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  • 1
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    Online Resource
    Tacrolimus ameliorates tubulointerstitial inflammation in diabetic nephropathy via inhibiting the NFATc1/TRPC6 pathway
    Wiley ; 2020
    In:  Journal of Cellular and Molecular Medicine Vol. 24, No. 17 ( 2020-09), p. 9810-9824
    Details
    In: Journal of Cellular and Molecular Medicine, Wiley, Vol. 24, No. 17 ( 2020-09), p. 9810-9824
    Abstract: Tubulointerstitial inflammation is crucial for the progression of diabetic nephropathy (DN), and tubular cells act as a driving force in the inflammatory cascade. Emerging data suggested that tacrolimus (TAC) ameliorates podocyte injury and macrophage infiltration in streptozotocin (STZ) mice. However, the effect of TAC on tubulointerstitial inflammation remains unknown. We found that albuminuria and tubulointerstitial damage improved in db/db mice treated with TAC. Macrophage infiltration and expression of IL‐6, TNF‐α, fibronectin, collagen 1 and cleaved caspase 3 were inhibited as well. In addition, the expression of nuclear factor of activated T cell 1 (NFATc1) and transient receptor potential channel 6 (TRPC6) was up‐regulated in the kidneys of DN patients and correlated with tubular injury and inflammation. The expression of NFATc1 and TRPC6 also increased in the kidneys of db/db mice and HK‐2 cells with high glucose (HG), while TAC inhibited these effects. HG‐induced inflammatory markers and apoptosis were reversed by TAC and NFATc1 siRNA in HK‐2 cells, which was abolished by TRPC6 plasmid. Furthermore, HG‐induced TRPC6 expression was inhibited by NFATc1 siRNA, while NFATc1 nuclear translocation was inhibited by TAC, but was restored by TRPC6 plasmid in HK‐2 cells under HG conditions. These findings suggest that TAC ameliorates tubulointerstitial inflammation in DN through NFATc1/TRPC6 feedback loop.
    Type of Medium: Online Resource
    ISSN: 1582-1838 , 1582-4934
    URL: Issue
    URL: Article
    DOI: 10.1111/jcmm.v24.17
    DOI: 10.1111/jcmm.15562
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2076114-4
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  • 2
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    Development of Conductive Hydrogels for Fabricating Flexible Strain Sensors
    Wiley ; 2022
    In:  Small Vol. 18, No. 5 ( 2022-02)
    Details
    In: Small, Wiley, Vol. 18, No. 5 ( 2022-02)
    Abstract: Conductive hydrogels can be prepared by incorporating various conductive materials into polymeric network hydrogels. In recent years, conductive hydrogels have been developed and applied in the field of strain sensors owing to their unique properties, such as electrical conductivity, mechanical properties, self‐healing, and anti‐freezing properties. These remarkable properties allow conductive hydrogel‐based strain sensors to show excellent performance for identifying external stimuli and detecting human body movement, even at subzero temperatures. This review summarizes the properties of conductive hydrogels and their application in the fabrication of strain sensors working in different modes. Finally, a brief prospectus for the development of conductive hydrogels in the future is provided.
    Type of Medium: Online Resource
    ISSN: 1613-6810 , 1613-6829
    URL: Issue
    URL: Article
    DOI: 10.1002/smll.v18.5
    DOI: 10.1002/smll.202101518
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2168935-0
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  • 3
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    Creation of aromatic maize by CRISPR/Cas
    Wiley ; 2021
    In:  Journal of Integrative Plant Biology Vol. 63, No. 9 ( 2021-09), p. 1664-1670
    Details
    In: Journal of Integrative Plant Biology, Wiley, Vol. 63, No. 9 ( 2021-09), p. 1664-1670
    Abstract: Aroma is an important quality parameter for breeding in rice ( Oryza sativa ). For example, the aromatic rice varieties basmati and jasmine rice, with a popcorn‐like scent, are popular worldwide and routinely command a price premium. 2‐acetyl‐1‐pyrroline (2AP) is a key flavor compound among over 200 volatiles identified in fragrant rice. A naturally fragrant germplasm exists in multiple plant species besides rice, which all exhibit lower activity of BETAINE ALDEHYDE DEHYDROGENASE 2 (BADH2). However, no equivalent aromatic germplasm has been described in maize ( Zea mays ). Here, we characterized the two maize BADH2 homologs, ZmBADH2a and ZmBADH2b . We generated zmbadh2a and zmbadh2b single mutants and the zmbadh2a‐zmbadh2b double mutant by CRISPR/Cas in four inbred lines. A popcorn‐like scent was only noticeable in seeds from the double mutant, but not from either single mutant or in wild type. In agreement, we only detected 2AP in fresh kernels and dried mature seeds from the double mutant, which accumulated between 0.028 and 0.723 mg/kg 2AP. These results suggest that ZmBADH2a and ZmBADH2b redundantly participate in 2AP biosynthesis in maize, and represent the creation of the world's first aromatic maize by simultaneous genome editing of the two BADH2 genes.
