In:
Journal of Surgical Oncology, Wiley, Vol. 112, No. 6 ( 2015-11), p. 634-642
Abstract:
Hepatectomy in hepatocellular carcinoma (HCC) patients lead to postoperative hepatitis B virus (HBV) reactivation (PHR) as well as immunosuppression. Methods This prospective study involved 135 HBV‐related HCC patients and 42 control hepatic hemangioma patients. Results Among HCC patients, 26 (19.3%) suffered PHR. Risk factors for PHR were HBV‐cAg S1 positivity [hazard ratio (HR) = 404.82, P = 0.004], high preoperative total bilirubin level (HR = 186.38, P = 0.036), small preoperative proportions of CD3−CD16 + CD56 + cells (HR = 0.01, P = 0.014) and CD19 + B cells (HR = 0.02, P = 0.016), blood transfusion (HR = 157.03, P = 0.006) and high liver cirrhosis S score (HR = 270.45, P = 0.004). On postoperative day (POD) 3, PHR patients showed much greater immunosuppression than non‐PHR patients based on proportions of T cells (CD3+, CD3 + CD4+, CD3 + CD8+), B cells (CD19+) and on levels of IgG, IgA antibodies, complement proteins C3, and C4. By POD 7, PHR patients had partially recovered but not as quickly as non‐PHR patients: PHR patients still showed deficits in T cells (CD3+, CD3 + CD4+), CD3−CD16 + CD56+ cells and in levels of IgM, C3, C4, and C‐reactive protein. Conclusion PHR may be associated with resection‐induced immunosuppression in patients with HBV‐related HCC. J. Surg. Oncol. 2015;112:634–642 . © 2015 Wiley Periodicals, Inc.
Type of Medium:
Online Resource
ISSN:
0022-4790
,
1096-9098
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
1475314-5
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