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  • 1
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    Online Resource
    Imputation of the major histocompatibility complex region identifies major independent variants associated with bullous pemphigoid and dermatomyositis in Han Chinese
    Wiley ; 2022
    In:  The Journal of Dermatology Vol. 49, No. 10 ( 2022-10), p. 998-1004
    Details
    In: The Journal of Dermatology, Wiley, Vol. 49, No. 10 ( 2022-10), p. 998-1004
    Abstract: As autoimmune skin diseases, both bullous pemphigoid (BP) and dermatomyositis (DM) show significant associations with the major histocompatibility complex (MHC) region. In fact, the coexistence of BP and DM has been previously reported. Therefore, we hypothesized that there may be a potential genetic correlation between BP and DM. Based on data for 312 BP patients, 128 DM patients, and 6793 healthy control subjects, in the MHC region, we imputed single‐nucleotide polymorphisms (SNP), insertions and deletions (INDEL), and copy number variations (CNV) using the 1KGP phase 3 dataset and amino acids (AA) and SNP using a Han‐MHC reference database. An association study revealed the most significant SNP associated with BP, namely, rs580921 ( p  = 1.06E‐08, odds ratio [OR] = 1.61, 95% confidence interval [CI]  = 1.37–1.90), which is located in the C6orf10 gene, and the most significant classic human leukocyte antigen (HLA) allele associated with DM, namely, HLA‐DPB1*1701 ( p  = 6.56E‐10, OR = 3.61, 95% CI = 2.40–5.42). Further stepwise regression analyses with rs580921 identified a threonine at position 163 of the HLA‐B gene as a new independent disease‐associated AA, and HLA‐DPB1*1701 indicated that no loci were significant. Three‐dimensional ribbon models revealed that the HLA‐B AA position 163 ( p  = 3.93E‐07, OR = 1.64, 95% CI = 1.35–1.98) located in the α2 domain of the HLA‐B molecule was involved in the process of specific antigen presentation. The calculations showed that there was no significant genetic correlation between BP and DM. Our study identified three significant loci in the MHC region, proving that the HLA region was significantly correlated with BP and DM separately. Our research highlights the key role of the MHC region in disease susceptibility.
    Type of Medium: Online Resource
    ISSN: 0385-2407 , 1346-8138
    URL: Issue
    URL: Article
    DOI: 10.1111/jde.v49.10
    DOI: 10.1111/1346-8138.16499
    RVK:
    XA 53120
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2222121-9
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  • 2
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    Nomograms for predicting prognostic value of inflammatory biomarkers in colorectal cancer patients after radical resection
    Wiley ; 2016
    In:  International Journal of Cancer Vol. 139, No. 1 ( 2016-07), p. 220-231
    Details
    In: International Journal of Cancer, Wiley, Vol. 139, No. 1 ( 2016-07), p. 220-231
    Abstract: What's new? Host inflammatory response plays a critical role in the development and progression of colorectal cancer (CRC). Hence, inflammatory biomarkers, such as neutrophil‐to‐lymphocyte ratio, platelet‐to‐lymphocyte ratio, lymphocyte‐to‐monocyte ratio and albumin/globulin ratio, are potentially able to predict patient outcome in CRC. In this study, pretreatment serum levels of inflammatory biomarkers were found to predict overall survival and disease‐free survival in CRC, based on retrospective analysis of 5,336 CRC patients admitted to China's Fudan University Shanghai Cancer Center between 2007 and 2014. Nomograms incorporating the inflammatory markers were successfully established and could be used to refine predictions of CRC outcome.
