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  • 1
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    Association between birth weight and diabetes: Role of body mass index and lifestyle in later life
    Wiley ; 2020
    In:  Journal of Diabetes Vol. 12, No. 1 ( 2020-01), p. 10-20
    Details
    In: Journal of Diabetes, Wiley, Vol. 12, No. 1 ( 2020-01), p. 10-20
    Abstract: 本研究旨在调查中国中老年人群出生体重与糖尿病之间的关系, 以及成年后体重指数(body mass index, BMI)和生活方式是否会影响这种关联。 方法 我们的研究人群来自全国性的REACTION研究, 即中国2型糖尿病患者肿瘤发生风险的流行病学研究(Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study, REACTION)。最终, 49118名40岁及以上的参与者被纳入研究, 并按回忆的出生体重分为四组: 〈 2500 g, 2500~3499 g, 3500~3999 g, ≥4000 g。 糖尿病的诊断基于口服葡萄糖耐量试验和糖化血红蛋白测定。Logistic回归模型用于评估出生体重与成年后糖尿病风险之间的关系。 结果 低出生体重或高出生体重都与成年后糖尿病发生有关。与出生体重2500~3499g的人相比, 出生体重 〈 2500g、3500~3999g、≥4000g的参与者其多因素校正后的糖尿病比值比(OR)和95%置信区间(CI)分别为1.28(1.11~1.47), 1.11(1.04~1.19)和1.20(1.07~1.34)。在BMI ≥ 24 kg/m 2 的参与者中, 出生体重与糖尿病的这种相关性显著, 但在BMI正常者中无显著差异(OR, 95% CI分别为:1.20, 0.96~1.49；1.11, 0.98~1.25和1.10, 0.89~1.37)。此外, 在低出生体重但饮食习惯健康或具有理想体力活动的人群中并未发现糖尿病风险显著升高(OR, 95% CI分别为:0.94, 0.68~1.29；1.41, 0.97~2.04)。 结论 我们的研究表明, 出生体重和成年后糖尿病风险之间呈U形关联。健康的生活方式(如健康的饮食习惯或理想的体力活动)可以抵消低出生体重对糖尿病发生风险的影响, 但不能消除高出生体重的影响。
    Type of Medium: Online Resource
    ISSN: 1753-0393 , 1753-0407
    URL: Issue
    URL: Article
    DOI: 10.1111/jdb.v12.1
    DOI: 10.1111/1753-0407.12960
    Language: English
    Publisher: Wiley
    Publication Date: 2020
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  • 2
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    Metabolomics study reveals systematic metabolic dysregulation and early detection markers associated with incident pancreatic cancer
    Wiley ; 2022
    In:  International Journal of Cancer Vol. 150, No. 7 ( 2022-04), p. 1091-1100
    Details
    In: International Journal of Cancer, Wiley, Vol. 150, No. 7 ( 2022-04), p. 1091-1100
    Abstract: Biomarkers for early detection of pancreatic cancer are in urgent need. To explore systematic circulating metabolites unbalance and identify potential biomarkers for pancreatic cancer in prospective Chinese cohorts, we conducted an untargeted metabolomics study in subjects with incident pancreatic cancer and matched controls (n = 192) from the China Cardiometabolic Disease and Cancer Cohort (4C) Study. We characterized 998 metabolites in baseline serum and calculated 156 product‐to‐precursor ratios based on the KEGG database. The identified metabolic profiling revealed systematic metabolic network disorders before pancreatic cancer diagnosis. Forty‐Five metabolites or product‐to‐precursor ratios showed significant associations with pancreatic cancer ( P   〈  .05 and FDR  〈  0.1), revealing abnormal metabolism of amino acids (especially alanine, aspartate and glutamate), lipids (especially steroid hormones), vitamins, nucleotides and peptides. A novel metabolite panel containing aspartate/alanine (OR [95% CI]: 1.97 [1.31‐2.94] ), androstenediol monosulfate (0.69 [0.49‐0.97]) and glycylvaline (1.68 [1.04‐2.70] ) was significantly associated with risk of pancreatic cancer. Area under the receiver operating characteristic curves (AUCs) was improved from 0.573 (reference model of CA 19‐9) to 0.721. The novel metabolite panel was validated in an independent cohort with AUC improved from 0.529 to 0.661. These biomarkers may have a potential value in early detection of pancreatic cancer.
