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  • 1
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    Online Resource
    Natural Affinity Driven Modification by Silicene to Construct a “Thermal Switch” for Tumorous Bone Loss
    Wiley ; 2024
    In:  Advanced Science
    Details
    In: Advanced Science, Wiley
    Abstract: Tumorous bone defects present significant challenges for surgical bio‐reconstruction due to the dual pathological conditions of residual tumor presence and extensive bone loss following excision surgery. To address this challenge, a “thermal switch” smart bone scaffold based on the silicene nanosheet‐modified decalcified bone matrix (SNS@DBM) is developed by leveraging the natural affinity between collagen and silicene, which is elucidated by molecular dynamics simulations. Benefitting from its exceptional photothermal ability, biodegradability, and bioactivity, the SNS@DBM “thermal switch” provides an integrated postoperative sequential thermotherapy for tumorous bone loss by exerting three levels of photothermal stimulation (i.e., strong, moderate, and nonstimulation). During the different phases of postoperative bioconstruction, the SNS@DBM scaffold realizes simultaneous residual tumor ablation, tumor recurrence prevention, and bone tissue regeneration. These biological effects are verified in the tumor‐bearing nude mice of patient‐derived tissue xenografts and critical cranium defect rats. Mechanism research prompts moderate heat stimulus generated by and coordinating with SNSs can upregulate osteogenic genes, promote macrophages M2 polarization, and intensify angiogenesis of H‐type vessels. This study introduces a versatile approach to the management of tumorous bone defects.
    Type of Medium: Online Resource
    ISSN: 2198-3844 , 2198-3844
    URL: Article
    DOI: 10.1002/advs.202404534
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2808093-2
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  • 2
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    Wood–polymer composites prepared by the in situ polymerization of monomers within wood
    Wiley ; 2011
    In:  Journal of Applied Polymer Science Vol. 119, No. 6 ( 2011-03-15), p. 3207-3216
    Details
    In: Journal of Applied Polymer Science, Wiley, Vol. 119, No. 6 ( 2011-03-15), p. 3207-3216
    Abstract: Wood–polymer composites (WPCs) were prepared from poplar wood ( P. ussuriensis Komarov) in a two‐step procedure. Maleic anhydride (MAN) was first dissolved in acetone and impregnated into wood; this was followed by a heat process; and then, glycidyl methacrylate (GMA) and styrene (St) were further impregnated into the MAN‐treated wood, followed by a second thermal treatment. Finally, the novel WPC was fabricated. The reactions occurring in the WPC, the aggregation of the resulting polymers, and their interaction with the wood substrate were analyzed by scanning electron microscopy, Fourier transform infrared spectroscopy, X‐ray diffraction, and dynamic mechanical analysis. The performance of WPC was also evaluated in terms of the mechanical properties and durability, which were then correlated with the structural analysis of the WPC. The test results show that MAN and GMA/St chemically reacted with the wood cell walls in sequence, and the quantity of hydroxyl groups in the wood cell walls was evidently reduced. Meanwhile, St copolymerized with GMA or MAN, and the resulting polymers mainly filled in the wood cell lumen in an amorphous form, tightly contacting the wood cell walls without noticeable gaps. As a result, the mechanical properties, decay resistance, and dimensional stability of the WPC were remarkably improved over those of the untreated wood, and its glass‐transition temperature also increased. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
    Type of Medium: Online Resource
    ISSN: 0021-8995 , 1097-4628
    URL: Issue
    URL: Article
    DOI: 10.1002/app.v119.6
    DOI: 10.1002/app.32837
    Language: English
    Publisher: Wiley
    Publication Date: 2011
    detail.hit.zdb_id: 240694-9
    detail.hit.zdb_id: 1491105-X
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  • 3
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    Clinical Outcomes of Drug-Eluting versus Bare-Metal In-Stent Restenosis after the Treatment of Drug-Eluting Stent or Drug-Eluting Balloon: A Systematic Review and Meta-Analysis
    Wiley ; 2020
    In:  Journal of Interventional Cardiology Vol. 2020 ( 2020-06-27), p. 1-11
    Details
    In: Journal of Interventional Cardiology, Wiley, Vol. 2020 ( 2020-06-27), p. 1-11
    Abstract: Background . Although drug-eluting stents (DES) have reduced the rates of in-stent restenosis (ISR) compared with bare-metal stents (BMS), DES related ISR (DES-ISR) still occurs and outcomes of DES-ISR remain unclear. The objective of this meta-analysis was to investigate the long-term clinical outcomes of patients with DES-ISR compared with patients with BMS related ISR (BMS-ISR) after the treatment of DES or drug-eluting balloon (DEB). Methods and results . We searched the literature in the main electronic databases including PUBMED, EMBASE, Cochrane Library, and Web of Science. The primary endpoints were target lesion revascularization (TLR) and target vessel revascularization (TVR). The secondary endpoints included all cause death (ACD), cardiac death (CD), myocardial infarction (MI), stent thrombosis or re-in-stent restenosis (ST/RE-ISR), and major adverse cardiovascular events (MACEs). A total of 19 studies with 6256 participants were finally included in this meta-analysis. Results showed that the rates of TLR ( P 〈 0.00001 ), TVR ( P 〈 0.00001 ), CD ( P = 0.02 ), ST/RE-ISR ( P 〈 0.00001 ), and MACEs ( P 〈 0.00001 ) were significantly higher in the DES-ISR group than in the BMS-ISR group. No significant differences were found between the two groups in the rates of MI ( P = 0.05 ) and ACD ( P = 0.21 ). Conclusions . Our study demonstrated that patients with DES-ISR had worse clinical outcomes at the long-term follow-up than patients with BMS-ISR after the treatment of DES or DEB, suggesting that DES and DEB may be more effective for BMS-ISR than that for DES-ISR. Positive prevention of DES-ISR is indispensable and further studies concentrating on detecting the predictors of outcomes of DES-ISR are required.