    Type of Medium: Online Resource
    ISSN: 0020-7136 , 1097-0215
    URL: Issue
    URL: Article
    DOI: 10.1002/ijc.v139.1
    DOI: 10.1002/ijc.30071
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 218257-9
    detail.hit.zdb_id: 1474822-8
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  • 3
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    Changes in proteomics profile during maturation of marrow-derived dendritic cells treated with oxidized low-density lipoprotein
    Wiley ; 2011
    In:  PROTEOMICS Vol. 11, No. 10 ( 2011-05), p. 1893-1902
    Details
    In: PROTEOMICS, Wiley, Vol. 11, No. 10 ( 2011-05), p. 1893-1902
    Type of Medium: Online Resource
    ISSN: 1615-9853
    URL: Article
    DOI: 10.1002/pmic.201000658
    Language: English
    Publisher: Wiley
    Publication Date: 2011
    detail.hit.zdb_id: 2037674-1
    SSG: 12
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  • 4
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    Determination of cyantraniliprole and its major metabolite residues in vegetable and soil using ultra-performance liquid chromatography/tandem mass spectrometry : Determination of cyantraniliprole and its metabolite residues
    Wiley ; 2011
    In:  Biomedical Chromatography ( 2011-06), p. n/a-n/a
    Details
    In: Biomedical Chromatography, Wiley, ( 2011-06), p. n/a-n/a
    Type of Medium: Online Resource
    ISSN: 0269-3879
    URL: Article
    DOI: 10.1002/bmc.1669
    Language: English
    Publisher: Wiley
    Publication Date: 2011
    detail.hit.zdb_id: 1479945-5
    SSG: 12
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  • 5
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    Clinical value of the new I nternational A ssociation for the S tudy of L ung C ancer/ A merican T horacic S ociety /E uropean R espiratory S ociety classification of lung adenocarcinoma
    Wiley ; 2017
    In:  Thoracic Cancer Vol. 8, No. 3 ( 2017-05), p. 159-169
    Details
    In: Thoracic Cancer, Wiley, Vol. 8, No. 3 ( 2017-05), p. 159-169
    Abstract: We explored correlations between the new I nternational A ssociation for the S tudy of L ung C ancer/ A merican T horacic S ociety/ E uropean R espiratory S ociety classification, epidermal growth factor receptor ( EGFR ) mutation status, and prognosis. Methods Data from 293 patients with lung adenocarcinoma were classified according to the new classification. F isher’s exact, χ 2 , and log‐rank tests and C ox regression analysis were used to analyze correlations between EGFR mutation status, lung cancer prognosis, and the new histologic subtype. Disease‐free survival and progression‐free survival ( PFS ) were estimated using the K aplan– M eier method. Results L epidic and non‐solid adenocarcinomas showed significantly elevated EGFR mutation rates (79.0% and 65.8%, respectively; P   〈 0.05). EGFR mutation status was only associated with gender ( P   〈 0.001). EGFR mutation‐positive patients who received targeted therapy had better median PFS than those who received chemotherapy as first‐line treatment ( P   〈 0.001). The median PFS of patients with exon 19 and exon 21 mutations who received first‐line targeted therapy were 12.5 and 9.5 months, respectively ( P  = 0.970). Patients with micropapillary predominant adenocarcinomas had the shortest disease‐free survival ( 〈 18 months) and PFS . Histologic subtype ( P  = 0.036), treatment type ( P  = 0.031), and EGFR mutation status ( P  = 0.019) might be good prognostic factors for lung adenocarcinoma. Conclusion Patients with exon 19 mutations obtained greater benefits from targeted therapy. In the new classification, EGFR mutation rates are higher in lepidic cases and in cases without the solid subtype. The micropapillary subtype of adenocarcinoma has the worst prognosis, while the lepidic subtype has the best.
    Type of Medium: Online Resource
    ISSN: 1759-7706 , 1759-7714
    URL: Issue
    URL: Article
    DOI: 10.1111/tca.2017.8.issue-3
    DOI: 10.1111/1759-7714.12419
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2559245-2
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  • 6
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    Accurate characterization of full pore size distribution of tight sandstones by low‐temperature nitrogen gas adsorption and high‐pressure mercury intrusion combination method
    Wiley ; 2021
    In:  Energy Science & Engineering Vol. 9, No. 1 ( 2021-01), p. 80-100
    Details
    In: Energy Science & Engineering, Wiley, Vol. 9, No. 1 ( 2021-01), p. 80-100
    Abstract: The full pore size distribution represents the integrated characteristics of micro‐nano pore‐throat systems in tight reservoirs. And it involves experiments of different scales to fully analyze the microscope properties. In this paper, we established a new approach for full pore size characterization through conducting the high‐pressure mercury intrusion (HPMI) experiments and low‐temperature nitrogen gas adsorption (LTN 2 GA) experiments. Meanwhile, we studied the petrology feature of the tight sandstones through X‐ray diffraction (X‐rD) and TESCAN Integrated Mineral Analyzer (TIMA). Then, we investigated the HPMI capillary pressure curves and pore size distribution characteristics, as well as the adsorption‐desorption isotherms features and BET‐specific surface area. Finally, the BJH, non‐local density functional theory (NLDFT) and the quenched solid density functional theory (QSDFT) are contrasted for analyzing the adsorption and pore size distribution characteristics. The HPMI method characterizes the macropores distribution accurately, and the micro/mesopores take up of 14.47% of the total pore spaces. The physisorption isotherms take on the combining shape of type II and IV(a), and the hysteresis loops are like type H3 combined with H4. The BET‐specific surface area is inversely proportional to permeability, and the constant of adsorption heat shows consistence with the analysis results of mineral content. QSDFT can characterize the pore size distribution of micro/mesopores more accurately than the BJH, HPMI, and NLDFT method. By combining the pores narrower than 34 nm calculated from QSDFT method and pores larger than 34 nm calculated from HPMI data with mercury intrusion pressure lower than 42.65 MPa, the full pore size distribution features of tight sandstones are accurately characterized. The micro/mesopores from the new combination method are 3.72% more than that calculated from the HPMI data, and it is of great significance for the accurate pore distribution evaluation and development of tight reservoirs.
