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  • Wiley  (137)
  • 1
    Online Resource
    Online Resource
    Deep‐Penetrating Triple‐Responsive Prodrug Nanosensitizer Actuates Efficient Chemoradiotherapy in Pancreatic Ductal Adenocarcinoma Models
    Wiley ; 2022
    In:  Small Vol. 18, No. 31 ( 2022-08)
    Details
    In: Small, Wiley, Vol. 18, No. 31 ( 2022-08)
    Abstract: Chemoradiotherapy (CRT) is the most accepted treatment for locally advanced pancreatic ductal adenocarcinoma (PDAC) and can significantly improve the R0 resection rate. However, there are few long‐term survivors after CRT. Although some polymer nanoparticles have shown potential in alleviating the dose‐limiting toxicity and assisting the chemotherapy of PDAC, there are few efficient nanosensitizers (NS) available for CRT of this malignancy, especially in the context of its hypoxic nature. Herein, based on the biological features of PDAC, a γ‐glutamyl transpeptidase (GGT)/glutathione (GSH)/hypoxia triple‐responsive prodrug NS to overcome the biological barrier and microenvironmental limitations confronted by CRT in PDAC is developed. Due to triple‐responsiveness, deep tumor penetration, GSH/hypoxia‐responsive drug release/activation, and hypoxia‐induced chemoradio‐sensitization can be simultaneously achieved with this NS. As a result, tumor shrinkage after CRT with this NS can be observed in both subcutaneous and orthotopic PDAC models, foreshadowing its potential in clinical neoadjuvant CRT.
    Type of Medium: Online Resource
    ISSN: 1613-6810 , 1613-6829
    URL: Issue
    URL: Article
    DOI: 10.1002/smll.v18.31
    DOI: 10.1002/smll.202202834
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2168935-0
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  • 2
    Online Resource
    Online Resource
    A retrospective analysis of the optimal time and psychological impact of decoronation in children and adolescents
    Wiley ; 2021
    In:  Dental Traumatology Vol. 37, No. 3 ( 2021-06), p. 440-446
    Details
    In: Dental Traumatology, Wiley, Vol. 37, No. 3 ( 2021-06), p. 440-446
    Abstract: Decoronation offers one of the best and most predictable clinical outcomes for dentoalveolar ankylosis. The aim of this study was to determine the factors associated with the efficacy and psychological impact of decoronation for bone preservation. Materials and Methods The study included 42 paediatric patients with 42 infrapositioned replanted permanent teeth. Twelve of these teeth were decoronated. Variables such as the time of injury, stage of root development and the extent of infraposition were analysed. The vertical changes in the alveolar bone level of the decoronated teeth were assessed on radiographs using a three‐point scoring system. Parents of 30 patients with teeth that were not decoronated completed a questionnaire addressing their considerations and concerns regarding the treatment of infraposition. Results Teeth with root development in stages 2 and 3 showed a significantly higher rate of severe infraposition during the follow‐up visits. Decoronation was performed on 12 teeth within 1.5–5 years (mean 3.8 ± 1.3 years) after replantation and 11 of these cases developed a considerable alveolar bone level. The alveolar bone levels of boys and girls showed improvements of 2.2 and 3.2 mm, respectively. The optimal age for decoronation to have a considerable increase in bone level was 12.12 ± 0.83 years for boys and 11.25 ± 1.77 years for girls. Complicated treatments, followed by parents’ lack knowledge regarding decoronation, children's fear, follow‐up times, and cost were the major concerns regarding decoronation. Conclusion The optimal time for decoronation should be decided after considering the age, gender, skeletal growth pattern, and the degree of infraposition at the time of decoronation.
