In:
International Journal of Cancer, Wiley, Vol. 149, No. 5 ( 2021-09), p. 1166-1180
Abstract:
What's new? Protein kinases have long been thought to be important in the biology of many cancers. However, kinase expression levels don't always correlate with prognosis. Could it be kinase activity that determines tumor behavior? In this study, the authors characterized the kinome of head and neck squamous cell carcinoma (HNSCC). They found that increased activity of Src family kinases (SFK) was associated with worse prognosis, and that blocking SFK activity blocked tumor cell growth. These results indicate that functional kinome profiling may provide a valuable tool for understanding tumor biology and identifying targeted therapies.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2021
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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