    Type of Medium: Online Resource
    ISSN: 0020-7136 , 1097-0215
    URL: Issue
    URL: Article
    DOI: 10.1002/ijc.v150.7
    DOI: 10.1002/ijc.33877
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 218257-9
    detail.hit.zdb_id: 1474822-8
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  • 3
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    The association between age at diagnosis of type 2 diabetes and albuminuria in Chinese adults: A nationwide population study
    Wiley ; 2021
    In:  Journal of Diabetes Vol. 13, No. 12 ( 2021-12), p. 987-997
    Details
    In: Journal of Diabetes, Wiley, Vol. 13, No. 12 ( 2021-12), p. 987-997
    Abstract: 2型糖尿病的诊断年龄在全球及中国呈年轻化的趋势。目前较少研究糖尿病诊断年龄与白蛋白尿患病风险的相关性。本研究拟探讨糖尿病诊断年龄是否为白蛋白尿风险相关的独立危险因素。 方法 我们使用了来自中国大陆207961名研究对象的全国多中心研究数据。从年龄、性别和研究中心匹配的非糖尿病人群中随机选择正常对照, 另外对已诊断糖尿病患者的病程进行匹配, 最终共有31366 名新诊断2型糖尿病患者和 31366名正常对照, 及7490名已诊断2型糖尿病和7490名正常对照纳入分析。使用多元Logistic回归分析在不同糖尿病诊断年龄层中2型糖尿病患者与正常对照患白蛋白尿的风险。 结果 虽然年龄越大, 白蛋白尿患病风险越高, 但是2型糖尿病患者与正常对照组白蛋白尿的比值比随着诊断年龄的增加而降低。与正常对照组相比, 年龄 〈 50、50‐59、60‐69 或≥70 岁诊断为糖尿病的患者经过多变量校正后白蛋白尿风险仍然增加, 新诊断糖尿病分别增加了 81%、60%、45% 和 33%, 已诊断糖尿病分别增加了 135%、121%、90% 和 58%。 结论 在中国成人中, 2型糖尿病诊断年龄越低, 其白蛋白尿风险升高越明显。
    Type of Medium: Online Resource
    ISSN: 1753-0393 , 1753-0407
    URL: Issue
    URL: Article
    DOI: 10.1111/jdb.v13.12
    DOI: 10.1111/1753-0407.13213
    Language: English
    Publisher: Wiley
    Publication Date: 2021
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  • 4
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    Gestational hyperglycemia and the risk of cardiovascular diseases among elderly Chinese women: Findings from the REACTION study
    Wiley ; 2021
    In:  Journal of Diabetes Vol. 13, No. 12 ( 2021-12), p. 949-959
    Details
    In: Journal of Diabetes, Wiley, Vol. 13, No. 12 ( 2021-12), p. 949-959
    Abstract: 妊娠高血糖会增加以后患糖尿病的风险。然而，与妊娠高血糖相关的未来心血管疾病(Cardiovascular diseases, CVD)的风险仍然不确定。本研究旨在探讨妊娠高血糖对中国老年女性后续心血管疾病风险的影响及其可能的影响因素。 方法 我们在中国2型糖尿病患者恶性肿瘤发生风险的流行病学(REACTION)研究的老年妇女中开展了一项病例对照研究。研究纳入82名妊娠高血糖女性及410名按年龄和研究中心匹配的对照女性。心血管疾病信息(包括冠心病、中风和心肌梗死)通过调查员辅助的标准化问卷收集。 结果 有妊娠高血糖的女性更容易发生糖尿病 [比值比(Odd ratio, OR)，2.51； 95%可信区间(Confidence interval, CI)，1.50‐4.18] 和CVD(OR，1.98； 95%CI，1.05‐3.74)。即使没有进展为 2 型糖尿病，妊娠高血糖也与 CVD 风险增加相关(OR，2.88；95%CI，1.18‐7.00)。然而，亚组分析表明，与没有妊娠期高血糖或高血压的女性相比，同时有妊娠期高血糖和高血压的女性患心血管疾病的风险更高(OR，3.98；95%CI，1.65‐9.58)，而CVD风险在单纯有妊娠高血糖的女性中没有显著变化(OR，2.15；95%CI，0.71‐6.57)。分层分析表明，在超重/肥胖、缺乏体力活动或饮食不健康的人群中，妊娠高血糖会显著增加CVD风险。 结论 在中国老年女性中，妊娠期高血糖与晚年 CVD 风险增加有关。这种关联与是否发展为糖尿病无关，而可能会受到生活方式和高血压的影响。
