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  • 1
    Online Resource
    Online Resource
    Clinicopathological features, treatment modalities, and prognosis of esophageal neuroendocrine carcinoma: A single‐center retrospective study
    Wiley ; 2023
    In:  Journal of Digestive Diseases Vol. 24, No. 8-9 ( 2023-08), p. 472-479
    Details
    In: Journal of Digestive Diseases, Wiley, Vol. 24, No. 8-9 ( 2023-08), p. 472-479
    Abstract: Esophageal neuroendocrine carcinoma (ENEC) is a rare cancer that is highly malignant and related to a poor prognosis. In this retrospective study we aimed to elucidate the clinical characteristics, diagnosis and management of patients with ENEC and to evaluate the potential prognostic factors. Methods Altogether 82 patients diagnosed with ENEC between January 2009 and December 2020 at the Fudan University Shanghai Cancer Center were retrospectively enrolled. Patients’ survival was analyzed using the Kaplan–Meier and log‐rank methods. Univariate and multivariate analyses and a Cox regression model were used to identify the prognostic factors. Results The median overall survival (mOS) was 13 months in all patients. Multivariate analysis revealed that advanced tumor stage (hazard ratio [HR] 2.67, 95% confidence interval [CI] 1.07–6.66, P  = 0.0353), liver (HR 3.36, 95% CI 1.53–7.41, P  = 0.0026) and lung metastasis (HR 3.37, 95% CI 1.20–9.51, P  = 0.0214) were associated with a poor prognosis. While positive chromogranin A (CgA) expression was related to a favorable outcome (HR 0.21, 95% CI 0.09–0.49, P   〈  0.001). Also, patients had adjustment of chemotherapy (dose reduction or less than three cycles) were prone to a worse prognosis compared with those did not (HR 4.36, 95% CI 2.10–9.08, P   〈  0.001). Conclusion In patients with ENEC, advanced cancer stage, adjustment of chemotherapy, liver and lung metastasis were associated with a poor survival, while CgA expression was related to a favorable prognosis.
    Type of Medium: Online Resource
    ISSN: 1751-2972 , 1751-2980
    URL: Issue
    URL: Article
    DOI: 10.1111/cdd.v24.8-9
    DOI: 10.1111/1751-2980.13219
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2317117-0
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  • 2
    Online Resource
    Online Resource
    Dietary oligochitosan supplementation enhances immune status of broilers
    Wiley ; 2007
    In:  Journal of the Science of Food and Agriculture Vol. 87, No. 1 ( 2007-01-15), p. 153-159
    Details
    In: Journal of the Science of Food and Agriculture, Wiley, Vol. 87, No. 1 ( 2007-01-15), p. 153-159
    Type of Medium: Online Resource
    ISSN: 0022-5142 , 1097-0010
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.1002/jsfa.v87:1
    DOI: 10.1002/(ISSN)1097-0010
    DOI: 10.1002/jsfa.2694
    Language: English
    Publisher: Wiley
    Publication Date: 2007
    detail.hit.zdb_id: 2001807-1
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  • 3
    Online Resource
    Online Resource
    Optimizing the Ratio of Sn 4+ and Sn 2+ in Cu 2 ZnSn(S,Se) 4 Precursor Solution via Air Environment for Highly Efficient Solar Cells
    Wiley ; 2021
    In:  Solar RRL Vol. 5, No. 11 ( 2021-11)
    Details
    In: Solar RRL, Wiley, Vol. 5, No. 11 ( 2021-11)
    Abstract: The use of different Sn valence states (such as Sn 4+ and Sn 2+ ) in the Cu 2 ZnSn(S,Se) 4 (CZTSSe) precursor solution is especially important for the quality of the subsequent growth of the CZTSSe films. The latest study has found that replacing SnCl 2 ·2H 2 O with anhydrous SnCl 4 can remarkably improve the performance of CZTSSe solar cells, but it needs to be operated in the glovebox. Herein, for the precursor solution, SnCl 4 ·5H 2 O powder is used instead of anhydrous SnCl 4 in air environment, and the proportion of Sn 4+ and Sn 2+ precursor solutions is further systematically studied. When the ratio of Sn 4+ to Sn 2+ is 1:1, a uniform, compact, and noncracking CZTSSe thin film is obtained, effectively alleviating the interface recombination and reducing the concentration of deep‐level defects. In particular, the concentration of Cu Zn antisite defects is decreased by an order of magnitude, and the carrier recombination and band tail effect are alleviated. When J SC is maintained, V OC and FF are considerably improved. Finally, CZTSSe thin‐film solar cells are fabricated with an efficiency of over 11%. Herein, the feasibility of controlling the ratio of Sn 4+ to Sn 2+ in the CZTSSe precursor solution for higher efficiency of CZTSSe thin‐film solar cells is demonstrated.
