possibly increased destruction. Increased RBC uptake may be due to changes in RBC morphology and the RBC membrane during inflammatory processes. In particular, a rapid increase in RBC sphericity correlated with a decreased surface carbohydrate membrane content and alterations in the lipid bilayer with increased peroxidation and phosphatidylserine exposure in the outer leaflet of the membrane. Better understanding of these alterations could facilitate new strategies to prevent the development of anemia in sepsis.
    Type of Medium: Online Resource
    ISSN: 1295-9022 , 1778-428X
    URL: Issue
    URL: Article
    DOI: 10.1111/tatm.2007.9.issue-3
    DOI: 10.1111/j.1778-428X.2007.00072.x
    Language: English
    Publisher: Wiley
    Publication Date: 2007
    detail.hit.zdb_id: 2299406-3
    detail.hit.zdb_id: 2251463-6
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  • 7
    Online Resource
    Online Resource
    Interpretation of C-Reactive Protein Concentrations in Critically Ill Patients
    Wiley ; 2013
    In:  BioMed Research International Vol. 2013 ( 2013), p. 1-11
    Details
    In: BioMed Research International, Wiley, Vol. 2013 ( 2013), p. 1-11
    Abstract: Infection is often difficult to recognize in critically ill patients because of the marked coexisting inflammatory process. Lack of early recognition prevents timely resuscitation and effective antimicrobial therapy, resulting in increased morbidity and mortality. Measurement of a biomarker, such as C-reactive protein (CRP) concentration, in addition to history and physical signs, could facilitate diagnosis. Although frequently measured in clinical practice, few studies have reported on the pathophysiological role of this biomarker and its predictive value in critically ill patients. In this review, we discuss the pathophysiological role of CRP and its potential interpretation in the inflammatory processes observed in critically ill patients.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2013/124021
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 2698540-8
    detail.hit.zdb_id: 2705584-X
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