    Type of Medium: Online Resource
    ISSN: 2050-0505 , 2050-0505
    URL: Issue
    URL: Article
    DOI: 10.1002/ese3.v9.1
    DOI: 10.1002/ese3.817
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2720339-6
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  • 7
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    Is It Feasible to Implement Enteral Nutrition in Patients With Enteroatmospheric Fistulae? A Single‐Center Experience
    Wiley ; 2014
    In:  Nutrition in Clinical Practice Vol. 29, No. 5 ( 2014-10), p. 656-661
    Details
    In: Nutrition in Clinical Practice, Wiley, Vol. 29, No. 5 ( 2014-10), p. 656-661
    Abstract: Background: Published experience in feeding patients with enteroatmospheric fistulae is scarce. This study aimed to determine if enteral nutrition (EN) could be safely delivered in the presence of enteroatmospheric fistula. Materials and Methods : This is a retrospective descriptive study from a major fistula treatment center in China. Medical records of patients who developed enteroatmospheric fistulae in the open abdomen after abdominal trauma were reviewed. The timing of initiation and achievement of full strength (25 kcal/kg/d) EN after enteroatmospheric fistula were noted, as well as the incidence of feeding‐associated complications and weaning of parenteral nutrition (PN). The outcomes of open abdomen and enteroatmospheric fistula were also noted. Results : Nine patients were included in this study. EN was successfully implemented in all patients. The median timing of initiation and achievement of full strength of EN after enteroatmospheric fistula was 9 (interquartile range [IQR], 3–22) and 27 (IQR, 22–43) days, respectively. Feeding‐associated complications developed in 1 (11.1%) patient. All patients were liberated from PN at hospital discharge. Split‐thickness skin grafting was performed in all patients, of whom 5 underwent successful delayed abdominal closure, and 4 were awaiting definitive closure. Repair or resection of enteroatmospheric fistula occurred in 8 (88.9%) patients. Conclusion : This study showed that EN could be safely implemented in patients with enteroatmospheric fistulae without complicating the treatment of open abdomen and enteroatmospheric fistula.
    Type of Medium: Online Resource
    ISSN: 0884-5336 , 1941-2452
    URL: Article
    DOI: 10.1177/0884533614536587
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2170063-1
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  • 8
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    Identification of key genes involved in polysaccharide bioflocculant synthesis in Bacillus licheniformis
    Wiley ; 2017
    In:  Biotechnology and Bioengineering Vol. 114, No. 3 ( 2017-03), p. 645-655
    Details
    In: Biotechnology and Bioengineering, Wiley, Vol. 114, No. 3 ( 2017-03), p. 645-655
    Abstract: The present study reports the sequenced genome of Bacillus licheniformis CGMCC 2876, which is composed of a 4,284,461 bp chromosome that contains 4,188 protein‐coding genes, 72 tRNA genes, and 21 rRNA genes. Additional analysis revealed an eps gene cluster with 16 open reading frames. Conserved Domains Database analysis combined with qPCR experiments indicated that all genes in this cluster were involved in polysaccharide bioflocculant synthesis. Phosphoglucomutase and UDP‐glucose pyrophosphorylase were supposed to be key enzymes in polysaccharide secretion in B. licheniformis . A biosynthesis pathway for the production of polysaccharide bioflocculant involving the integration of individual genes was proposed based on functional analysis. Overexpression of epsDEF from the eps gene cluster in B. licheniformis CGMCC 2876 increased the flocculating activity of the recombinant strain by 90% compared to the original strain. Similarly, the crude yield of polysaccharide bioflocculant was enhanced by 27.8%. Overexpression of the UDP‐glucose pyrophosphorylase gene not only increased the flocculating activity by 71% but also increased bioflocculant yield by 13.3%. Independent of UDP‐N‐acetyl‐D‐mannosamine dehydrogenase gene, flocculating activity, and polysaccharide yield were negatively impacted by overexpression of the UDP‐N‐acetylglucosamine 2‐epimerase gene. Overall, epsDEF and gtaB2 were identified as key genes for polysaccharide bioflocculant synthesis in B. licheniformis . These results will be useful for further engineering of B. licheniformis for industrial bioflocculant production. Biotechnol. Bioeng. 2017;114: 645–655. © 2016 Wiley Periodicals, Inc.