    Type of Medium: Online Resource
    ISSN: 0896-4327 , 1540-8183
    URL: Article
    DOI: 10.1155/2020/8179849
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 1036325-7
    detail.hit.zdb_id: 2103585-4
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  • 4
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    A Preliminary Observation on Auto‐Cholinergic Synapse Dysfunction in Patients with Different Types of Epilepsy
    Wiley ; 1992
    In:  Psychiatry and Clinical Neurosciences Vol. 46, No. 2 ( 1992-06), p. 401-403
    Details
    In: Psychiatry and Clinical Neurosciences, Wiley, Vol. 46, No. 2 ( 1992-06), p. 401-403
    Abstract: Abstract: Serum anti‐acetylcholine receptor antibodies (A AchFt Ab) and anti‐synaptic premembrane antibodies (A PrM Ab) were measured in 21 :patients with absence epilepsy, 21 :cases with benign childhood epilepsy with centro‐temporal spikes (BCECTs) and 13 :cases with atypical epilepsy. Respectively, in five (23.8%), eleven (51.2%) and eight (66.7%) of the above mentioned groups of patients both A AchR Ab and A PrM Ab were found.
    Type of Medium: Online Resource
    ISSN: 1323-1316 , 1440-1819
    URL: Issue
    URL: Article
    DOI: 10.1111/pcn.1992.46.issue-2
    DOI: 10.1111/j.1440-1819.1992.tb00882.x
    Language: English
    Publisher: Wiley
    Publication Date: 1992
    detail.hit.zdb_id: 1292906-2
    detail.hit.zdb_id: 2010264-1
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  • 5
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    Online Resource
    The performance of T‐cell Xtend reagent in increasing blood storage times for interferon gamma release assays
    Wiley ; 2018
    In:  Journal of Clinical Laboratory Analysis Vol. 32, No. 2 ( 2018-02)
    Details
    In: Journal of Clinical Laboratory Analysis, Wiley, Vol. 32, No. 2 ( 2018-02)
    Abstract: T‐cell Xtend ( TCX ) was introduced to extend the blood storage time for T‐ SPOT . TB test, a widely used commercial interferon gamma release assay ( IGRA ) for rapid in vitro tuberculosis. Methods A total of 99 Uyghur suspected tuberculosis patients were recruited in this study. T‐ SPOT . TB test was performed with fresh blood (controls), 36 hours delayed blood and delayed and TCX ‐treated (at 36 hours) blood from each patient, respectively. Results White blood cells and lymphocytes proportion in peripheral blood mononuclear cells s and spot‐forming cells in positive control wells decreased significantly in delayed blood samples when compared with controls, while this decrease was not detected in TCX ‐treated group. In the 58 patients with paired T‐ SPOT . TB results of three groups of samples, a higher positive rate was observed in TCX ‐treated group than both in controls and untreated group (41.4% vs 37.9% and 25.9%). The concordance of T‐ SPOT . TB results between the treated group and controls was 0.856, whereas the agreement between controls and untreated group was unsatisfactory (0.649). In the 23 elderly patients ( 〉 70 years old) with paired T‐ SPOT . TB results of controls and TCX group, treated group showed a non‐significant trend toward higher positive rate than controls (43.5% vs 26.1%, P =.22). Meanwhile, TCX treatment reduced the risk of false negative T‐ SPOT . TB results in the elderly population. Conclusion Deterioration of blood sample caused by long storage time can be neutralized by TCX treatment. The results provide data for the utility of TCX in a novel population and in Asian region, and reveal the potential of TCX to improve the accuracy of T‐ SPOT . TB test in elderly population.
