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  • 1
    Online Resource
    Online Resource
    A fully bio‐based epoxy resin with excellent mechanical properties combines flame retardancy and degradability
    Wiley ; 2024
    In:  Polymers for Advanced Technologies Vol. 35, No. 6 ( 2024-06)
    Details
    In: Polymers for Advanced Technologies, Wiley, Vol. 35, No. 6 ( 2024-06)
    Abstract: Traditional epoxy resins are made from non‐renewable fossil resources, which are difficult to reprocess and recycle, and their flammability makes them unsafe during use. In this experiment, an epoxy resin containing Schiff base (TA‐VAN‐EP) was synthesized successfully with biomass‐derived raw materials. This new material not only had favorable mechanical properties but also had good flame retardancy and degradation properties. The chemical structure of TA‐VAN‐EP was characterized by Fourier transform infrared (FTIR) spectroscopy and 1 H nuclear magnetic resonance (NMR) spectroscopy. Its mechanical properties, thermal stability, flame‐retardant properties, and other properties were tested. The results showed that, compared with the pure epoxy resin (EP), the mechanical properties of TA‐VAN‐EP were significantly improved, and the glass transition temperature ( T g ) was increased from 152°C to 190°C. Additionally, TA‐VAN‐EP reached a V‐1 rating during the UL‐94 test, and the limited oxygen index (LOI) value increased from 24.7% to 28.4%. Also, the total heat release (THR), smoke production rate (SPR), and total smoke release (TSR) decreased extremely. Moreover, TA‐VAN‐EP demonstrated good degradation performance under acidic conditions. In conclusion, this work provided a new idea for the production of bio‐based flame‐retardant epoxy resin with promising degradable abilities and mechanical properties.
    Type of Medium: Online Resource
    ISSN: 1042-7147 , 1099-1581
    URL: Issue
    URL: Article
    DOI: 10.1002/pat.v35.6
    DOI: 10.1002/pat.6481
    RVK:
    VA 6586
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 1481102-9
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  • 2
    Online Resource
    Online Resource
    Retzius‐sparing robot‐assisted radical prostatectomy improves early recovery of urinary continence: a randomized, controlled, single‐blind trial with a 1‐year follow‐up
    Wiley ; 2020
    In:  BJU International Vol. 126, No. 5 ( 2020-11), p. 633-640
    Details
    In: BJU International, Wiley, Vol. 126, No. 5 ( 2020-11), p. 633-640
    Abstract: To evaluate the impact of Retzius‐sparing robot‐assisted radical prostatectomy (posterior approach) on early recovery of urinary continence (UC) compared to the conventional approach (anterior approach) for the treatment of clinically localized prostate cancer (PCa). Methods A total of 110 consecutive patients with clinically localized PCa were prospectively randomized in a 1:1 ratio to an anterior group ( n = 55) or a posterior group ( n = 55). The primary outcome was immediate UC, defined as freedom from any pad use within 1 week after removal of the urinary catheter. The UC rate following surgery was also calculated with Kaplan–Meier curves, and the log‐rank test was used for statistical comparison. Intra‐operative outcomes, pathological data and oncological outcomes, including positive surgical margin (PSM) status and biochemical recurrence‐free survival (BCRFS), were also compared between the two groups. The comparison of the two approaches was also analysed in subgroups after risk stratification. Results Of the patients who underwent the posterior approach, 69.1% achieved immediate UC compared with 30.9% in the anterior group (relative risk 2.24, 95% confidence interval [CI] 1.48–3.51; P = 0.000). The relative Kaplan–Meier curves for UC during the 12‐month follow‐up revealed statistically better recovery in the posterior group when compared with the anterior group (hazard ratio [HR] 1.51, 95% CI 1.01–2.24; log‐rank P = 0.007). No statistically significant differences were observed between the groups regarding complications ( P = 0.399), PSM status ( P = 0.225) or BCRFS (HR 4.80, 95% CI 0.97–23.78; log‐rank P = 0.111). In sub‐analyses, no significant difference between the two approaches with regard to UC recovery in patients with high‐risk PCa was observed (HR 1.26, 95% CI 0.63–2.51; log‐rank P = 0.415). Conclusions The Retzius‐sparing approach significantly improved early recovery of UC compared to the conventional approach. Further prospective studies are needed to confirm the benefits of the Retzius‐sparing approach for clinically localized PCa, especially for high‐risk cases.
