In:
British Journal of Haematology, Wiley, Vol. 176, No. 1 ( 2017-01), p. 86-91
Abstract:
Cure rates of children and adults with acute myeloid leukaemia ( AML ) remain unsatisfactory partly due to chemotherapy resistance. We investigated the genetic basis of AML in 107 primary cases by sequencing 670 genes mutated in haematological malignancies. SETBP 1 , ASXL 1 and RELN mutations were significantly associated with primary chemoresistance. We identified genomic alterations not previously described in AML , together with distinct genes that were significantly overexpressed in therapy‐resistant AML . Defined gene mutations were sufficient to explain primary induction failure in only a minority of cases. Thus, additional genetic or molecular mechanisms must cause primary chemoresistance in paediatric and adult AML .
Type of Medium:
Online Resource
ISSN:
0007-1048
,
1365-2141
DOI:
10.1111/bjh.2017.176.issue-1
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
1475751-5
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