In:
Glia, Wiley, Vol. 47, No. 1 ( 2004-07), p. 30-34
Abstract:
The distribution of metallothioneins I/II in the mouse brain and their specific area distribution upon physical stress were studied. To induce physical stress, groups of mice were subjected to total darkness for different periods (2 weeks, 1 month, and 2 months). The concentration of metallothioneins, evaluated by immunohistochemistry, as well as area‐specific protein expression, were found in the following quantitative order: corpus striatum, cerebellum, mesencephalon, hippocampus with fornix, parts of thalamus, and pons. All other brain areas were marginally affected, or even unaffected, in terms of immunopositive metallothionein reaction. Metallothionein I/II expression was compared with the immunopositivity of glial fibrillary acidic protein (GFAP). It is noteworthy that metallothioneins and GFAP are expressed in different types of astrocytes. © 2004 Wiley‐Liss, Inc.
Type of Medium:
Online Resource
ISSN:
0894-1491
,
1098-1136
Language:
English
Publisher:
Wiley
Publication Date:
2004
detail.hit.zdb_id:
1474828-9
SSG:
12
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