    Type of Medium: Online Resource
    ISSN: 1464-4096 , 1464-410X
    URL: Issue
    URL: Article
    DOI: 10.1111/bju.v126.5
    DOI: 10.1111/bju.15195
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2019983-1
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  • 3
    Online Resource
    Online Resource
    Decreased microRNA‐126 expression in psoriatic CD4 + T cells promotes T‐helper 17 cell differentiation and the formation of dermatitis in imiquimod‐induced psoriasis‐like mice
    Wiley ; 2022
    In:  The Journal of Dermatology Vol. 49, No. 4 ( 2022-04), p. 432-440
    Details
    In: The Journal of Dermatology, Wiley, Vol. 49, No. 4 ( 2022-04), p. 432-440
    Abstract: Psoriasis is a chronic inflammatory skin disease with multiple genetic backgrounds, whose etiology and pathogenesis are still unclear. Complex T‐cell immune imbalance has been demonstrated to play an important role in pathogenesis of psoriasis. This study reported that microRNA‐126 (miR‐126) expression was decreased in CD4 + T cells of both psoriasis patients and psoriasis‐like mouse models and its expression was negatively correlated with the Psoriasis Area and Severity Index (PASI) score of psoriasis patients. Conditional Mir126 knockout in mouse CD4 + T cells can obviously aggravate the psoriasis‐like dermatitis and promote T‐helper (Th)1 and Th17 cells’ infiltration in spleen of imiquimod (IMQ)‐induced psoriasis‐like mouse model. In addition, the mRNA expression of Il17a and Il17f were significantly increased in mouse naïve CD4 + T cells with Mir126 knockout after stimulating with CD3 and CD28. Compared with naïve CD4 + T cells, the expression of Mir126 was decreased in Th17 cells, and Mir126 knockout notably promoted the differentiation of naïve CD4 + T cells to Th17 cells as well as the mRNA expression of Il17a , Il17f , Rorc , and Il23R . Our results revealed that decreased miR‐126 in psoriatic CD4 + T cells might accelerate the formation of skin lesions through promoting the differentiation of Th17 cells, thus suggesting a potential intervention target for psoriasis.
    Type of Medium: Online Resource
    ISSN: 0385-2407 , 1346-8138
    URL: Issue
    URL: Article
    DOI: 10.1111/jde.v49.4
    DOI: 10.1111/1346-8138.16272
    RVK:
    XA 53120
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2222121-9
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  • 4
    Online Resource
    Online Resource
    Interactions of nanomaterials with ion channels and related mechanisms
    Wiley ; 2019
    In:  British Journal of Pharmacology Vol. 176, No. 19 ( 2019-10), p. 3754-3774
    Details
    In: British Journal of Pharmacology, Wiley, Vol. 176, No. 19 ( 2019-10), p. 3754-3774
    Abstract: The pharmacological potential of nanotechnology, especially in drug delivery and bioengineering, has developed rapidly in recent decades. Ion channels, which are easily targeted by external agents, such as nanomaterials (NMs) and synthetic drugs, due to their unique structures, have attracted increasing attention in the fields of nanotechnology and pharmacology for the treatment of ion channel‐related diseases. NMs have significant effects on ion channels, and these effects are manifested in many ways, including changes in ion currents, kinetic characteristics and channel distribution. Subsequently, intracellular ion homeostasis, signalling pathways, and intracellular ion stores are affected, leading to the initiation of a range of biological processes. However, the effect of the interactions of NMs with ion channels is an interesting topic that remains obscure. In this review, we have summarized the recent research progress on the direct and indirect interactions between NMs and ion channels and discussed the related molecular mechanisms, which are crucial to the further development of ion channel‐related nanotechnological applications.
