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  • Wiley  (13)
  • 1
    Online Resource
    Online Resource
    Data mining of an acoustic biomarker in tongue cancers and its clinical validation
    Wiley ; 2021
    In:  Cancer Medicine Vol. 10, No. 11 ( 2021-06), p. 3822-3835
    Details
    In: Cancer Medicine, Wiley, Vol. 10, No. 11 ( 2021-06), p. 3822-3835
    Abstract: The promise of speech disorders as biomarkers in clinical examination has been identified in a broad spectrum of neurodegenerative diseases. However, to the best of our knowledge, a validated acoustic marker with established discriminative and evaluative properties has not yet been developed for oral tongue cancers. Here we cross‐sectionally collected a screening dataset that included acoustic parameters extracted from 3 sustained vowels /ɑ/, /i/, /u/ and binary perceptual outcomes from 12 consonant‐vowel syllables. We used a support vector machine with linear kernel function within this dataset to identify the formant centralization ratio (FCR) as a dominant predictor of different perceptual outcomes across gender and syllable. The Acoustic analysis, Perceptual evaluation and Quality of Life assessment (APeQoL) was used to validate the FCR in 33 patients with primary resectable oral tongue cancers. Measurements were taken before (pre‐op) and four to six weeks after (post‐op) surgery. The speech handicap index (SHI), a speech‐specific questionnaire, was also administrated at these time points. Pre‐op correlation analysis within the APeQoL revealed overall consistency and a strong correlation between FCR and SHI scores. FCRs also increased significantly with increasing T classification pre‐operatively, especially for women. Longitudinally, the main effects of T classification, the extent of resection, and their interaction effects with time (pre‐op vs. post‐op) on FCRs were all significant. For pre‐operative FCR, after merging the two datasets, a cut‐off value of 0.970 produced an AUC of 0.861 (95% confidence interval: 0.785–0.938) for T 3‐4 patients. In sum, this study determined that FCR is an acoustic marker with the potential to detect disease and related speech function in oral tongue cancers. These are preliminary findings that need to be replicated in longitudinal studies and/or larger cohorts.
    Type of Medium: Online Resource
    ISSN: 2045-7634 , 2045-7634
    URL: Issue
    URL: Article
    DOI: 10.1002/cam4.v10.11
    DOI: 10.1002/cam4.3872
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2659751-2
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  • 2
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    Online Resource
    Potassium Ion Mediated Double‐Layered Upright Assembly of Negatively Charged Amyloid‐Like Peptides at Mica/Water Interface
    Wiley ; 2022
    In:  Advanced Materials Interfaces Vol. 9, No. 24 ( 2022-08)
    Details
    In: Advanced Materials Interfaces, Wiley, Vol. 9, No. 24 ( 2022-08)
    Abstract: Insight into the surface‐assisted self‐assembly of amyloid‐like peptides is essential to the design and fabrication of novel functional nanomaterials as well as to uncovering the pathogenesis of various neurodegenerative diseases. Despite extensive research, how to control the self‐assembly of amyloid‐like peptides effectively remains challenging. Here, through a combined experimental and theoretical approach, it is demonstrated that cations could modulate the mica/water interface and further induce the self‐assembly of the negatively charged amyloid‐like peptide Ac–VGGAVVAGV–COO − (Ac–GAV–9) into multilayered nanofilaments with a surprising all‐upright parallel β‐sheet conformation. In particular, highly ordered double‐layered nanofilaments are observed on the negatively charged mica surfaces in the presence of 0.5–1.5  m  KCl. The molecular dynamics simulations further reveal that the double‐layered nanofilaments have intriguing parallel β‐sheet structures with the C‐termini of the first parallel monolayer pointing to the mica surface and the C‐termini of the second parallel monolayer pointing to the solvent. Moreover, the stability of the nanofilaments could be modulated by peptide and ion concentrations. Further studies show that the growth of double‐layered fibrils at the mica/water interface is a common phenomenon for Ac–GAV–9 in the presence of a variety of salt types.
