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  • 1
    In: Aging Cell, Wiley, Vol. 23, No. 4 ( 2024-04)
    Abstract: Unlike chronological age, biological age is a strong indicator of health of an individual. However, the molecular fingerprint associated with biological age is ill‐defined. To define a high‐resolution signature of biological age, we analyzed metabolome, circulating senescence‐associated secretome (SASP)/inflammation markers and the interaction between them, from a cohort of healthy and rapid agers. The balance between two fatty acid oxidation mechanisms, β‐oxidation and ω‐oxidation, associated with the extent of functional aging. Furthermore, a panel of 25 metabolites, Healthy Aging Metabolic (HAM) index, predicted healthy agers regardless of gender and race. HAM index was also validated in an independent cohort. Causal inference with machine learning implied three metabolites, β‐cryptoxanthin, prolylhydroxyproline, and eicosenoylcarnitine as putative drivers of biological aging. Multiple SASP markers were also elevated in rapid agers. Together, our findings reveal that a network of metabolic pathways underlie biological aging, and the HAM index could serve as a predictor of phenotypic aging in humans.
    Type of Medium: Online Resource
    ISSN: 1474-9718 , 1474-9726
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2024
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  • 2
    In: The Laryngoscope, Wiley, Vol. 133, No. 3 ( 2023-03), p. 521-527
    Abstract: Upper esophageal sphincter opening (UESO), and laryngeal vestibule closure (LVC) are two essential kinematic events whose timings are crucial for adequate bolus clearance and airway protection during swallowing. Their temporal characteristics can be quantified through time‐consuming analysis of videofluoroscopic swallow studies (VFSS). Objectives We sought to establish a model to predict the odds of penetration or aspiration during swallowing based on 15 temporal factors of UES and laryngeal vestibule kinematics. Methods Manual temporal measurements and ratings of penetration and aspiration were conducted on a videofluoroscopic dataset of 408 swallows from 99 patients. A generalized estimating equation model was deployed to analyze association between individual factors and the risk of penetration or aspiration. Results The results indicated that the latencies of laryngeal vestibular events and the time lapse between UESO onset and LVC were highly related to penetration or aspiration. The predictive model incorporating patient demographics and bolus presentation showed that delayed LVC by 0.1 s or delayed LVO by 1% of the swallow duration (average 0.018 s) was associated with a 17.19% and 2.68% increase in odds of airway invasion, respectively. Conclusion This predictive model provides insight into kinematic factors that underscore the interaction between the intricate timing of laryngeal kinematics and airway protection. Recent investigation in automatic noninvasive or videofluoroscopic detection of laryngeal kinematics would provide clinicians access to objective measurements not commonly quantified in VFSS. Consequently, the temporal and sequential understanding of these kinematics may interpret such measurements to an estimation of the risk of aspiration or penetration which would give rise to rapid computer‐assisted dysphagia diagnosis. Level of Evidence 2 Laryngoscope , 133:521–527, 2023
    Type of Medium: Online Resource
    ISSN: 0023-852X , 1531-4995
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2023
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  • 3
    In: PM&R, Wiley, Vol. 8, No. 6 ( 2016-06), p. 520-528
    Abstract: Traditional exercise programs for older adults, which focus on aerobic and strength training, have had only modest effects on walking. Recently, a motor learning exercise program was shown to have greater effects on walking compared with a traditional exercise program. Translating this novel motor learning exercise program into a group exercise program would allow it to be offered as an evidence‐based, community‐based program for older adults. Objective To translate a walking rehabilitation program based on motor learning theory from one‐on‐one to group delivery (On the Move) and evaluate multiple aspects of implementation in older adults with impaired mobility. Design The translation process involved multiple iterations, including meetings of experts in the field (Phase I), focus groups (Phase II), and implementation of the newly developed program (Phase III). Phase III was based on a one‐group model of intervention development for feasibility, safety, potential effects, and acceptability. Setting Community sites, including 2 independent living facilities, an apartment building, and a community center. Participants Adults 65 years of age or older who could ambulate independently and who were medically stable. Thirty‐one adults, mean age 82.3 ± 5.6 years, were eligible to participate. Methods The group exercise program was held twice a week for 12 weeks. Main Outcome Measurements Acceptability of the program was determined by retention and adherence rates and a satisfaction survey. Risk was measured by adverse events and questions on perceived challenge and safety. Mobility was assessed pre‐ and postintervention by gait speed, Figure of 8 Walk Test, and 6‐minute walk test. Results Modifications to the program included adjustments to format/length, music, education, and group interaction. The 12‐week program was completed by 24 of 31 entrants (77%). Adherence was high, with participants attending on average 83% of the classes. Safety was excellent, with only 1 subject experiencing a controlled, noninjurious fall. There was preliminary evidence for improved mobility after the intervention: gait speed improved from 0.76 ± 0.21 to 0.81 ± 0.22 m/s, P = .06; Figure of 8 Walk Test from 13.0 ± 3.9 to 12.0 ± 3.9 seconds, P = .07; and 6‐minute walk test from 246 ± 75 to 281 ± 67 m, P = .02. Conclusions The group‐based program was safe and acceptable to older adults with impaired mobility and resulted in potentially clinically meaningful improvements in mobility.
