GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    Combination of the advantages of chromatographic methods based on active components for the quality evaluation of licorice : Liquid Chromatography
    Wiley ; 2015
    In:  Journal of Separation Science Vol. 38, No. 24 ( 2015-12), p. 4180-4186
    Details
    In: Journal of Separation Science, Wiley, Vol. 38, No. 24 ( 2015-12), p. 4180-4186
    Type of Medium: Online Resource
    ISSN: 1615-9306
    URL: Article
    DOI: 10.1002/jssc.201500770
    RVK:
    VA 5450
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2047990-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Orthostatic blood pressure changes do not influence cognitive outcomes following intensive blood pressure control
    Wiley ; 2023
    In:  Journal of Internal Medicine
    Details
    In: Journal of Internal Medicine, Wiley
    Abstract: Effects of intensive blood pressure (BP) control on cognitive outcomes in patients with excess orthostatic BP changes are unclear. We aimed to evaluate whether orthostatic BP changes modified the effects of BP intervention on cognitive impairment. Methods We analyzed 8547 participants from the Systolic Blood Pressure Intervention Trial Memory and cognition IN Decreased Hypertension. Associations between orthostatic BP changes and incident cognitive outcomes were evaluated by restricted cubic spline curves based on Cox models. The interactions between orthostatic BP changes and intensive BP intervention were assessed. Results The U‐shaped associations were observed between baseline orthostatic systolic BP changes and cognitive outcomes. However, there were insignificant interactions between either change in orthostatic systolic BP (P for interaction = 0.81) or diastolic BP (P for interaction = 0.32) and intensive BP intervention for the composite outcome of probable dementia or mild cognitive impairment (MCI). The hazard ratio of intensive versus standard target for the composite cognitive outcome was 0.82 (95% CI 0.50–1.35) in those with an orthostatic systolic BP reduction of 〉 20 mmHg and 0.41 (95% CI 0.21–0.80) in those with an orthostatic systolic BP increase of 〉 20 mmHg. Results were similar for probable dementia and MCI. The annual changes in global cerebral blood flow (P for interaction = 0.86) consistently favored intensive BP treatment across orthostatic systolic BP changes. Conclusion Intensive BP control did not have a deteriorating effect on cognitive outcomes among hypertensive patients experiencing significant postural BP changes.
    Type of Medium: Online Resource
    ISSN: 0954-6820 , 1365-2796
    URL: Article
    DOI: 10.1111/joim.13758
    RVK:
    XA 54380
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2006883-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Identification of atrial fibrillation phenotypes at low risk of stroke in patients with CHA2DS2‐VASc ≥2: Insight from the China‐AF study
    Wiley ; 2023
    In:  Pacing and Clinical Electrophysiology
    Details
    In: Pacing and Clinical Electrophysiology, Wiley
    Abstract: Patients with atrial fibrillation (AF) are highly heterogeneous, and current risk stratification scores are only modestly good at predicting an individual's stroke risk. We aim to identify distinct AF clinical phenotypes with cluster analysis to optimize stroke prevention practices. Methods From the prospective Chinese Atrial Fibrillation Registry cohort study, we included 4337 AF patients with CHA 2 DS 2 ‐VASc≥2 for males and 3 for females who were not treated with oral anticoagulation. We randomly split the patients into derivation and validation sets by a ratio of 7:3. In the derivation set, we used outcome‐driven patient clustering with metric learning to group patients into clusters with different risk levels of ischemic stroke and systemic embolism, and identify clusters of patients with low risks. Then we tested the results in the validation set, using the clustering rules generated from the derivation set. Finally, the survival decision tree was applied as a sensitivity analysis to confirm the results. Results Up to the follow‐up of 1 year, 140 thromboembolic events (ischemic stroke or systemic embolism) occurred. After supervised metric learning from six variables involved in CHA 2 DS 2 ‐VASc scheme, we identified a cluster of patients (255/3035, 8.4%) at an annual thromboembolism risk of 0.8% in the derivation set. None of the patients in the low‐risk cluster had prior thromboembolism, heart failure, diabetes, or age older than 70 years. After applying the regularities from metric learning on the validation set, we also identified a cluster of patients (137/1302, 10.5%) with an incident thromboembolism rate of 0.7%. Sensitivity analysis based on the survival decision tree approach selected a subgroup of patients with the same phenotypes as the metric‐learning algorithm. Conclusions Cluster analysis identified a distinct clinical phenotype at low risk of stroke among high‐risk [CHA 2 DS 2 ‐VASc≥2 (3 for females)] patients with AF. The use of the novel analytic approach has the potential to prevent a subset of AF patients from unnecessary anticoagulation and avoid the associated risk of major bleeding.
