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  • 1
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    Online Resource
    Enantioselective Synthesis of Arene cis ‐Dihydrodiols from 2‐Pyrones
    Wiley ; 2019
    In:  Angewandte Chemie Vol. 131, No. 41 ( 2019-10-07), p. 14704-14709
    Details
    In: Angewandte Chemie, Wiley, Vol. 131, No. 41 ( 2019-10-07), p. 14704-14709
    Abstract: An enantioselective chemical synthesis of arene cis ‐dihydrodiols has been realized from 2‐pyrones through sequential ytterbium‐catalyzed asymmetric inverse‐electron‐demand Diels–Alder (IEDDA) reaction of 2‐pyrones and retro‐Diels–Alder extrusion of CO 2 . By using this strategy, a series of substituted arene cis ‐dihydrodiols can be obtained efficiently with high enantioselectivity ( 〉 99 % ee in many cases). Based on this strategy, efficient and concise asymmetric total syntheses of (+)‐MK7607 and 1‐ epi ‐(+)‐MK7607 were accomplished.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v131.41
    DOI: 10.1002/ange.201908284
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2019
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    detail.hit.zdb_id: 505872-7
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    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
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  • 2
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    Novel variants, muscle imaging, and myopathological changes in Chinese patients with VCP ‐related multisystem proteinopathy
    Wiley ; 2023
    In:  Molecular Genetics & Genomic Medicine Vol. 11, No. 7 ( 2023-07)
    Details
    In: Molecular Genetics & Genomic Medicine, Wiley, Vol. 11, No. 7 ( 2023-07)
    Abstract: The objective of this research was to study the clinical features, genetic characteristics, muscle imaging, and muscle pathological changes of a cohort of Chinese patients with mutations in the valosin‐containing protein ( VCP ) gene. Methods Nine patients from seven Chinese pedigrees were recruited. Variants were detected by next‐generation sequencing and confirmed by Sanger sequencing. Thigh muscle MRIs were performed in five patients. All the patients received muscle biopsies. Results Seven variants in VCP were identified, and two were novel. All the patients presented with adult‐onset muscle weakness. The appearance of “isolated island sign” or “contra‐isolated island sign” was observed in four of the five the patients on muscle MRIs. Muscle biopsies demonstrated the combination of neuropathic and myopathic changes in seven patients and muscle dystrophic changes in two patients. Notably, rimmed vacuoles and cytoplasmic VCP and p62‐positive protein aggregates were observed in all the patients. Conclusion Our finding of novel variants expanded the mutational spectrum of the VCP gene. This cohort of Chinese patients with VCP mutations mainly present with inclusion body myopathy with predominant limb–girdle distribution. The characteristic pattern of fatty infiltration, especially the “isolated island” and “contra‐isolated island” on muscle MRI, along with rimmed vacuoles in muscle biopsy, provides valuable clues for guiding genetic diagnostic workup.
    Type of Medium: Online Resource
    ISSN: 2324-9269 , 2324-9269
    URL: Issue
    URL: Article
    DOI: 10.1002/mgg3.v11.7
    DOI: 10.1002/mgg3.2176
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2734884-2
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  • 3
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    Online Resource
    Enantioselective Synthesis of Arene cis ‐Dihydrodiols from 2‐Pyrones
    Wiley ; 2019
    In:  Angewandte Chemie International Edition Vol. 58, No. 41 ( 2019-10-07), p. 14562-14567
    Details
    In: Angewandte Chemie International Edition, Wiley, Vol. 58, No. 41 ( 2019-10-07), p. 14562-14567
    Abstract: An enantioselective chemical synthesis of arene cis ‐dihydrodiols has been realized from 2‐pyrones through sequential ytterbium‐catalyzed asymmetric inverse‐electron‐demand Diels–Alder (IEDDA) reaction of 2‐pyrones and retro‐Diels–Alder extrusion of CO 2 . By using this strategy, a series of substituted arene cis ‐dihydrodiols can be obtained efficiently with high enantioselectivity ( 〉 99 % ee in many cases). Based on this strategy, efficient and concise asymmetric total syntheses of (+)‐MK7607 and 1‐ epi ‐(+)‐MK7607 were accomplished.