    Type of Medium: Online Resource
    ISSN: 1753-0393 , 1753-0407
    URL: Issue
    URL: Article
    DOI: 10.1111/jdb.v13.12
    DOI: 10.1111/1753-0407.13222
    Language: English
    Publisher: Wiley
    Publication Date: 2021
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  • 5
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    High concentrations of triglycerides are associated with diabetic kidney disease in new‐onset type 2 diabetes in C hina: Findings from the C hina C ardiometabolic D isease and C ancer C ohort ( 4C ) S tudy
    Wiley ; 2021
    In:  Diabetes, Obesity and Metabolism Vol. 23, No. 11 ( 2021-11), p. 2551-2560
    Details
    In: Diabetes, Obesity and Metabolism, Wiley, Vol. 23, No. 11 ( 2021-11), p. 2551-2560
    Abstract: The aims of this study were to evaluate the associations of metabolic abnormalities with incident diabetic kidney disease (DKD) and to explore whether dyslipidaemia, particularly high fasting triglyceride (TG), was associated with the development of DKD. Methods In total, 11 142 patients with new‐onset type 2 diabetes with baseline estimated glomerular filtration rates (eGFR) ≥60 mL/min/1.73 m 2 were followed up during 2011‐2016. Incident DKD was defined as eGFR 〈 60 mL/min/1.73 m 2 at follow‐up. Multiple logistic regression analysis was conducted to explore the relationship of metabolic abnormalities at baseline and at follow‐up with risks of DKD. High TG was defined by TG ≥1.70 mmol/L. Low high‐density lipoprotein cholesterol (HDL‐c) was defined by HDL‐c 〈 1.0 mmol/L for men or 〈 1.3 mmol/L for women. Results Participants who developed DKD had higher levels of waist circumference and systolic blood pressure, and lower levels of HDL‐c at both baseline and follow‐up visits. The DKD group also had higher levels of post‐load plasma glucose and TG at follow‐up. Multivariate logistic regression analysis revealed that both high TG at baseline [odds ratio (OR) = 1.37, p  = .012) and high TG at follow‐up (OR = 1.71, p   〈  .001) were significantly associated with increased risks of DKD. Patients with high TG levels at both baseline and follow‐up had higher risk of DKD compared with constantly normal TG (OR = 1.65, p   〈  .001) after adjustment for covariates. Conclusions In a large population of patients with new‐onset type 2 diabetes, a high TG level was an independent risk factor for the development of DKD. Tight TG control might delay the occurrence of DKD.
