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  • 1
    In: ChemistrySelect, Wiley, Vol. 7, No. 33 ( 2022-09-06)
    Abstract: When being used as anodes for lithium‐ion batteries (LIBs), environmental friendly and easily available biomass‐derived carbon materials often suffer from complex preparation conditions, underdeveloped pore structures and relatively low circulation capacities. In this context, three novel biomass‐derived porous carbon materials including LRK‐6, LRK‐7 and LRK‐8 sourced from lotus roots are activated and carbonized by a simple method. The prepared material has a three‐dimensional honeycomb structure. The effects of carbonization temperature on the structure, morphology and electrochemical properties of the material are investigated in detail. Owing to its high specific surface area (831.017 m 2  g −1 ), appropriate microporous content (0.217 cm 3  g −1 ) and the highest mesopore capacity (0.325 cm 3  g −1 ) together with suitable doping of N and O atoms, the as‐optimized LRK‐7 material shows a reversible specific capacity of 725.25 mAh g −1 after 100 cycles at 0.1 A g −1 and 614.60 mAh g −1 after 223 cycles at 0.3 A g −1 . Besides, LRK‐7 material also exhibits high rate performance, achieving a capacity of 153.5 mAh g −1 at 9.0 A g −1 . The results verify that the application of LRK‐7 as a potential anode material in the LIB will embrace a bright future.
    Type of Medium: Online Resource
    ISSN: 2365-6549 , 2365-6549
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2844262-3
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  • 2
    In: Diabetes, Obesity and Metabolism, Wiley, Vol. 20, No. 7 ( 2018-07), p. 1578-1584
    Abstract: Despite the inverse association between cigarette smoking and body mass index (BMI), it is unknown whether the effect of smoking on insulin is mediated through decreased BMI. This study aims to examine the temporal relationship between BMI and insulin, the impact of smoking on this relationship and the mediation effect of BMI on the association between smoking and insulin levels. Methods The longitudinal cohort consisted of 1121 adults (807 white and 314 black participants, mean age, 42.0 years at follow‐up) for whom BMI and fasting insulin were measured twice, with an average follow‐up period of 17.1 years. Cross‐lagged panel and mediation analysis models were used to examine the temporal relationship between BMI and insulin, and the mediation effect of BMI on the smoking‐insulin association. Results Smoking was inversely associated with insulin (regression coefficient, −0.073; P = .015 at baseline and −0.121; P 〈 .001 at follow‐up), adjusting for age, race and gender. After additional adjustment for follow‐up periods, the cross‐lagged path coefficient from BMI to insulin (β, 0.226; P 〈 .001) was significantly greater than that from insulin to BMI (β, −0.029; P = .208), with P 〈 .001 for the difference. The path coefficient from BMI to insulin was significantly greater in non‐smokers (β, 0.273; P 〈 .001) than in smokers (β, 0.122; P = .046), with P = .013 for the difference. The mediation effect of BMI on the smoking‐insulin association was estimated at 53.4% ( P = .030) at baseline and 58.7% ( P 〈 .001) at follow‐up. Conclusions These findings suggest that cigarette smoking has a significant impact on the one‐directional relationship from BMI to insulin. The insulin‐lowering effect of smoking is predominantly mediated through decreased BMI as the result of smoking.
    Type of Medium: Online Resource
    ISSN: 1462-8902 , 1463-1326
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2004918-3
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  • 3
    In: Obesity, Wiley, Vol. 30, No. 4 ( 2022-04), p. 943-952
    Abstract: The authors hypothesize that an untargeted metabolomics study will identify novel mechanisms underlying smoking‐associated weight loss. Methods This study performed cross‐sectional analyses among 1,252 participants in the Bogalusa Heart Study and assessed 1,202 plasma metabolites for mediation effects on smoking‐BMI associations. Significant metabolites were tested for associations with smoking genetic risk scores among a subset of participants ( n  = 654) with available genomic data, followed by direction dependence analysis to investigate causal relationships between the metabolites and smoking and BMI. All analyses controlled for age, sex, race, education, alcohol drinking, and physical activity. Results Compared with never smokers, current and former smokers had a 3.31‐kg/m 2 and 1.77‐kg/m 2 lower BMI after adjusting for all covariables, respectively. A total of 22 xenobiotics and 94 endogenous metabolites were significantly associated with current smoking. Eight xenobiotics were also associated with former smoking. Forty metabolites mediated the smoking‐BMI associations, and five showed causal relationships with both smoking and BMI. These metabolites, including 1‐oleoyl‐GPE (18:1), 1‐linoleoyl‐GPE (18:2), 1‐stearoyl‐2‐arachidonoyl‐GPE (18:0/20:4), α‐ketobutyrate, and 1‐palmitoyl‐GPE (16:0), mediated 26.0% of the association between current smoking and BMI. Conclusions This study cataloged plasma metabolites altered by cigarette smoking and identified five metabolites that partially mediated the association between current smoking and BMI.