    Type of Medium: Online Resource
    ISSN: 2196-7350 , 2196-7350
    URL: Issue
    URL: Article
    DOI: 10.1002/admi.v9.24
    DOI: 10.1002/admi.202200402
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2750376-8
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  • 3
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    Botanical Drug Puerarin Coordinates with Nerve Growth Factor in the Regulation of Neuronal Survival and Neuritogenesis via Activating ERK 1/2 and PI 3K/Akt Signaling Pathways in the Neurite Extension Process
    Wiley ; 2015
    In:  CNS Neuroscience & Therapeutics Vol. 21, No. 1 ( 2015-01), p. 61-70
    Details
    In: CNS Neuroscience & Therapeutics, Wiley, Vol. 21, No. 1 ( 2015-01), p. 61-70
    Abstract: Nerve growth factor ( NGF ) regulates neuronal survival and differentiation by activating extracellular signal‐regulated‐kinases ( ERK ) 1/2 and phosphoinositide‐3‐kinase ( PI 3K)/Akt pathways in two distinct processes: latency process and neurite extension process. This study was designed to investigate whether botanical drug C‐glucosylated isoflavone puerarin coordinates with NGF to regulate neuritogenesis via activating ERK 1/2 and PI 3K/Akt in neurite extension process. Methods We investigated the neuroprotective and neurotrophic activities of puerarin in MPTP ‐lesioned mice and dopaminergic PC 12 cells. The effects of puerarin on ERK 1/2, Akt, Nrf2, and HO ‐1 were assessed by Western blotting. The neurite outgrowth was assayed by neurite outgrowth staining kit. Results Puerarin protected dopaminergic cells and ameliorated the behavioral impairments in MPTP ‐lesioned mice. Puerarin potentiated the effect of NGF on neuritogenesis in PC 12 cells by 〉 10‐fold. Mechanistic studies revealed: (1) puerarin rapidly activated ERK 1/2 and Akt, leading to the activation of Nrf2/heme oxygenase‐1 ( HO ‐1) pathways; (2) ERK 1/2, PI 3K/Akt, and HO ‐1 inhibitors attenuated the neuritogenic activity of puerarin. Notably, puerarin enhanced NGF ‐induced neuritogenesis in a timing‐dependent manner. Conclusion Puerarin effectively coordinated with NGF to stimulate neuritogenesis via activating ERK 1/2 and PI 3K/Akt pathways in neurite extension process. These results demonstrated a general mechanism supporting the therapeutic application of puerarin‐related compounds in neurodegenerative diseases.
    Type of Medium: Online Resource
    ISSN: 1755-5930 , 1755-5949
    URL: Issue
    URL: Article
    DOI: 10.1111/cns.2014.21.issue-1
    DOI: 10.1111/cns.12334
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2423467-9
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  • 4
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    Online Resource
    Effect of Asymmetric Tension on Biomechanics and Metabolism of Vertebral Epiphyseal Plate in a Rodent Model of Scoliosis
    Wiley ; 2017
    In:  Orthopaedic Surgery Vol. 9, No. 3 ( 2017-08), p. 311-318
    Details
    In: Orthopaedic Surgery, Wiley, Vol. 9, No. 3 ( 2017-08), p. 311-318
    Abstract: To investigate the effect of asymmetric tension on idiopathic scoliosis ( IS ) and to understand its pathogenic mechanism. Methods The rodent model of scoliosis was established using Sprague–Dawley rats with left rib‐tethering from T 6 to T 12 , tail and shoulder amputation, and high‐cage feeding. Vertebrae epiphyseal cartilage plates were harvested from the convex and concave sides. To analyze differences on the convex and concave sides, finite element analysis was carried out to determine the mechanical stress. Protein expression on epiphyseal cartilage was evaluated by western blot. Micro‐ CT was taken to evaluate the bone quality of vertebral on both sides. Results Scoliosis curves presented in X ‐ray radiographs of the rats. Finite element analysis was carried out on the axial and transverse tension of the spine. Stresses of the convex side were −170.14, −373.18, and −3832.32 MPa ( X , Y , and Z axis, respectively), while the concave side showed stresses of 361.99, 605.55, and 3661.95 MPa. Collagen type II , collagen type X , S ox 9, R un X 2, VEGF , and aggrecan were expressed significantly more on the convex side ( P   〈  0.05). There was asymmetric expression of protein on the epiphyseal cartilage plate at molecular level. Compared with the convex side, the concave side had significantly lower value in the BV / TV and Tb.N , but higher value in the Tb.Sp ( P   〈  0.05). There was asymmetry of bone quality in micro‐architecture. Conclusions In this study, asymmetric tension contributed to asymmetry in protein expression and bone quality on vertebral epiphyseal plates, ultimately resulting in asymmetry of anatomy. In addition, asymmetry of anatomy aggravated asymmetric tension. It is the first study to show that there is an asymmetrical vicious circle in IS .