    Type of Medium: Online Resource
    ISSN: 1600-4469 , 1600-9657
    URL: Issue
    URL: Article
    DOI: 10.1111/edt.v37.3
    DOI: 10.1111/edt.12651
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2027107-4
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  • 3
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    Antibacterial and antifouling properties of a polyurethane surface modified with perfluoroalkyl and silver nanoparticles
    Wiley ; 2017
    In:  Journal of Biomedical Materials Research Part A Vol. 105, No. 2 ( 2017-02), p. 531-538
    Details
    In: Journal of Biomedical Materials Research Part A, Wiley, Vol. 105, No. 2 ( 2017-02), p. 531-538
    Abstract: Inspired by mussel‐adhesion phenomena in nature, a simple, mild surface modification process was elaborated to endow the polyurethane (PU) substrate with antibacterial/antifouling properties. In the present study, polydopamine was coated directly onto polyurethane surfaces. AgNO 3 was then added and absorbed onto the surface by the active catechol and amine groups of the polydopamine coating. Meanwhile, the adsorbed Ag + ions were reduced in situ into metallic silver nanoparticles by the “bridge” of the polydopamine coating which yielded a coating with good antimicrobial properties. Finally, 1 H , 1 H , 2 H , 2 H ‐perfluorodecanethiol (CF 3 (CF 2 ) 7 CH 2 CH 2 SH, F‐SH) was attached on the PDA coating via the Michael addition reaction . The hydrophobic F‐SH layer above the antibacterial layer yielded a surface with excellent antifouling properties. Preliminary antibacterial assays indicate that the coated surfaces show enhanced antibacterial activity against Escherichia coli (Gram‐negative bacteria) and Staphylococcus aureus (Gram‐positive bacteria). Platelet adhesion was significantly reduced for the F‐SH‐coated PU film. These results suggest that the modified PU could be used as an antibacterial material for future biomedical applications. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 531–538, 2017.
    Type of Medium: Online Resource
    ISSN: 1549-3296 , 1552-4965
    URL: Issue
    URL: Article
    DOI: 10.1002/jbm.a.v105.2
    DOI: 10.1002/jbm.a.35929
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 1477192-5
    SSG: 12
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  • 4
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    Beneficial effects of intramyocardial mesenchymal stem cells and VEGF 165 plasmid injection in rats with furazolidone induced dilated cardiomyopathy
    Wiley ; 2015
    In:  Journal of Cellular and Molecular Medicine Vol. 19, No. 8 ( 2015-08), p. 1868-1876
    Details
    In: Journal of Cellular and Molecular Medicine, Wiley, Vol. 19, No. 8 ( 2015-08), p. 1868-1876
    Abstract: To explore the impact of myocardial injection of mesenchymal stem cells ( MSC s) and specific recombinant human VEGF 165 ( hVEGF 165 ) plasmid on collagen remodelling in rats with furazolidone induced dilated cardiomyopathy ( DCM ). DCM was induced by furazolidone (0.3 mg/bodyweight (g)/day per gavage for 8 weeks). Rats were then divided into four groups: ( i ) PBS group ( n  = 18): rats received equal volume myocardial PBS injection; ( ii ) MSC s group ( n  = 17): 100 μl culture medium containing 10 5 MSC s were injected into four sites of left ventricular free wall (25 μl per site); ( iii ) GENE group ( n  = 18): pCMV en‐ MLC 2v‐ EGFP ‐ VEGF 165 plasmid [5 × 109 pfu (0.2 ml)] were injected into four sites of left ventricular free wall (0.05 ml per site)] and ( iv ) MSC s+ GENE group ( n  = 17): rats received both myocardial MSC s and pCMV en‐ MLC 2v‐ EGFP ‐ VEGF 165 plasmid injections. After 4 weeks, cardiac function was evaluated by echocardiography. Myocardial mRNA expressions of type I, type III collagen and transforming growth factor ( TGF )‐β1 were detected by RT ‐ PCR . The protein expression of hVEGF 165 was determined by Western blot. Myocardial protein expression of hVEGF 165 was demonstrated in GENE and MSC s+ GENE groups. Cardiac function was improved in MSC s, GENE and MSC s+ GENE groups. Collagen volume fraction was significantly reduced and myocardial TGF ‐β1 mRNA expression significantly down‐regulated in both GENE and MSC s+ GENE groups, collagen type I/III ratio reduction was more significant in MSC s+ GENE group than in MSC s or GENE group. Myocardial MSC s and hVEGF 165 plasmid injection improves cardiac function possibly through down‐regulating myocardial TGF ‐β1 expression and reducing the type I/III collagen ratio in this DCM rat model.