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    URL: Article
    DOI: 10.1002/anie.v58.41
    DOI: 10.1002/anie.201908284
    RVK:
    VA 2100
    Language: English
    Publisher: Wiley
    Publication Date: 2019
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    detail.hit.zdb_id: 123227-7
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  • 4
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    Berberine‐loaded Janus nanocarriers for magnetic field‐enhanced therapy against hepatocellular carcinoma
    Wiley ; 2017
    In:  Chemical Biology & Drug Design Vol. 89, No. 3 ( 2017-03), p. 464-469
    Details
    In: Chemical Biology & Drug Design, Wiley, Vol. 89, No. 3 ( 2017-03), p. 464-469
    Abstract: Berberine, an bioactive isoquinolin alkaloid from traditional Chinese herbs, is considered to be a promising agent based on its remarkable activity against hepatocellular carcinoma. However, the clinical application of this nature compound had been hampered owing to its properties such as poor aqueous solubility, low gastrointestinal absorption, and reduced bioavailability. Therefore, we developed Janus magnetic mesoporous silica nanoparticles (Fe 3 O 4 ‐ mSiO 2 NP s) consisting of a Fe 3 O 4 head for magnetic targeting and a mesoporous SiO 2 body for berberine delivery. A pH ‐sensitive group was introduced on the surface of mesoporous silica for berberine loading to develop a tumor microenvironment‐responsive nanocarrier, which exhibited uniform morphology, good superparamagnetic properties, high drug‐loading amounts, superior endocytic ability, and low cytotoxicity. Berberine‐loaded Fe 3 O 4 ‐ mSiO 2 NP s exerted extraordinarily high specificity for hepatocellular carcinoma cells, which was due to the pH ‐responsive berberine release, as well as higher endocytosis capacity in hepatocellular carcinoma cells rather than normal liver cells. More importantly, an external magnetic field could significantly improve antitumor activity of Ber‐loaded Fe 3 O 4 ‐ mSiO 2 NP s through enhancing berberine internalization. Taken together, our results suggest that Janus nanocarriers driven by the magnetic field may provide an effective and safe way to facilitate clinical use of berberine against hepatocellular carcinoma.
    Type of Medium: Online Resource
    ISSN: 1747-0277 , 1747-0285
    URL: Issue
    URL: Article
    DOI: 10.1111/cbdd.2017.89.issue-3
    DOI: 10.1111/cbdd.12866
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2216600-2
    SSG: 12
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  • 5
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    Online Resource
    Modulation of fried spring roll wrapper quality upon treatment of batter with maltogenic amylase, transglutaminase and bromelain
    Wiley ; 2024
    In:  Journal of the Science of Food and Agriculture
    Details
    In: Journal of the Science of Food and Agriculture, Wiley
    Abstract: Fried foods are favored for their unique crispiness, golden color and flavor, but they also face great challenge because of their high oil content, high calories and the existence of compounds such as acrylamide and polycyclic aromatic hydrocarbons. Long‐term consumption of fried foods may adversely affect health. Therefore, it is necessary to explore fried foods with lower oil contents and a high quality to meet the demand. RESULTS A method of enzyme treatment was explored to investigate the effects of maltogenic amylase (MA), transglutaminase (TG) and bromelain (BRO) on the physicochemical properties of the batter and the quality of fried spring roll wrapper (FSRW). The results showed that the MA‐, TG‐ or BRO‐treated batters had a significant shear‐thinning behavior, especially with an increase in viscosity upon increasing TG contents. FSRW enhanced its fracturability from 419.19 g (Control) to 616.50 g (MA‐6 U g −1 ), 623.49 g (TG‐0.75 U g −1 ) and 644.96 g (BRO‐10 U g −1 ). Meanwhile, in comparison with BRO and MA, TG‐0.5 U g −1 endowed batter with the highest density and thermal stability. MA‐15 U g −1 and TG‐0.5 U g −1 displayed FSRW with uniform and dense pores, and significantly reduced its oil content by 18.05% and 25.02%, respectively. Moreover, compared to MA and TG, BRO‐50 U g −1 improved the flavor of FSRW. CONCLUSION MA, TG or BRO played a key role in affecting the physicochemical properties of the batter and the quality of FSRW. TG‐0.5 U g −1 remarkly reduced the oil content of FSRW with a great potential in practical application. © 2024 Society of Chemical Industry.
