In:
Vox Sanguinis, Wiley, Vol. 118, No. 7 ( 2023-07), p. 577-581
Abstract:
Weak D type 42 accounts for an unusually high proportion of weak D phenotypes in Québec (Canada), which contrasts with other predominantly White populations. However, its prevalence in the general population is unknown. We estimated the prevalence of weak D type 42 and other common weak D phenotypes in Québec. Materials and Methods We screened for RHD*01W.42 alleles among 1000 individuals of CARTaGENE—a cohort representative of Québec's population. The prevalence of weak D type 42 was calculated based on the allele frequency of RHD*01W.42 and d (i.e., all recessive alleles that confer a D− phenotype), assuming a Hardy–Weinberg equilibrium. This prevalence was then leveraged to calculate that of other common weak D phenotypes, using published prevalence estimates among weak D phenotypes. Results Two individuals harboured the RHD*01W.42/RHD*01 heterozygous genotype. Assuming an allele frequency of 38.19% for d , the overall prevalence of weak D type 42 was 0.08%. The following prevalence estimates were also obtained: 0.44% for all weak D phenotypes and 0.07%, 0.01% and 0.04% for weak D types 1, 2 and 3, respectively. Conclusion Québec has the highest documented prevalence of weak D type 42, which was estimated at 0.08%.
Type of Medium:
Online Resource
ISSN:
0042-9007
,
1423-0410
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
1483587-3
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