    Type of Medium: Online Resource
    ISSN: 1757-7853 , 1757-7861
    URL: Issue
    URL: Article
    DOI: 10.1111/os.2017.9.issue-3
    DOI: 10.1111/os.12344
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2483883-4
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  • 5
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    Accumulated Spinal Axial Biomechanical Loading Induces Degeneration in Intervertebral Disc of Mice Lumbar Spine
    Wiley ; 2018
    In:  Orthopaedic Surgery Vol. 10, No. 1 ( 2018-02), p. 56-63
    Details
    In: Orthopaedic Surgery, Wiley, Vol. 10, No. 1 ( 2018-02), p. 56-63
    Abstract: To investigate the effect of accumulated spinal axial biomechanical loading on mice lumbar disc and the feasibility of applying this method to establish a mice intervertebral disc degeneration model using a custom‐made hot plate cage. In previous studies, we observed that the motion pattern of mice was greatly similar to that of humans when they were standing and jumping on their lower limbs. There is little data to demonstrate whether or not accumulated spinal axial biomechanical loading could induce intervertebral disc degeneration in vivo. Methods Twenty‐four 0‐week‐old mice were randomly divided into model 1‐month and 3‐month groups, and control 1‐month and 3‐month groups ( n  = 6 per group). The model groups was transferred into the custom‐made hot plate cage three times per day for modeling. The control group was kept in a regular cage. The intervertebral disc samples of the L 3 –L 5 were harvested for histologic, molecular, and immunohistochemical studies after modeling for 1 and 3 months. Results Accumulated spinal axial biomechanical loading affects the histologic, molecular, and immunohistochemical changes of mice L 3– L 5 intervertebral discs. Decreased height of disc and endplate, fissures of annulus fibrosus, and ossification of cartilage endplate were found in morphological studies. Immunohistochemical studies of the protein level showed a similar expression of type II collagen at 1 month, but a slightly decreased expression at 3 months, and an increased expression level of type X collagen and matrix metalloproteinase 13 (MMP13). Molecular studies showed that ColIIa1 and aggrecan mRNA expression levels were slightly increased at 1 month ( P   〉  0.05), but then decreased slightly ( P   〉  0.05). ColXa1, ADAMTS‐5, and MMP‐13 expression levels werer increased both at 1 and 3 months ( P   〈  0.05). In addition, increased expression of Runx2 was observed. Conclusion Accumulated spinal axial loading provided by a custom‐made hot plate accelerated mice lumbar disc and especially endplate degeneration. However, this method requires further development to establish a lumbar disc degeneration model.
    Type of Medium: Online Resource
    ISSN: 1757-7853 , 1757-7861
    URL: Issue
    URL: Article
    DOI: 10.1111/os.2018.10.issue-1
    DOI: 10.1111/os.12365
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2483883-4
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  • 6
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    Transection of Double‐level Spinal Cord without Radiographic Abnormalities in an Adult: a Case Report
    Wiley ; 2013
    In:  Orthopaedic Surgery Vol. 5, No. 4 ( 2013-11), p. 302-304
    Details
    In: Orthopaedic Surgery, Wiley, Vol. 5, No. 4 ( 2013-11), p. 302-304
    Type of Medium: Online Resource
    ISSN: 1757-7853 , 1757-7861
    URL: Issue
    URL: Article
    DOI: 10.1111/os.2013.5.issue-4
    DOI: 10.1111/os.12065
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 2483883-4
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  • 7
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    Toward Scalable Nanofluidic Osmotic Power Generation from Hypersaline Water Sources with a Metal–Organic Framework Membrane
    Wiley ; 2023
    In:  Angewandte Chemie Vol. 135, No. 19 ( 2023-05-02)
    Details
    In: Angewandte Chemie, Wiley, Vol. 135, No. 19 ( 2023-05-02)
    Abstract: Nanofluidic membranes have shown great promise in harvesting osmotic energy but its scalablity remains challenging since most studies only tested with a membrane area of ≈10 −2 mm 2 or smaller. We demonstrate that metal‐organic‐framework membranes with subnanometer pores can be used for scalable osmotic power generation from hypersaline water sources. Our membrane can be scaled up to a few mm 2 , and the power density can be stabilized at 1.7 W m −2 . We reveal that the key is to improve the out‐of‐membrane conductance while keeping the membrane's charge selectivity, contradicting the previous conception that the ionic conductivity of the membrane plays the dominating role. We highlight that subnanometer pores are essential to ensure the charge selectivity in hypersaline water sources. Our results suggest the importance to engineer the interplay between the in‐membrane and out‐of‐membrane ion transport properties for scalable osmotic power generation.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v135.19
