In:
Brain and Behavior, Wiley, Vol. 8, No. 3 ( 2018-03)
Abstract:
This study aims to investigate the association between the presence and frequency of cortical lesions ( CL s), and the clinical and psychological features of multiple sclerosis ( MS ). Methods A total of 19 patients with MS were examined using double inversion recovery ( DIR ) sequences with 3T magnetic resonance imaging ( MRI ) and classified into two groups: CL and nonâ CL . Inâhouse software was used to quantitatively determine the atrophy of each brain region. Activities of daily living ( ADL ) were estimated using the Kurtzke Expanded Disability Status Scale ( EDSS ). Cognitive function was assessed using the following tests: MiniâMental State Examination ( MMSE ), Trail Making Test ( TMT ), and Paced Auditory Serial Addition Task ( PASAT ). Z âscores were used to assess significant differences in the neuropsychological test outcomes between the groups. Results Six of 19 patients had subcortical and deep WM lesions (nonâ CL group; diagnosed with relapsingâremitting MS ). Thirteen of 19 patients had both subcortical and cortical lesions ( CL group; 9ârelapsingâremitting MS ; 4âprimary/secondary progressive MS ). There were no significant differences in age, education, and disease duration, but EDSS scores were significantly higher in the CL group compared to the nonâ CL group. There were no significant differences in gray and white matter volume between the CL and the nonâ CL groups, but the white matter lesion volume was significantly higher in the CL group compared to the nonâ CL group. Neuropsychological tests showed significant performance worsening in the CL group as compared to the standard values for healthy individuals in their age group, especially in the TMT data. Conclusions Progressive MS , which was associated with decreased physical functioning, ADL , and cognitive impairment, was found in patients in the CL group.
Type of Medium:
Online Resource
ISSN:
2162-3279
,
2162-3279
DOI:
10.1002/brb3.2018.8.issue-3
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2623587-0
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