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  • 1
    Online Resource
    Online Resource
    Implication of CD38 gene in podocyte epithelial-to-mesenchymal transition and glomerular sclerosis
    Wiley ; 2012
    In:  Journal of Cellular and Molecular Medicine Vol. 16, No. 8 ( 2012-08), p. 1674-1685
    Details
    In: Journal of Cellular and Molecular Medicine, Wiley, Vol. 16, No. 8 ( 2012-08), p. 1674-1685
    Type of Medium: Online Resource
    ISSN: 1582-1838
    URL: Issue
    URL: Article
    DOI: 10.1111/jcmm.2012.16.issue-8
    DOI: 10.1111/j.1582-4934.2011.01462.x
    Language: English
    Publisher: Wiley
    Publication Date: 2012
    detail.hit.zdb_id: 2076114-4
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  • 2
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    Parishin alleviates vascular ageing in mice by upregulation of Klotho
    Wiley ; 2023
    In:  Journal of Cellular and Molecular Medicine Vol. 27, No. 10 ( 2023-05), p. 1398-1409
    Details
    In: Journal of Cellular and Molecular Medicine, Wiley, Vol. 27, No. 10 ( 2023-05), p. 1398-1409
    Abstract: Senescence of vascular endothelial cells is the major risk of vascular dysfunction and disease among elderly people. Parishin, which is a phenolic glucoside derived from Gastrodia elata , significantly prolonged yeast lifespan. However, the action of parishin in vascular ageing remains poorly understood. Here, we treated human coronary artery endothelial cells (HCAEC) and naturally aged mice by parishin. Parishin alleviated HCAEC senescence and general age‐related features in vascular tissue in naturally aged mice. Network pharmacology approach was applied to determine the compound‐target networks of parishin. Our analysis indicated that parishin had a strong binding affinity for Klotho. Expression of Klotho, a protein of age‐related declines, was upregulated by parishin in serum and vascular tissue in naturally aged mice. Furthermore, FoxO1, on Klotho/FoxO1 signalling pathway, was increased in the parishin‐intervened group, accompanied by the downregulated phosphorylated FoxO1. Taken together, parishin can increase Klotho expression to alleviate vascular endothelial cell senescence and vascular ageing.
    Type of Medium: Online Resource
    ISSN: 1582-1838 , 1582-4934
    URL: Issue
    URL: Article
    DOI: 10.1111/jcmm.v27.10
    DOI: 10.1111/jcmm.17740
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2076114-4
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  • 3
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    Activation of Inflammasomes as a Triggering Mechanism of Glomerular Injury in Mice on the High Fat Diet
    Wiley ; 2011
    In:  The FASEB Journal Vol. 25, No. S1 ( 2011-04)
    Details
    In: The FASEB Journal, Wiley, Vol. 25, No. S1 ( 2011-04)
    Type of Medium: Online Resource
    ISSN: 0892-6638 , 1530-6860
    URL: Issue
    URL: Article
    DOI: 10.1096/fsb2.v25.S1
    DOI: 10.1096/fasebj.25.1_supplement.1028.6
    Language: English
    Publisher: Wiley
    Publication Date: 2011
    detail.hit.zdb_id: 1468876-1
    SSG: 12
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  • 4
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    Characterization of Adult Plant Resistance to Leaf Rust and Stripe Rust in Indian Wheat Cultivar ‘New Pusa 876’
    Wiley ; 2018
    In:  Crop Science Vol. 58, No. 2 ( 2018-03), p. 630-638
    Details
    In: Crop Science, Wiley, Vol. 58, No. 2 ( 2018-03), p. 630-638
    Abstract: Growing resistant varieties is the most effective and economical method for controlling rust of wheat ( Triticum aestivum L.). Resistance to leaf rust and stripe rust, caused by Puccinia triticina Erikss. and P. striiformis Westend. f. sp. tritici , respectively, was investigated in 148 F 5 recombinant inbred lines derived from a cross between ‘Avocet’ and ‘New Pusa 876’ (NP876). The parents and population were phenotyped for resistance in field trials for 3 and 2 yr for leaf rust and stripe rust, respectively, and genotyped with gene‐linked molecular markers. The segregation analyses indicated that the adult plant resistance to leaf rust and stripe rust was conferred by five and four additive effect genes, respectively. Among them, the slow‐rusting adult plant resistance gene Lr46/Yr29 reduced 14 and 16% of mean leaf rust and stripe rust severities, respectively, whereas a severity reduction of 26% occurred due to Lr67/Yr46 for both rusts. Both resistance genes were contributed by NP876. An additive effect between leaf rust resistance genes Lr46 and Lr67 was detected, with a reduction up to 11% when they were present together. The effect of combining Yr29 and Yr46 was additive but not significant, with a mean reduction of 5% in severity. New Pusa 876 can be used as a multiple rust resistance source to breed wheat varieties that may contribute towards durable resistance.