    Type of Medium: Online Resource
    ISSN: 1462-8902 , 1463-1326
    URL: Issue
    URL: Article
    DOI: 10.1111/dom.v23.11
    DOI: 10.1111/dom.14502
    Language: English
    Publisher: Wiley
    Publication Date: 2021
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  • 6
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    Isotemporal substitution of different behaviour patterns with the presence of MAFLD in Chinese adults
    Wiley ; 2022
    In:  Liver International Vol. 42, No. 12 ( 2022-12), p. 2683-2695
    Details
    In: Liver International, Wiley, Vol. 42, No. 12 ( 2022-12), p. 2683-2695
    Abstract: Lack of physical activity and excessive sitting time contributed to ectopic fat accumulation, especially in the liver. Previous studies have illustrated the harm of sedentary behaviour and the benefits of physical activity on fatty liver disease. We aimed to explore the association between the behaviour patterns and the risk of metabolic dysfunction‐associated fatty liver disease (MAFLD) using isotemporal substitution model to examine the effect of replacing one behaviour to another while keeping the total time and other behaviours fixed among Chinese middle‐aged and elderly population. Methods This study included 161 147 participants aged ≥40 years old from the nationwide, population‐based cohort of the REACTION study. The International Physical Activity Questionnaire was used to measure self‐reported time for sleeping, sitting, walking and moderate‐to‐vigorous physical activity (MVPA). MAFLD was defined by evidence of fatty liver index (FLI) ≥ 60 in addition to one of the following three patterns, namely overweight/obesity, presence of diabetes, or evidence of metabolic dysregulation. Isotemporal substitution models using logistic regression models to evaluate the association of replacement of different behaviour patterns with each other and the risk of MAFLD. Results Substitution of 60 minutes per day of sleeping, walking or total MVPA for sitting was associated with a 2%–8% reduction of MAFLD risk in overall participants. In employed individuals, replacing sitting time with occupational MVPA or nonoccupational MVPA both could bring benefits to liver steatosis. Stratified analysis found that replacing 60 minutes of sitting time with an equivalent time of other behaviour pattern could reduce approximately 8% of the risk among MAFLD participants with metabolic abnormalities. Such a relationship might be explained by the important mediated role of metabolic elements, such as waist circumference, body mass index, triglycerides and homoeostasis model assessment of insulin resistance. Furthermore, replacing sitting with MVPA showed a stronger association among participants who got enough sleep (sleep duration ≥7 hours per day). Conclusion Replacing sitting with other behaviour patterns could reduce the prevalence of MAFLD, and such substitution effect was much remarkably in individuals with