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  • Wiley  (14)
  • 1
    Online Resource
    Online Resource
    Heritability of tea drinking and its relationship with cigarette smoking in the Chinese male adult twins
    Wiley ; 2022
    In:  Addiction Biology Vol. 27, No. 2 ( 2022-03)
    Details
    In: Addiction Biology, Wiley, Vol. 27, No. 2 ( 2022-03)
    Abstract: The aims of this study are to estimate the contributions of genetic factors to the variation of tea drinking and cigarette smoking, to examine the roles of genetic factors in their correlation and further to investigate underlying causation between them. We included 11 625 male twin pairs from the Chinese National Twin Registry (CNTR). Bivariate genetic modelling was fitted to explore the genetic influences on tea drinking, cigarette smoking and their correlation. Inference about Causation through Examination of FAmiliaL CONfounding (ICE FALCON) was further used to explore the causal relationship between them. We found that genetic factors explained 17% and 23% of the variation in tea drinking and cigarette smoking, respectively. A low phenotypic association between them was reported ( r ph  = 0.21, 95% confidence interval [CI]: [0.19, 0.24] ), which was partly attributed to common genetic factors ( r A  = 0.45, 95% CI [0.19, 1.00]). In the ICE FALCON analysis with current smoking as the exposure, tea drinking was associated with his own (βself = 0.39, 95% CI [0.23, 0.55] ) and his co‐twin's smoking status (βco‐twin = 0.25, 95% CI [0.10, 0.41]). Their association attenuated with borderline significance conditioning on his own smoking status ( p  = 0.045), indicating a suggestive causal effect of smoking status on tea drinking. On the contrary, when we used tea drinking as the predictor, we found familial confounding between them only. In conclusion, both tea drinking and cigarette smoking were influenced by genetic factors, and their correlation was partly explained by common genetic factors. In addition, our finding suggests that familial confounders account for the relationship between tea drinking and cigarette smoking. And current smoking might have a causal effect on weekly tea drinking, but not vice versa.
    Type of Medium: Online Resource
    ISSN: 1355-6215 , 1369-1600
    URL: Issue
    URL: Article
    DOI: 10.1111/adb.v27.2
    DOI: 10.1111/adb.13129
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1495537-4
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  • 2
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    Association of psychological distress and DNA methylation: A 5‐year longitudinal population‐based twin study
    Wiley ; 2023
    In:  Psychiatry and Clinical Neurosciences
    Details
    In: Psychiatry and Clinical Neurosciences, Wiley
    Abstract: To identify the psychological distress (PD) associated 5'‐cytosine‐phosphate‐guanine‐3' (CpG) sites (CpGs), and investigate the temporal relationship between dynamic changes in DNA methylation (DNAm) and PD. Methods This study included 1,084 twins from the Chinese National Twin Register (CNTR). The CNTR conducted epidemiological investigations and blood withdrawal twice in 2013 and 2018. These included twins were used to perform Epigenome‐Wide Association Studies (EWAS) and to validate the previously reported PD‐associated CpGs selected from previous EWAS in PubMed, EMBASE and the EWAS catalogue. Next, a cross‐lagged study was performed to examine the temporality between changes in DNAm and PD in 308 twins who completed both 2013 and 2018 surveys. Results The EWAS analysis of our study identified 25 CpGs. In the validation analysis, 741 CpGs from 29 previous EWAS studies on PD were selected for validation, and 101 CpGs were validated to be significant at FDR 〈 0.05. The cross‐lagged analysis found a unidirectional path from PD to DNAm at 14 CpGs, while no sites showed significance from DNAm to PD. Conclusions This study identified and validated PD‐related CpG sites in Chinese twin population, and suggested that PD may be the cause of changes in DNAm over time. The findings provide new insights into the molecular mechanisms underlying PD pathophysiology. This article is protected by copyright. All rights reserved.
