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  • 1
    Online Resource
    Online Resource
    DNA barcoding of Chinese snakes reveals hidden diversity and conservation needs
    Wiley ; 2023
    In:  Molecular Ecology Resources Vol. 23, No. 5 ( 2023-07), p. 1124-1141
    Details
    In: Molecular Ecology Resources, Wiley, Vol. 23, No. 5 ( 2023-07), p. 1124-1141
    Abstract: DNA barcoding has greatly facilitated studies of taxonomy, biodiversity, biological conservation, and ecology. Here, we establish a reliable DNA barcoding library for Chinese snakes, unveiling hidden diversity with implications for taxonomy, and provide a standardized tool for conservation management. Our comprehensive study includes 1638 cytochrome c oxidase subunit I ( COI ) sequences from Chinese snakes that correspond to 17 families, 65 genera, 228 named species (80.6% of named species) and 36 candidate species. A barcode gap analysis reveals gaps, where all nearest neighbour distances exceed maximum intraspecific distances, in 217 named species and all candidate species. Three species‐delimitation methods (ABGD, sGMYC, and sPTP) recover 320 operational taxonomic units (OTUs), of which 192 OTUs correspond to named and candidate species. Twenty‐eight other named species share OTUs, such as Azemiops feae and A. kharini , Gloydius halys , G. shedaoensis , and G. intermedius , and Bungarus multicinctus and B. candidus , representing inconsistencies most probably caused by imperfect taxonomy, recent and rapid speciation, weak taxonomic signal, introgressive hybridization, and/or inadequate phylogenetic signal. In contrast, 43 species and candidate species assign to two or more OTUs due to having large intraspecific distances. If most OTUs detected in this study reflect valid species, including the 36 candidate species, then 30% more species would exist than are currently recognized. Several OTU divergences associate with known biogeographic barriers, such as the Taiwan Strait. In addition to facilitating future studies, this reliable and relatively comprehensive reference database will play an important role in the future monitoring, conservation, and management of Chinese snakes.
    Type of Medium: Online Resource
    ISSN: 1755-098X , 1755-0998
    URL: Issue
    URL: Article
    DOI: 10.1111/men.v23.5
    DOI: 10.1111/1755-0998.13784
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2406833-0
    SSG: 12
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  • 2
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    Uniformly Dispersed Ru Nanoparticles Constructed by In Situ Confined Polymerization of Ionic Liquids for the Electrocatalytic Hydrogen Evolution Reaction
    Wiley ; 2021
    In:  Small Methods Vol. 5, No. 7 ( 2021-07)
    Details
    In: Small Methods, Wiley, Vol. 5, No. 7 ( 2021-07)
    Abstract: Design and development of cost‐effective electrocatalysts with high efficiency and stability for scalable and sustainable hydrogen production through water splitting is still challenging. Herein, with the aid of divinyl functionalized ionic liquids, uniformly distributed Ru nanoparticles (NPs) on nitrogen‐doped carbon frameworks are obtained via an in situ confined polymerization strategy. Attributed to the unique lamellar structure and confinement effect of carbon supports, the optimized homo‐PIL‐Ru/C‐600 (with Ru 10 wt%) catalyst exhibits superior catalytic efficiency for the hydrogen evolution reaction with the overpotential of only 16 mV at a current density of 10 mA cm −2 and the corresponding Tafel slope of only 42 mV dec −1 . Moreover, the performance can be well reserved even after 10 000 cycles, demonstrating excellent stability and promising potentials for industrial application. This work not only provides a facile approach for the preparation of highly efficient Ru‐based catalysts, but also guides the synthesis of other highly dispersed metallic NPs for special applications.