    Type of Medium: Online Resource
    ISSN: 1582-1838 , 1582-4934
    URL: Issue
    URL: Article
    DOI: 10.1111/jcmm.2015.19.issue-8
    DOI: 10.1111/jcmm.12558
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2076114-4
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  • 5
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    Hypertension among Mongolian adults in China: A cross‐sectional study of prevalence, awareness, treatment, control, and related factors : Hypertension among Mongolian adults in China
    Wiley ; 2021
    In:  The Journal of Clinical Hypertension Vol. 23, No. 9 ( 2021-09), p. 1786-1801
    Details
    In: The Journal of Clinical Hypertension, Wiley, Vol. 23, No. 9 ( 2021-09), p. 1786-1801
    Abstract: The objectives of the study were to comprehend the prevalence of hypertension (HTN) and prehypertension (PHT), awareness, treatment, and control of HTN and its distribution in urban, agricultural, pastoral, and semi‐agricultural/semi‐pastoral areas, and to explore the related factors of HTN among Mongolian adults in China. From August 2018 to August 2020, a multi‐stage stratified cluster random sampling method was conducted to investigate the prevalence of HTN among Mongolian adults aged ≥18 years living in China ( n  = 2558). Inclusion criteria for HTN were systolic blood pressure ≥ 140 mm Hg and/or diastolic blood pressure ≥ 90 mm Hg and/or had hypertensive history and/or taking antihypertensive drugs for HTN. The prevalence rates of HTN and PHT were 44.77% and 32.03%, respectively. The prevalence rates of PHT in urban, agricultural, pastoral, and semi‐agricultural/semi‐pastoral areas were 34.93%, 34.73%, 26.03%, and 33.44%, respectively, and the prevalence rates of HTN were 35.97%, 40.15%, 49.68%, and 48.07%, respectively. The awareness, treatment and control rates of HTN were 66.48%, 58.93%, and 16.48%, respectively. In this survey, the overweight, obesity, and central obesity rates were 34.30%, 30.67%, and 58.08%, respectively. Compared with Chinese adults ≥18 years, the prevalence rate of HTN among Mongolian adults in China aged ≥ 18 years was relatively high; the prevalence rate of PHT and HTN awareness, treatment, and control rates were similar. The prevalence of HTN and the rates of obesity and central obesity were higher in pastoral regions than in the other three types of regions, and the rate of overweight was highest in agricultural regions.
    Type of Medium: Online Resource
    ISSN: 1524-6175 , 1751-7176
    URL: Issue
    URL: Article
    DOI: 10.1111/jch.v23.9
    DOI: 10.1111/jch.14348
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2058690-5
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  • 6
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    Exome sequencing reveals the genetic landscape and frequent inactivation of PCDHB3 in Chinese rectal cancers
    Wiley ; 2018
    In:  The Journal of Pathology Vol. 245, No. 2 ( 2018-06), p. 222-234
    Details
    In: The Journal of Pathology, Wiley, Vol. 245, No. 2 ( 2018-06), p. 222-234
    Abstract: Colorectal cancer (CRC) is the third most common cancer worldwide, with more than 1.3 million new cases and 690 000 deaths each year. In China, the incidence of CRC has increased dramatically due to dietary and lifestyle changes, to become the fifth leading cause of cancer‐related death. Here, we performed whole‐exome sequencing in 50 rectal cancer cases among the Chinese population as part of the International Cancer Genome Consortium research project. Frequently mutated genes and enriched pathways were identified. Moreover, a previously unreported gene, PCDHB3 , was found frequently mutated in 5.19% cases. Additionally, PCDHB3 expression was found decreased in 81.6% of CRC tissues and all eight CRC cell lines tested. Low expression and cytoplasmic localization of PCDHB3 predict poor prognosis in advanced CRC. Copy number decrease and/or CpG island hypermethylation contributes to the pervasive decreased expression of PCDHB3. PCDHB3 inhibits CRC cell proliferation, migration, and epithelial–mesenchymal transition. The tumor‐suppressive effects of PCDHB3 are partially due to inhibition of NF‐κB transcriptional activity through K63 deubiquitination of p50 at lysine 244/252, which increases the binding affinity of inactive p50 homodimer to κB DNA, resulting in competitive inhibition of the transcription of NF‐κB target genes by p65 dimers. Our study identified PCDHB3 as a novel tumor suppressor in CRC via inhibition of the NF‐κB pathway, and its expression and localization may serve as prognostic markers for advanced CRC. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