    Type of Medium: Online Resource
    ISSN: 0022-5142 , 1097-0010
    URL: Article
    DOI: 10.1002/jsfa.13470
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2001807-1
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  • 6
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    Genome‐wide identification of long non‐coding RNAs ( lncRNAs ) associated with malathion resistance in Bactrocera dorsalis
    Wiley ; 2021
    In:  Pest Management Science Vol. 77, No. 5 ( 2021-05), p. 2292-2301
    Details
    In: Pest Management Science, Wiley, Vol. 77, No. 5 ( 2021-05), p. 2292-2301
    Abstract: Long non‐coding RNAs (lncRNAs) play important roles in the regulation of biological processes and have been identified in many species including insects. However, the association between lncRNAs and pesticide resistance in insect species such as Bactrocera dorsalis is unknown. RESULTS RNA‐seq was performed on malathion resistant (MR1) and susceptible (MS) strains of B. dorsalis and a total of 6171 lncRNAs transcripts were identified. These included 3728 lincRNAs, 653 antisense lncRNAs, 1402 intronic lncRNAs, and 388 sense lncRNAs. A total of 40 and 52 upregulated lncRNAs were found in females and males of the MR1 strain compared to 54 and 49 in the same sexes of the MS strain, respectively. Twenty‐seven of these lncRNAs showed the same trend of expression in both females and males in the MR1 strain, in which 15 lncRNAs were upregulated and 12 were downregulated. RT‐qPCR results indicated that the differentially expressed lncRNAs were associated with malathion resistance. The lnc15010.10 and lnc3774.2 were highly expressed in the cuticle of the MR1 strain, indicating that these two lncRNAs may be related to malathion resistance. RNAi of lnc3774.2 and a bioassay showed that malathion resistance was possibly influenced by changes in the B. dorsalis cuticle. CONCLUSION LncRNAs of B. dorsalis potentially related to the malathion resistance were identified. Two lncRNAs appear to influence malathion resistance via modulating the structure, or components, of the cuticle. © 2021 Society of Chemical Industry
    Type of Medium: Online Resource
    ISSN: 1526-498X , 1526-4998
    URL: Issue
    URL: Article
    DOI: 10.1002/ps.v77.5
    DOI: 10.1002/ps.6256
    Language: English
    Publisher: Wiley
    Publication Date: 2021
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    SSG: 12
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  • 7
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    Anxiolytic effects of hippocampal neurosteroids in normal and neuropathic rats with spared nerve injury
    Wiley ; 2017
    In:  Journal of Neurochemistry Vol. 141, No. 1 ( 2017-04), p. 137-150
    Details
    In: Journal of Neurochemistry, Wiley, Vol. 141, No. 1 ( 2017-04), p. 137-150
    Abstract: Neurosteroids are synthesized in the nervous system from cholesterol or steroidal precursors imported from peripheral sources. These compounds are important allosteric modulators of GABA A receptors, which play a vital role in modulating hippocampal functions. Chronic pain is accompanied by increased neurosteroid production in the spinal cord and thalamus. We hypothesize that hippocampal neurosteroids participate in pain or pain‐associated emotions, which we tested with high‐performance liquid chromatography/tandem mass spectrometry and pharmacological behavioral tests. We observed increased levels of hippocampal neurosteroids (pregnenolone, progesterone, deoxycorticosterone, and allopregnanolone) in rats with chronic neuropathic pain (28 days after spared nerve injury). Meanwhile, the expression of the translocator protein, the upstream steroidogenesis rate‐limiting enzyme, increased in the ventral but not dorsal hippocampus of neuropathic rats. In both naïve and neuropathic rats, in vivo stereotaxic microinjection of PK 11195, the translocator protein inhibitor, into the ventral hippocampus exacerbated anxiety‐like behaviors. These results indicate anxiolytic effects of hippocampal neurosteroids in both normal and neuropathic rats. Neurosteroids could be considered as agents for treatment of general and pain‐related anxiety disorders. image
    Type of Medium: Online Resource
    ISSN: 0022-3042 , 1471-4159
    URL: Issue
    URL: Article
    DOI: 10.1111/jnc.2017.141.issue-1
    DOI: 10.1111/jnc.13965
    Language: English
    Publisher: Wiley
    Publication Date: 2017
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    SSG: 12
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  • 8
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    A glutathione S ‐transferase (BdGSTd9) participates in malathion resistance via directly depleting malathion and its toxic oxide malaoxon in Bactrocera dorsalis (Hendel)
    Wiley ; 2020
    In:  Pest Management Science Vol. 76, No. 8 ( 2020-08), p. 2557-2568
    Details
    In: Pest Management Science, Wiley, Vol. 76, No. 8 ( 2020-08), p. 2557-2568