    Type of Medium: Online Resource
    ISSN: 1323-1316 , 1440-1819
    URL: Article
    DOI: 10.1111/pcn.13606
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2010264-1
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  • 3
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    Education, income, and obesity: A nationwide Chinese twin study
    Wiley ; 2022
    In:  Obesity Vol. 30, No. 4 ( 2022-04), p. 931-942
    Details
    In: Obesity, Wiley, Vol. 30, No. 4 ( 2022-04), p. 931-942
    Abstract: This study aimed to examine the association of socioeconomic status with obesity. Methods A total of 39,262 twin individuals were included from the Chinese National Twin Registry (CNTR). Generalized estimating equation models for unmatched twin individual analyses and conditional logistic regression for the co‐twin matched design were used. Inference about Causation through Examination of FAmiliaL CONfounding (ICE FALCON) was used to explore the evidence of a causal relationship. Results In general estimating equation models, high education level and income were associated with lower risk of obesity (odds ratio [OR] = 0.74 [95% CI: 0.65 to 0.84] and 0.86 [95% CI: 0.77 to 0.96]). In conditional logistic regression analysis, the association with education was significant (OR = 0.50 [95% CI: 0.34 to 0.74] ) but the association with income was insignificant (OR = 0.74 [95% CI: 0.48 to 1.15]). From the ICE FALCON analysis, a twin’s obesity was associated with the co‐twin’s education and income. After adjusting for the twin’s own education, the association disappeared ( = −0.10 [95% CI: −0.26 to 0.07] ), whereas the twin’s obesity was still associated with the co‐twin’s income but attenuated toward the null ( = −0.21 [95% CI: −0.36 to −0.06]). Conclusions Socioeconomic status is negatively associated with obesity. Education may have a causal effect on obesity, whereas the association between income and obesity is confounded by familial factors.
    Type of Medium: Online Resource
    ISSN: 1930-7381 , 1930-739X
    URL: Article
    DOI: 10.1002/oby.23390
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2027211-X
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  • 4
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    Online Resource
    Diabetes, plasma glucose and incidence of pancreatic cancer: A prospective study of 0.5 million C hinese adults and a meta‐analysis of 22 cohort studies
    Wiley ; 2017
    In:  International Journal of Cancer Vol. 140, No. 8 ( 2017-04-15), p. 1781-1788
    Details
    In: International Journal of Cancer, Wiley, Vol. 140, No. 8 ( 2017-04-15), p. 1781-1788
    Abstract: What's new? Diabetes is associated with increased risk of pancreatic cancer (PC) in Western populations, but uncertainty remains about the relevance of plasma glucose among people without diabetes. In this first prospective study investigating the association of diabetes with PC risk in China, where the increase in diabetes prevalence has been very recent, diabetes was associated with an almost twofold increased risk of PC, with random plasma glucose being positively associated with PC risk among participants without prior diagnosis of diabetes. In meta‐analysis, the results were consistent with previous evidence in Western populations, highlighting diabetes as a potential aetiological factor of PC.
    Type of Medium: Online Resource
    ISSN: 0020-7136 , 1097-0215
    URL: Issue
    URL: Article
    DOI: 10.1002/ijc.v140.8
    DOI: 10.1002/ijc.30599
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 218257-9
    detail.hit.zdb_id: 1474822-8
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  • 5
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    Smoking, alcohol, and diet in relation to risk of pancreatic cancer in China: a prospective study of 0.5 million people
    Wiley ; 2018
    In:  Cancer Medicine Vol. 7, No. 1 ( 2018-01), p. 229-239
    Details
    In: Cancer Medicine, Wiley, Vol. 7, No. 1 ( 2018-01), p. 229-239
    Abstract: In China, the incidence of pancreatic cancer (PC) has increased in recent decades. However, little is known about the relevance to PC risk of lifestyle and behavioral factors such as smoking, alcohol drinking, and diet. The China Kadoorie Biobank prospective study recruited 512,891 adults (210,222 men, 302,669 women) aged 30–79 (mean 52) years from 10 diverse areas during 2004–08. During ~9 years of follow‐up, 688 incident cases of PC were recorded among those who had no prior history of cancer at baseline. Cox regression yielded adjusted hazard ratios (HR) for PC associated with smoking, alcohol and selected dietary factors. Overall, 74% of men were ever‐regular smokers and 33% of men drank at least weekly, compared with only 3% and 2% of women, respectively. Among men, current regular smoking was associated with an adjusted HR of 1.25 (95% CI 1.08–1.44) for PC, with greater excess risk in urban than rural areas (1.46 [1.19–1.79] vs 1.04 [0.86–1.26]). Heavy, but not light to moderate, alcohol drinking (i.e. ≥420 g/week) was associated with significant excess risk (1.69 [1.21–2.37] ), again more extreme in urban than rural areas (1.93 [1.29–2.87] vs 1.35 [0.74–2.48] ). Overall, regular consumption of certain foodstuffs was associated with PC risk, with adjusted daily vs never/rare consumption HRs of 0.66 (0.56–0.79) for fresh fruit and 1.16 (1.01–1.33) for red meat. In China, smoking and heavy alcohol drinking were independent risk factors for PC in men. Lower fresh fruit and higher red meat consumption were also associated with higher risk of PC.
