GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Wiley  (1,187)
Material
Publisher
  • Wiley  (1,187)
Person/Organisation
Language
Years
FID
Subjects(RVK)
  • 1
    Online Resource
    Online Resource
    Risk of osteoporotic fractures as a consequence of haemophilia: A nationwide population‐based cohort study
    Wiley ; 2019
    In:  Haemophilia Vol. 25, No. 5 ( 2019-09), p. 876-884
    Details
    In: Haemophilia, Wiley, Vol. 25, No. 5 ( 2019-09), p. 876-884
    Abstract: Low bone mineral density occurs more commonly in patients with haemophilia (PWH) than the general population. However, the risk of haemophilia‐related osteoporotic fractures has not been well established. We aim to explore the relationship between haemophilia and the development of osteoporotic fractures following haemophilia. Methods This was a nationwide population‐based cohort study based on the data in the Taiwan National Health Insurance Research Database (TNHIRD). Patients who were diagnosed with haemophilia were selected. A comparison cohort was formed of patients without haemophilia who were matched according to age and sex. The incidence rate and the hazard ratios (HRs) of new‐onset osteoporotic fractures were calculated for both cohorts. Results The haemophilia cohort consisted of 75 patients, and the comparison cohort comprised 300 matched control patients without haemophilia. The risk of osteoporotic fractures was higher in the haemophilia cohort than in the comparison cohort (HR = 5.41, 95% confidence interval [CI] = 2.42‐12.1, P   〈  0.001). After adjustments for age, sex, comorbidities, urbanizations and socio‐economic status, PWH were 4.37 times more likely to develop osteoporotic fractures (95% CI = 1.88‐10.17, P  = 0.001) as compared to matched cohort. In addition, the incidence of newly diagnosed osteoporotic fractures was significantly increased after 5‐year follow‐up durations. Conclusion Though our study by TNHIRD presented methodologic flaws by its design nature, we observed that haemophilia may increase the risk of osteoporotic fractures and the cumulative incidence was significantly higher for PWH diagnosed more than 5 years. Clinicians should pay particular attention to osteoporotic fractures following haemophilia in PWH as they age.
    Type of Medium: Online Resource
    ISSN: 1351-8216 , 1365-2516
    URL: Issue
    URL: Article
    DOI: 10.1111/hae.v25.5
    DOI: 10.1111/hae.13814
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2006344-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    SEMA3B‐AS1 suppresses colorectal carcinoma progression by inhibiting Semaphorin 3B‐dependent VEGF signaling pathway activation
    Wiley ; 2023
    In:  MedComm Vol. 4, No. 5 ( 2023-10)
    Details
    In: MedComm, Wiley, Vol. 4, No. 5 ( 2023-10)
    Abstract: Mounting evidence has demonstrated the considerable regulatory effects of long noncoding RNAs (lncRNAs) in the tumorigenesis and progression of various carcinomas. LncRNA Semaphorin 3B (SEMA3B) antisense RNA 1 ( SEMA3B‐AS1 ) has been found to be dysregulated in a few carcinomas recently. However, its potential function and mechanism in colorectal carcinoma (CRC) have not yet been examined. Here we show that SEMA3B‐AS1 acts as a crucial regulator of CRC progression. We found that SEMA3B‐AS1 expression was downregulated in CRC cell lines and tissues. Downregulation of SEMA3B‐AS1 was significantly associated with poor survival in CRC patients. Overexpression of SEMA3B‐AS1 reduced the cell growth and metastasis of CRC in vivo and in vitro. In addition, SEMA3B‐AS1 promoted the expression of its sense‐cognate gene SEMA3B, a member of the Semaphorin family (SEMAs), by recruiting EP300 to induce H3K9 acetylation at the SEMA3B promoter. Furthermore, we proved that SEMA3B‐AS1 suppressed CRC angiogenesis by affecting the vascular endothelial growth factor signaling pathway activation which was regulated by the SEMA3B‐NRP1 axis. Our work unravels a novel mechanism of SEMA3B‐AS1 in the inhibition of CRC malignant progression and highlights its probability as a new promising diagnostic marker and therapeutic target for CRC interventions.