    Type of Medium: Online Resource
    ISSN: 2367-198X , 2367-198X
    URL: Issue
    URL: Article
    DOI: 10.1002/solr.v5.11
    DOI: 10.1002/solr.202100574
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2882014-9
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  • 4
    Online Resource
    Online Resource
    A Characterization of Entangled Two‐Qubit States via Partial‐Transpose‐Moments
    Wiley ; 2022
    In:  Annalen der Physik Vol. 534, No. 11 ( 2022-11)
    Details
    In: Annalen der Physik, Wiley, Vol. 534, No. 11 ( 2022-11)
    Abstract: Although quantum entanglement is an important resource, its characterization is quite challenging. The partial transposition is a common method to detect bipartite entanglement. In this paper, the authors study the partial‐transpose(PT)‐moments of two‐qubit states, and completely describe the whole region, composed of the second and third PT‐moments, for all two‐qubit states. Furthermore, they determine the accurate region corresponding to all entangled two‐qubit states. The states corresponding to those boundary points of the whole region, and to the border lines between separable and entangled states are analyzed. As an application, they characterize the entangled region of PT‐moments for the two families of Werner states and Bell‐diagonal states. The relations between entanglement and the pairs of PT‐moments are revealed from these typical examples. They also numerically plot the whole region of possible PT‐moments for all two‐qubit X ‐states, and find that this region is almost the same as the whole region of PT‐moments for all two‐qubit states. Moreover, they extend their results to detect the entanglement of multiqubit states. By utilizing the PT‐moment‐based method to characterize the entanglement of the multiqubit states mixed by the GHZ and W states, they propose an operational way of verifying the genuine entanglement in such states.
    Type of Medium: Online Resource
    ISSN: 0003-3804 , 1521-3889
    URL: Issue
    URL: Article
    DOI: 10.1002/andp.v534.11
    DOI: 10.1002/andp.202200289
    RVK:
    UA 2050
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1479791-4
    detail.hit.zdb_id: 2165600-9
    detail.hit.zdb_id: 287-2
    SSG: 25
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  • 5
    Online Resource
    Online Resource
    Selective and effective targeting of chronic myeloid leukemia stem cells by topoisomerase II inhibitor etoposide in combination with imatinib mesylate in vitro
    Wiley ; 2017
    In:  Cell Biology International Vol. 41, No. 1 ( 2017-01), p. 16-23
    Details
    In: Cell Biology International, Wiley, Vol. 41, No. 1 ( 2017-01), p. 16-23
    Abstract: Imatinib mesylate (IM) and other BCR‐ABL tyrosine kinase inhibitors (TKIs) have improved chronic myeloid leukemia (CML) patient survival markedly but fail to eradicate quiescent CML leukemia stem cells (LSCs). Thus, strategies targeting LSCs are required to induce long‐term remission and achieve cure. Here, we investigated the ability of topoisomerase II (Top II) inhibitor etoposide (Eto) to target CML LSCs. Treatment with Eto combined with IM markedly induced apoptosis in primitive CML CD34 + CD38 − stem cells resistant to eradication by IM alone, but not in normal hematopoietic stem cells, CML and normal mature CD34 − cells, and other leukemia and lymphoma cell lines. The interaction of IM and Eto significantly inhibited phosphorylation of PDK1, AKT, GSK3, S6, and ERK proteins; increased the expression of pro‐apoptotic gene Bax; and decreased the expression of anti‐apoptotic gene c‐Myc in CML CD34 + cells. Top II inhibitors treatment represents an attractive approach for targeting LSCs in CML patients undergoing TKIs monotherapy.