abnormal metabolic status. Observably, obese individuals were more likely to benefit from appropriate changes in behaviour patterns. Moreover, the analysis of sleep duration stratification appealed that the adequacy of individual sleep duration also had a significant impact on the substitution effect. It is worth noting that adjusting the time allocation of behaviour patterns might have a beneficial impact on liver‐metabolic health, and these findings might help us better recognize the importance of reasonable arrangement of behaviour patterns according to the individual's situation.
    Type of Medium: Online Resource
    ISSN: 1478-3223 , 1478-3231
    URL: Issue
    URL: Article
    DOI: 10.1111/liv.v42.12
    DOI: 10.1111/liv.15439
    Language: English
    Publisher: Wiley
    Publication Date: 2022
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  • 7
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    Age at menarche, ideal cardiovascular health metrics, and risk of diabetes in adulthood: Findings from the REACTION study
    Wiley ; 2021
    In:  Journal of Diabetes Vol. 13, No. 6 ( 2021-06), p. 458-468
    Details
    In: Journal of Diabetes, Wiley, Vol. 13, No. 6 ( 2021-06), p. 458-468
    Abstract: 既往研究提示月经初潮年龄与糖尿病风险有关。然而尚不清楚理想的心血管健康指标对月经初潮年龄与成年后糖尿病风险之间关系的影响。 方法 我们纳入全国多中心REACTION研究(中国2型糖尿病患者恶性肿瘤发生风险的流行病学研究)中121431名女性。糖尿病的诊断基于口服葡萄糖耐量试验和糖化血红蛋白测值。使用Logistic回归和乘法项交互作用分析理想的心血管健康指标在月经初潮年龄与糖尿病相关性之间的潜在交互作用。 结果 多变量校正后; 与月经初潮年龄14‐17岁者相比; 月经初潮年龄 〈 14岁和 〉  17岁组的糖尿病风险比值比(95%可信区间)分别为1.22(1.17‐1.28)和0.89(0.85‐0.93)。分层分析中; 在总胆固醇; 血压水平和月经初潮年龄与糖尿病风险之间存在显著的交互作用(交互作用P 值分别为 0.0091和0.0019)。在有≤3个理想的心血管健康指标的女性中观察到月经初潮年龄 〈 14岁与成年后糖尿病发生风险增加显著相关; 但在有4个或更多理想的心血管健康指标的女性中则没有观察到显著的风险增加(理想的心血管健康指标的数量与月经初潮年龄之间的交互作用P值 = 0.0001)。 结论 女性成年后患糖尿病的风险与月经初潮年龄呈负相关; 而这种关系或可因理想的心血管健康指标而改变。需进一步研究以阐明其中的相互关系以及研究结果的普遍性。
    Type of Medium: Online Resource
    ISSN: 1753-0393 , 1753-0407
    URL: Issue
    URL: Article
    DOI: 10.1111/jdb.v13.6
    DOI: 10.1111/1753-0407.13128
    Language: English
    Publisher: Wiley
    Publication Date: 2021
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  • 8
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    Associations between parity, pregnancy loss, and breastfeeding duration and risk of maternal type 2 diabetes: An observational cohort study
    Wiley ; 2021
    In:  Journal of Diabetes Vol. 13, No. 11 ( 2021-11), p. 857-867
    Details
    In: Journal of Diabetes, Wiley, Vol. 13, No. 11 ( 2021-11), p. 857-867
    Abstract: 胎次、流产和母乳喂养时间被认为与糖尿病风险相关, 但相关研究结果并不一致。此外, 尚无流行病学研究在同一人群中评估这些生育因素与糖尿病的相关性。本文旨在研究中国中老年女性的胎次、流产、母乳喂养时间与未来2型糖尿病风险之间的关系。 方法 本研究纳入REACTION(中国2型糖尿病患者肿瘤发生风险)研究中131174名年龄≥40岁的女性, 采用多元线性回归分析和logistic回归分析评估胎次、流产和母乳喂养时间与2型糖尿病风险之间的关系。 结果 胎次数和母乳喂养时间与空腹血糖、餐后2小时血糖、糖化血红蛋白及胰岛素抵抗的稳态模型评估呈正相关。与生育1胎的妇女相比, 未生育妇女或生育2胎或≥3胎的妇女患糖尿病的风险显著增加, 优势比(OR)和95%置信区间(CI)分别为1.27(1.10‐1.48)、1.17(1.12‐1.22)和1.28(1.21‐1.35)。与没有流产的女性相比, 经历2次(OR 1.09；95% CI, 1.04‐1.14)或≥3次流产(OR 1.11；95% CI, 1.04‐1.18)的女性, 糖尿病风险显著增加。 此外, 母乳喂养时间0 ~6个月(OR 0.82；95% CI, 0.75‐0.90)和6 ~12个月(OR 0.94；95% CI, 0.89‐0.99)的妇女, 糖尿病风险显著降低。 结论 未生育、多胎或不止一次流产的妇女糖尿病风险增加, 而母乳喂养0~12个月妇女, 糖尿病的风险较低。
