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  • 1
    Online Resource
    Online Resource
    Alterations in hippocampal subfield and amygdala subregion volumes in posttraumatic subjects with and without posttraumatic stress disorder
    Wiley ; 2021
    In:  Human Brain Mapping Vol. 42, No. 7 ( 2021-05), p. 2147-2158
    Details
    In: Human Brain Mapping, Wiley, Vol. 42, No. 7 ( 2021-05), p. 2147-2158
    Abstract: The hippocampus and amygdala are important structures in the posttraumatic stress disorder (PTSD); however, the exact relationship between these structures and stress or PTSD remains unclear. Moreover, they consist of several functionally distinct subfields/subregions that may serve different roles in the neuropathophysiology of PTSD. Here we present a subregional profile of the hippocampus and amygdala in 145 survivors of a major earthquake and 56 non‐traumatized healthy controls (HCs). We found that the bilateral hippocampus and left amygdala were significantly smaller in survivors than in HCs, and there was no difference between survivors with ( n = 69) and without PTSD (trauma‐exposed controls [TCs], n = 76). Analyses revealed similar results in most subfields/subregions, except that the right hippocampal body (in a head‐body‐tail segmentation scheme), right presubiculum, and left amygdala medial nuclei (Me) were significantly larger in PTSD patients than in TCs but smaller than in HCs. Larger hippocampal body were associated with the time since trauma in PTSD patients. The volume of the right cortical nucleus (Co) was negatively correlated with the severity of symptoms in the PTSD group but positively correlated with the same measurement in the TC group. This correlation between symptom severity and Co volume was significantly different between the PTSD and TCs. Together, we demonstrated that generalized smaller volumes in the hippocampus and amygdala were more likely to be trauma‐related than PTSD‐specific, and their subfields/subregions were distinctively affected. Notably, larger left Me, right hippocampal body and presubiculum were PTSD‐specific; these could be preexisting factors for PTSD or reflect rapid posttraumatic reshaping.
    Type of Medium: Online Resource
    ISSN: 1065-9471 , 1097-0193
    URL: Issue
    URL: Article
    DOI: 10.1002/hbm.v42.7
    DOI: 10.1002/hbm.25356
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1492703-2
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  • 2
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    Online Resource
    Lack of association between LGMN and Alzheimer’s disease in the Southern Han Chinese population
    Wiley ; 2020
    In:  European Journal of Neuroscience Vol. 52, No. 8 ( 2020-10), p. 4009-4017
    Details
    In: European Journal of Neuroscience, Wiley, Vol. 52, No. 8 ( 2020-10), p. 4009-4017
    Abstract: Recently, functional studies have demonstrated that legumain (LGMN) cleaves both amyloid β‐protein precursor and tau, promoting senile plaques and formation of neurofibrillary tangles, which may play a crucial role in the pathogenesis of Alzheimer's disease (AD). However, the genetic role of LGMN in AD has not been clearly elucidated. Here, we used Sanger sequencing to investigate the single independent (single‐variant association test) and cumulative (gene‐based association test) effects of variants in the LGMN gene as potential susceptibility factors for AD, in a cohort comprising 676 AD cases and 365 elderly controls from the Han population of South China. In single‐variant association analysis, none of the common variants in LGMN were statistically significant. In gene‐based analysis, the LGMN gene also showed no association with AD. The results of our replication study in the Alzheimer's Disease Neuroimaging Initiative cohort also showed no association between LGMN and AD. These findings suggest that the LGMN gene may not be a critical factor for AD development.
    Type of Medium: Online Resource
    ISSN: 0953-816X , 1460-9568
    URL: Issue
    URL: Article
    DOI: 10.1111/ejn.v52.8
    DOI: 10.1111/ejn.14857
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2005178-5
    SSG: 12
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  • 3
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    Online Resource
    Modulating the Growth of Nonfullerene Acceptors Toward Efficient and Stable Organic Solar Cells Processed by High‐Boiling‐Point Solvents
    Wiley ; 2023
    In:  Advanced Energy Materials
    Details
    In: Advanced Energy Materials, Wiley
    Abstract: High‐boiling‐point solvents are considered to be decent solvents for the preparation of large‐area organic solar cells (OSCs) because of their wide processing window. However, the efficiency of OSCs processed by high‐boiling‐point solvents is still unsatisfactory. Herein, it is found that the agglomerate growth of nonfullerene acceptors into micrometer‐sized domains is the main reason for poor efficiency. A facile rapid molding process (RMP) scheme is proposed to solve this problem by adjusting the nucleation and growth behavior of acceptor molecules. RMP enables the blend films with interpenetrating networks and higher crystallinity, which is in favor of faster exciton separation and lower recombination losses. As a result, the power convention efficiency (PCE) is improved from 15.91% (reference) to 18.32% (RMP) for PL1:BTP‐eC9‐4F OSCs. To the best of the authors' knowledge, this is the champion efficiency of OSCs processed with high‐boiling‐point solvents. Meanwhile, RMP devices maintain 85% or 90% of the initial PCE after real day/night cycling in the air for over 2000 h or after continuous thermal aging at 85 °C in nitrogen for 500 h, respectively.