    Type of Medium: Online Resource
    ISSN: 2688-2663 , 2688-2663
    URL: Issue
    URL: Article
    DOI: 10.1002/mco2.v4.5
    DOI: 10.1002/mco2.365
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 3021470-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Recent Progress in Polymer Cubosomes and Hexosomes
    Wiley ; 2021
    In:  Macromolecular Rapid Communications Vol. 42, No. 15 ( 2021-08)
    Details
    In: Macromolecular Rapid Communications, Wiley, Vol. 42, No. 15 ( 2021-08)
    Abstract: Polymer cubosomes and hexosomes are polymer colloids with inverted lyotropic liquid crystal phases as internal structures. They are composed of regular networks of water‐filled channels surrounded by a bilayer membrane made from amphiphilic block copolymers. Due to the uniform, tunable, and highly ordered porous structure, polymer cubosomes and hexosomes present numerous advantages over polymer micelles and vesicles, such as the high loading volumes for both hydrophilic and hydrophobic substances, large specific surface areas, and good mechanical and chemical stabilities. The polymer chemistry also enables unlimited molecular design to endow these polymer colloids with a lot of adjustable physical and chemical properties. Therefore, polymer cubosomes and hexosomes have attracted increasing attention for their potential applications in materials science and nanotechnology. This review outlines the recent progress in this field with an emphasis on the polymer architectures, the self‐assembly conditions and mechanisms, and some application examples which are special for these inverted polymer colloids. It is hoped to provide some practical guidance for researchers interested in polymer cubosomes and hexosomes.
    Type of Medium: Online Resource
    ISSN: 1022-1336 , 1521-3927
    URL: Issue
    URL: Article
    DOI: 10.1002/marc.v42.15
    DOI: 10.1002/marc.202100194
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1475027-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Polymersomes with Red/Near‐Infrared Emission and Reactive Oxygen Species Generation
    Wiley ; 2023
    In:  Macromolecular Rapid Communications Vol. 44, No. 4 ( 2023-02)
    Details
    In: Macromolecular Rapid Communications, Wiley, Vol. 44, No. 4 ( 2023-02)
    Abstract: In photodynamic therapy (PDT), the uses of nanoparticles bearing photosensitizers (PSs) can overcome some of the drawbacks of using a PS alone (e.g., poor water solubility and low tumor selectivity). However, numerous nano‐formulations are developed by physical encapsulation of PSs through Van der Waals interactions, which have not only a limited load efficiency but also some in vivo biodistribution problems caused by leakage or burst release. Herein, polymersomes made from an amphiphilic block copolymer, in which a PS with aggregation‐induced emission (AIE‐PS) is covalently attached to its hydrophobic poly(amino acid) block, are reported. These AIE‐PS polymersomes dispersed in aqueous solution have a high AIE‐PS load efficiency (up to 46% as a mass fraction), a hydrodynamic diameter of 86 nm that is suitable for in vivo applications, and an excellent colloidal stability for at least 1 month. They exhibit a red/near‐infrared photoluminescence and ability to generate reactive oxygen species (ROS) under visible light. They are non‐cytotoxic in the dark as tested on Hela cells up to concentration of 100 µ m . Benefiting from colloidal stability, AIE property and ROS generation capability, such a family of polymersomes can be great candidates for image‐guided PDT.