    Type of Medium: Online Resource
    ISSN: 0006-3592 , 1097-0290
    URL: Issue
    URL: Article
    DOI: 10.1002/bit.v114.3
    DOI: 10.1002/bit.26189
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 1480809-2
    detail.hit.zdb_id: 280318-5
    SSG: 12
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  • 9
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    Achieving distributed consensus for networked uncertain Euler–Lagrange systems with average dwell time approach
    Wiley ; 2023
    In:  Asian Journal of Control
    Details
    In: Asian Journal of Control, Wiley
    Abstract: This paper proposes a novel distributed consensus achieving algorithm for switched networked Lagrange systems with uncertain parameters, in order to solve the abruptly occurrence problem of parameters changing and communication topologies switching. We first model the multirobot systems as switched networked Lagrange systems. Then, by introducing the network topology into the sliding mode vector, a unified distributed consensus tracking strategy is then proposed by systematically combining the average dwell time (ADT) approach and adaptive control method. Besides, a sufficient condition regarding the ADT among subsystems is derived to ensure the asymptotical consensus performance of the multirobot systems. A unified analysis methodology is developed to perform the convergence analysis for the closed‐loop system by Lyapunov stable theory. Finally, illustrative examples and simulations are provided to demonstrate and validate the theoretical results.
    Type of Medium: Online Resource
    ISSN: 1561-8625 , 1934-6093
    URL: Article
    DOI: 10.1002/asjc.3068
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2438393-4
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  • 10
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    High Prevalence of Suboptimal Vitamin D Status and Bone Loss in Adult Short Bowel Syndrome Even After Weaning Off Parenteral Nutrition
    Wiley ; 2017
    In:  Nutrition in Clinical Practice Vol. 32, No. 2 ( 2017-04), p. 258-265
    Details
    In: Nutrition in Clinical Practice, Wiley, Vol. 32, No. 2 ( 2017-04), p. 258-265
    Abstract: Background: Previous studies have noticed the high incidence of suboptimal vitamin D (VtD) status and bone loss in short bowel syndrome (SBS) with parenteral nutrition (PN) dependence. However, limited data have focused on adult SBS without PN dependence. Therefore, our objective was to investigate the incidence and risk factors of suboptimal VtD status and bone loss in adult SBS even after weaning off PN. Materials and Methods: We performed a prospective study of 60 adult patients with SBS. Serum 25‐hydroxyvitamin D (25‐OHD) was measured by radioimmunoassay. Bone mineral density (BMD) was measured using dual‐energy x‐ray absorptiometry (DEXA). Medical records and various laboratory parameters were collected in all participants. Results: Suboptimal VtD status was identified in all individuals, including 3 (5.0%) with VtD insufficiency and 57 (95.0%) with VtD deficiency. Residual small bowel length (B, 0.072, P = .001) and duration of SBS (B, –0.066, P = .020) were both significantly correlated with suboptimal VtD levels. Overall, only 2 patients presented a normal BMD; osteopenia and osteoporosis were noted in 41 (68.3%) and 17 (28.3%) individuals, respectively. Low 25‐OHD concentration was associated with a decreased BMD (B, 0.065, P = .029). There were no other demographic characteristics or clinical examinations associated with suboptimal VtD levels and bone loss. Conclusion: Suboptimal VtD status and bone loss were common in adult SBS even after weaning off PN. Despite routine oral VtD supplementation, most patients did not achieve satisfactory status. This emphasizes the critical importance of routine surveillance of 25‐OHD and BMD, as well as consideration of alternative methods of supplementation after weaning off PN.
    Type of Medium: Online Resource
    ISSN: 0884-5336 , 1941-2452
    URL: Article
    DOI: 10.1177/0884533616665784
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2170063-1
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