In:
Magnetic Resonance in Medicine, Wiley, Vol. 80, No. 1 ( 2018-07), p. 200-210
Abstract:
A new diffusion‐mapping method based on single‐shot overlapping‐echo detachment (DM‐OLED) planar‐imaging sequence, along with a corresponding separation algorithm, is proposed to achieve reliable quantitative diffusion mapping in a single shot. The method can resist the effects of motion and help in detecting the quick variation of diffusion under different physiological status. Methods The echo‐planar imaging method is combined with two excitation pulses with small flip angle to gain overlapping‐echo signal in a single shot. Then the overlapping signals are separated by a separation algorithm and used for diffusion computation. Numerical simulation, phantom, and in vivo rat experiments were performed to verify the efficiency, accuracy, and motion tolerance of DM‐OLED. Results The DM‐OLED sequence could obtain reliable diffusion maps within milliseconds in numerical simulation, phantom, and in vivo experiments. Compared with conventional diffusion mapping with spin‐echo echo‐planar imaging, DM‐OLED has higher time resolution and fewer motion‐incurred errors in the apparent diffusion coefficient maps. Conclusions As a reliable fast diffusion measurement tool, DM‐OLED shows promise for real‐time dynamic diffusion mapping and functional magnetic resonance imaging. Magn Reson Med 80:200–210, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Type of Medium:
Online Resource
ISSN:
0740-3194
,
1522-2594
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
1493786-4
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