    Type of Medium: Online Resource
    ISSN: 1934-1482 , 1934-1563
    Language: English
    Publisher: Wiley
    Publication Date: 2016
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  • 4
    In: PM&R, Wiley, Vol. 9, No. 9S1 ( 2017-09)
    Type of Medium: Online Resource
    ISSN: 1934-1482 , 1934-1563
    Language: English
    Publisher: Wiley
    Publication Date: 2017
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  • 5
    Online Resource
    Online Resource
    Wiley ; 2006
    In:  Journal of the American Geriatrics Society Vol. 54, No. 11 ( 2006-11), p. 1772-1777
    In: Journal of the American Geriatrics Society, Wiley, Vol. 54, No. 11 ( 2006-11), p. 1772-1777
    Abstract: Chronic low back pain (CLBP) is a common and debilitating problem in older adults. Little exists in the literature about primary care physicians' (PCPs') knowledge of and confidence in managing this problem. A self‐administered survey was mailed to PCPs in western Pennsylvania to measure knowledge of the evaluation and treatment of common contributors to CLBP in older adults, confidence in diagnosing these contributors through physical examination, and the association between confidence levels and knowledge. The survey combined items with an ordinal scale on which PCPs ranked their confidence in detecting various contributors to CLBP (e.g., fibromyalgia) using physical examination and patient vignettes followed by multiple choice questions designed to assess knowledge. One hundred fifty‐three of 634 surveys were returned (24.1%). Overall, the majority of PCPs did not feel “very confident” in their ability to diagnose any of the contributors of CLBP listed (most items 〈 40%). PCPs felt most confident in detecting scoliosis and least confident detecting myofascial pain of the piriformis muscle. There was a wide range in the number of respondents answering all questions related to a particular topic correctly (3.9% for sacroiliac joint syndrome to 70.4% for hip osteoarthritis). There was no relationship between knowledge scores and confidence ratings ( P 〉 .05 for all comparisons). The results point to a need for more PCP education about CLBP in older adults. It also suggests that accurate needs assessment should not rely on physician confidence ratings alone.
    Type of Medium: Online Resource
    ISSN: 0002-8614 , 1532-5415
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2006
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  • 6
    In: Journal of the American Geriatrics Society, Wiley, Vol. 56, No. 5 ( 2008-05), p. 808-815
    Abstract: OBJECTIVES: To develop a consensus list of agreed‐upon laboratory, pharmacy, and Minimum Data Set signals that a computer system can use in the nursing home to detect potential adverse drug reactions (ADRs). DESIGN: Literature search for potential ADR signals, followed by an internet‐based, a two‐round, modified Delphi survey. SETTING: A nationally representative survey of experts in geriatrics. PARTICIPANTS: Panel of 13 physicians, 10 pharmacists, and 13 advanced practitioners. MEASUREMENTS: Mean score and 95% confidence interval (CI) for each of 80 signals rated on a 5‐point Likert scale (5=strong agreement with likelihood of indicating potential ADRs). Consensus agreement indicated by a lower‐limit 95% CI of 4.0 or greater. RESULTS: Panelists reached consensus agreement on 40 signals: 15 laboratory and medication combinations, 12 medication concentrations, 10 antidotes, and three Resident Assessment Protocols (RAPs). Highest consensus scores (4.6, 95% CI=4.4–4.9 or 4.4–4.8) were for naloxone when taking opioid analgesics; phytonadione when taking warfarin; dextrose, glucagon, or liquid glucose when taking hypoglycemic agents; medication‐induced hypoglycemia; supratherapeutic international normalized ratio when taking warfarin; and triggering the Falls RAP when taking certain medications. CONCLUSION: A multidisciplinary expert panel was able to reach consensus agreement on a list of signals to detect potential ADRs in nursing home residents. The results of this study can be used to prioritize an initial list of signals to be included in paper‐ or computer‐based methods for potential ADR detection.