    Type of Medium: Online Resource
    ISSN: 0011-183X , 1435-0653
    URL: Article
    DOI: 10.2135/cropsci2017.06.0396
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 1480918-7
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  • 5
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    Neural stem cells transplantation combined with ethyl stearate improve PD rats motor behavior by promoting NSCs migration and differentiation
    Wiley ; 2023
    In:  CNS Neuroscience & Therapeutics Vol. 29, No. 6 ( 2023-06), p. 1571-1584
    Details
    In: CNS Neuroscience & Therapeutics, Wiley, Vol. 29, No. 6 ( 2023-06), p. 1571-1584
    Abstract: In recent years, the ability of neural stem cells (NSCs) transplantation to treat Parkinson's disease (PD) has attracted attention. However, it is still a challenge to promote the migration of NSCs to the lesion site and their directional differentiation into dopaminergic neurons in PD. C‐C motif chemokine ligand 5 (CCL5) and C‐C motif chemokine receptor 5 (CCR5) are expressed in the brain and are important regulators of cell migration. It has been reported that ethyl stearate (PubChem CID: 8122) has a protective effect in 6‐OHDA‐induced PD rats. Methods Parkinson's disease rats were injected with 6‐hydroxydopamine (6‐OHDA) into the right substantia nigra, and striatum followed by 8 μL of an NSC cell suspension containing 100 μM ethyl stearate and 8 × 10 5 cells in the right striatum. The effect of transplantation NSCs combined with ethyl stearate was assessed by evaluating apomorphine (APO)‐induced turning behavior and performance in the pole test. Quantitative real‐time reverse transcription–polymerase chain reaction (qRT‐PCR), Western blotting (WB), and immunofluorescence staining were also performed. Results NSCs transplantation combined with ethyl stearate ameliorated the behavioral deficits of PD rats. PD rats that received transplantation NSCs combined with ethyl stearate exhibited increased expression of tyrosine hydroxylase (TH) and an increased number of green fluorescent protein (GFP)‐positive cells. Furthermore, GFP‐positive cells migrated into the substantia nigra and differentiated into dopaminergic neurons. The expression of CCL5 and CCR5 was significantly increased after transplantation NSCs combined with ethyl stearate. Conclusions These findings suggest that NSCs transplantation combined with ethyl stearate can improve the motor behavioral performance of PD rats by promoting NSCs migration from the striatum to the substantia nigra via CCL5/CCR5 and promoting the differentiation of NSCs into dopaminergic neurons.
    Type of Medium: Online Resource
    ISSN: 1755-5930 , 1755-5949
    URL: Article
    DOI: 10.1111/cns.14119
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2423467-9
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  • 6
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    Computed Diffusion‐Weighted Images of Rectal Cancer: Image Quality, Restaging, and Treatment Response after Neoadjuvant Therapy
    Wiley ; 2023
    In:  Journal of Magnetic Resonance Imaging
    Details
    In: Journal of Magnetic Resonance Imaging, Wiley
    Abstract: Computed diffusion‐weighted images (cDWI) of random b value could be derived from acquired DWI (aDWI) with at least two different b values. However, its comparison between aDWI and cDWI images in locally advanced rectal cancer (LARC) patients after neoadjuvant therapy (NT) is needed. Purpose To compare the cDWI and aDWI in image quality, restaging, and treatment response of LARC after NT. Study Type Retrospective. Population Eighty‐seven consecutive patients. Field Strength/Sequence 3.0 T/DWI. Assessment All patients underwent two DWI sequences, including conventional acquisition with b  = 0 and 1000 s/mm 2 (aDWI b1000 ) and another with b  = 0 and 700 s/mm 2 on a 3.0‐T MR scanner. The images of the latter were used to compute the diffusion images with b  = 1000 s/mm 2 (cDWI b1000 ). Four radiologists with 3, 4, 14, and 25 years of experience evaluated the images to compare the image quality, TN restaging performance, and treatment response between aDWI b1000 and cDWI b1000 . Statistical Tests Interclass correlation coefficients, weighted κ coefficient, paired Wilcoxon, and McNemar or Fisher test were used. A significance level of 0.05 was used. Results The cDWI b1000 images were superior to the aDWI b1000 ones in both subjective and objective image quality. In T restaging, the overall diagnostic accuracy of cDWI b1000 images was higher than that of aDWI b1000 images (57.47% vs. 49.43%, P  = 0.289 for the inexperienced radiologist; 77.01% vs. 63.22%, significant for the experienced radiologist), with better sensitivity in determining ypT0‐Tis tumors. Additionally, it increased the sensitivity in detecting ypT2 tumors for the inexperienced radiologist and ypT3 tumors for the experienced radiologist. N restaging and treatment response were found to be similar between two sequences for both radiologists. Data Conclusion Compared to aDWI b1000 images, the computed ones might serve as a wise approach, providing comparable or better image quality, restaging performance, and treatment response assessment for LARC after NT. Level of Evidence 3 Technical Efficacy Stage 2
    Type of Medium: Online Resource
    ISSN: 1053-1807 , 1522-2586
    URL: Article
    DOI: 10.1002/jmri.28766
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1497154-9
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  • 7
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    Antimicrobial Agents Used in the Treatment of Peri‐Implantitis Alter the Physicochemistry and Cytocompatibility of Titanium Surfaces
    Wiley ; 2016
    In:  Journal of Periodontology Vol. 87, No. 7 ( 2016-07), p. 809-819
    Details
    In: Journal of Periodontology, Wiley, Vol. 87, No. 7 ( 2016-07), p. 809-819
    Abstract: Background: Chemotherapeutic agents (ChAs) are considered an integral part of current treatment protocols for the decontamination of titanium implants with peri‐implantitis, based on their antimicrobial effect. Despite the proven antimicrobial effect of ChAs on titanium‐bound biofilms, previous studies have elucidated an unexpected disassociation between bacterial reduction and biologically acceptable treatment outcomes. In this study, the authors hypothesize that ChAs residues alter titanium physicochemistry and thus compromise cellular response to decontaminated surfaces. Methods: Grit‐blasted acid‐etched titanium disks were contaminated with multispecies microcosm biofilms grown from in vivo peri‐implant plaque samples. To simulate implant decontamination, the contaminated disks were burnished with 0.12% chlorhexidine, 20% citric acid, 24% EDTA/1.5% NaOCl, or sterile saline and assessed surface physicochemical properties. Sterile untreated surfaces were the controls. The biologic effects of decontamination were assessed via cell proliferation and differentiation assays. Results: Bacterial counts after decontamination confirmed that the ChAs were antimicrobial. X‐ray photoelectron spectroscopy invariably detected elemental contaminants associated with each ChA molecule or salt that significantly altered wettability compared with controls. Notably, all surfaces with ChA residues showed some cytotoxic effect compared with controls ( P 〈 0.05). Increased cell counts were consistently found in the saline‐treated group compared with chlorhexidine ( P = 0.03). Interestingly, no association was found between antimicrobial effect and cell counts ( P 〉 0.05). Conclusions: ChA‐specific residues left on the titanium surfaces altered titanium physical properties and adversely affected the osteoblastic response irrespective of their observed antimicrobial effect. Chlorhexidine may compromise the biocompatibility of titanium surfaces, and its use is not recommended to detoxify implants. Sterile saline, citric acid, and NaOCl‐EDTA may be proposed for use in the treatment of peri‐implantitis. Contrary to previous studies that recommended the selection of ChAs for the decontamination of titanium implants according to their antimicrobial effects, the present study demonstrated that the restoration of the biocompatibility of contaminated titanium surfaces is also contingent on the preservation of titanium material properties.