    Type of Medium: Online Resource
    ISSN: 1614-6832 , 1614-6840
    URL: Article
    DOI: 10.1002/aenm.202302554
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2594556-7
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  • 4
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    Mitigating Exciton Recombination Losses in Organic Solar Cells by Engineering Nonfullerene Molecular Crystallization Behavior
    Wiley ; 2023
    In:  Advanced Energy Materials
    Details
    In: Advanced Energy Materials, Wiley
    Abstract: Although the advances in organic solar cells (OSCs) have been considerable, their efficiency is still limited by recombination losses. Photogenerated electrons and holes are generally bound as localized excitons in organic semiconductors. The transition from excitons into free charges requires diffusion and dissociation processes, in which parasitic recombination losses exist. Reducing these losses is necessary for highly efficient OSCs. The crystallization behavior of the active layers can influence the efficiency of exciton diffusion and dissociation. In this work, different additives are delicately designed to control the crystallization behavior. It is found that the crystallization quality of active layers can be improved by controlling the aggregation of nonfullerene acceptors. The π–π stacking of blend films becomes compact, meanwhile, the crystallization in the vertical direction is more uniform. These are beneficial to the diffusion and dissociation of excitons. As a consequence, recombination losses are reduced and power convention efficiencies (PCEs) are improved significantly. Meanwhile, the general applicability of the additive is demonstrated in various organic photovoltaic systems, in which a PCE of 19.3% is achieved in D18:BTP‐eC9‐4F OSCs. This work provides a facile strategy to reduce the recombination losses of excitons for efficient devices.
    Type of Medium: Online Resource
    ISSN: 1614-6832 , 1614-6840
    URL: Article
    DOI: 10.1002/aenm.202302063
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2594556-7
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  • 5
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    Nicotinamide riboside intervention alleviates hematopoietic system injury of ionizing radiation‐induced premature aging mice
    Wiley ; 2023
    In:  Aging Cell
    Details
    In: Aging Cell, Wiley
    Abstract: Radiotherapy destroys cancer cells and inevitably harms normal human tissues, causing delayed effects of acute radiation exposure (DEARE) and accelerating the aging process in most survivors. However, effective methods for preventing premature aging induced by ionizing radiation are lacking. In this study, the premature aging mice of DEARE model was established after 6 Gy total body irradiation (TBI). Then the therapeutic effects and mechanism of nicotinamide riboside on the premature aging mice were evaluated. The results showed that 6 Gy TBI induced premature aging of the hematopoietic system in mice. Nicotinamide riboside treatment reversed aging spleen phenotypes by inhibiting cellular senescence and ameliorated serum metabolism profiles. Further results demonstrated that nicotinamide riboside supplementation alleviated the myeloid bias of hematopoietic stem cells and temporarily restored the regenerative capacity of hematopoietic stem cells probably by mitigating the reactive oxygen species activated GCN2/eIF2α/ATF4 signaling pathway. The results of this study firstly indicate that nicotinamide riboside shows potential as a DEARE therapeutic agent for radiation‐exposed populations and patients who received radiotherapy.