    Type of Medium: Online Resource
    ISSN: 0007-1188 , 1476-5381
    URL: Issue
    URL: Article
    DOI: 10.1111/bph.v176.19
    DOI: 10.1111/bph.14792
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2029728-2
    SSG: 15,3
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  • 5
    Online Resource
    Online Resource
    Silaindacenodithiophene‐Based Fused‐Ring Non‐Fullerene Electron Acceptor for Efficient Polymer Solar Cells
    Wiley ; 2018
    In:  Chinese Journal of Chemistry Vol. 36, No. 6 ( 2018-06), p. 495-501
    Details
    In: Chinese Journal of Chemistry, Wiley, Vol. 36, No. 6 ( 2018-06), p. 495-501
    Abstract: In this work, a new A‐D‐A type nonfullerene small molecular acceptor SiIDT‐IC, with a fused‐ring silaindacenodithiophene (SiIDT) as D unit and 2‐(3‐oxo‐2,3‐dihydroinden‐1‐ylidene)malononitrile (INCN) as the end A unit, was design and synthesized. The SiIDT‐IC film shows absorption peak and edge at 695 and 733 nm, respectively. The HOMO and LUMO of SiIDT‐IC are of −5.47 and −3.78 eV, respectively. Compared with carbon‐bridging, the Si‐bridging can result in an upper‐lying LUMO level of an acceptor, which is benefit to achieve a higher open‐circuit voltage in polymer solar cells (PSCs). Complementary absorption and suitable energy level alignment between SiIDT‐IC and wide bandgap polymer donor PBDB‐T were found. For the PBDB‐T:SiIDT‐IC based inverted PSCs, a D/A ratio of 1: 1 was optimal to achieve a power conversion efficiency (PCE) of 7.27%. With thermal annealing (TA) of the blend film, a higher PCE of 8.16% could be realized due to increasing of both short‐circuit current density and fill factor. After the TA treatment, hole and electron mobilities were elevated to 3.42 × 10 −4 and 1.02 × 10 −4 cm 2 ·V −1 ·s −1 , respectively. The results suggest that the SiIDT, a Si‐bridged fused ring, is a valuable D unit to construct efficient nonfullerene acceptors for PSCs.
    Type of Medium: Online Resource
    ISSN: 1001-604X , 1614-7065
    URL: Issue
    URL: Article
    DOI: 10.1002/cjoc.v36.6
    DOI: 10.1002/cjoc.201700809
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2144352-X
    SSG: 6,25
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  • 6
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    Online Resource
    ADAMTS13 inhibits oxidative stress and ameliorates progressive chronic kidney disease following ischaemia/reperfusion injury
    Wiley ; 2021
    In:  Acta Physiologica Vol. 231, No. 3 ( 2021-03)
    Details
    In: Acta Physiologica, Wiley, Vol. 231, No. 3 ( 2021-03)
    Abstract: Reduced A Disintegrin And Metalloproteinase with a ThromboSpondin type 1 motif member 13 (ADAMTS13) levels are observed in kidney disease. We test whether recombinant human ADAMTS13 (rhADAMTS13) mitigates renal injury in chronic kidney disease (CKD) and the potential mechanisms. Methods CKD was established 3 months after ischaemia/reperfusion (IR). ADAMTS13 and von Willebrand factor ( vWF ) levels, renal function and morphological changes were analysed. Afferent arteriolar responses to angiotensin II (Ang II) and acetylcholine (ACh) were measured. Oxidative stress‐related molecules were detected. Results Higher vWF and lower ADAMTS13 levels were observed in CKD mice, which were markedly attenuated by rhADAMTS13. rhADAMTS13 alleviated renal dysfunction, as documented by decreased blood urea nitrogen (BUN), serum creatinine, kidney injury molecule‐1 (KIM‐1) and neutrophil gelatinase‐associated lipocalin (NGAL) levels in CKD mice. Moreover, rhADAMTS13 attenuated transforming growth factor (TGF)‐β1/Smad3 activation. Plasma vWF : ADAMTS13 ratio showed positive correlations with malondialdehyde (MDA), hydrogen peroxide (H 2 O 2 ) and proteinuria, and correlated inversely with superoxide dismutase (SOD) and catalase (CAT). Finally, rhADAMTS13 inhibited reactive oxygen species (ROS) levels and improved microvascular functional disorders, accompanied by the inhibition of glycogen synthase kinase (GSK) 3β hyperactivity and upregulation of nuclear factor erythroid 2‐related factor 2 (Nrf2) expression. Conclusions Acute kidney injury (AKI) reduces the expression of ADAMTS13 that contributes to progressive CKD, microvascular dysfunction, oxidative stress, inhibition of Nrf2 activity and renal histopathological damage. All of which can be alleviated by administration of rhADAMTS13.