    Type of Medium: Online Resource
    ISSN: 2366-9608 , 2366-9608
    URL: Issue
    URL: Article
    DOI: 10.1002/smtd.v5.7
    DOI: 10.1002/smtd.202100505
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2884448-8
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  • 3
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    Oxyresveratrol, a Stilbene Compound from Morus alba L. Twig Extract Active Against Trichophyton rubrum
    Wiley ; 2017
    In:  Phytotherapy Research Vol. 31, No. 12 ( 2017-12), p. 1842-1848
    Details
    In: Phytotherapy Research, Wiley, Vol. 31, No. 12 ( 2017-12), p. 1842-1848
    Abstract: Morus alba L. (mulberry) twig is known to have an inhibitory effect on pathogens in traditional Chinese medicine. In the present study, the dermophytic fungus, Trichophyton rubrum , was used to evaluate the inhibitory effect of total M. alba twig extract and extracts obtained using solvents with different polarities by the method of 96‐well MTT colorimetry. The main active substance was isolated and identified by tracking its activity. In addition, the inhibitory effects of active extracts and a single active substance were investigated in combination with miconazole nitrate. Our data indicated that ethyl acetate extracts of mulberry twig (TEE) exhibited a desired inhibitory activity on T. rubrum with the minimum inhibitory concentration (MIC) of 1.000 mg/mL. With activity tracking, the main substance showing antimicrobial activity was oxyresveratrol (OXY), which was isolated from TEE. Its MIC for inhibiting the growth of T. rubrum was 0.500 mg/mL. The combined use of miconazole nitrate and OXY showed a synergistic inhibitory effect, as shown by a significant decrease in the MIC of both components. Based on the OXY content in TEE, the contribution rate of OXY to the inhibitory effect of TEE on T. rubrum was 80.52%, so it was determined to be the main antimicrobial substance in M. alba twig. Copyright © 2017 John Wiley & Sons, Ltd.
    Type of Medium: Online Resource
    ISSN: 0951-418X , 1099-1573
    URL: Issue
    URL: Article
    DOI: 10.1002/ptr.v31.12
    DOI: 10.1002/ptr.5926
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 1493490-5
    SSG: 15,3
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  • 4
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    Hydrogen gas reduces chronic intermittent hypoxia‐induced hypertension by inhibiting sympathetic nerve activity and increasing vasodilator responses via the antioxidation
    Wiley ; 2019
    In:  Journal of Cellular Biochemistry Vol. 120, No. 3 ( 2019-03), p. 3998-4008
    Details
    In: Journal of Cellular Biochemistry, Wiley, Vol. 120, No. 3 ( 2019-03), p. 3998-4008
    Abstract: Molecular hydrogen is reported to be used medically to ameliorate various systemic pathological conditions. This study aimed to investigate the effect of hydrogen (H 2 ) gas on hypertension induced by intermittent hypoxia in rats. The adult rats were exposed to chronic intermittent hypoxia (CIH) 8 hours/day for 5 weeks and/or H 2 gas 2 hours/day. We found that the systolic and diastolic blood pressure (BP) increased significantly in rats exposed to intermittent hypoxia, both of which were markedly attenuated after H treatment. Furthermore, intermittent hypoxia exposure elevated renal sympathetic nerve activity, consistent with plasma norepinephrine. Additionally, H 2 gas significantly improved CIH‐induced abnormal vascular relaxation. Nevertheless, inhalation of H 2 gas alone did not cause such changes. Moreover, H 2 gas‐treated rats exposed to CIH showed a significant reduction in 8‐hydroxy‐2 deoxyguanosine content and increases in superoxide dismutase activity, indicating improved oxidative stress. Taken together, these results indicate that H 2 gas has significant effects on the reduction of BP without any side effects. Mechanistically, inhibition of sympathetic activity and reduction of systemic vascular resistance may participate in this process via the antioxidant activity of H 2 .
