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  • 1
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    Online Resource
    Effect and mechanism of high‐fat diet on the preference for sweeteners on mice
    Wiley ; 2021
    In:  Journal of the Science of Food and Agriculture Vol. 101, No. 5 ( 2021-03-30), p. 1844-1853
    Details
    In: Journal of the Science of Food and Agriculture, Wiley, Vol. 101, No. 5 ( 2021-03-30), p. 1844-1853
    Abstract: Male Kunming mice were divided into a normal diet group (control group) and a high‐fat diet group (HF group) (185 g·kg −1 protein, 600 g·kg −1 fat and 205 g·kg −1 carbohydrate). After 8 weeks' feeding, behavioral indicators and biochemical indicators in serum were determined. The double‐bottle preference experiment was used to study the preferences of mice for five sweeteners. The monoamine neurotransmitter content, gene expression related to dopamine (DA), and opioid receptors were also determined. RESULTS The body weight of the mice in the HF group increased significantly ( P   〈  0.05) after 36 days compared with the control group. The feed intake of the HF group increased sharply in the first 12 days, and then it became basically unchanged. The preference of the HF group for all of the five sweeteners was highly significantly lower ( P   〈  0.01) than that of the control group. Depression‐related behavior was observed in the HF group mice. The triglyceride (TG), total cholesterol (TC), and low‐density lipoprotein cholesterol (LDLC) content in the HF group were very much higher ( P   〈  0.01) than those of the control group. The gene expression related to DA and opioid receptor in the HF group was significantly lower than that of the control group, except for preproenkephalin (PENK). CONCLUSIONS In summary, this study suggested that a long‐term high‐fat diet could result in a decrease in the preference for sweeteners and could result in a state of reward hypofunction in mice. © 2020 Society of Chemical Industry
    Type of Medium: Online Resource
    ISSN: 0022-5142 , 1097-0010
    URL: Issue
    URL: Article
    DOI: 10.1002/jsfa.v101.5
    DOI: 10.1002/jsfa.10798
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2001807-1
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  • 2
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    The transcription factors MS 188 and AMS form a complex to activate the expression of CYP 703A2 for sporopollenin biosynthesis in Arabidopsis thaliana
    Wiley ; 2016
    In:  The Plant Journal Vol. 88, No. 6 ( 2016-12), p. 936-946
    Details
    In: The Plant Journal, Wiley, Vol. 88, No. 6 ( 2016-12), p. 936-946
    Abstract: Sporopollenin in the pollen wall is produced by the tapetum, but how genes encoding the required biosynthetic enzymes are regulated is unclear. Here we show that two transcription factors, MS188 and AMS, positively regulate the gene encoding CYP703A2, a cytochrome P450 required for sporopollenin biosynthesis.
    Type of Medium: Online Resource
    ISSN: 0960-7412 , 1365-313X
    URL: Issue
    URL: Article
    DOI: 10.1111/tpj.2016.88.issue-6
    DOI: 10.1111/tpj.13284
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2020961-7
    SSG: 12
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  • 3
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    Identification of functional genes associated with the biotransformation of limonene to trans ‐dihydrocarvone in Klebsiella sp. O852
    Wiley ; 2022
    In:  Journal of the Science of Food and Agriculture Vol. 102, No. 8 ( 2022-06), p. 3297-3307
    Details
    In: Journal of the Science of Food and Agriculture, Wiley, Vol. 102, No. 8 ( 2022-06), p. 3297-3307
    Abstract: Natural dihydrocarvone has been widely used in the food, cosmetics, agrochemicals and pharmaceuticals industries because of its sensory properties and physiological effects. In our previous study, Klebsiella sp. O852 was shown to be capable of converting limonene to trans ‐dihydrocarvone with high catalytic efficiency. Thus, it was essential to identify and characterize the functional genes involved in limonene biotransformation using genome sequencing and heterologous expression. RESULTS The 5.49‐Mb draft genome sequence of Klebsiella sp. O852 contained 5218 protein‐encoding genes. Seven candidate genes participating in the biotransformation of limonene to trans ‐dihydrocarvone were identified by genome analysis. Heterologous expression of these genes in Escherichia coli BL21(DE3) indicated that 0852_GM005124 and 0852_GM003417 could hydroxylate limonene in the six position to yield carveol, carvone and trans ‐dihydrocarvone. 0852_GM002332 and 0852_GM001602 could catalyze the oxidation of carveol to carvone and trans ‐dihydrocarvone. 0852_GM000709, 0852_GM001600 and 0852_GM000954 had high carvone reductase activity toward the hydrogenation of carvone to trans ‐dihydrocarvone. CONCLUSION The results obtained in the present study suggest that the seven genes described above were responsible for converting limonene to trans ‐dihydrocarvone. The present study contributes to providing a foundation for the industrial production of trans ‐dihydrocarvone in microbial chassis cells using synthetic biology strategies. © 2021 Society of Chemical Industry.