    Type of Medium: Online Resource
    ISSN: 0147-8389 , 1540-8159
    URL: Article
    DOI: 10.1111/pace.14829
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2037547-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Intestinal Conditioning After Cardiac Arrest: The Use of Normothermic Extracorporeal Membrane Oxygenation in the Non‐Heart‐Beating Animal Model
    Wiley ; 2016
    In:  Artificial Organs Vol. 40, No. 8 ( 2016-08), p. 738-745
    Details
    In: Artificial Organs, Wiley, Vol. 40, No. 8 ( 2016-08), p. 738-745
    Abstract: The effect of normothermic extracorporeal membrane oxygenation (NECMO) on small bowel preservation in a clinically relevant large animal model of expected donation after cardiac death (eDCD) was evaluated. Thirty domestic crossbred donor pigs were divided into five groups. The first group served as the live donation (LD) group, the second group served as the donation after cardiac death (DCD) group, and the remaining were further assigned into three subgroups: E1 group (1 h NECMO support), E3 group (3 h NECMO support), and E5 group (5 h NECMO support). Pathology, electron microscopy, energy metabolism, cell apoptosis, and tight junction (TJ) protein expression level of intestinal mucosa and the level of plasma d ‐lactic acid were evaluated in normal, cardiac death and at the end of extracorporeal support, respectively. The mean arterial pressure and PaO 2 were maintained over 60 and 267 mm Hg during NECMO support, respectively. One hour of extracorporeal support could improve the energy status in intestines of the DCD group. Although the histologic damage and apoptosis of the E1 group had no significant difference with those of the LD and DCD groups ( P   〉  0.05), the levels of intestinal mucosa TJ protein decreased ( P   〈  0.05), and plasma d ‐lactic acid increased progressively ( P   〈  0.05). With the extension of extracorporeal support, the degree of intestinal mucosa damage and intestinal permeability gradually increased, as well as the content of adenosine triphosphate in intestinal mucosa. The normothermic extracorporeal support for 1 h in DCD is beneficial for improving the energy status and viability of the bowel. However, the integrity of intestinal mucosa was destroyed gradually as extracorporeal support time went by. And the activation of intestinal epithelial apoptosis and hyperoxia might be the factors that lead to intestinal mucosa injury.