    Type of Medium: Online Resource
    ISSN: 0730-2312 , 1097-4644
    URL: Issue
    URL: Article
    DOI: 10.1002/jcb.v120.3
    DOI: 10.1002/jcb.27684
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 1479976-5
    SSG: 12
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  • 5
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    Rapid and sensitive detection of the phenoxy acid herbicides in environmental water samples by magnetic solid‐phase extraction combined with liquid chromatography–tandem mass spectrometry
    Wiley ; 2018
    In:  Journal of Separation Science Vol. 41, No. 10 ( 2018-05), p. 2221-2228
    Details
    In: Journal of Separation Science, Wiley, Vol. 41, No. 10 ( 2018-05), p. 2221-2228
    Abstract: Phenoxy acid herbicides are widely used herbicides that play an important role in improving the yield and quality of crops. However, some research has shown that this kind of herbicide is poisonous to human and animals. In this study, a rapid and sensitive method was developed for the detection of seven phenoxy acid herbicides in water samples based on magnetic solid‐phase extraction followed by liquid chromatography and tandem mass spectrometry. Magnetic amino‐functionalized multiwalled carbon nanotubes were prepared by mixing bare magnetic Fe 3 O 4 nanoparticles with commercial amino‐functionalized multiwalled carbon nanotubes in water. Then the amino‐functionalized multiwalled carbon nanotubes were used to enrich phenoxy acid herbicides from water samples based on hydrophobic and ionic interactions. The effects of experimental variables on the extraction efficiency have been studied in detail. Under the optimized conditions, the method validation was performed. Good linearities for seven phenoxy acid herbicides were obtained with squared regression coefficients ranging from 0.9971 to 0.9989. The limits of detection ranged from 0.01 to 0.02 μg/L. The method recoveries of seven phenoxy acid herbicides spiked at three concentration levels in a blank sample were from 92.3 to 103.2%, with inter‐ and intraday relative standard deviations less than 12.6%.
    Type of Medium: Online Resource
    ISSN: 1615-9306 , 1615-9314
    URL: Issue
    URL: Article
    DOI: 10.1002/jssc.v41.10
    DOI: 10.1002/jssc.201701325
    RVK:
    VA 5450
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2047990-6
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  • 6
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    Reaction Mechanism of 3,4‐Dinitrofuroxan Formation from Glyoxime: Dehydrogenation and Cyclization of Oxime
    Wiley ; 2016
    In:  ChemPhysChem Vol. 17, No. 4 ( 2016-02), p. 541-547
    Details
    In: ChemPhysChem, Wiley, Vol. 17, No. 4 ( 2016-02), p. 541-547
    Abstract: The reaction pathway of the formation of 3,4‐dinitrofuroxan from glyoxime is theoretically investigated under experimental conditions with 25 % nitric acid and dinitrogentetroxide reagents to clarify the mechanism of formation of a furoxan ring by glyoxime. The geometric configurations of minima and transition‐state species are optimized at the (U)B3LYP/6‐311++G** level. The CCSD(T) and CASSCF(10e,8o)/CASSCF(9e,8o) single‐point energy corrections at the same level are performed on top of the optimized geometries. A subsequent dynamic correlation by using NEVPT2/6‐311++G**‐level single‐point energy calculations based on the CASSCF results is also performed to obtain accurate energy values. The formation reaction is analyzed from two processes: glyoxime nitration and 3,4‐dinitroglyoxime (nitration product) oxidative cyclization. Calculation results indicate that the electrophilic substitution of nitronium ions from the protonated HNO 3 and the abstraction of hydrogen ions by HNO 3 molecules are requisites of glyoxime nitration. The formation of a furoxan ring from 3,4‐dinitroglyoxime involves two possible mechanisms: 1) oxydehydrogenation by NO 2 molecules and the subsequent torsion of NO radical groups to form a ring and 2) the alternation of dehydrogenation and cyclization. The intermediates and transition states in both routes exhibit monoradical and diradical characteristics. Singlet and triplet reactions are considered for the diradical species. Results show that the singlet reaction mechanism is more favorable for cyclization than the triplet reaction. The formation of a furoxan ring from oxime is in accordance with the stepwise intermolecular dehydrogenation and intramolecular torsion to the ring.