    Type of Medium: Online Resource
    ISSN: 0022-5142 , 1097-0010
    URL: Issue
    URL: Article
    DOI: 10.1002/jsfa.v102.8
    DOI: 10.1002/jsfa.11675
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2001807-1
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  • 4
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    Isolation, purification, and mass spectrometry identification of the enzyme involved in citrus flavor (+)‐valencene biotransformation to (+)‐nootkatone by Yarrowia lipolytica
    Wiley ; 2023
    In:  Journal of the Science of Food and Agriculture Vol. 103, No. 10 ( 2023-08-15), p. 4792-4802
    Details
    In: Journal of the Science of Food and Agriculture, Wiley, Vol. 103, No. 10 ( 2023-08-15), p. 4792-4802
    Abstract: (+)‐Nootkatone is a highly valuable sesquiterpene compound that can be used as an aromatic in the food industry because of its grapefruit flavor and low sensory threshold. The unconventional yeast Yarrowia lipolytica has many unique physical and chemical properties, metabolic characteristics, and genetic structure, which has aroused the interest of researchers. Previous research showed that Y. lipolytica possesses the ability to transform the sesquiterpene (+)‐valencene to (+)‐nootkatone. The aim of this study was to isolate, purify, and identify the enzyme involved in the (+)‐valencene bioconversion to (+)‐nootkatone by Y. lipolytica. RESULTS In this study, ultrasonic‐assisted extraction, ammonium sulfate precipitation, anion‐exchange chromatography, and gel‐filtration chromatography were used to separate and purify the enzyme involved in the (+)‐valencene bioconversion by Y. lipolytica . The protein was identified as aldehyde dehydrogenase (ALDH) (gene0658) using sodium dodecyl sulfate polyacrylamide gel electrophoresis and liquid chromatography–tandem mass spectrometry analysis. The ALDH had the highest activity when the pH value was 6.0 and the temperature was 30 °C. The activity of ALDH was significantly stimulated by ferrous ions and inhibited by barium, calcium, and magnesium ions. CONCLUSION This is the first time that ALDH was found to participate in (+)‐valencene biotransformation by Y. lipolytica . It may be involved in regulating the microbial transformation of (+)‐valencene to (+)‐nootkatone through redox characteristics. This study provides a theoretical basis and reference for the biological synthesis of citrus flavor (+)‐nootkatone. © 2023 Society of Chemical Industry.
    Type of Medium: Online Resource
    ISSN: 0022-5142 , 1097-0010
    URL: Issue
    URL: Article
    DOI: 10.1002/jsfa.v103.10
    DOI: 10.1002/jsfa.12545
    Language: English
    Publisher: Wiley
    Publication Date: 2023
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  • 5
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    Online Resource
    Effects of xanthan and sugar on the release of aroma compounds in model solution
    Wiley ; 2017
    In:  Flavour and Fragrance Journal Vol. 32, No. 2 ( 2017-03), p. 112-118
    Details
    In: Flavour and Fragrance Journal, Wiley, Vol. 32, No. 2 ( 2017-03), p. 112-118
    Abstract: The effects of the interaction of xanthan and sugar on the release of aroma compounds (α‐pinene, ethyl acetate, ethyl butyrate, perillaldehyde, hexenal, and d‐limonene) were investigated in model solutions (xanthan, sugar and xanthan‐sugar solutions). The released aroma compounds were analysed by solid‐phase microextraction and gas chromatography‐mass spectrometer (SPME/GC‐MS). The results showed that the six aroma compounds decreased differently in the 0.4 g·L ‐1 xanthan solution. A slightly stronger release of these aroma compounds in glucose solution was observed than that in sucrose solution. The release of these aroma compounds increased in the xanthan solution after the addition of the sucrose. This indicated that the release of these aroma compounds was inhibited in the xanthan solution. But the addition of sucrose in the xanthan solution could promote the release of the aroma compounds. Additionally, the rheology results showed that the xanthan solution exhibited a gradual shear thinning and the C* of xanthan was 2 g·L ‐1 . However, the concentrations of the xanthan solution which could inhibit the release of the six aroma compounds were not fully consistent with C*. And this indicated that viscosity was not the main factor influencing the release of aroma compounds in the xanthan solution. Copyright © 2016 John Wiley & Sons, Ltd.