    Abstract: The oriental fruit fly, Bactrocera dorsalis (Hendel), is a widespread agricultural pest that has evolved resistance to many commonly used insecticides including malathion. Glutathione S ‐transferases (GSTs) are multifunctional enzymes that metabolize insecticides directly or indirectly. The specific mechanism used by GSTs to confer malathion resistance in B. dorsalis is unclear. RESULTS BdGSTd9 was identified from B. dorsalis and was expressed at twice the level in a malathion‐resistant strain (MR) than in a susceptible strain (MS). By using RNAi of BdGSTd9 , the toxicity of malathion against MR was increased. Protein modelling and docking of BdGSTd9 with malathion and malaoxon indicated key amino acid residues for direct binding in the active site. In vitro assays with engineered Sf9 cells overexpressing BdGSTd9 demonstrated lower cytotoxicity of malathion. High performance liquid chromatography (HPLC) analysis indicated that malathion could be broken down significantly by BdGSTd9, and it also could deplete the malathion metabolite malaoxon, which possesses a higher toxicity to B. dorsalis . Taken together, the BdGSTd9 of B. dorsalis could not only deplete malathion, but also react with malaoxon and therefore enhance malathion resistance. CONCLUSION BdGSTd9 is a component of malathion resistance in B. dorsalis . It acts by depleting both malathion and malaoxon. © 2020 Society of Chemical Industry
    Type of Medium: Online Resource
    ISSN: 1526-498X , 1526-4998
    URL: Issue
    URL: Article
    DOI: 10.1002/ps.v76.8
    DOI: 10.1002/ps.5810
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2003455-6
    SSG: 12
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  • 9
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    Portal vein thrombosis compromises the performance of MELD and MELD‐Na scores in patients with cirrhosis
    Wiley ; 2023
    In:  Journal of Gastroenterology and Hepatology Vol. 38, No. 1 ( 2023-01), p. 129-137
    Details
    In: Journal of Gastroenterology and Hepatology, Wiley, Vol. 38, No. 1 ( 2023-01), p. 129-137
    Abstract: The accuracy of model for end‐stage liver disease (MELD) and MELD with sodium (MELD‐Na) scores in reflecting the clinical outcomes of patients with cirrhosis and portal vein thrombosis (PVT) remains unclear. This study aimed to evaluate the performance of scores in predicting 90‐day mortality in patients with cirrhosis and PVT. Methods Post hoc analysis was performed in two prospective cohorts (NCT02457637 and NCT03641872). The correlation between the MELD/MELD‐Na score and 90‐day liver transplantation (LT)‐free mortality was investigated in patients with cirrhosis with and without PVT. Results In this study, 2826 patients with cirrhosis were included, and 255 (9.02%) had PVT. The cumulative incidence of 90‐day LT‐free mortality did not significantly differ between patients with and without PVT (log‐rank P  = 0.0854). MELD [area under the receiver operating curve (AUROC), 0.649 vs. 0.842; P  = 0.0036] and MELD‐Na scores (AUROC, 0.691 vs. 0.851; P  = 0.0108) were compared in patients with and without PVT, regarding the prediction of 90‐day LT‐free mortality. In MELD  〈  15 and MELD‐Na  〈  20 subgroups, patients with PVT had a higher 90‐day LT‐free mortality than those without PVT (7.91% vs. 2.64%, log‐rank P  = 0.0011; 7.14% vs. 3.43%, log‐rank P  = 0.0223), whereas in MELD ≥ 15 and MELD‐Na ≥ 20 subgroups, no significant difference was observed between patients with and without PVT. Conclusions The performance of MELD and MELD‐Na scores in predicting 90‐day LT‐free mortality of patients with cirrhosis was compromised by PVT. MELD  〈  15 or MELD‐Na  〈  20 may underestimate the 90‐day LT‐free mortality in patients with PVT.
    Type of Medium: Online Resource
    ISSN: 0815-9319 , 1440-1746
    URL: Issue
    URL: Article
    DOI: 10.1111/jgh.v38.1
    DOI: 10.1111/jgh.16053
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2006782-3
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  • 10
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    Transporter mining and metabolic engineering of Escherichia coli for high‐level D‐allulose production from D‐fructose by thermo‐swing fermentation
    Wiley ; 2024
    In:  Biotechnology Journal Vol. 19, No. 1 ( 2024-01)
    Details
    In: Biotechnology Journal, Wiley, Vol. 19, No. 1 ( 2024-01)
    Abstract: D‐Allulose is an ultra‐low‐calorie sweetener with broad market prospects in the fields of food, beverage, health care, and medicine. The fermentative synthesis of D‐allulose is still under development and considered as an ideal route to replace enzymatic approaches for large‐scale production of D‐allulose in the future. Generally, D‐allulose is synthesized from D‐fructose through Izumoring epimerization. This biological reaction is reversible, and a high temperature is beneficial to the conversion of D‐fructose. Mild cell growth conditions seriously limit the efficiency of producing D‐allulose through fermentation. FryABC permease was identified to be responsible for the transport of D‐allulose in Escherichia coli by comparative transcriptomic analysis. A cell factory was then developed by expression of ptsG‐F , dpe , and deletion of fryA , fruA , manXYZ , mak , and galE . The results show that the newly engineered E. coli was able to produce 32.33 ± 1.33 g L −1 of D‐allulose through a unique thermo‐swing fermentation process, with a yield of 0.94 ± 0.01 g g −1 on D‐fructose.
    Type of Medium: Online Resource
    ISSN: 1860-6768 , 1860-7314
    URL: Issue
    URL: Article
    DOI: 10.1002/biot.v19.1
    DOI: 10.1002/biot.202300085
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2214038-4
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