    Type of Medium: Online Resource
    ISSN: 1439-4235 , 1439-7641
    URL: Issue
    URL: Article
    DOI: 10.1002/cphc.v17.4
    DOI: 10.1002/cphc.201500968
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2025223-7
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  • 7
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    Aryl‐to‐Vinyl 1,4‐Nickel Migration/Reductive Cross‐Coupling Reaction for the Stereoselective Synthesis of Multisubstituted Olefins
    Wiley ; 2023
    In:  Angewandte Chemie Vol. 135, No. 28 ( 2023-07-10)
    Details
    In: Angewandte Chemie, Wiley, Vol. 135, No. 28 ( 2023-07-10)
    Abstract: The aryl‐to‐vinyl nickel 1,4‐migration (1,4‐Ni migration) reaction has been reported for the first time. The generated alkenyl Ni species undergo a reductive coupling reaction with unactivated brominated alkanes affording a series of trisubstituted olefins. This tandem reaction exhibits mild conditions, a broad substrate scope, high regioselectivity, and excellent Z / E stereoselectivity. A series of controlled experiments have shown that the critical 1,4‐Ni migration process is reversible. In addition, the alkenyl nickel intermediates obtained after migration are highly Z / E stereoselective and do not undergo Z / E isomerization. The obtained trace isomerization products are caused by the instability of the product.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v135.28
    DOI: 10.1002/ange.202304447
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 505868-5
    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
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  • 8
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    Formulating the Electrolyte Towards High‐Energy and Safe Rechargeable Lithium–Metal Batteries
    Wiley ; 2021
    In:  Angewandte Chemie Vol. 133, No. 30 ( 2021-07-19), p. 16690-16696
    Details
    In: Angewandte Chemie, Wiley, Vol. 133, No. 30 ( 2021-07-19), p. 16690-16696
    Abstract: Rechargeable lithium–metal batteries with a cell‐level specific energy of 〉 400 Wh kg −1 are highly desired for next‐generation storage applications, yet the research has been retarded by poor electrolyte–electrode compatibility and rigorous safety concerns. We demonstrate that by simply formulating the composition of conventional electrolytes, a hybrid electrolyte was constructed to ensure high (electro)chemical and thermal stability with both the Li‐metal anode and the nickel‐rich layered oxide cathodes. By employing the new electrolyte, Li∥LiNi 0.6 Co 0.2 Mn 0.2 O 2 cells show favorable cycling and rate performance, and a 10 Ah Li∥LiNi 0.8 Co 0.1 Mn 0.1 O 2 pouch cell demonstrates a practical specific energy of 〉 450 Wh kg −1 . Our findings shed light on reasonable design principles for electrolyte and electrode/electrolyte interfaces toward practical realization of high‐energy rechargeable batteries.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v133.30
    DOI: 10.1002/ange.202103850
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 505868-5
    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
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  • 9
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    Mild Chronic Colitis Triggers Parkinsonism in LRRK2 Mutant Mice Through Activating TNF ‐α Pathway
    Wiley ; 2022
    In:  Movement Disorders Vol. 37, No. 4 ( 2022-04), p. 745-757
    Details
    In: Movement Disorders, Wiley, Vol. 37, No. 4 ( 2022-04), p. 745-757