    Type of Medium: Online Resource
    ISSN: 1065-6995 , 1095-8355
    URL: Issue
    URL: Article
    DOI: 10.1002/cbin.v41.1
    DOI: 10.1002/cbin.10686
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 1462519-2
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    Verbascoside enhances radiosensitivity of hepatocellular carcinoma cells through regulating miR ‐101‐3p/Wee1 axis
    Wiley ; 2022
    In:  Drug Development Research Vol. 83, No. 4 ( 2022-06), p. 891-899
    Details
    In: Drug Development Research, Wiley, Vol. 83, No. 4 ( 2022-06), p. 891-899
    Abstract: Verbascoside is a kind of phenylpropanoid glycoside derived from multiple medicinal plants, exerting anti‐tumor effects in diverse human malignancies. However, the function of Verbascoside on the radiosensitivity of hepatocellular carcinoma (HCC) cells remains unknown. Human Huh7 and HepG2 cell lines were treated with Verbascosideis, and cell viability was detected with cell counting kit‐8 (CCK‐8) assay. Quantitative real‐time polymerase chain reaction (qRT‐PCR) was applied to detect miR‐101‐3p expression, and Western blot was used to quantify the expression of WEE1 G2 checkpoint kinase (WEE1). Then, CCK‐8 and flow cytometry assays were used to detect the proliferation and apoptosis of HCC cells after Verbascoside and X‐ray combined treatment, and the expressions of WEE1 and apoptosis‐related proteins Bax and Bcl‐2 were detected by Western blot. Verbascoside could improve the radiosensitivity of HCC cells in a dose‐dependent manner. Verbascoside increased the expression of miR‐101‐3p but reduced WEE1 expression in HCC cells. Additionally, WEE1 was identified as a target of miR‐101‐3p. MiR‐101‐3p inhibition or WEE1 overexpression could reverse the effect of Verbascoside on the viability and apoptosis of HCC cells. Verbascoside increases the radiosensitivity of hepatocellular carcinoma cells via modulating miR‐101‐3p/WEE1 axis.
    Type of Medium: Online Resource
    ISSN: 0272-4391 , 1098-2299
    URL: Issue
    URL: Article
    DOI: 10.1002/ddr.v83.4
    DOI: 10.1002/ddr.21914
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1500191-X
    SSG: 15,3
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  • 7
    Online Resource
    Online Resource
    Modeling of ultra‐wideband indoor channels with the modified leapfrog ADI‐FDTD method
    Wiley ; 2015
    In:  International Journal of Numerical Modelling: Electronic Networks, Devices and Fields Vol. 28, No. 1 ( 2015-01), p. 50-64
    Details
    In: International Journal of Numerical Modelling: Electronic Networks, Devices and Fields, Wiley, Vol. 28, No. 1 ( 2015-01), p. 50-64
    Abstract: Full‐wave time‐domain electromagnetic methods are usually effective in rigorously modeling and evaluating ultra‐wideband (UWB) wireless channels. However, their computational expenditures are expensive, when they are used to deal with electrically large‐size problems consisting of fine structures. In order to reduce computational time, the unconditionally stable leapfrog alternating‐direction implicit finite‐difference time‐domain (leapfrog ADI‐FDTD) method has been proposed recently. In this paper, the leapfrog ADI‐FDTD algorithm is developed for simulating lossy objects, such as office walls, floors, and ceilings, for UWB communication channel characterization. It leads to effective UWB channel characterization with power‐decay time constant, path loss exponent, and probability distribution of power gain. In comparison with the conventional FDTD, the proposed method can achieve 60% saving in computational time while retaining good accuracy. Copyright © 2014 John Wiley & Sons, Ltd.
