In:
Ecology and Evolution, Wiley, Vol. 7, No. 21 ( 2017-11), p. 8895-8902
Abstract:
Bone morphogenetic proteins ( BMP s) and the growth factors ( GDF s) play an important role in ovarian folliculogenesis and essential regulator of processes of numerous granulosa cells. BMP 15 gene variations linked to various ovarian phenotypic consequences subject to the species, from infertility to improved prolificacy in sheep, primary ovarian insufficiency in women or associated with minor subfertility in mouse. To study the evolving role of BMP 15 and GDF 9, a phylogenetic analysis was performed. To find out the candidate gene associated with prolificacy in mammals, the nucleotide sequence of BMP 15 and GDF 9 genes was recognized under positive selection in various mammalian species. Maximum‐likelihood approaches used on BMP 15 and GDF 9 genes exhibited a robust divergence and a prompted evolution as compared to other TGF β family members. Furthermore, among 32 mammalian species, we identified positive selection signals in the hominidae clade resulting to 132D, 147E, 163Y, 191W, and 236P codon sites of BMP 15 and 162F, 188K, 206R, 240A, 244L, 246H, 248S, 251D, 253L, 254F and other codon sites of GDF 9. The positively selected amino acid sites such as Alanine, Lucien, Arginine, and lysine are important for signaling. In conclusion, this study evidences that GDF 9 and BMP 15 genes have rapid evolution than other TGF ß family members and was subjected to positive selection in the mammalian clade. Selected sites under the positive selection are of remarkable significance for the particular functioning of the protein and consequently for female fertility.
Type of Medium:
Online Resource
ISSN:
2045-7758
,
2045-7758
DOI:
10.1002/ece3.2017.7.issue-21
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2635675-2
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