In:
Experimental Dermatology, Wiley, Vol. 27, No. 3 ( 2018-03), p. 285-288
Abstract:
Skin cancer is the most common type of cancer. The incidence rate of skin cancer has continuously increased over the past decades. In an effort to discover novel anticancer agents, we identified a novel tubulin inhibitor STK 899704, which is structurally distinct from other microtubule‐binding agents such as colchicine, vinca alkaloids and taxanes. STK 899704 inhibited microtubule polymerization leading to mitotic arrest and suppressed the proliferation of various cancer cell lines as well as multidrug resistance cancer cell lines. In this study, our investigation is further extended into animal model to evaluate the effect of STK 899704 on skin carcinogenesis in vivo. Surprisingly, almost 80% of the tumors treated with STK 899704 were regressed with a one‐fifth reduction in tumor volume. Furthermore, the efficacy of STK 899704 was nearly 2 times higher than that of 5‐fluorouracil, a widely used skin cancer therapeutic. Overall, our results suggest that STK 899704 is a promising anticancer chemotherapeutic that may replace existing therapies, particularly for skin cancer.
Type of Medium:
Online Resource
ISSN:
0906-6705
,
1600-0625
DOI:
10.1111/exd.2018.27.issue-3
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2026228-0
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