    Type of Medium: Online Resource
    ISSN: 1672-9072 , 1744-7909
    URL: Issue
    URL: Article
    DOI: 10.1111/jipb.v63.9
    DOI: 10.1111/jipb.13105
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2130095-1
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  • 4
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    A Multiple Stimuli‐Sensitive Low‐Molecular‐Weight Gel with an Aggregate‐Induced Emission Effect for Sol–Gel Transition Detection
    Wiley ; 2018
    In:  ChemistryOpen Vol. 7, No. 6 ( 2018-06), p. 457-462
    Details
    In: ChemistryOpen, Wiley, Vol. 7, No. 6 ( 2018-06), p. 457-462
    Abstract: A low‐molecular‐weight gel (LMWG) with a hydrazone moiety and an aggregate‐induced emission (AIE) unit was fabricated; the self‐assembly and disassembly of the LMWG under different stimuli conditions were studied. The LMWG exhibited multiple stimuli sensitivity with temperature, light, ions, and ionic strength. The hydrazone was integrated into the gelator to act as ion sensing sites and hydrogen bond donor groups to fulfil the task of ion recognition of Ni 2+ , BH 4 − , and OH − , as well as ion‐controlled reversible sol–gel recovery by adding H + for deprotonation; it also broke under UV irradiation to evoke light‐sensitivity. In addition, the sol–gel transition of the gel was detected by the AIE effect. The research provided an effective strategy in fabricating multiple stimuli‐sensitive LMWGs for potential biomedical applications.
    Type of Medium: Online Resource
    ISSN: 2191-1363 , 2191-1363
    URL: Issue
    URL: Article
    DOI: 10.1002/open.v7.6
    DOI: 10.1002/open.201800063
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2655605-4
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  • 5
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    Tunable Bright White Light Emission with Ultra‐High Color Rendering Index Induced by Trigonal Bipyramid Unit
    Wiley ; 2023
    In:  Advanced Optical Materials Vol. 11, No. 3 ( 2023-02)
    Details
    In: Advanced Optical Materials, Wiley, Vol. 11, No. 3 ( 2023-02)
    Abstract: Efficient broadband emitting organic–inorganic metal hybrids (OIMHs) have attracted great attention recently as promising single‐component white light emitters. Here a new zero‐dimensional (0D) OIMH (C 13 H 14 N) 2 InCl 5 (C 13 H 14 N +  =  N ‐methyldiphenylammonium) is reported, which features unique five‐coordinated [InCl 5 ] 2− trigonal bipyramid motif. For the first time, it is demonstrated that the trigonal bipyramid units in 0D OIMH can act as luminescence centers, showing blue emission under UV light. Remarkably, incorporating Sb 3+ in [InCl 5 ] 2− trigonal bipyramids induces a new dual‐band emission at 540 and 735 nm resulting from the singlet and triplet self‐trapped excitons in [SbCl 5 ] 2− , leading to complete coverage of the entire visible spectrum. The resulting emissions in (C 13 H 14 N) 2 InCl 5 :Sb 3+ are tunable from cold to warm white with the correlated color temperatures changing from 5574 to 3473 K and more importantly, an ultra‐high color rendering index (CRI) up to 96 being observed, which is comparable to the highest value in hybrid metal halides. A high photoluminescence quantum yield of 46.26% is simultaneously obtained in this system. This work demonstrates that the 0D OIMH with trigonal bipyramid motif is an excellent system for realizing the single‐component white light emission with both high efficiency and ultra‐high CRI.