    Type of Medium: Online Resource
    ISSN: 1748-1708 , 1748-1716
    URL: Issue
    URL: Article
    DOI: 10.1111/apha.2021.231.issue-3
    DOI: 10.1111/apha.13586
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2617148-X
    detail.hit.zdb_id: 2219379-0
    SSG: 12
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  • 7
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    ZrO 2 / Dy 2 O 3 Solid Solution Nano‐Materials: Tunable Composition, Visible light–Responsive Photocatalytic Activities and Reaction Mechanism
    Wiley ; 2013
    In:  Journal of the American Ceramic Society Vol. 96, No. 9 ( 2013-09), p. 2979-2986
    Details
    In: Journal of the American Ceramic Society, Wiley, Vol. 96, No. 9 ( 2013-09), p. 2979-2986
    Abstract: A series of ZrO 2 / Dy 2 O 3 solid solution nano‐materials with tunable compositions were successfully synthesized by the molten salt–assisted method. Structural characterization results show the positions, intensity, and width of the X ‐ray diffraction peaks of products show a regular variation with increasing Dy 3+ content which implies the gradually changes of crystal spacing and product size. In addition, all the products are single phase without the coexistence of zirconia and Dy 2 O 3 further demonstrating the perfect formation of targeted solid solutions. Photocatalytic experiments reveal that Zr 0.8 Dy 0.2 O 2−δ nano‐crystals have pretty photocatalytic degradation activities on Rhodamine B and Methylene blue under visible light irradiations. Reaction mechanism indicates that the excellent photocatalytic activities of Zr 0.8 Dy 0.2 O 2−δ nano‐crystals result from the special defect structure, smaller size, and larger specific surface area. It follows that Zr 0.8 Dy 0.2 O 2−δ nano‐crystals are promising visible light–responsive photocatalysts with better prospect in environmental protection and dye wastewater treatment. Moreover, the present molten salt–assisted route might be generalized to synthesize other solid solution nano‐crystals with more complicated structures.