    Type of Medium: Online Resource
    ISSN: 0882-5734 , 1099-1026
    URL: Issue
    URL: Article
    DOI: 10.1002/ffj.v32.2
    DOI: 10.1002/ffj.3360
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 1483463-7
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  • 6
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    Dietary essential oil from navel orange alleviates depression in reserpine‐treated mice by monoamine neurotransmitters
    Wiley ; 2019
    In:  Flavour and Fragrance Journal Vol. 34, No. 4 ( 2019-07), p. 252-259
    Details
    In: Flavour and Fragrance Journal, Wiley, Vol. 34, No. 4 ( 2019-07), p. 252-259
    Abstract: This study was intended to examine the effects of navel orange ( Citrus sinensis (L.) Osbeck) essential oil ( OEO ) on depression in the reserpine‐treated mice. And the chemical composition of OEO was analysed by gas chromatography ( GC ) analysis. The results indicated that the major compounds of OEO were terpenes. And OEO treatment produced an antidepressant‐like effect in mice, as indicated by the increased locomotor activity in the open field test ( OFT ) and attenuated dyslipidemia, but it had no effect on duration of immobility in the forced swim test ( FST ). Dietary OEO counteracted the reserpine‐induced hypothermia and palpebral ptosis. Moreover, OEO treatment increased the levels of serotonin (5‐ HT ) and dopamine ( DA ) in the mice brain. These antidepressant‐like effects of OEO are essentially similar to the effects of the antidepressant fluoxetine. And the action of OEO may be mediated by the central serotonergic and dopaminergic systems.
    Type of Medium: Online Resource
    ISSN: 0882-5734 , 1099-1026
    URL: Issue
    URL: Article
    DOI: 10.1002/ffj.2019.34.issue-4
    DOI: 10.1002/ffj.3497
    Language: English
    Publisher: Wiley
    Publication Date: 2019
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  • 7
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    Online Resource
    Effects of orange essential oil on intestinal microflora in mice
    Wiley ; 2019
    In:  Journal of the Science of Food and Agriculture Vol. 99, No. 8 ( 2019-06), p. 4019-4028
    Details
    In: Journal of the Science of Food and Agriculture, Wiley, Vol. 99, No. 8 ( 2019-06), p. 4019-4028
    Abstract: The intestinal microbiota has a wide variety of functions in the host. A positive effect of plant extract on intestinal microbiota in animals has been reported. However, the effect of orange essential oil and its components limonene, linalool and citral on intestinal microflora in mice has seldom been reported. The effects of intragastric administration of orange essential oil and limonene, linalool and citral on intestinal microflora and biochemical indexes in mice were studied. RESULTS The effect of essential oil, linalool and citral on immune organ index (spleen and thymus index), IgM and IL‐2 was not significant ( P   〉  0.05). A significant increase ( P   〈  0.05) of H + K + ‐ATPase activity, IgA, IgG, and IL‐2 in the limonene group was observed when compared with the control group. Orange essential oil, limonene, linalool and citral could significantly reduce the content of short‐chain fatty acids in the cecum and colon of mice. Principal coordinates analysis showed that intestinal bacterial structure of limonene group cecum and colon was apparently separated from other groups. The relative abundance of Lactobacillus in cecum and colon in essential oil, limonene, linalool and citral groups was higher than that in the control group. CONCLUSIONS Orange essential oil and limonene, linalool and citral could affect the intestinal microflora of mice, and enhance the relative abundance of Lactobacillus . The intestinal bacterial structure of cecum and colon in the limonene group was quite different from other groups. This indicated a more obvious effect of limonene on intestinal bacteria, also resulting in significant changes in blood immune index and short‐chain fatty acids in mice. © 2019 Society of Chemical Industry
