In:
Pediatrics International, Wiley, Vol. 48, No. 3 ( 2006-06), p. 313-320
Abstract:
Background: The aim of this study was to evaluate cardiac function and cardiac reserved function in asymptomatic anthracycline‐treated long‐time survivors of childhood cancer using dobutamine (DOB) stress echocardiography. Methods: A total of 26 patients (19 males and 7 females) were divided into four groups according to cumulative dose of anthracycline (ATC): non‐anthracycline group (N group), seven cases; low anthracycline cumulative dose group (L group), five cases (≤200 mg/m 2 ); medium anthracycline cumulative dose group (M group), seven cases (200– 〈 400 mg/m 2 ); high anthracycline group (H group), seven cases (≥400 mg/m 2 ). DOB infusion was begun at 5 μg/kg per min (γ) and increased up to 30γ. Cardiac function and cardiac reserved function at rest, after low‐dose and high‐dose DOB stress, were estimated. Results: In the H group, % left ventricular posterior wall thickening (%PWT) at rest and ratio of maximum early filling peak velocity (E) and atrial contraction peak velocity (A) from the left ventricular transmitral flow wave (E/A) and %PWT at DOB 5γ stress were significantly lower than in other groups ( P 〈 0.05). After DOB 30γ stress in groups given 〉 200 mg/m 2 end‐systolic wall stress was significantly higher and E/A and %PWT were significantly lower than those of other groups ( P 〈 0.05). ATC cumulative dose strongly correlated with %PWT after DOB 30γ stress ( P 〈 0.001). Conclusions: Subclinical ATC cardiotoxicity was detected by high‐dose DOB stress echocardiography at lower cumulative doses than with other methods. %PWT appears to be a useful index for detection of ATC cardiotoxicity.
Type of Medium:
Online Resource
ISSN:
1328-8067
,
1442-200X
DOI:
10.1111/ped.2006.48.issue-3
DOI:
10.1111/j.1442-200X.2006.02210.x
Language:
English
Publisher:
Wiley
Publication Date:
2006
detail.hit.zdb_id:
2008621-0
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