    Type of Medium: Online Resource
    ISSN: 1474-9718 , 1474-9726
    URL: Article
    DOI: 10.1111/acel.13976
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2099130-7
    SSG: 12
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  • 6
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    Long‐Acting Protective Ocular Surface by Instilling Adhesive Dual‐Antiviral Nanoparticles
    Wiley ; 2022
    In:  Advanced Healthcare Materials Vol. 11, No. 14 ( 2022-07)
    Details
    In: Advanced Healthcare Materials, Wiley, Vol. 11, No. 14 ( 2022-07)
    Abstract: The eye is susceptible to viral infections, causing severe ocular symptoms or even respiratory diseases. Methods capable of protecting the eye from external viral invasion in a long‐term and highly effective way are urgently needed but have been proved to be extremely challenging. Here, a strategy of forming a long‐acting protective ocular surface is described by instilling adhesive dual‐antiviral nanoparticles. Taking pseudotyped severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) as a model virus, antiviral agent‐loaded nanoparticles are coated with a “double‐lock” hybrid cell membrane abundant with integrin‐ β 1 and angiotensin converting enzyme II (ACE2). After instillation, the presence of integrin‐ β 1 endows coated nanoparticles with steady adhesion via specific binding to Arg‐Gly‐Asp sequence on the fibronectin of ocular epithelium, achieving durable retention on the ocular surface. In addition to loaded inhibitors, the exposure of ACE2 can trap SARS‐CoV‐2 and subsequently neutralize the associated spike protein, playing a dual antiviral effect of the resulting nanoparticles. Adhesive dual‐antiviral nanoparticles enabled by coating with a “double‐lock” hybrid cell membrane could be a versatile platform for topical long‐acting protection against viral infection of the eye.
    Type of Medium: Online Resource
    ISSN: 2192-2640 , 2192-2659
    URL: Issue
    URL: Article
    DOI: 10.1002/adhm.v11.14
    DOI: 10.1002/adhm.202200283
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2645585-7
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  • 7
    Online Resource
    Online Resource
    Long‐Acting Protective Ocular Surface by Instilling Adhesive Dual‐Antiviral Nanoparticles (Adv. Healthcare Mater. 14/2022)
    Wiley ; 2022
    In:  Advanced Healthcare Materials Vol. 11, No. 14 ( 2022-07)
    Details
    In: Advanced Healthcare Materials, Wiley, Vol. 11, No. 14 ( 2022-07)
    Type of Medium: Online Resource
    ISSN: 2192-2640 , 2192-2659
    URL: Issue
    URL: Article
    DOI: 10.1002/adhm.v11.14
    DOI: 10.1002/adhm.202270087
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2645585-7
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  • 8
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    Synthesis, extracorporeal nephrotoxicity, and 3D‐QSAR of andrographolide derivatives
    Wiley ; 2021
    In:  Chemical Biology & Drug Design Vol. 97, No. 3 ( 2021-03), p. 592-606
    Details
    In: Chemical Biology & Drug Design, Wiley, Vol. 97, No. 3 ( 2021-03), p. 592-606
    Abstract: Andrographolide is a traditional Chinese medicine monomer with many pharmacological activities, but has potential nephrotoxicity. Here, we aim to investigate the relationship between modification of andrographolide structure and its nephrotoxicity. Twenty‐three andrographolide derivatives were synthesized, and their structures were confirmed by 1 H‐NMR and HRMS. Nephrotoxicity of these compounds against human renal tubular epithelial (HK‐2) cells was evaluated using the MTT assay. The results indicated that most of them had significantly reduced nephrotoxicity, especially compounds III , V , and IX c , with IC 50 values of 1,985, 1,300, and 806.9 μmol/L, respectively, which were obviously superior to andrographolide (IC 50 30.60 μmol/L). However, compounds I a – I f (IC 50 values  〈  30 μmol/L), the 14‐OH derivatives of andrographolide, showed higher nephrotoxicity than that of andrographolide. Three‐dimensional quantitative structure‐activity relationship (3D‐QSAR) models of COMFA and COMSIA were established (COMFA: q 2  = 0.639, r 2  = 0.951; COMSIA: q 2  = 0.569, r 2  = 0.857). This model allowed proposing five new compounds with lower theoretical nephrotoxicity, which would be worthwhile to synthesize and evaluate. We believe that predicted models will help us to understand the structural modification requirements of andrographolide to reduce the nephrotoxicity, and further investigations will be needed to determine the mechanism involved in the effect of less nephrotoxic compounds.