    Type of Medium: Online Resource
    ISSN: 0894-3370 , 1099-1204
    URL: Issue
    URL: Article
    DOI: 10.1002/jnm.v28.1
    DOI: 10.1002/jnm.1983
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2030930-2
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  • 8
    Online Resource
    Online Resource
    A novel inhibitor of the new antibiotic resistance protein OptrA
    Wiley ; 2018
    In:  Chemical Biology & Drug Design Vol. 92, No. 2 ( 2018-08), p. 1458-1467
    Details
    In: Chemical Biology & Drug Design, Wiley, Vol. 92, No. 2 ( 2018-08), p. 1458-1467
    Abstract: The antibiotic resistance ( ARE ) subfamily of ABC ( ATP ‐binding cassette) proteins confers resistance to a variety of clinically important ribosome‐targeting antibiotics and plays an important role in infections caused by pathogenic bacteria. However, inhibitors of ARE proteins have rarely been reported. Here, OptrA, a new member of the ARE proteins, was used to study inhibitors of these types of proteins. We first confirmed that destroying the catalytic activity of OptrA could restore the sensitivity of host cells to antibiotics. Then, fragment‐based screening, a drug screening method, was used to screen for inhibitors of OptrA. The competitive saturation transfer difference experiments, docking, and molecular dynamics were used to determine the binding sites and mode of interactions between OptrA and fragment screening hits. In this study, we first find a novel and specific inhibitor of OptrA ( CP 1), which suppressed the ATP ase activity of OptrA in vitro by 30%. A hydrogen bond formed between the 8‐position phenylcyclic cyano group in CP 1 and the amino acid residue Lys‐271 allows CP 1 to form a stable complex with OptrA protein. These findings provide a theoretical basis for the further optimization of the inhibitor structure to obtain inhibitors with higher efficiencies.
    Type of Medium: Online Resource
    ISSN: 1747-0277 , 1747-0285
    URL: Issue
    URL: Article
    DOI: 10.1111/cbdd.2018.92.issue-2
    DOI: 10.1111/cbdd.13311
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2216600-2
    SSG: 12
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  • 9
    Online Resource
    Online Resource
    Microstructure and Mechanical Properties of a Low Carbon Bainitic Steel
    Wiley ; 2013
    In:  steel research international Vol. 84, No. 4 ( 2013-04), p. 352-361
    Details
    In: steel research international, Wiley, Vol. 84, No. 4 ( 2013-04), p. 352-361
    Abstract: A low carbon bainitic steel with microstructure of granular bainite (GB), acicular ferrite (AF), and bainitic ferrite (BF) is obtained under different deformation and cooling rate. The effect of deformation and cooling rate on microstructural characteristics such as the type of the matrix, the size, and area fraction of the martensite–austenite (M–A) constituents is investigated. In addition, the nanohardness of these three kinds of matrix as well as that of the M–A constituents in them is characterized. Further, the effect of matrix and M–A constituents on strength–toughness balance is studied. Results indicate that deformation expands the transformation region. The size as well as the area fraction of the M–A constituent decreases with the increasing of the cooling rate. After deformation, the area fraction of the M–A constituents increases. Nanohardness of GB, AF, and BF increases orderly, but that of the M–A constituents in them decreases accordingly. The nanohardness of the M–A constituent is significantly affected by its carbon concentration. AF is the optimum microstructure having superior strength–toughness balance.
    Type of Medium: Online Resource
    ISSN: 1611-3683 , 1869-344X
    URL: Issue
    URL: Article
    DOI: 10.1002/srin.v84.4
    DOI: 10.1002/srin.201200186
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 2148555-0
    SSG: 19,1
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  • 10
    Online Resource
    Online Resource
    Phylogenetic analysis of the fecal flora of the wild pygmy loris
    Wiley ; 2010
    In:  American Journal of Primatology Vol. 72, No. 8 ( 2010-08), p. 699-706
    Details
    In: American Journal of Primatology, Wiley, Vol. 72, No. 8 ( 2010-08), p. 699-706
    Abstract: The bacterial diversity in fecal samples from the wild pygmy loris was examined with a 16S rDNA clone library and restriction fragment length polymorphism analysis. The clones were classified as Firmicutes (43.1%), Proteobacteria (34.5%), Actinobacteria (5.2%), and Bacteroidetes (17.2%). The 58 different kinds of 16S rDNA sequences were classified into 16 genera and 20 uncultured bacteria. According to phylogenetic analysis, the major genera within the Proteobacteria was Pseudomonas , comprising 13.79% of the analyzed clone sequences. Many of the isolated rDNA sequences did not correspond to known microorganisms, but had high homology to uncultured clones found in human feces. Am. J. Primatol. 72:699–706, 2010. © 2010 Wiley‐Liss, Inc.
    Type of Medium: Online Resource
    ISSN: 0275-2565 , 1098-2345
    URL: Issue
    URL: Article
    DOI: 10.1002/ajp.v72:8
    DOI: 10.1002/ajp.20826
    Language: English
    Publisher: Wiley
    Publication Date: 2010
    detail.hit.zdb_id: 1495834-X
    SSG: 12
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