In:
Angewandte Chemie, Wiley, Vol. 133, No. 30 ( 2021-07-19), p. 16473-16478
Abstract:
Nanodevices, harvesting the power of synthetic catalysts and enzymes to perform enantioselective synthesis inside cell, have never been reported. Here, we synthesized round bottom jar‐like silica nanostructures ( SiJAR s) with a chemo‐responsive metal‐silicate lid . This was isolated as an intermediate structure during highly controlled solid‐state nanocrystal‐conversion at the arc‐section of silica shell. Different catalytic noble metals (Pt, Pd, Ru) were selectively modified on the lid ‐section through galvanic reactions. And, lid aperture‐opening was regulated by mild acidic conditions or intracellular environment which accommodated the metal nanocrystals and enzymes, and in turn created an open‐mouth nanoreactor. Distinct from the free enzymes, SiJAR s performed asymmetric aldol reactions with high activity and enantioselectivity (yield 〉 99 %, ee =95 %) and also functioned as the artificial catalytic organelles inside living cells. This work bridges the enormous potential of sophisticated nanocrystal‐conversion chemistry and advanced platforms for new‐to‐nature catalysis.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v133.30
DOI:
10.1002/ange.202103165
Language:
English
Publisher:
Wiley
Publication Date:
2021
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