    DOI: 10.1002/ange.202218129
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 505868-5
    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
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  • 8
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    The Study of Magnetic Field Models for Philippines and Its Neighboring Regions
    Wiley ; 2011
    In:  Chinese Journal of Geophysics Vol. 54, No. 4 ( 2011-07), p. 508-515
    Details
    In: Chinese Journal of Geophysics, Wiley, Vol. 54, No. 4 ( 2011-07), p. 508-515
    Type of Medium: Online Resource
    ISSN: 0898-9591
    URL: Issue
    URL: Article
    DOI: 10.1002/cjg2.v54.4
    DOI: 10.1002/cjg2.1633
    Language: English
    Publisher: Wiley
    Publication Date: 2011
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  • 9
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    Activation of TNF ‐α/ NF ‐κB axis enhances CRL 4 B DCAF 11 E3 ligase activity and regulates cell cycle progression in human osteosarcoma cells
    Wiley ; 2018
    In:  Molecular Oncology Vol. 12, No. 4 ( 2018-04), p. 476-494
    Details
    In: Molecular Oncology, Wiley, Vol. 12, No. 4 ( 2018-04), p. 476-494
    Abstract: Cullin 4B, a member of the Cullins, which serve as scaffolds to facilitate the assembly of E3 ligase complexes, is aberrantly expressed in many cancers, including osteosarcoma. Recently, we observed that CUL 4B forms the CRL 4 B DCAF 11 E3 ligase, which specifically ubiquitinates and degrades the cyclin‐dependent kinase ( CDK ) inhibitor p21 Cip1 in human osteosarcoma cells. However, the underlying mechanisms regarding the aberrant expression of CUL 4B and the upstream members of this signaling pathway are mostly unknown. In this study, we demonstrate that nuclear factor kappaB ( NF ‐κB) is a direct modulator of CUL 4B expression. The CUL 4B promoter is responsive to several NF ‐κB subunits, including RelA, RelB, and c‐Rel, but not to p50 or p52. Additional studies reveal that the tumor necrosis factor alpha ( TNF ‐α)/ NF ‐κB axis pathway is activated in human osteosarcoma cells. This activation causes both CUL 4B and NF ‐κB subunits to become abundant in the nucleus of human osteosarcoma cells. The down‐regulation of individual genes, including TNFR 1 , RelA , RelB , c‐Rel , and CUL 4B , or pairs of them, including TNFR 1  +  RelA , TNFR 1  +  RelB , TNFR 1  +  c‐Rel , and RelA + CUL 4B , has similar effects on cell growth inhibition, colony formation, cell invasion, and in vivo tumor formation, whereas the overexpression of CUL 4B in these knockdown cells significantly reverses their phenotypes. The inhibition of the TNF ‐α/ NF ‐κB pathway greatly attenuates CRL 4 B DCAF 11 E3 ligase activity and causes the accumulation of p21 Cip1 , thereby leading to cell cycle arrest at the S phase. Taken together, our results support a model in which the activation of the TNF ‐α/ NF ‐κB axis contributes to an increase in CRL 4 B DCAF 11 activity and a decrease in p21 Cip1 protein levels, thereby controlling cell cycle progression in human osteosarcoma cells.
    Type of Medium: Online Resource
    ISSN: 1574-7891 , 1878-0261
    URL: Issue
    URL: Article
    DOI: 10.1002/mol2.2018.12.issue-4
    DOI: 10.1002/1878-0261.12176
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2322586-5
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  • 10
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    Structure elucidation and NMR assignments of two unusual isomeric aromatic monacolin analogs from Monascus purpureus : Two unusual isomeric aromatic monacolin analogs from Monascus purpureus
    Wiley ; 2015
    In:  Magnetic Resonance in Chemistry Vol. 53, No. 3 ( 2015-03), p. 233-236
    Details
    In: Magnetic Resonance in Chemistry, Wiley, Vol. 53, No. 3 ( 2015-03), p. 233-236
    Type of Medium: Online Resource
    ISSN: 0749-1581
    URL: Issue
    URL: Article
    DOI: 10.1002/mrc.v53.3
    DOI: 10.1002/mrc.4162
    RVK:
    VA 5830
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 1475029-6
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