    Type of Medium: Online Resource
    ISSN: 2045-7634 , 2045-7634
    URL: Issue
    URL: Article
    DOI: 10.1002/cam4.2018.7.issue-1
    DOI: 10.1002/cam4.1261
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2659751-2
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  • 6
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    Boosting Trapping in Dark Mode and Emission in Bright Mode using a Quad‐Nanohole
    Wiley ; 2023
    In:  Advanced Optical Materials Vol. 11, No. 12 ( 2023-06)
    Details
    In: Advanced Optical Materials, Wiley, Vol. 11, No. 12 ( 2023-06)
    Abstract: Single‐emitter luminescence is attractive for various applications, including single‐molecular biology, super‐resolution optical imaging, and single‐photon sources. Optical trapping as a particle positioning method is promising for enhancing luminescence by a precise matching of the nanoemitter to the sub‐wavelength mode volume of the photonic structure. Simultaneously satisfying the requirement of both luminescence and trapping enhancement, however, is challenging. Here, stable optical trapping and the in situ excitation of highly bright photoluminescence of a single up‐conversion nanoparticle (UCNP) are demonstrated. A quad‐nanohole structure with two bright‐field modes for enhanced excitation and emission of the UCNP, as well as a dark‐field mode for enhanced optical trapping is designed. It is experimentally demonstrated that the photoluminescence of the UCNP optically trapped in the quad‐nanohole is enhanced by a factor of 87 (as compared to a UCNP trapped in the single nanohole), and this enhancement factor surpasses that from a bowtie nanohole—one of the “gold standards” for local field enhancement. This work provides a route to assemble super‐bright single‐emitter luminescence by optical trapping.
    Type of Medium: Online Resource
    ISSN: 2195-1071 , 2195-1071
    URL: Issue
    URL: Article
    DOI: 10.1002/adom.v11.12
    DOI: 10.1002/adom.202202924
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2708158-8
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  • 7
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    Exfoliated Ultrathin ZnIn 2 S 4 Nanosheets with Abundant Zinc Vacancies for Enhanced CO 2 Electroreduction to Formate
    Wiley ; 2021
    In:  ChemSusChem Vol. 14, No. 3 ( 2021-02-05), p. 852-859
    Details
    In: ChemSusChem, Wiley, Vol. 14, No. 3 ( 2021-02-05), p. 852-859
    Abstract: Electrocatalytic conversion of carbon dioxide (CO 2 ) is promising for balancing carbon cycles while producing value‐added feedstocks. Herein, ultrathin ZnIn 2 S 4 nanosheets with abundant Zn vacancies are demonstrated for electrochemically reducing CO 2 to formate. Specifically, a partial current density of 245 mA cm −2 with a near‐unity faradaic efficiency of 94 % for formate generation was achieved over the ultrathin ZnIn 2 S 4 nanosheets in a flow cell configuration. Experimental and theoretical results revealed that abundant Zn vacancies in the ultrathin ZnIn 2 S 4 nanosheets with a high electrochemically active surface area synergistically optimized the intermediate binding energy and contributed to the boosted selectivity and activity. This work may provide useful understandings in designing efficient catalysts for selective CO 2 electroreduction.
    Type of Medium: Online Resource
    ISSN: 1864-5631 , 1864-564X
    URL: Issue
    URL: Article
    DOI: 10.1002/cssc.v14.3
    DOI: 10.1002/cssc.202002785
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2411405-4
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  • 8
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    Association of dietary patterns, circulating lipid profile, and risk of obesity
    Wiley ; 2023
    In:  Obesity Vol. 31, No. 5 ( 2023-05), p. 1445-1454
    Details
    In: Obesity, Wiley, Vol. 31, No. 5 ( 2023-05), p. 1445-1454
    Abstract: The aim of this study was to simultaneously explore the associations of major dietary patterns (DP) with lipid profiles and the associations of these profiles with general and central obesity risks and to evaluate the extent to which the metabolites mediate such associations. Methods Habitual food consumption of 4778 participants with an average age of 47.0 from the China Kadoorie Biobank was collected using a 12‐item food frequency questionnaire. Plasma samples were analyzed via targeted nuclear magnetic resonance (NMR) spectroscopy to quantify 129 lipid‐related metabolites. Anthropometric information was measured by trained staff. Results Two DPs were derived by factor analysis. The newly affluent southern pattern was characterized by high intakes of rice, meat, poultry, and fish, whereas the balanced pattern was characterized by consuming meat, poultry, fish, fresh fruit, fresh vegetables, dairy, eggs, and soybean. The newly affluent southern pattern was positively associated with 45 metabolites, which were positively associated with risks of obesity at the same time. The global lipid profile potentially explained 30.9%, 34.7%, and 53.1% of the effects of this DP on general obesity, waist circumference‐defined central obesity, and waist‐hip ratio‐defined central obesity, respectively. Conclusions The newly affluent southern pattern points to an altered lipid profile, which showed higher general and central obesity risks. These findings partly suggest the biological mechanism for the obesogenic effects of this DP.