    Type of Medium: Online Resource
    ISSN: 1022-1336 , 1521-3927
    URL: Issue
    URL: Article
    DOI: 10.1002/marc.v44.4
    DOI: 10.1002/marc.202200716
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1475027-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    AIE Fluorescent Gelators with Thermo‐, Mechano‐, and Vapochromic Properties
    Wiley ; 2019
    In:  Chemistry – An Asian Journal Vol. 14, No. 6 ( 2019-03-15), p. 781-788
    Details
    In: Chemistry – An Asian Journal, Wiley, Vol. 14, No. 6 ( 2019-03-15), p. 781-788
    Abstract: A series of aggregation‐induced emission (AIE) fluorescent gelators (TPE‐C n ‐Chol) were synthesized by attaching tetraphenylethylene (TPE) to cholesterol through an alkyl chain. The properties of the gel, nano‐/microaggregate, and condensed phases were studied carefully. TPE‐C n ‐Chol molecules form AIE fluorescent gels in acetone and in DMF. Their fluorescence can be reversibly switched between the “on” and “off” states by a gel–sol phase transition upon thermal treatment. The AIE properties of aggregated nano‐/microstructures in acetone/water mixtures with different water fractions were studied by using fluorescence spectrometry and scanning electron microscopy (SEM). In different acetone/water mixtures, the TPE‐C n ‐Chol molecules formed different nano‐/microaggregates, such as rodlike crystallites and spherical nanoparticles that showed different fluorescence colors. Finally, the condensed phase behavior of TPE‐C n ‐Chol was studied by using polarizing microscopy (POM), differential scanning calorimetry (DSC), fluorescence spectrometry, fluorescence optical microscopy, and wide‐angle X ray scattering (WAXS). The clover‐shaped TPE unit introduced into the rodlike cholesterol mesogen inhibits not only the formation of a liquid‐crystal phase but also recrystallization upon cooling from the isotropic liquid phase. Very interestingly, TPE‐C n ‐Chol molecules in the condensed state change their fluorescence color under external stimuli, such as melting, grinding, and solvent fuming. The phase transition is the origin of these thermo‐, mechano‐, and vapochromic properties. These findings offer a simple and interesting platform for the creation of multistimuli‐responsive fluorescent sensors.
    Type of Medium: Online Resource
    ISSN: 1861-4728 , 1861-471X
    URL: Issue
    URL: Article
    DOI: 10.1002/asia.v14.6
    DOI: 10.1002/asia.201801689
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2233006-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Ethylene, not ABA , is closely linked to the recovery of gas exchange after drought in four Caragana species
    Wiley ; 2021
    In:  Plant, Cell & Environment Vol. 44, No. 2 ( 2021-02), p. 399-411
    Details
    In: Plant, Cell & Environment, Wiley, Vol. 44, No. 2 ( 2021-02), p. 399-411
    Abstract: Drought is a cyclical phenomenon in natural environments. During dehydration, stomatal closure is mainly regulated by abscisic acid (ABA) dynamics that limit transpiration in seed plants, but the mechanisms of gas exchange recovery are still not clear following rehydration. The results in this study indicate that ethylene is a key factor regulating the drought‐recovery ability in terms of gas exchange, which may shape species adaptation to drought and potential species distribution.
    Type of Medium: Online Resource
    ISSN: 0140-7791 , 1365-3040
    URL: Issue
    URL: Article
    DOI: 10.1111/pce.v44.2
    DOI: 10.1111/pce.13934
    RVK:
    WA 15000
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 391893-2
    detail.hit.zdb_id: 2020843-1
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Cover Image
    Wiley ; 2021
    In:  Plant, Cell & Environment Vol. 44, No. 2 ( 2021-02)
    Details
    In: Plant, Cell & Environment, Wiley, Vol. 44, No. 2 ( 2021-02)
    Type of Medium: Online Resource
    ISSN: 0140-7791 , 1365-3040
    URL: Issue
    URL: Article
    DOI: 10.1111/pce.v44.2
    DOI: 10.1111/pce.13997
    RVK:
    WA 15000
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 391893-2
    detail.hit.zdb_id: 2020843-1
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    CO 2 ‐Activated Reversible Transition between Polymersomes and Micelles with AIE Fluorescence
    Wiley ; 2019
    In:  Angewandte Chemie Vol. 131, No. 30 ( 2019-07-22), p. 10366-10371
    Details
    In: Angewandte Chemie, Wiley, Vol. 131, No. 30 ( 2019-07-22), p. 10366-10371