    Type of Medium: Online Resource
    ISSN: 0022-3417 , 1096-9896
    URL: Issue
    URL: Article
    DOI: 10.1002/path.2018.245.issue-2
    DOI: 10.1002/path.5073
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 1475280-3
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  • 7
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    Synthesis of highly soluble and transparent polyimides
    Wiley ; 2012
    In:  Polymer International Vol. 61, No. 10 ( 2012-10), p. 1503-1509
    Details
    In: Polymer International, Wiley, Vol. 61, No. 10 ( 2012-10), p. 1503-1509
    Abstract: A novel aromatic diamine, 3,3′‐diisopropyl‐4,4′‐diaminophenyl‐4″‐methyltoluene with a 4‐methylphenyl pendant group and isopropyl side groups, was designed and synthesized in this study. Then it was polymerized with various aromatic dianhydrides including pyromellitic dianhydride, 3,3′,4,4′‐biphenyltetracarboxylic dianhydride, 4,4′‐oxydiphthalic anhydride, 3,3′,4,4′‐benzophenone tetracarboxylic dianhydride and 4,4′‐(hexafluoroisopropylidene)diphthalic anhydride via a one‐pot high temperature polycondensation procedure to produce a series of aromatic polyimides. These polyimides exhibited excellent solubility even in common organic solvents, such as chloroform and tetrahydrofuran. The flexible and tough films can be conveniently obtained by solution casting. The films were nearly colorless and exhibited high optical transparency, with the UV cutoff wavelength in the range 302–365 nm and the wavelength of 80% transparency in the range 385–461 nm. Moreover, they showed low dielectric constants (2.73–3.23 at 1 MHz) and low moisture absorption (0.13%–0.46%). Furthermore, they also possessed good thermal and thermo‐oxidative stability with 10% weight loss temperatures ( T 10% ) in the range 489–507 °C in a nitrogen atmosphere. The glass transition temperatures of all polyimides are in the range 262–308 °C. Copyright © 2012 Society of Chemical Industry
    Type of Medium: Online Resource
    ISSN: 0959-8103 , 1097-0126
    URL: Issue
    URL: Article
    DOI: 10.1002/pi.v61.10
    DOI: 10.1002/pi.4235
    Language: English
    Publisher: Wiley
    Publication Date: 2012
    detail.hit.zdb_id: 2004753-8
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  • 8
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    Spatiotemporal Ultrasound‐Driven Bioorthogonal Catalytic Therapy
    Wiley ; 2023
    In:  Advanced Materials Vol. 35, No. 7 ( 2023-02)
    Details
    In: Advanced Materials, Wiley, Vol. 35, No. 7 ( 2023-02)
    Abstract: Bioorthogonal chemistry, referring to the rapid and selective synthesis of imaging and/or therapeutic molecules in live animals via transition metal‐mediated non‐natural chemical transformation without disrupting endogenous reactions, has greatly expanded the tools and techniques for biomedicine. However, owing to safety concerns associated with metal toxicity, selectivity, sensitivity and stability, efficient bioorthogonal reactions that can be reliably executed in complex biological environments remain challenging. In this study, an intelligent, versatile bioorthogonal catalyst based on ultrasmall poly(acrylic acid)‐modified copper nanocomplexes (Cu@PAA NCs) to achieve high spatiotemporal catalytic efficacy is established. The catalytic activity of the Cu@PAA NCs can be reversibly regulated via valence state interconversion between Cu(II) and Cu(I) under exogenous ultrasound irradiation, promoting off‐target prodrug activation in lesion sites through the Cu(I)‐catalyzed azide–alkyne cycloaddition reaction. Moreover, ultrasound‐triggered electron–hole separation endows the Cu@PAA NCs with robust sonosensitizing ability for sonodynamic therapy. Furthermore, the Cu@PAA NCs exhibit enhanced contrast in magnetic resonance and photoacoustic imaging. Notably, the renal‐clearable Cu@PAA NCs exhibit intrinsically benign biocompatibility. This spatiotemporally ultrasound‐mediated bioorthogonal catalysis not only expands the repertoire of in situ therapeutic agents but also provides a new avenue for disease theranostics.
