In:
Cancer Science, Wiley, Vol. 94, No. 10 ( 2003-10), p. 858-863
Abstract:
Malignant lymphoma frequently develops in the pleural cavity of patients with over 20 years' history of pyothorax. The term pyothorax‐associated lymphoma (PAL) has been proposed for this type of tumor. We established four novel lymphoma cell lines (OPL‐3, ‐4, ‐5, and ‐7) from four patients with PAL. Characteristics of the four cell lines are as follows: B‐cell nature with defective expression of B‐cell and T‐cell surface antigens, monoclonal pattern of Epstein‐Barr virus (EBV) infection in lymphoma cells (thus indicating an etiological role of EBV for lymphomagenesis), complicated chromosomal abnormalities with numerous structural and numerical abnormalities, and occasional but distinct genome instability. These abnormalities in cell character might be caused by the specific circumstances of PAL lymphomagenesis, i.e., chronic inflammation. Thus, PAL cell lines could be useful in analysis of molecular mechanisms leading to malignancy in chronic inflammation.
Type of Medium:
Online Resource
ISSN:
1347-9032
,
1349-7006
DOI:
10.1111/cas.2003.94.issue-10
DOI:
10.1111/j.1349-7006.2003.tb01367.x
Language:
English
Publisher:
Wiley
Publication Date:
2003
detail.hit.zdb_id:
2115647-5
detail.hit.zdb_id:
2111204-6
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