    Type of Medium: Online Resource
    ISSN: 1930-7381 , 1930-739X
    URL: Issue
    URL: Article
    DOI: 10.1002/oby.v31.5
    DOI: 10.1002/oby.23720
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2027211-X
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  • 9
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    Metabolic‐associated fatty liver disease in relation to site‐specific and multiple‐site subclinical atherosclerosis
    Wiley ; 2023
    In:  Liver International Vol. 43, No. 8 ( 2023-08), p. 1691-1698
    Details
    In: Liver International, Wiley, Vol. 43, No. 8 ( 2023-08), p. 1691-1698
    Abstract: Non‐alcoholic fatty liver disease (NAFLD) and the newly proposed metabolic‐associated fatty liver disease (MAFLD) were each associated with subclinical atherosclerosis. However, there is limited evidence on risk of atherosclerosis in individuals who meet the criteria for one but not the other. We aimed to investigate the associations of MAFLD or NAFLD status with site‐specific and multiple‐site atherosclerosis. Methods This is a prospective cohort study involving 4524 adults within the MJ health check‐up cohort. Logistic regression model was used to estimate odds ratios (ORs) and confidence intervals (CIs) for subclinical atherosclerosis (elevated carotid intima‐media thickness [CIMT], carotid plaque [CP] , coronary artery calcification [CAC] and retinal atherosclerosis [RA] ) associated with MAFLD or NAFLD status, MAFLD subtypes and fibrosis status. Results MAFLD was associated with higher risks of elevated CIMT, CP, CAC and RA (OR: 1.41 [95% CI 1.18–1.68], 1.23 [1.02–1.48] , 1.60 [1.24–2.08], and 1.79 [1.28–2.52] , respectively), whereas NAFLD per se did not increase risk of atherosclerosis except for elevated CIMT. Individuals who met both definitions or the definition for MAFLD but not NAFLD had higher risk of subclinical atherosclerosis. Among MAFLD subtypes, MAFLD with diabetes had the highest risk of subclinical atherosclerosis, but the associations did not differ by fibrosis status. Stronger positive associations were observed of MAFLD with multiple‐site than single‐site atherosclerosis. Conclusions In Chinese adults, MAFLD was associated with subclinical atherosclerosis, with stronger associations for multiple‐site atherosclerosis. More attention should be paid to MAFLD with diabetes, and MAFLD might be a better predictor for atherosclerotic disease than NAFLD.
    Type of Medium: Online Resource
    ISSN: 1478-3223 , 1478-3231
    URL: Issue
    URL: Article
    DOI: 10.1111/liv.v43.8
    DOI: 10.1111/liv.15591
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2124684-1
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  • 10
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    Advanced Catalyst Design and Reactor Configuration Upgrade in Electrochemical Carbon Dioxide Conversion
    Wiley ; 2023
    In:  Advanced Materials
    Details
    In: Advanced Materials, Wiley
    Abstract: Electrochemical carbon dioxide reduction reaction (CO 2 RR) driven by renewable energy shows great promise in mitigating and potentially reversing the devastating effects of anthropogenic climate change and environmental degradation. The simultaneous synthesis of energy‐dense chemicals can meet global energy demand while decoupling emissions from economic growth. However, the development of CO 2 RR technology faces challenges in catalyst discovery and device optimization that hinder their industrial implementation. In this contribution, we provide a comprehensive overview of the current state of CO 2 RR research, starting with the background and motivation for this technology, followed by the fundamentals and evaluated metrics. We then discuss the underlying design principles of electrocatalysts, emphasizing their structure–performance correlations and advanced electrochemical assembly cells that can increase CO 2 RR selectivity and throughput. Finally, we look to the future and identify opportunities for innovation in mechanism discovery, material screening strategies, and device assemblies to move toward a carbon‐neutral society. This article is protected by copyright. All rights reserved
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Article
    DOI: 10.1002/adma.202303052
    RVK:
    UA 1538
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1474949-X
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