    Type of Medium: Online Resource
    ISSN: 0022-3492 , 1943-3670
    URL: Article
    DOI: 10.1902/jop.2016.150684
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2040047-0
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  • 8
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    Deciphering genetic basis of developmental and agronomic traits by integrating high‐throughput optical phenotyping and genome‐wide association studies in wheat
    Wiley ; 2023
    In:  Plant Biotechnology Journal Vol. 21, No. 10 ( 2023-10), p. 1966-1977
    Details
    In: Plant Biotechnology Journal, Wiley, Vol. 21, No. 10 ( 2023-10), p. 1966-1977
    Abstract: Dissecting the genetic basis of complex traits such as dynamic growth and yield potential is a major challenge in crops. Monitoring the growth throughout growing season in a large wheat population to uncover the temporal genetic controls for plant growth and yield‐related traits has so far not been explored. In this study, a diverse wheat panel composed of 288 lines was monitored by a non‐invasive and high‐throughput phenotyping platform to collect growth traits from seedling to grain filling stage and their relationship with yield‐related traits was further explored. Whole genome re‐sequencing of the panel provided 12.64 million markers for a high‐resolution genome‐wide association analysis using 190 image‐based traits and 17 agronomic traits. A total of 8327 marker‐trait associations were detected and clustered into 1605 quantitative trait loci (QTLs) including a number of known genes or QTLs. We identified 277 pleiotropic QTLs controlling multiple traits at different growth stages which revealed temporal dynamics of QTLs action on plant development and yield production in wheat. A candidate gene related to plant growth that was detected by image traits was further validated. Particularly, our study demonstrated that the yield‐related traits are largely predictable using models developed based on i‐traits and provide possibility for high‐throughput early selection, thus to accelerate breeding process. Our study explored the genetic architecture of growth and yield‐related traits by combining high‐throughput phenotyping and genotyping, which further unravelled the complex and stage‐specific contributions of genetic loci to optimize growth and yield in wheat.
    Type of Medium: Online Resource
    ISSN: 1467-7644 , 1467-7652
    URL: Issue
    URL: Article
    DOI: 10.1111/pbi.v21.10
    DOI: 10.1111/pbi.14104
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2136367-5
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  • 9
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    Overview and Application of QTL for Adult Plant Resistance to Leaf Rust and Powdery Mildew in Wheat
    Wiley ; 2014
    In:  Crop Science Vol. 54, No. 5 ( 2014-09), p. 1907-1925
    Details
    In: Crop Science, Wiley, Vol. 54, No. 5 ( 2014-09), p. 1907-1925
    Abstract: Leaf rust and powdery mildew, caused by Puccinia triticina and Blumeria graminis f. sp. tritici , respectively, are widespread fungal diseases of wheat ( Triticum aestivum L.). Development of cultivars with durable resistance is crucially important for global wheat production. This paper reviews the progress of genetic study and application of adult plant resistance (APR) to wheat leaf rust and powdery mildew. Eighty leaf rust and 119 powdery mildew APR quantitative trait loci (QTL) have been reported on 16 and 21 chromosomes, respectively, in over 50 publications during the last 15 yr. More important, we found 11 loci located on chromosomes 1BS, 1BL, 2AL, 2BS (2), 2DL, 4DL, 5BL, 6AL, 7BL, and 7DS showing pleiotropic effects on resistance to leaf rust, stripe rust, and powdery mildew. Among these, QTL on chromosomes 1BL, 4DL, and 7DS also correlate with leaf tip necrosis. Fine mapping and cloning of these QTL will be achieved with the advent of cheaper high‐throughput genotyping technologies. Germplasm carrying these potential resistance genes will be useful for developing cultivars with durable multidisease resistance. In addition to its non‐NBS–LRR (nucleotide binding site–leucine rich repeat) structure, the senescence‐like processes induced by Lr34 could be the reason for durability of resistance; however, more information is needed for a full understanding of the molecular mechanism related to durability. Adult plant resistance genes have been used by CIMMYT for more than 30 yr and have also been transferred to many Chinese wheat varieties through shuttle breeding.
    Type of Medium: Online Resource
    ISSN: 0011-183X , 1435-0653
    URL: Article
    DOI: 10.2135/cropsci2014.02.0162
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 1480918-7
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  • 10
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    Quantitative trait loci mapping reveals the complexity of adult plant resistance to leaf rust in spring wheat ‘Copio’
    Wiley ; 2022
    In:  Crop Science Vol. 62, No. 3 ( 2022-05), p. 1037-1050
    Details
    In: Crop Science, Wiley, Vol. 62, No. 3 ( 2022-05), p. 1037-1050
    Abstract: Seven quantitative trait loci (QTL) for leaf rust resistance were mapped in spring wheat ‘Copio’. A QTL on 2AS was colocalized to Lr37 in the 2NS/2AS translocation in Copio. A QTL on 3BS consistently mapped to the Sr2/Yr30/Lr27 region can be a new leaf rust adult plant resistance locus. Allelic combination of Lr46 and the QTL on 2AS and 3BS reduced leaf rust coefficient of infection up to 52% in Mexico.
    Type of Medium: Online Resource
    ISSN: 0011-183X , 1435-0653
    URL: Issue
    URL: Article
    DOI: 10.1002/csc2.v62.3
    DOI: 10.1002/csc2.20728
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1480918-7
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