    Abstract: Leucine‐rich repeat kinase 2 ( LRRK2 ) is a common risk gene for Parkinson's disease (PD) and inflammatory bowel disorders. However, the penetrance of the most prevalent LRRK2 mutation, G2019S, is 〈 50%. Factors other than genetic mutations are needed in PD process. Objectives To examine whether and how gut inflammation may act as an environmental trigger to neurodegeneration in PD. Methods A mild and chronic dextran sodium sulfate (DSS)‐induced colitis mice model harboring LRRK2 G2019S mutation was established. The colitis severity, immune responses, locomotor function, dopaminergic neuron, and microglia integrity were compared between littermate controls, transgenic LRRK2 wild type ( WT ), and LRRK2 G2019S mice. Results The LRRK2 G2019S mice are more vulnerable to DSS‐induced colitis than littermate controls or LRRK2 WT animals with increased intestinal expressions of pattern‐recognition receptors, including toll‐like receptors (TLRs), nuclear factor (NF)‐κB activation, and pro‐inflammatory cytokines secretion, especially tumor necrosis factor (TNF)‐α. Notably, the colonic expression of α‐synuclein was significantly increased in LRRK2 G2019S colitis mice. We subsequently observed more aggravated locomotor defect, microglia activation, and dopaminergic neuron loss in LRRK2 G2019S colitis mice than control animals. Treatment with anti‐TNF‐α monoclonal antibody, adalimumab, abrogated both gut and neuroinflammation, mitigated neurodegeneration, and improved locomotor function in LRRK2 G2019S colitis mice. Finally, we validated increased colonic expressions of LRRK2, TLRs, and NF‐κB pathway proteins and elevated plasma TNF‐α level in PD patients compared to controls, especially in those with LRRK2 risk variants. Conclusions Our findings demonstrate that chronic colitis promotes parkinsonism in genetically susceptible mice and TNF‐α plays a detrimental role in the gut‐brain axis of PD. © 2021 International Parkinson and Movement Disorder Society
    Type of Medium: Online Resource
    ISSN: 0885-3185 , 1531-8257
    URL: Issue
    URL: Article
    DOI: 10.1002/mds.v37.4
    DOI: 10.1002/mds.28890
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2041249-6
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  • 10
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    Sensitivity of Sniffer Dogs for a Diagnosis of Parkinson's Disease: A Diagnostic Accuracy Study
    Wiley ; 2022
    In:  Movement Disorders Vol. 37, No. 9 ( 2022-09), p. 1807-1816
    Details
    In: Movement Disorders, Wiley, Vol. 37, No. 9 ( 2022-09), p. 1807-1816
    Abstract: The diagnostic criteria for Parkinson's disease (PD) remain complex, which is especially problematic for nonmovement disorder experts. A test is required to establish a diagnosis of PD with improved accuracy and reproducibility. Objective The study aimed to investigate the sensitivity and specificity of tests using sniffer dogs to diagnose PD. Methods A prospective, diagnostic case‐control study was conducted in four tertiary medical centers in China to evaluate the accuracy of sniffer dogs to distinguish between 109 clinically established medicated patients with PD, 654 subjects without PD, 37 drug‐naïve patients with PD, and 185 non‐PD controls. The primary outcomes were sensitivity and specificity of sniffer dog's identification. Results In the study with patients who were medicated, when two or all three sniffer dogs yielded positive detection results in a sample tested, the index test sensitivity, specificity, and positive and negative likelihood ratios were 91% (95% CI: 84%–96%), 95% (95% CI: 93%–97%), and 19.16 (95% CI: 13.52–27.16) and 0.10 (95% CI: 0.05–0.17), respectively. The corresponding sensitivity, specificity, and positive and negative likelihood ratios in patients who were drug‐naïve were 89% (95% CI: 75%–96%), 86% (95% CI: 81%–91%), and 6.6 (95% CI: 4.51–9.66) and 0.13 (95% CI: 0.05–0.32), respectively. Conclusions Tests using sniffer dogs may be a useful, noninvasive, fast, and cost‐effective method to identify patients with PD in community screening and health prevention checkups as well as in neurological practice. © 2022 International Parkinson and Movement Disorder Society.
    Type of Medium: Online Resource
    ISSN: 0885-3185 , 1531-8257
    URL: Issue
    URL: Article
    DOI: 10.1002/mds.v37.9
    DOI: 10.1002/mds.29180
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2041249-6
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