    Type of Medium: Online Resource
    ISSN: 2195-1071 , 2195-1071
    URL: Issue
    URL: Article
    DOI: 10.1002/adom.v11.3
    DOI: 10.1002/adom.202202304
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2708158-8
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  • 6
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    Characteristics of patients who leave the emergency department without being seen: The first report in C hina
    Wiley ; 2014
    In:  Emergency Medicine Australasia Vol. 26, No. 3 ( 2014-06), p. 243-248
    Details
    In: Emergency Medicine Australasia, Wiley, Vol. 26, No. 3 ( 2014-06), p. 243-248
    Abstract: The incidence of patients who leave without being seen ( LWBS ) by a doctor in the ED in C hina has not been reported. The purpose of this study is to identify the prevalence and characteristics of the LWBS patient population as well as predictors of LWBS in the ED of a tertiary hospital of C hina. Methods We conducted a retrospective cohort study of all ED patients from N ovember 2011 to O ctober 2012 in our hospital. Patient age, sex, nationality, time of day, day of week and month of patient presentation, mode of arrival, and triage category were examined as potential predictors of LWBS . Multivariate logistic regression was performed to identify independent predictors of LWBS patients. Results The prevalence of LWBS patients was 10.7%. LWBS patients were nearly equally divided between men and women (52.8% men, 47.2% women). The average age of LWBS patients was significantly younger than non‐ LWBS patients ( P   〈  0.001). The majority of LWBS patients (82.2%) arrived on foot, and very few LWBS patients (0.3%) were non‐Chinese. The majority of LWBS patients (94.6%) were assigned to Emergency Severity Index level 3 or 4. Independent predictors of LWBS included paediatric age, lower triage acuity, arrival on foot, time of the day, day of the week and month of presentation. Conclusions Independent LWBS predictors include paediatric patients arriving on foot in the evening with lower acuity problems. Potential risk management strategies should be implemented to decrease or eliminate the LWBS population by improving communication and providing increased comfort measures.
    Type of Medium: Online Resource
    ISSN: 1742-6731 , 1742-6723
    URL: Issue
    URL: Article
    DOI: 10.1111/emm.2014.26.issue-3
    DOI: 10.1111/1742-6723.12167
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 1502447-7
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  • 7
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    Engineered Microstructure Derived Hierarchical Deformation of Flexible Pressure Sensor Induces a Supersensitive Piezoresistive Property in Broad Pressure Range
    Wiley ; 2020
    In:  Advanced Science Vol. 7, No. 18 ( 2020-09)
    Details
    In: Advanced Science, Wiley, Vol. 7, No. 18 ( 2020-09)
    Abstract: Fabricating flexible pressure sensors with high sensitivity in a broad pressure range is still a challenge. Herein, a flexible pressure sensor with engineered microstructures on polydimethylsiloxane (PDMS) film is designed. The high performance of the sensor derives from its unique pyramid‐wall‐grid microstructure (PWGM). A square array of dome‐topped pyramids and crossed strengthening walls on the film forms a multiheight hierarchical microstructure. Two pieces of PWGM flexible PDMS film, stacked face‐to‐face, form a piezoresistive sensor endowed with ultrahigh sensitivity across a very broad pressure range. The sensitivity of the device is as high as 383 665.9 and 269 662.9 kPa −1 in the pressure ranges 0–1.6 and 1.6–6 kPa, respectively. In the higher pressure range of 6.1–11 kPa, the sensitivity is 48 689.1 kPa −1 , and even in the very high pressure range of 11–56 kPa, it stays at 1266.8 kPa −1 . The pressure sensor possesses excellent bending and torsional strain detection properties, is mechanically durable, and has potential applications in wearable biosensing for healthcare. In addition, 2 × 2 and 4 × 4 sensor arrays are prepared and characterized, suggesting the possibility of manufacturing a flexible tactile sensor.