    Type of Medium: Online Resource
    ISSN: 1930-7381 , 1930-739X
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2027211-X
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  • 4
    In: International Wound Journal, Wiley, Vol. 16, No. 2 ( 2019-04), p. 360-369
    Abstract: The pathogenesis of hypertrophic scar (HS) is still poorly understood. Macrophages, especially the polarisation of that to M1 or M2, play a pivotal role in control of the degree of scar formation. Profiling of macrophage phenotypes in human specimens during long‐term period of wound healing and HS formation may provide valuable clinical evidence for understanding the pathology of human scars. Human wound and HS specimens were collected, the macrophage phenotype was identified by immunofluorescence, and biomarkers and cytokines associated with M1 and M2 macrophages were detected by RT‐PCR. The correlation between the macrophage phenotype and HS characteristics was analysed by linear regression analyses. We found excessive and persistent infiltration by M1 macrophages around the blood vessels in the superficial layer of the dermis at early wound tissues, whereas M2 macrophages predominated in later wound tissues and the proliferative phase of HS and were scattered throughout the dermis. The density of M1 macrophages was positively correlated with mRNA expression levels of tumour necrosis factor‐alpha (TNF‐α) and IL‐6. The density of M2 macrophages was positively correlated with ARG1 and negatively correlated with the duration of HS. The sequential infiltration by M1 macrophage and M2 macrophages in human wound and HS tissues was confirmed.
    Type of Medium: Online Resource
    ISSN: 1742-4801 , 1742-481X
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2152163-3
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  • 5
    In: ChemElectroChem, Wiley, Vol. 9, No. 9 ( 2022-05-13)
    Abstract: Hydrogen energy is considered as promising renewable resource and desirable alternative to fossil fuels for future energy supply. Hydrogen production from electrocatalytic water splitting is a green and key approach for hydrogen energy development and application, and the effective electrocatalysts for hydrogen evolution reaction (HER) with low cost is the focus of ongoing research. Currently, noble metals‐based materials are the most effective and durable electrocatalysts for HER, while the high cost and low reserves greatly hinder their commercial applications. Recently, layered double hydroxides (LDHs) with interesting properties, such as the tunability of metal cation and interlayer anions, the adjustability of the thickness and spacing for the layers, low cost, and memory effect, have emerged as excellent electrocatalysts to enhance HER performance. Herein, the principal mechanisms and some key parameters for HER are firstly briefly introduced. Afterwards, the structural features and characteristics of LDHs are provided, and the typical design strategies to improve the HER activity of binary and ternary LDHs‐based catalysts are analyzed and discussed. In addition, the relationship between the morphology, structure, composition and involved electronic effects are focused and emphasized. Finally, the challenges and prospects of LDHs‐based catalysts for enhanced HER performance are proposed.
    Type of Medium: Online Resource
    ISSN: 2196-0216 , 2196-0216
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2724978-5
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  • 6
    Online Resource
    Online Resource
    Wiley ; 2018
    In:  The Journal of Clinical Hypertension Vol. 20, No. 3 ( 2018-03), p. 515-517
    In: The Journal of Clinical Hypertension, Wiley, Vol. 20, No. 3 ( 2018-03), p. 515-517
    Type of Medium: Online Resource
    ISSN: 1524-6175 , 1751-7176
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2058690-5
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  • 7
    In: Pediatric Obesity, Wiley, Vol. 14, No. 7 ( 2019-07)
    Abstract: Childhood body mass index (BMI) predicts adult obesity. How growth trajectories during childhood relate to adult obesity risk is not well defined. Objective We aimed to characterize BMI growth trajectories from childhood to midlife and to examine the associations between BMI growth rates at childhood age points and adult obesity risk. Methods The longitudinal study included 2732 participants with repeated BMI measurements from childhood (4‐19 y) to adulthood (20‐51 y). A random‐effects model was used to construct BMI growth curves by race and sex. Model‐estimated levels and linear growth rates of BMI were linked to adult obesity in separate multivariable logistic regression models at individual childhood age points. Results BMI followed cubic growth curves. Childhood BMI linear slope estimates were higher in adults with obesity than in adults without obesity ( P   〈  0.001). The association between childhood BMI growth rate and adult obesity was significantly higher in puberty and postpuberty (12‐19 y) than in early childhood (4‐11 y) with a peak at age 14 (odds ratio = 3.1 and 95% confidence interval, 2.7‐3.5). Conclusions Rates of change in BMI at different childhood ages are differentially associated with adult obesity. Puberty and postpuberty are crucial periods for the development of obesity in later life.