    Type of Medium: Online Resource
    ISSN: 0002-7820 , 1551-2916
    URL: Issue
    URL: Article
    DOI: 10.1111/jace.2013.96.issue-9
    DOI: 10.1111/jace.12414
    RVK:
    VA 1120
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 2008170-4
    detail.hit.zdb_id: 219232-9
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  • 8
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    Online Resource
    The genetic variations in DNA repair genes ERCC2 and XRCC1 were associated with the overall survival of advanced non‐small‐cell lung cancer patients
    Wiley ; 2016
    In:  Cancer Medicine Vol. 5, No. 9 ( 2016-09), p. 2332-2342
    Details
    In: Cancer Medicine, Wiley, Vol. 5, No. 9 ( 2016-09), p. 2332-2342
    Abstract: It was reported that DNA repair can confer cancer cell resistance to therapeutic treatments by activating antiapoptotic cellular defense. We hypothesized that genetic variants of DNA repair genes may be associated with lung cancer prognosis. Seventeen tagging single‐nucleotide polymorphism (tag SNP s) selected from 12 DNA repair genes were genotyped in 280 advanced non‐small‐cell lung cancer ( NSCLC ) patients by TaqMan assay. The associations of these SNP s and overall survival of advanced NSCLC patients were investigated. Advanced NSCLC patients carrying ERCC 2 rs50872 CT + TT genotypes had significantly longer median survival time ( MST ) and decreased death risk than patients with rs50872 CC genotype [log‐rank P  =   0.031; adjusted HR (95% CI ) = 0.73 (0.55–0.98), P  =   0.033]. These effects were mainly seen among younger patients (≤65 years old) [ HR (95% CI ) = 0.57 (0.37–0.87), P  =   0.010], patients without surgery [ HR (95% CI ) = 0.68 (0.47–0.98), P  =   0.036] but with chemotherapy [ HR (95% CI ) = 0.64 (0.46–0.91), P  =   0.012] or radiotherapy [ HR (95% CI ) = 0.58 (0.38–0.89), P  =   0.013]. Meanwhile, compared to advanced NSCLC patients with rs25487 GG genotype, patients carrying XRCC 1 rs25487 GA + AA genotypes had significantly shorter MST ( MST  = 11.7 vs. 16.7, log‐rank P  =   0.048). In addition, advanced NSCLC patients carrying the ERCC 2 rs50872 CC in combination with XRCC 1 rs25487 GA + AA genotype had the shortest MST (11.2 month) and highest death risk [ HR (95% CI ) = 1.70 (1.15–2.52), P  =   0.008] when compared with those carrying rs50872 CT + TT and rs25487 GG genotype ( MST  = 22.0 month). The ERCC 2 rs50872 T allele was associated with favorable but XRCC 1 rs25487 A allele with bad survival for advanced NSCLC in Chinese population, which may offer novel biomarkers for predicting clinical outcomes.
    Type of Medium: Online Resource
    ISSN: 2045-7634 , 2045-7634
    URL: Issue
    URL: Article
    DOI: 10.1002/cam4.2016.5.issue-9
    DOI: 10.1002/cam4.822
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2659751-2
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  • 9
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    Benzoxadiazole and Benzoselenadiazole as π‐Bridges in Nonfullerene Acceptors for Efficient Polymer Solar Cells
    Wiley ; 2018
    In:  Asian Journal of Organic Chemistry Vol. 7, No. 11 ( 2018-11), p. 2285-2293
    Details
    In: Asian Journal of Organic Chemistry, Wiley, Vol. 7, No. 11 ( 2018-11), p. 2285-2293
    Abstract: Fused‐ring electron acceptors with acceptor‐donor‐acceptor (A‐D‐A) structure have become a hot research field in recent years. In this work, 2,1,3‐benzoxadiazole (BO) and 2,1,3‐benzoselenadiazole (BS) were introduced as π‐bridges between indaceno [1,2‐ b  : 5,6‐ b ′] dithiophene (IDT) cores and rhodanine termini for two nonfullerene acceptors IDTBOR and IDTBSR, to compare the structure‐property relationship. Inserting BO as the π‐bridge afforded IDTBOR with deeper LUMO and HOMO levels, whereas BS‐based IDTBSR possessed a smaller optical band gap. With PBDB‐T as polymer donor, IDTBOR‐ and IDTBSR‐based solar cells showed power conversion efficiencies of 7.74 and 6.95%, respectively. A higher open‐circuit voltage of 0.95 V was found for IDTBSR, owing to its up‐lying LUMO level. A higher short‐circuit current density of 15.98 mA/cm 2 and fill factor of 54.67% were achieved for IDTBOR, mainly because of the higher electron mobility and better structure order in the blend film. The results suggest that BO and BS units are valuable π‐bridges to construct efficient nonfullerene acceptors.
    Type of Medium: Online Resource
    ISSN: 2193-5807 , 2193-5815
    URL: Issue
    URL: Article
    DOI: 10.1002/ajoc.v7.11
    DOI: 10.1002/ajoc.201800389
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2679333-7
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