    Type of Medium: Online Resource
    ISSN: 1747-0277 , 1747-0285
    URL: Issue
    URL: Article
    DOI: 10.1111/cbdd.v97.3
    DOI: 10.1111/cbdd.13796
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2216600-2
    SSG: 12
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  • 9
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    Temporal variability of regional intrinsic neural activity in drug‐naïve patients with obsessive–compulsive disorder
    Wiley ; 2021
    In:  Human Brain Mapping Vol. 42, No. 12 ( 2021-08-15), p. 3792-3803
    Details
    In: Human Brain Mapping, Wiley, Vol. 42, No. 12 ( 2021-08-15), p. 3792-3803
    Abstract: Obsessive–compulsive disorder (OCD) displays alterations in regional brain activity represented by the amplitude of low‐frequency fluctuation (ALFF), but the time‐varying characteristics of this local neural activity remain to be clarified. We aimed to investigate the dynamic changes of intrinsic brain activity in a relatively large sample of drug‐naïve OCD patients using univariate and multivariate analyses. We applied a sliding‐window approach to calculate the dynamic ALFF (dALFF) and compared the difference between 73 OCD patients and age‐ and sex‐matched healthy controls (HCs). We also utilized multivariate pattern analysis to determine whether dALFF could differentiate OCD patients from HCs at the individual level. Compared with HCs, OCD patients exhibited increased dALFF mainly within regions of the cortical–striatal–thalamic–cortical (CSTC) circuit, including the bilateral dorsal anterior cingulate cortex, medial prefrontal cortex and striatum, and right dorsolateral prefrontal cortex (dlPFC). Decreased dALFF was identified in the bilateral inferior parietal lobule (IPL), posterior cingulate cortex, insula, fusiform gyrus, and cerebellum. Moreover, we found negative correlations between illness duration and dALFF values in the right IPL and between dALFF values in the left cerebellum and Hamilton Depression Scale scores. Furthermore, dALFF can distinguish OCD patients from HCs with the most discriminative regions located in the IPL, dlPFC, middle occipital gyrus, and cuneus. Taken together, in the current study, we demonstrated a characteristic pattern of higher variability of regional brain activity within the CSTC circuits and lower variability in regions outside the CSTC circuits in drug‐naïve OCD patients.
    Type of Medium: Online Resource
    ISSN: 1065-9471 , 1097-0193
    URL: Issue
    URL: Article
    DOI: 10.1002/hbm.v42.12
    DOI: 10.1002/hbm.25465
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1492703-2
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  • 10
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    The protective effects of Xuebijing injection on intestinal injuries of mice exposed to irradiation
    Wiley ; 2022
    In:  Animal Models and Experimental Medicine Vol. 5, No. 6 ( 2022-12), p. 565-574
    Details
    In: Animal Models and Experimental Medicine, Wiley, Vol. 5, No. 6 ( 2022-12), p. 565-574
    Abstract: Gastrointestinal (GI) injury is one of the most common side effects of radiotherapy. However, there is no ideal therapy method except for symptomatic treatment in the clinic. Xuebijing (XBJ) is a traditional Chinese medicine, used to treat sepsis by injection. In this study, the protective effects of XBJ on radiation‐induced intestinal injury (RIII) and its mechanism were explored. Methods The effect of XBJ on survival of irradiated C57BL/6 mice was monitored. Histological changes including the number of crypts and the length of villi were evaluated by H & E. The expression of Lgr5 + intestinal stem cells (ISCs), Ki67 + cells, villin and lysozymes were examined by immunohistochemistry. The expression of cytokines in the intestinal crypt was detected by RT‐PCR. DNA damage and apoptosis rates in the small intestine were also evaluated by immunofluorescence. Results In the present study, XBJ improved the survival rate of the mice after 8.0 and 9.0 Gy total body irradiation (TBI). XBJ attenuated structural damage of the small intestine, maintained regenerative ability and promoted proliferation and differentiation of crypt cells, decreased apoptosis rate and reduced DNA damage in the intestine. Elevation of IL‐6 and TNF‐α was limited, but IL‐1, TNF‐ 𝛽 and IL‐10 levels were increased in XBJ‐treated group after irradiation. The expression of Bax and p53 were decreased after XBJ treatment. Conclusions Taken together, XBJ provides a protective effect on RIII by inhibiting inflammation and blocking p53‐related apoptosis pathway.
    Type of Medium: Online Resource
    ISSN: 2576-2095 , 2576-2095
    URL: Issue
    URL: Article
    DOI: 10.1002/ame2.v5.6
    DOI: 10.1002/ame2.12285
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 3009615-7
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