    Type of Medium: Online Resource
    ISSN: 0887-8013 , 1098-2825
    URL: Issue
    URL: Article
    DOI: 10.1002/jcla.2018.32.issue-2
    DOI: 10.1002/jcla.22253
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2001635-9
    detail.hit.zdb_id: 645095-7
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  • 6
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    Modelling of the Automatic Depth Control Electrohydraulic System Using RBF Neural Network and Genetic Algorithm
    Wiley ; 2010
    In:  Mathematical Problems in Engineering Vol. 2010, No. 1 ( 2010-01)
    Details
    In: Mathematical Problems in Engineering, Wiley, Vol. 2010, No. 1 ( 2010-01)
    Abstract: The automatic depth control electrohydraulic system of a certain minesweeping tank is complex nonlinear system, and it is difficult for the linear model obtained by first principle method to represent the intrinsic nonlinear characteristics of such complex system. This paper proposes an approach to construct accurate model of the electrohydraulic system with RBF neural network trained by genetic algorithm‐based technique. In order to improve accuracy of the designed model, a genetic algorithm is used to optimize centers of RBF neural network. The maximum distance measure is adopted to determine widths of radial basis functions, and the least square method is utilized to calculate weights of RBF neural network; thus, computational burden of the proposed technique is relieved. The proposed technique is applied to the modelling of the electrohydraulic system, and the results clearly indicate that the obtained RBF neural network can emulate the complex dynamic characteristics of the electrohydraulic system satisfactorily. The comparison results also show that the proposed algorithm performs better than the traditional clustering‐based method.
    Type of Medium: Online Resource
    ISSN: 1024-123X , 1563-5147
    URL: Issue
    URL: Article
    DOI: 10.1155/mpe.v2010.1
    DOI: 10.1155/2010/124014
    Language: English
    Publisher: Wiley
    Publication Date: 2010
    detail.hit.zdb_id: 2014442-8
    detail.hit.zdb_id: 1385243-7
    SSG: 11
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  • 7
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    Uric Acid Promotes Osteogenic Differentiation and Inhibits Adipogenic Differentiation of Human Bone Mesenchymal Stem Cells
    Wiley ; 2015
    In:  Journal of Biochemical and Molecular Toxicology Vol. 29, No. 8 ( 2015-08), p. 382-387
    Details
    In: Journal of Biochemical and Molecular Toxicology, Wiley, Vol. 29, No. 8 ( 2015-08), p. 382-387
    Abstract: To investigate the effect of uric acid on the osteogenic and adipogenic differentiation of human bone mesenchymal stem cells (hBMSCs). The hBMSCs were isolated from bone marrow of six healthy donors. Cell morphology was observed by microscopy and cell surface markers (CD44 and CD34) of hBMSCs were analyzed by immunofluorescence. Cell morphology and immunofluorescence analysis showed that hBMSCs were successfully isolated from bone marrow. The number of hBMSCs in uric acid groups was higher than that in the control group on day 3, 4, and 5. Alizarin red staining showed that number of calcium nodules in uric acid groups was more than that of the control group. Oil red‐O staining showed that the number of red fat vacuoles decreased with the increased concentration of uric acid. In summary, uric acid could promote the proliferation and osteogenic differentiation of hBMSCs while inhibit adipogenic differentiation of hBMSCs.
    Type of Medium: Online Resource
    ISSN: 1095-6670 , 1099-0461
    URL: Issue
    URL: Article
    DOI: 10.1002/jbt.2015.29.issue-8
    DOI: 10.1002/jbt.21707
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 1481995-8
    detail.hit.zdb_id: 1410020-4
    SSG: 12
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  • 8
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    Total Synthesis and Antibacterial Study of Cyclohexapeptides Desotamide B, Wollamide B and Their Analogs
    Wiley ; 2018
    In:  Chemistry & Biodiversity Vol. 15, No. 1 ( 2018-01)
    Details
    In: Chemistry & Biodiversity, Wiley, Vol. 15, No. 1 ( 2018-01)
    Abstract: As natural‐product‐derived antibiotics, desotamides A – D and wollamides exhibit growth inhibitory activity against Gram ‐posivite bacteria ( IC 50 0.6 – 7 μ m ) and are noncytotoxic to mammalian cells ( IC 50   〉  30 μ m ). Herein we firstly report the total synthesis of above two cyclohexapeptides as well as a series of structural variants through solid phase peptide synthesis, of which 3 displayed a 2‐fold increase of antibacterial activity when compared with the original peptide 1 . This strategy may offer good improvements for the synthesis of other cyclic peptides.