    Type of Medium: Online Resource
    ISSN: 0022-5142 , 1097-0010
    URL: Issue
    URL: Article
    DOI: 10.1002/jsfa.2019.99.issue-8
    DOI: 10.1002/jsfa.9629
    Language: English
    Publisher: Wiley
    Publication Date: 2019
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  • 8
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    Online Resource
    The genomic landscape of Cronkhite–Canada syndrome: Possible clues for pathogenesis
    Wiley ; 2022
    In:  Journal of Digestive Diseases Vol. 23, No. 5-6 ( 2022-05), p. 288-294
    Details
    In: Journal of Digestive Diseases, Wiley, Vol. 23, No. 5-6 ( 2022-05), p. 288-294
    Abstract: Cronkhite – Canada syndrome (CCS) is a rare hamartomatous polyposis syndrome with a proposed association with chronic autoimmune inflammation. To date, genetic background of patients with CCS remains less investigated. In this study we aimed to explore the genomic landscape of CCS. Methods Whole exome sequencing was performed on peripheral blood samples extracted from 18 patients with CCS. Potential function‐impacting germline variants were filtered by R software. Through systematic data analysis, a number of genetic variants were identified. Enrichment analysis was performed using the R package ClusterProfiler. Results Overall, 3960 low‐frequency ( 〈 0.05 or not reported in the Exome Aggregation Consortium East Asian, 1000 Genomes, or ESP6500 database) potentially function‐impacting germline variants were identified, with 18 genes ( FDFT1, LOC400863, MUC3A, MUC4, ZNF806, GXYLT1, MUC6, PABPC3, PSPH, ZFPM1, CIC, LOC283710, ARSD, GOLGA6L2, LOC388282, SLC25A5, TMEM247 , WDR89 ) involved over half the patients. Functional enrichment of these genes revealed several biological processes in relation to innate immune responses and glycosylation. Only one likely pathogenic germline variant of an hamartomatous polyposis syndrome‐associated gene, PTCH1 , was detected in one patient. Conclusions CCS has genomic alteration patterns completely distinct from those of traditional hamartomatous polyposis syndrome. The germline mutation landscape indicates potential roles of innate immune responses and glycosylation in the pathogenesis of CCS.
    Type of Medium: Online Resource
    ISSN: 1751-2972 , 1751-2980
    URL: Issue
    URL: Article
    DOI: 10.1111/cdd.v23.5-6
    DOI: 10.1111/1751-2980.13101
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2317117-0
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  • 9
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    Etiological analysis of chronic pancreatitis in 215 cases
    Wiley ; 2002
    In:  Chinese Journal of Digestive Diseases Vol. 3, No. 4 ( 2002-12), p. 164-166
    Details
    In: Chinese Journal of Digestive Diseases, Wiley, Vol. 3, No. 4 ( 2002-12), p. 164-166
    Type of Medium: Online Resource
    ISSN: 1443-9611 , 1443-9573
    URL: Article
    DOI: 10.1046/j.1443-9573.2002.00094.x
    Language: English
    Publisher: Wiley
    Publication Date: 2002
    detail.hit.zdb_id: 2034220-2
    detail.hit.zdb_id: 2317117-0
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  • 10
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    Evaluating the role of imaging methods in the diagnosis of chronic pancreatitis : Imaging of chronic pancreatitis
    Wiley ; 2003
    In:  Chinese Journal of Digestive Diseases Vol. 4, No. 2 ( 2003-07), p. 84-88
    Details
    In: Chinese Journal of Digestive Diseases, Wiley, Vol. 4, No. 2 ( 2003-07), p. 84-88
    Type of Medium: Online Resource
    ISSN: 1443-9611
    URL: Article
    DOI: 10.1046/j.1443-9573.2001.00119.x
    Language: English
    Publisher: Wiley
    Publication Date: 2003
    detail.hit.zdb_id: 2317117-0
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