    Type of Medium: Online Resource
    ISSN: 0002-8614 , 1532-5415
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2008
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  • 7
    In: Journal of the American Geriatrics Society, Wiley, Vol. 61, No. 11 ( 2013-11), p. 1879-1886
    Abstract: To compare the effect of motor learning with that of standard exercise on measures of mobility and perceived function and disability. Design Single‐blind randomized trial. Setting University research center. Participants Older adults (n = 40) with a mean age of 77.1 ± 6.0, normal walking speed (≥1.0 m/s), and impaired motor skills (Figure of 8 walk time 〉 8 seconds). Interventions The motor learning program incorporated goal‐oriented stepping and walking to promote timing and coordination within the phases of the gait cycle. The standard program employed endurance training by treadmill walking. Both included strength training and were offered twice weekly for 1 hour for 12 weeks. Measurements Primary outcomes were mobility performance (gait efficiency, motor skill in walking, gait speed, walking endurance); secondary outcomes were perceived function and disability (Late‐Life Function and Disability Instrument). Results Thirty‐eight of 40 participants completed the trial (motor learning, n = 18; standard, n = 20). The motor learning group improved more than the standard group in gait speed (0.13 vs 0.05 m/s, P  =   .008) and motor skill (−2.2 vs −0.89 seconds, P  〈   .001). Both groups improved in walking endurance (28.3 and 22.9 m, P  = .14). Changes in gait efficiency and perceived function and disability were not different between the groups ( P   〉  .10). Conclusion In older adults with subclinical gait dysfunction, motor learning exercise improved some parameters of mobility performance more than standard exercise.
    Type of Medium: Online Resource
    ISSN: 0002-8614 , 1532-5415
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2013
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  • 8
    In: Journal of the American Geriatrics Society, Wiley, Vol. 62, No. 10 ( 2014-10), p. 1923-1927
    Abstract: To examine whether older adults taking nonsteroidal anti‐inflammatory drugs ( NSAID s) decreased the underuse of gastroprotective agents over time. Design Before‐and‐after study. Setting Health, Aging and Body Composition Study. Participants Daily users of a NSAID (prescription and over the counter ( OTC )) at visits in 2002–03 (preperiod; n = 404) and 2006–07 (postperiod; n = 172). The sample had a mean ± standard deviation age of 78.2 ± 2.7 at the preperiod visit and 81.9 ± 2.7 at the postperiod visit. The majority were white and female and had 12 or more years of education. Measurements Underusers were defined as persons taking nonselective NSAID s who were at risk of peptic ulcer disease ( PUD ; because of current warfarin or glucocorticoid use or history of PUD ) and not using a proton pump inhibitor ( PPI ) or persons taking cyclooxygenase 2 ( COX ‐2) selective NSAID s and aspirin who were at risk of PUD (having at least one risk factor) and not using a PPI . Results Daily NSAID use decreased from 17.6% to 11.3% ( P   〈  .001), and gastroprotective agent underuse decreased from 23.5% to 15.1% ( P  = .008). Controlling for important covariates, having prescription insurance was somewhat protective against underuse in the preperiod (adjusted odds ratio ( AOR ) = 0.78, 95% confidence interval ( CI ) = 0.46–1.34; P  = .37), but more so and significantly in the postperiod ( AOR  = 0.41, 95% CI  = 0.18–0.93; P  = .03). Having prescription insurance was more protective in the post‐ than in the preperiod (less gastroprotective agent underuse; adjusted ratio of OR  = 0.53, 95% CI  = 0.22–1.29; P  = .16), but this increased protection was not statistically significant. Conclusion In older daily NSAID users at high risk of PUD , having prescription insurance and adequate gastroprotective use was more common in the post‐ than in the preperiod.