    Type of Medium: Online Resource
    ISSN: 2198-3844 , 2198-3844
    URL: Issue
    URL: Article
    DOI: 10.1002/advs.v7.18
    DOI: 10.1002/advs.202000154
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2808093-2
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  • 8
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    CXCR4 antagonist delivery on decellularized skin scaffold facilitates impaired wound healing in diabetic mice by increasing expression of SDF‐1 and enhancing migration of CXCR4‐positive cells
    Wiley ; 2017
    In:  Wound Repair and Regeneration Vol. 25, No. 4 ( 2017-08), p. 652-664
    Details
    In: Wound Repair and Regeneration, Wiley, Vol. 25, No. 4 ( 2017-08), p. 652-664
    Abstract: C‐X‐C chemokine receptor type 4 (CXCR4) is an alpha‐chemokine receptor specific for stromal cell‐derived factor 1 (SDF‐1 also called CXCL12). The antagonist of CXCR4 can mobilize CD34+ cells and hematopoietic stem cells from bone marrow within several hours, and it has an efficacy on diabetes ulcer through acting on the SDF‐1/CXCR4 axis. In this study, we investigated for the first time whether the antagonist of CXCR4 (Plerixafor/AMD3100) delivered on acellular dermal matrix (ADM) may accelerate diabetes‐impaired wound healing. ADM scaffolds were fabricated from nondiabetic mouse skin through decellularization processing and incorporated with AMD3100 to construct ADM‐AMD3100 scaffold. Full‐thickness cutaneous wound in streptozotocin (STZ)‐induced diabetic mice were treated with ADM, AMD3100, or ADM‐AMD3100. 21 days after treatment, wound closure in ADM‐AMD3100‐treated mice was more complete than ADM group and AMD3100 group, and it was accompanied by thicker collagen formation. Correspondingly, diabetic mice treated with ADM‐AMD3100 demonstrated prominent neovascularization (higher capillary density and vascular smooth muscle actin), which were accompanied by up‐regulated mRNA levels of SDF‐1 and enhanced migration of CXCR4 in the granulation tissue. Our results demonstrate that ADM scaffold provide perfect niche for loading AMD3100 and ADM‐AMD3100 is a promising method for diabetic wound healing mainly by increasing expression of SDF‐1 and enhancing migration of CXCR4‐positive cells.
    Type of Medium: Online Resource
    ISSN: 1067-1927 , 1524-475X
    URL: Issue
    URL: Article
    DOI: 10.1111/wrr.2017.25.issue-4
    DOI: 10.1111/wrr.12552
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2011990-2
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  • 9
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    Mutation in NPPA causes atrial fibrillation by activating inflammation and cardiac fibrosis in a knock‐in rat model
    Wiley ; 2019
    In:  The FASEB Journal Vol. 33, No. 8 ( 2019-08), p. 8878-8891
    Details
    In: The FASEB Journal, Wiley, Vol. 33, No. 8 ( 2019-08), p. 8878-8891
    Type of Medium: Online Resource
    ISSN: 0892-6638 , 1530-6860
    URL: Issue
    URL: Article
    DOI: 10.1096/fsb2.v33.8
    DOI: 10.1096/fj.201802455RRR
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 1468876-1
    SSG: 12
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  • 10
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    Multiple‐microarray analysis for identification of hub genes involved in tubulointerstial injury in diabetic nephropathy
    Wiley ; 2019
    In:  Journal of Cellular Physiology Vol. 234, No. 9 ( 2019-09), p. 16447-16462
    Details
    In: Journal of Cellular Physiology, Wiley, Vol. 234, No. 9 ( 2019-09), p. 16447-16462
    Abstract: Diabetic nephropathy (DN) is a primary cause of renal failure. However, studies providing renal gene expression profiles of diabetic tubulointerstitial injury are scarce and its molecular mechanisms still await clarification. To identify vital genes involved in the diabetic tubulointerstitial injury, three microarray data sets from gene expression omnibus (GEO) were downloaded. A total of 127 differentially expressed genes (DEGs) were identified by limma package. Gene set enrichment analysis (GSEA) plots showed that sister chromatid cohesion was the most significant enriched gene set positively correlated with the DN group while retinoid X receptor binding was the most significant enriched gene set positively correlated with the control group. Enriched Gene Ontology (GO) annotations and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of DEGs mostly included extracellular matrix organization, extracellular space, extracellular matrix structural constituent, and Staphylococcus aureus infection. Twenty hub genes from three significant modules were ascertained by Cytoscape. Correlation analysis and subgroup analysis between hub genes and clinical features of DN showed that ALB , ANXA1 , APOH , C3 , CCL19 , COL1A2 , COL3A1 , COL4A1 , COL6A3 , CXCL6 , DCN , EGF , HRG , KNG1 , LUM , SERPINA3 , SPARC , SRGN , and TIMP1 may involve in diabetic tubulointerstitial injury. ConnectivityMap analysis indicated the most significant three compounds are 5182598, thapsigargin and 5224221. In conclusion, this study may provide new insights into the molecular mechanisms underlying diabetic tubulointerstitial injury as well as potential targets for diagnosis and therapeutics of DN.
    Type of Medium: Online Resource
    ISSN: 0021-9541 , 1097-4652
    URL: Issue
    URL: Article
    DOI: 10.1002/jcp.v234.9
    DOI: 10.1002/jcp.28313
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 1478143-8
    SSG: 12
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