    Type of Medium: Online Resource
    ISSN: 0160-564X , 1525-1594
    URL: Issue
    URL: Article
    DOI: 10.1111/aor.2016.40.issue-8
    DOI: 10.1111/aor.12691
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2003825-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Discrimination of genuine and non‐genuine Magnolia officinalis leaves based on multi‐technique data fusion of ultra‐high performance liquid chromatography‐quadrupole time‐of‐flight tandem mass spectrometry, gas chromatography‐mass spectrometry, and chemometrics
    Wiley ; 2023
    In:  SEPARATION SCIENCE PLUS Vol. 6, No. 3 ( 2023-03)
    Details
    In: SEPARATION SCIENCE PLUS, Wiley, Vol. 6, No. 3 ( 2023-03)
    Abstract: Magnolia officinalis has tremendous value in healthcare systems and has been widely used in Chinese, Japanese, and Korean for over a thousand years. M. officinalis is a kind of deciduous tree with large leaves, and the leaves give a high yield every year. Moreover, M. officinalis leaves have various pharmacological activities, such as anti‐inflammatory, anti‐bacterial, and anti‐oxidant. This research aimed to establish an accurate and efficient method to comprehensively analyze their chemical constituents and to compare the differences between genuine and non‐genuine M. officinalis leaves. Ultra‐high performance liquid chromatography‐quadrupole time‐of‐flight tandem mass spectrometry and gas chromatography‐mass spectrometry were employed to identify the basic chemical compounds. An integration of chemometrics was initially developed to discriminate genuine and non‐genuine M. officinalis leaves. Thirty‐six non‐volatile components and thirty‐eight volatile oils were identified. Genuine samples exhibited higher quantities of six non‐volatile compounds and eight volatile oils of twenty‐two different components. Partial least squares discriminant analysis plots and heat map analysis highlighted the significant difference between genuine and non‐genuine samples. These comprehensive phytochemical investigations provide a theoretical reference for further research into or applications of genuine and non‐genuine M. officinalis leaves.
    Type of Medium: Online Resource
    ISSN: 2573-1815 , 2573-1815
    URL: Issue
    URL: Article
    DOI: 10.1002/sscp.v6.3
    DOI: 10.1002/sscp.202200074
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2920378-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Combining MGMT promoter pyrosequencing and protein expression to optimize prognosis stratification in glioblastoma
    Wiley ; 2021
    In:  Cancer Science Vol. 112, No. 9 ( 2021-09), p. 3699-3710
    Details
    In: Cancer Science, Wiley, Vol. 112, No. 9 ( 2021-09), p. 3699-3710
    Abstract: Pyrosequencing (PSQ) represents the golden standard for MGMT promoter status determination. Binary interpretation of results based on the threshold from the average of several CpGs tested would neglect the existence of the “gray zone”. How to define the gray zone and reclassify patients in this subgroup remains to be elucidated. A consecutive cohort of 312 primary glioblastoma patients were enrolled. CpGs 74‐81 in the promoter region of MGMT were tested by PSQ and the protein expression was assessed by immunohistochemistry (IHC). Receiver operating characteristic curves were constructed to calculate the area under the curves (AUC). Kaplan‐Meier plots were used to estimate the survival rate of patients compared by the log‐rank test. The optimal threshold of each individual CpG differed from 5% to 11%. Patients could be separated into the hypomethylated subgroup (all CpGs tested below the corresponding optimal thresholds, n = 126, 40.4%), hypermethylated subgroup (all CpGs tested above the corresponding optimal thresholds, n = 108, 34.6%), and the gray zone subgroup (remaining patients, n = 78, 25.0%). Patients in the gray zone harbored an intermediate prognosis. The IHC score instead of the average methylation levels could successfully predict the prognosis for the gray zone (AUC for overall survival, 0.653 and 0.519, respectively). Combining PSQ and IHC significantly improved the efficiency of survival prediction (AUC: 0.662, 0.648, and 0.720 for PSQ, IHC, and combined, respectively). Immunohistochemistry is a robust method to predict prognosis for patients in the gray zone defined by PSQ. Combining PSQ and IHC could significantly improve the predictive ability for clinical outcomes.