    Type of Medium: Online Resource
    ISSN: 2047-6302 , 2047-6310
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2648531-X
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  • 8
    Online Resource
    Online Resource
    Wiley ; 2006
    In:  The Journal of Clinical Hypertension Vol. 8, No. 5 ( 2006-05), p. 323-329
    In: The Journal of Clinical Hypertension, Wiley, Vol. 8, No. 5 ( 2006-05), p. 323-329
    Abstract: Differential impact of non–high‐density lipoprotein cholesterol (total cholesterol minus high‐density lipoprotein cholesterol) and blood pressure on arterial wall thickness and stiffness was examined in 900 black and white adults aged 24–43 years. Blacks compared with whites had greater values of pulse wave velocity (5.4 m/sec vs. 5.2 m/sec; p 〈 0.01) and carotid artery intima–media thickness (0.83 mm vs. 0.80 mm; p 〈 0.01). Non–high‐density lipoprotein cholesterol was significantly associated with carotid intima–media thickness (standardized regression coefficient [b]=0.21; p 〈 0.01), but not with pulse wave velocity (b=0.03; p =0.37), after adjusting for race, sex, age, body mass index, insulin, glucose, and smoking. Systolic blood pressure was associated significantly stronger with pulse wave velocity (b=0.36; p 〈 0.01) than with carotid intima–media thickness (b=0.15; p 〈 0.01). No race difference in these relationships was found. The results of this study indicate that atherogenic lipoproteins and blood pressure may play different roles in the development of arterial wall stiffness and atherosclerosis.
    Type of Medium: Online Resource
    ISSN: 1524-6175 , 1751-7176
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2006
    detail.hit.zdb_id: 2058690-5
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  • 9
    In: Diabetes, Obesity and Metabolism, Wiley
    Abstract: To investigate metabolic risk factors (RFs) that accumulated over 20 years related to left ventricular mass index (LVMI), relative wall thickness (RWT) and LV remodelling patterns in participants with versus without early‐onset type 2 diabetes (T2D) or prediabetes (pre‐D). Methods A total of 287 early‐onset T2D/pre‐D individuals versus 565 sociodemographic‐matched euglycaemic individuals were selected from the Coronary Artery Risk Development in Young Adults (CARDIA) study, years 0‐25. We used the area under the growth curve (AUC) derived from quadratic random‐effects models of four or more repeated measures of RFs (fasting glucose [FG], insulin, triglycerides [TG] , low‐density lipoprotein cholesterol, high‐density lipoprotein cholesterol (HDL‐c), total cholesterol (total‐c), blood pressure and body mass index) to estimate the cumulative burden, and their associations with LV outcomes. Results One standard deviation greater AUC of log (TG) (per 0.48) and HDL‐c (per 13.5 mg/dL) were associated with RWT (β 0.21 and −0.2) in the early‐onset T2D/pre‐D group, but not in the euglycaemia group (β 0.01 and 0.05, P interactions .02 and .03). In both the early‐onset T2D/pre‐D and euglycaemia groups, greater AUCs of log (FG) (per 0.17) and log (insulin) (per 0.43) were associated with higher RWT (β ranges 0.12‐0.24). Greater AUCs of systolic blood pressure (per 10 mmHg) and diastolic blood pressure (per 7.3 mmHg) were associated with higher RWT and LVMI, irrespective of glycaemic status (β ranges 0.17‐0.28). Cumulative TG (odds ratio 3.4, 95% confidence interval: 1.8‐6.3), HDL‐c (0.23, 0.09‐0.59), total‐c (1.9, 1.1‐3.1) and FG (2.2, 1.25‐3.9) were statistically associated with concentric hypertrophy in the T2D/pre‐D group only. Conclusions Sustained hyperglycaemia and hyperinsulinaemia are associated with RWT, and those individuals with early T2D/pre‐D are potentially at greater risk because of their higher levels of glucose and insulin. Dyslipidaemia was associated with LV structural abnormalities in those individuals with early‐onset T2D/pre‐D.
    Type of Medium: Online Resource
    ISSN: 1462-8902 , 1463-1326
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2004918-3
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  • 10
    In: Pediatric Investigation, Wiley, Vol. 5, No. 1 ( 2021-03), p. 21-27
    Abstract: The impact of long‐term burden of excessive body weight, beginning in childhood, on inflammatory status in adulthood has been poorly described. Objective To characterize the longitudinal body mass index (BMI) trajectory from childhood and examine its relationship with inflammatory status in adulthood. Methods We included 1285 adults who had 4–15 repeat measurements of BMI from childhood to adulthood. The area under the curve (AUC) of growth curves was calculated to characterize long‐term burden (total AUC) and trends (incremental AUC) of BMI. Results After adjusting for covariates, higher values of BMI in terms of childhood and adulthood, as well as total and incremental AUC, were strongly associated with elevated levels of adult C‐reactive protein (CRP) in the four race‐sex groups. There were significant differences in linear and nonlinear curve parameters between the normal and high CRP groups for all race‐sex groups ( P 〈 0.01). Compared with participants who had consistently low BMI in both childhood and adulthood, participants with high BMI in adulthood had higher CRP levels ( P 〈 0.001), irrespective of their childhood BMI status; participants with high BMI in childhood but low BMI in adulthood had similar adult CRP levels. Interpretation The impact of excessive body weight on inflammation is cumulative and exacerbated over time. The influence of childhood overweight/obesity on inflammatory status in adulthood can be alleviated by reducing adiposity in adulthood.
    Type of Medium: Online Resource
    ISSN: 2574-2272 , 2574-2272
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2934365-3
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