    Type of Medium: Online Resource
    ISSN: 0002-8614 , 1532-5415
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2014
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  • 9
    Online Resource
    Online Resource
    Wiley ; 2018
    In:  Journal of the American Geriatrics Society Vol. 66, No. 2 ( 2018-02), p. 316-320
    In: Journal of the American Geriatrics Society, Wiley, Vol. 66, No. 2 ( 2018-02), p. 316-320
    Abstract: To establish the prevalence of sarcopenia in a long‐term care population, assess agreement among different consensus sarcopenia diagnostic criteria, and examine agreement of a self‐reported questionnaire with consensus guidelines. Design Cross‐sectional secondary analysis. Setting Long‐term care communities in the greater Pittsburgh, Pennsylvania, area. Participants Women aged 65 and older (mean 83.6) undergoing eligibility screening for a fracture reduction trial (N = 141). Measurements We measured appendicular lean muscle mass using dual‐energy X‐ray absorptiometry. Hand grip strength and usual gait speed were also evaluated. Sarcopenia status was determined according to European Working Group on Sarcopenia in Older People ( EWGSOP ) and the Foundation for the National Institutes of Health ( FNIH ) Sarcopenia Project criteria and the SARC ‐F questionnaire. Results Eleven participants were sarcopenic (7.8%) according to the EWGSOP criteria, six (4.3%) according to FNIH conservative cut‐point guidelines, and 32.6% (n = 46) according to FNIH intermediate cut‐points. Only 2 of 141 participants met criteria for sarcopenia according to all three guidelines. Sarcopenia was identified in 30 (21.3%) participants according to the SARC ‐F questionnaire. Sensitivity of the SARC ‐F with consensus panel definitions ranged from 18.2% to 33.3%. Specificity ranged from 78.7% to 81.1%. Conclusion Current consensus criteria from the EWGSOP and FNIH Sarcopenia Project do not agree and have little overlap in older female long‐term care residents. The SARC ‐F questionnaire is a simple tool that could be implemented in long‐term care, but it has low sensitivity compared with current consensus guidelines in the identification of sarcopenic individuals.
    Type of Medium: Online Resource
    ISSN: 0002-8614 , 1532-5415
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2018
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  • 10
    Online Resource
    Online Resource
    Wiley ; 2018
    In:  Journal of the American Geriatrics Society Vol. 66, No. 2 ( 2018-02), p. 282-288
    In: Journal of the American Geriatrics Society, Wiley, Vol. 66, No. 2 ( 2018-02), p. 282-288
    Abstract: To examine the effect of interventions to optimize medication use on adverse drug reactions ( ADR s) in older adults. Design Systematic review and meta‐analysis. EMBASE , PubMed, OVID , Cochrane Library, Clinicaltrials.gov, and Google Scholar were searched through April 30, 2017. Setting Randomized controlled trials. Participants Older adults (mean age ≥65) taking medications. Measurements Two authors independently extracted relevant information and assessed studies for risk of bias. Discrepancies were resolved in consensus meetings. The outcomes were any and serious ADR s. Random‐effects models were used to combine the results of multiple studies and create summary estimates. Results Thirteen randomized controlled trials involving 6,198 older adults were included. The studies employed a number of different interventions that were categorized as pharmacist‐led interventions (8 studies), other health professional‐led interventions (3 studies), a brief educational session (1 study), and a technology intervention (1 study). The intervention group was 21% less likely than the control group to experience any ADR (odds ratio ( OR ) = 0.79, 95% confidence interval ( CI ) = 0.62–0.99). In the six studies that examined serious ADR s, the intervention group was 36% less likely than the control group to experience a serious ADR ( OR  = 0.64, 95% CI  = 0.42–0.98). Conclusion Interventions designed to optimize medication use reduced the risk of any and serious ADR s in older adults. Implementation of these successful interventions in healthcare systems may improve medication safety in older adults.
    Type of Medium: Online Resource
    ISSN: 0002-8614 , 1532-5415
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2018
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    detail.hit.zdb_id: 80363-7
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