    Type of Medium: Online Resource
    ISSN: 1347-9032 , 1349-7006
    URL: Issue
    URL: Article
    DOI: 10.1111/cas.v112.9
    DOI: 10.1111/cas.15024
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2115647-5
    detail.hit.zdb_id: 2111204-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Self‐Injection Locked Frequency Conversion Laser
    Wiley ; 2023
    In:  Laser & Photonics Reviews Vol. 17, No. 5 ( 2023-05)
    Details
    In: Laser & Photonics Reviews, Wiley, Vol. 17, No. 5 ( 2023-05)
    Abstract: High‐coherence visible and near‐visible laser sources are centrally important to the operation of advanced position/navigation/timing systems as well as classical/quantum sensing systems. However, the complexity and size of these bench‐top lasers are an impediment to their transition beyond the laboratory. Here, a system‐on‐chip that emits high‐coherence near‐visible lightwaves is demonstrated. The devices rely upon a new approach wherein wavelength conversion and coherence increase by self‐injection locking are combined within a single nonlinear resonator. This simplified approach is demonstrated in a hybridly‐integrated device and provides a short‐term linewidth of around 4.7 kHz (10 kHz before filtering). On‐chip converted optical power over 2 mW is also obtained. Moreover, measurements show that heterogeneous integration can result in a conversion efficiency higher than 25% with an output power over 11 mW. Because the approach uses mature III–V pump lasers in combination with thin‐film lithium niobate, it can be scaled for low‐cost manufacturing of high‐coherence visible emitters. Also, the coherence generation process can be transferred to other frequency conversion processes, including optical parametric oscillation, sum/difference frequency generation, and third‐harmonic generation.
    Type of Medium: Online Resource
    ISSN: 1863-8880 , 1863-8899
    URL: Issue
    URL: Article
    DOI: 10.1002/lpor.v17.5
    DOI: 10.1002/lpor.202200663
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2266512-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Characterization and clinical implications of different malignant transformation patterns in diffuse low‐grade gliomas
    Wiley ; 2023
    In:  Cancer Science Vol. 114, No. 9 ( 2023-09), p. 3708-3718
    Details
    In: Cancer Science, Wiley, Vol. 114, No. 9 ( 2023-09), p. 3708-3718
    Abstract: Malignant transformation (MT) of low‐grade gliomas (LGGs) to a higher‐grade variant seems inevitable, yet it remains unclear which LGG patients will progress to grade 3 or even directly to grade 4 after receiving a long course of treatment. To elucidate this, we conducted a retrospective cohort study based on 229 adults with recurrent LGG. Our study aimed to disclose the characteristics of different MT patterns and to build predictive models for patients with LGG. Patients were allocated into group 2–2 ( n  = 81, 35.4%), group 2–3 ( n  = 91, 39.7%), and group 2–4 ( n  = 57, 24.9%), based on their MT patterns. Patients who underwent MT showed lower Karnofsky performance scale (KPS) scores, larger tumor sizes, smaller extents of resection (EOR), higher Ki‐67 indices, lower rates of 1p/19q codeletion, but higher rates of subventricular involvement, radiotherapy, chemotherapy, astrocytoma, and post‐progression enhancement (PPE) compared with those in group 2–2 ( p   〈  0.01). On multivariate logistic regression, 1p/19q codeletion, Ki‐67 index, radiotherapy, EOR, and KPS score were independently associated with MT ( p   〈  0.05). Survival analyses demonstrated that patients in group 2–2 had the longest survival, followed by group 2–3 and then group 2–4 ( p   〈  0.0001). Based on these independent parameters, we constructed a nomogram model that exhibited superior potential (sensitivity: 0.864, specificity: 0.814, and accuracy: 0.843) compared with PPE in early prediction of MT. Combining the factors of 1p/19q codeletion, Ki‐67 index, radiotherapy, EOR, and KPS score that were presented at initial diagnosis could precisely forecast the subsequent MT patterns of patients with LGG.