    Type of Medium: Online Resource
    ISSN: 1753-0393 , 1753-0407
    URL: Issue
    URL: Article
    DOI: 10.1111/jdb.v13.11
    DOI: 10.1111/1753-0407.13176
    Language: English
    Publisher: Wiley
    Publication Date: 2021
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  • 9
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    Obesity mediates the opposite association of education and diabetes in Chinese men and women: Results from the REACTION study
    Wiley ; 2022
    In:  Journal of Diabetes Vol. 14, No. 11 ( 2022-11), p. 739-748
    Details
    In: Journal of Diabetes, Wiley, Vol. 14, No. 11 ( 2022-11), p. 739-748
    Abstract: 在发展中国家，关于教育对糖尿病风险的影响的证据很少。我们的目的是在中国的一个大人群样本中探索教育和糖尿病之间的联系，并确定可能的中介因素。 材料和方法 通过问卷调查，收集有关文化程度和生活方式因素的信息。糖尿病的诊断是通过自我报告和生化测量进行的。我们构建了结构方程模型量化了各变量的中介效应。 结果 与受教育程度最低的男性相比，受过大学教育的男性患糖尿病风险较高(优势比OR:1.19, 95%可信区间(95%CI):1.12~1.27)，而受过大学教育的女性患糖尿病风险较低(OR:0.77, 95%CI:0.73~0.82)。肥胖在两性中均是最强的中介因素(中介比例:男性11.6%，女性23.9%)，肥胖与教育呈正相关(β[SE]0.0387[0.0037] )，与女性中负相关(β[SE]‐0.0824[0.0030] )。所有行为因素加在一起，可以解释12.4%的男性和33.3%的女性患糖尿病的额外风险。 结论 在中国普通人群中，男性受教育程度与糖尿病之间存在正相关，而女性则为负相关。肥胖是糖尿病风险教育差异的主要中介因素，在女性中的中介作用更强。
    Type of Medium: Online Resource
    ISSN: 1753-0393 , 1753-0407
    URL: Issue
    URL: Article
    DOI: 10.1111/jdb.v14.11
    DOI: 10.1111/1753-0407.13325
    Language: English
    Publisher: Wiley
    Publication Date: 2022
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    Glycemic status and chronic kidney disease in C hinese adults: F indings from the REACTION study : 中国成年人糖代谢状态与慢性肾脏疾病的相关性:来自REACTION的研究发现
    Wiley ; 2017
    In:  Journal of Diabetes Vol. 9, No. 9 ( 2017-09), p. 837-845
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    In: Journal of Diabetes, Wiley, Vol. 9, No. 9 ( 2017-09), p. 837-845
    Abstract: 既往研究证实已诊断的糖尿病与慢性肾脏疾病(chronic kidney disease,CKD)具有相关性。然而,关于糖尿病前期高血糖是否与升高的CKD风险有关尚不明确。本研究旨在探讨中国成年人群不同糖代谢水平与CKD的相关性,并评估和讨论CKD患者的糖尿病患病率及血糖控制现状。 方法 本研究共纳入250752名40岁及以上受试者,均来自中国2型糖尿病患者恶性肿瘤发生风险的流行病学研究(Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study,REACTION study)的基线研究人群,并对所有受试者进行血糖、生化检测以及其他临床资料的收集。估算的肾小球滤过率(eGFR) 〈 60mL/min/1.73m 2 被定义为CKD。 结果 在男性和女性中,均可以观察到CKD的患病率随着糖代谢状态的恶化逐渐升高(男性和女性均为趋势 P 〈 0.001)。在男性中,与糖代谢正常的受试者相比,糖尿病前期与糖尿病人群的CKD患病风险增高(糖尿病前期:OR=1.15,95% CI = 1.02‐1.32;新诊断糖尿病:OR=1.27, 95% CI = 1.08‐1.49;已诊断糖尿病:OR=2.05,95% CI = 1.78‐2.35)。在女性中也发现了糖尿病与CKD患病风险的相关性,但是,女性糖尿病前期人群与CKD患病的相关性无统计学意义。在伴有糖尿病的男性CKD患者中,接受降糖治疗的比例是52.1%,其中41.8%患者的糖尿病得到了有效控制,该比例高于女性人群。 结论 在中国40岁及以上成年男性中,糖尿病前期状态和糖尿病与CKD患病风险的升高密切相关。中国CKD患者中血糖的控制情况不容乐观。
    Type of Medium: Online Resource
    ISSN: 1753-0393 , 1753-0407
    URL: Issue
    URL: Article
    DOI: 10.1111/jdb.2017.9.issue-9
    DOI: 10.1111/1753-0407.12490
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2485432-3
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