    Type of Medium: Online Resource
    ISSN: 1612-1872 , 1612-1880
    URL: Issue
    URL: Article
    DOI: 10.1002/cbdv.v15.1
    DOI: 10.1002/cbdv.201700414
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2136784-X
    detail.hit.zdb_id: 2139001-0
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  • 9
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    A series of 2‐phenylbenzothiazole‐based iridium complexes with N‐H derivatives: synthesis, photophysics, DFT calculations and a preliminary exploration in fluoride ions sensing
    Wiley ; 2024
    In:  ChemistrySelect Vol. 9, No. 7 ( 2024-02-19)
    Details
    In: ChemistrySelect, Wiley, Vol. 9, No. 7 ( 2024-02-19)
    Abstract: A series of new pbt‐based Ir(III) complexes containing N−H derivatives ancillary ligands (piz/pbiz) were designed and synthesized rationally, naming [(CH 3 Opbt) 2 Ir(piz)][PF 6 ] ( Ir1 ), [(CF 3 pbt) 2 Ir(piz)][PF 6 ] ( Ir2 ), [(Fpbt) 2 Ir(piz)][PF 6 ] ( Ir3 ), [(CH 3 Opbt) 2 Ir(pbiz)][PF 6 ] ( Ir4 ), [(CF 3 pbt) 2 Ir(pbiz)][PF 6 ] ( Ir5 ) and [(Fpbt) 2 Ir(pbiz)][PF 6 ] ( Ir6 ) (where pbt=2‐phenylbenzothiazole, piz=2‐(1H‐imidazol‐2‐yl)pyridine, and pbiz=2‐(pyridin‐2‐yl)‐1H‐benzoimidazole). Combined with photophysical properties and theoretical calculations, their structure‐property relationships were systematically researched. These iridium(III) complexes are phosphorescent in the green and yellow‐green region with quantum yields of 14.1–28.7 % and lifetimes of 0.35–0.88 μs. Considering the relatively high quantum yield and imidazole group on ancillary ligands, [(CF 3 pbt) 2 Ir(pbiz)][PF 6 ] ( Ir5 ) was preliminary explored as the phosphorescent sensor toward F − ions. The results showed that the addition of fluoride ions to complex Ir5 in dichloromethane solution induced a red shift of the emission color, along with an enhancement in the luminescent intensity. Theoretical calculations were carried out to understand the mechanism, and the results reveal that the hydrogen bonding interaction of N−H bond with F − influence the electron transfer processes of the lowest energy absorption and emission, leading to a significant change in the photophysical properties.
    Type of Medium: Online Resource
    ISSN: 2365-6549 , 2365-6549
    URL: Issue
    URL: Article
    DOI: 10.1002/slct.v9.7
    DOI: 10.1002/slct.202303172
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2844262-3
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  • 10
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    Ångstrom‐Scale Silver Particles as a Promising Agent for Low‐Toxicity Broad‐Spectrum Potent Anticancer Therapy
    Wiley ; 2019
    In:  Advanced Functional Materials Vol. 29, No. 23 ( 2019-06)
    Details
    In: Advanced Functional Materials, Wiley, Vol. 29, No. 23 ( 2019-06)
    Abstract: Cancer incidence is rising, and the efficacy of current available anticancer agents is limited by severe dose‐limiting toxicities and drug resistance problems. Nanoparticles are heralded as the next frontier in cancer treatment. Here, a pure physical method is used to efficiently fabricate very small silver particles even approaching the Ångstrom (Ång) dimension. Fructose is used as a dispersant and stabilizer to coat the Ång‐scale silver particles (AgÅPs). Functional and mechanistic studies demonstrate that fructose‐coated AgÅPs (F‐AgÅPs) can enter and accumulate in multiple cultured cancer cell lines to induce apoptotic death, whereas most normal cells are resistant to the efficacious dose of F‐AgÅPs; in vivo, intravenous administration of F‐AgÅPs potently inhibits the growth of pancreatic and lung cancer xenografts in nude mice, without inducing notable toxic effects on the healthy tissues. The results suggest the promising potential of F‐AgÅPs as a potent, safe, and broad‐spectrum agent for the cancer treatment.
    Type of Medium: Online Resource
    ISSN: 1616-301X , 1616-3028
    URL: Issue
    URL: Article
    DOI: 10.1002/adfm.v29.23
    DOI: 10.1002/adfm.201808556
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2029061-5
    detail.hit.zdb_id: 2039420-2
    SSG: 11
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