    Type of Medium: Online Resource
    ISSN: 1347-9032 , 1349-7006
    URL: Issue
    URL: Article
    DOI: 10.1111/cas.v114.9
    DOI: 10.1111/cas.15889
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2115647-5
    detail.hit.zdb_id: 2111204-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    In Situ Structure Transformation of a Sprayed Gel for pH‐Ultrasensitive Nano‐Catalytic Antibacterial Therapy
    Wiley ; 2023
    In:  Advanced Healthcare Materials Vol. 12, No. 10 ( 2023-04)
    Details
    In: Advanced Healthcare Materials, Wiley, Vol. 12, No. 10 ( 2023-04)
    Abstract: Nano‐catalytic bacterial killing provides new opportunities to address ever‐increasing antibiotic resistance. However, the intrinsic catalytic activity usually depends on a much lower pH conditions (pH = 2–5) than that in the weakly acidic bacterial microenvironments (pH = 6–7) for reactive oxygen species production by Fenton reactions. Herein, a MnSiO 3 ‐based pH‐ultrasensitive “in situ structure transformation” is first reported to significantly promote the adhesion between material and bacteria, and shorten the diffusion distance ( 〈 20 nm) to compensate ultra‐short life ( 〈 200 ns) of ·OH generated by Mn 2+ ‐mediated Fenton‐like reaction, finally enhancing its nano‐catalytic antibacterial performance in weakly acidic conditions. A separated spray bottle is further designed to achieve in situ gelation at the wound site, which demonstrates excellent shape adaptability to complicated and rough surfaces of wounds, allowing for long‐term nano‐catalyst release. As a result, bacterial‐infected wound healing is efficiently promoted. Herein, the in situ sprayed nano‐catalytic antibacterial gel presents a promising paradigm for bacterial infection treatment.
    Type of Medium: Online Resource
    ISSN: 2192-2640 , 2192-2659
    URL: Issue
    URL: Article
    DOI: 10.1002/adhm.v12.10
    DOI: 10.1002/adhm.202202441
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2645585-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Normothermic extracorporeal membrane oxygenation support: Improving the function of intestinal grafts obtained from cardiac death donors
    Wiley ; 2020
    In:  Artificial Organs Vol. 44, No. 10 ( 2020-10), p. 1098-1106
    Details
    In: Artificial Organs, Wiley, Vol. 44, No. 10 ( 2020-10), p. 1098-1106
    Abstract: Extracorporeal membrane oxygenation (ECMO) could ameliorate the energy status and viability of bowel grafts from cardiac death donors. However, the function of these grafts after transplantation is not clear. The purpose of the study was to evaluate the early function of intestinal grafts after transplantation from expected cardiac death donors supported with normothermic extracorporeal support using a porcine allogeneic orthotopic segmental small bowel transplantation model. Eighteen domestic crossbred donor pigs were assigned to living donation (LD), donation after cardiac death (DCD), and ECMO groups. In the LD group, small bowels were harvested and preserved immediately in cold storage. In the other two groups, the donor pigs received conventional rapid recovery treatment or 1‐hour normothermic extracorporeal support after 10‐minutes expected cardiac arrest. Subsequently, the small bowels were removed and preserved in cold storage. After 5‐6 hours of preservation, small bowel grafts were transplanted into the recipient pigs that underwent enterectomy. The pathology and electron microscopy results, cell apoptosis rate, tight junction protein expression level in the intestinal mucosa, and plasma endotoxin level were evaluated after transplantation. All grafts functioned on the basis of the maltose absorption test results at day 7 after transplantation. There were no significant differences in the morphological changes in the intestinal mucosa among the three groups at day 7 after transplantation. The cell apoptosis rate and plasma endotoxin level in the ECMO group did not differ significantly than those in the LD group, but were evidently lower than those in the DCD group ( P   〈  .001). The intestinal absorptive function improved significantly in the ECMO group in contrast with that in the DCD group ( P   〈  .001). Short‐term ECMO intervention can alleviate ischemia–reperfusion injuries in intestinal grafts and improve intestinal absorptive function in the early stage after transplantation. Reducing caspase‐3 protein expression and cell apoptosis in the intestinal mucosa may be one of the protective mechanisms of ECMO intervention.
    Type of Medium: Online Resource
    ISSN: 0160-564X , 1525-1594
    URL: Issue
    URL: Article
    DOI: 10.1111/aor.v44.10
    DOI: 10.1111/aor.13697
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2003825-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...