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Issue
    URL: Article
    DOI: 10.1002/adma.v35.7
    DOI: 10.1002/adma.202209179
    RVK:
    UA 1538
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1474949-X
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  • 9
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    Fast Fabrication of High‐Performance CoSb 3 ‐Based Thermoelectric Skutterudites via One‐Step Yb‐Promoted Peritectic Solidification
    Wiley ; 2023
    In:  Advanced Functional Materials
    Details
    In: Advanced Functional Materials, Wiley
    Abstract: As a most promising mid‐temperature thermoelectric material, CoSb 3 ‐based bulk material exhibits an applicable figure‐of‐merit ( ZT ) of more than one. However, their fabrication is historically time‐consuming due to the long‐time solid‐state phase transitions from CoSb 2 to CoSb 3 . To overcome this challenge, here, a fast one‐step process is developed to fabricate n‐type Yb‐doped CoSb 3 with stable ZT of 1.12 at 765 K in 〈 5 h. Experiments confirm Yb promotes peritectic reactions of CoSb + Liquid → CoSb 2 and CoSb 2 + Liquid → CoSb 3 , optimizes power factor, and suppresses thermal conductivity. Moreover, the dense grains, induced by the one‐step crystallization, result in outstanding mechanical properties with a Young's modulus of 171.4 GPa and a hardness of 8.8 GPa in the Yb‐doped CoSb 3 . This study indicates that the fast one‐step fabrication route can effectively promote the practical applications of CoSb 3 ‐based thermoelectrics and provide guidance for thermoelectric fabrication via rational phase design.
    Type of Medium: Online Resource
    ISSN: 1616-301X , 1616-3028
    URL: Article
    DOI: 10.1002/adfm.202305269
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2029061-5
    detail.hit.zdb_id: 2039420-2
    SSG: 11
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  • 10
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    A Noble Metal Dichalcogenide for High‐Performance Field‐Effect Transistors and Broadband Photodetectors
    Wiley ; 2020
    In:  Advanced Functional Materials Vol. 30, No. 5 ( 2020-01)
    Details
    In: Advanced Functional Materials, Wiley, Vol. 30, No. 5 ( 2020-01)
    Abstract: 2D layered materials are an emerging class of low‐dimensional materials with unique physical and structural properties and extensive applications from novel nanoelectronics to multifunctional optoelectronics. However, the widely investigated 2D materials are strongly limited in high‐performance electronics and ultrabroadband photodetectors by their intrinsic weaknesses. Exploring the new and narrow bandgap 2D materials is very imminent and fundamental. A narrow‐bandgap noble metal dichalcogenide (PtS 2 ) is demonstrated in this study. The few‐layer PtS 2 field‐effect transistor exhibits excellent electronic mobility exceeding 62.5 cm 2 V −1 s −1 and ultrahigh on/off ratio over 10 6 at room temperature. The temperature‐dependent conductance and mobility of few‐layer PtS 2 transistors show a direct metal‐to‐insulator transition and carrier scattering mechanisms, respectively. Remarkably, 2D PtS 2 photodetectors with broadband photodetection from visible to mid‐infrared and a fast photoresponse time of 175 µs at 830 nm illumination for the first time are obtained at room temperature. Our work opens an avenue for 2D noble‐metal dichalcogenides to be applied in high‐performance electronic and mid‐infrared optoelectronic devices.
    Type of Medium: Online Resource
    ISSN: 1616-301X , 1616-3028
    URL: Issue
    URL: Article
    DOI: 10.1002/adfm.v30.5
    DOI: 10.1002/adfm.201907945
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2029061-5
    detail.hit.zdb_id: 2039420-2
    SSG: 11
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