    Abstract: Fluorescent polymersomes with both aggregation‐induced emission (AIE) and CO 2 ‐responsive properties were developed from amphiphilic block copolymer PEG‐ b ‐P(DEAEMA‐ co ‐TPEMA) in which the hydrophobic block was a copolymer made of tetraphenylethene functionalized methacrylate (TPEMA) and 2‐(diethylamino)ethyl methacrylate (DEAEMA) with unspecified sequence arrangement. Four block copolymers with different DEAEMA/TPEMA and hydrophilic/hydrophobic ratios were synthesized, and bright AIE polymersomes were prepared by nanoprecipitation in THF/water and dioxane/water systems. Polymersomes of PEG 45 ‐ b ‐P(DEAEMA 36 ‐ co ‐TPEMA 6 ) were chosen to study the CO 2 ‐responsive property. Upon CO 2 bubbling vesicles transformed to small spherical micelles, and upon Ar bubbling micelles returned to vesicles with the presence of a few intermediate morphologies. These polymersomes might have promising applications as sensors, nanoreactors, or controlled release systems.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v131.30
    DOI: 10.1002/ange.201905089
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 505868-5
    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    CO 2 ‐Activated Reversible Transition between Polymersomes and Micelles with AIE Fluorescence
    Wiley ; 2019
    In:  Angewandte Chemie International Edition Vol. 58, No. 30 ( 2019-07-22), p. 10260-10265
    Details
    In: Angewandte Chemie International Edition, Wiley, Vol. 58, No. 30 ( 2019-07-22), p. 10260-10265
    Abstract: Fluorescent polymersomes with both aggregation‐induced emission (AIE) and CO 2 ‐responsive properties were developed from amphiphilic block copolymer PEG‐ b ‐P(DEAEMA‐ co ‐TPEMA) in which the hydrophobic block was a copolymer made of tetraphenylethene functionalized methacrylate (TPEMA) and 2‐(diethylamino)ethyl methacrylate (DEAEMA) with unspecified sequence arrangement. Four block copolymers with different DEAEMA/TPEMA and hydrophilic/hydrophobic ratios were synthesized, and bright AIE polymersomes were prepared by nanoprecipitation in THF/water and dioxane/water systems. Polymersomes of PEG 45 ‐ b ‐P(DEAEMA 36 ‐ co ‐TPEMA 6 ) were chosen to study the CO 2 ‐responsive property. Upon CO 2 bubbling vesicles transformed to small spherical micelles, and upon Ar bubbling micelles returned to vesicles with the presence of a few intermediate morphologies. These polymersomes might have promising applications as sensors, nanoreactors, or controlled release systems.
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    URL: Article
    DOI: 10.1002/anie.v58.30
    DOI: 10.1002/anie.201905089
    RVK:
    VA 2100
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2011836-3
    detail.hit.zdb_id: 123227-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Expression pattern and tissue localization of the class B scavenger receptor BmSCRBQ4 in Bombyx mori
    Wiley ; 2015
    In:  Insect Science Vol. 22, No. 6 ( 2015-12), p. 739-747
    Details
    In: Insect Science, Wiley, Vol. 22, No. 6 ( 2015-12), p. 739-747
    Abstract: Class B scavenger receptors (SR‐Bs) are cell surface glycoproteins involved in various physiological processes in vivo , including the transport and metabolism of lipids, binding and phagocytosis of xenobiotics, and signaling. But little information is available about silkworm SR‐Bs; it is necessary to study these SR‐Bs for revealing their function. In this study, we cloned the full‐length coding sequence of BmSCRBQ4 , a SR‐B gene from the silkworm Bombyx mori L. We found that the BmSCRBQ4 gene consists of nine exons and eight introns, with an open reading frame of 1371 bp encoding 456 amino acids. Gene expression studies determined that BmSCRBQ4 messenger RNA (mRNA) was expressed in unfertilized eggs, during embryonic development and throughout the majority of the larval period. Expression of mRNA was detected in the mid gut, middle silk gland, posterior silk gland, head, integumentum, fat body, testes and the ovaries of the larval B. mori Dazao strain, as well as in the silkworm cell lines BmN and BmE. Protein expression studies found BmSCRBQ4 protein was expressed only in the testes, fat body and middle silk gland of larvae, as well as in the silkworm cell lines BmN and BmE. The BmSCRBQ4 protein showed variability in banding patterns in different tissues and cells when analyzed by Western blotting. Immunohistochemical staining showed that the BmSCRBQ4 protein localizes to the constitutive membranes or cellular membranes of these tissues. These results indicated that BmSCRBQ4 gene may play some physiologically relevant roles at the cell surface in each tissue.
    Type of Medium: Online Resource
    ISSN: 1672-9609 , 1744-7917
    URL: Issue
    URL: Article
    DOI: 10.1111/ins.2015.22.issue-6
    DOI: 10.1111/1744-7917.12158
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2179775-4
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...