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  • 1
    In: Geriatrics & Gerontology International, Wiley, Vol. 17, No. 5 ( 2017-05), p. 810-818
    Abstract: To investigate the items that are considered by physicians when making decisions regarding the resumption of oral intake among patients with aspiration pneumonia who have undergone short‐term fasting. Methods We surveyed 2490 Japanese hospitals that had internal medicine and respiratory medicine departments. We mailed questionnaires that contained 24 items related to oral intake resumption after aspiration pneumonia to the head of the department at each hospital. Cronbach statistics, principal component analysis and cluster analysis were used to analyze the results. Results We received responses from 350 hospitals; 89.7% of the respondents answered that they “Strongly agree” that “level of consciousness” is a useful criterion for resuming oral intake. Furthermore, 66%, 66%, 63.4%, 58.5% and 51% of the respondents answered that they “strongly agree” regarding the use of SpO 2 , the discretion of the attending physician, body temperature, swallowing function test results, mental state and respiratory rate, respectively. In the cluster analysis, level of consciousness, body temperature, SpO 2 , respiratory rate, mental state and the discretion of the attending physician belonged to the first cluster. The second cluster consisted of the patient's request, the family's request, the opinions of the medical staff and non‐physician healthcare providers, and performance status. Conclusions Physicians consider several criteria during decision‐making regarding oral intake resumption, which can be assigned to two clusters. Future studies are required to develop generalizable and objective criteria. Geriatr Gerontol Int 2017; 17: 810–818.
    Type of Medium: Online Resource
    ISSN: 1444-1586 , 1447-0594
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2078308-5
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  • 2
    In: Journal of Neurochemistry, Wiley, Vol. 156, No. 6 ( 2021-03), p. 834-847
    Abstract: PRMT1, a major arginine methyltransferase, plays critical roles in transcription, DNA damage response, and cell proliferation. Although we have previously discovered the crucial roles of PRMT1 for oligodendrocyte lineage progression in the central nervous system of neural stem cell‐specific PRMT1 conditional knockout (PRMT1‐CKO) mice, the context of other glial cell states that may cause the hypomyelination phenotype in PRMT1‐CKO mice has not been explored so far. Here, we performed RNA‐seq of the neonatal cortices of PRMT1‐CKO mice to reveal overall gene expression changes and show the up‐regulation of inflammatory signaling which is generally mediated by astrocytes and microglia in advance of the myelination defects. In particular, qRT‐PCR analyses revealed Interleukin‐6 ( Il‐6 ), a major central nervous system cytokine, was dramatically increased in the PRMT1‐CKO brains. The gene expression changes led to augmentation of glial fibrillary acidic protein and Vimentin protein levels in PRMT1‐CKO mice, showing severe reactive astrogliosis after birth. We further show that IBA1‐positive and CD68‐positive activated microglia were increased in PRMT1‐CKO mice, in spite of intact Prmt1 gene expression in purified microglia from the mutant mice. Our results indicate that PRMT1 loss in the neural stem cell lineage causes disruptive changes in all glial types perturbing postnatal brain development and myelination. image
    Type of Medium: Online Resource
    ISSN: 0022-3042 , 1471-4159
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2020528-4
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    Wiley ; 2018
    In:  Journal of General and Family Medicine Vol. 19, No. 5 ( 2018-09), p. 160-165
    In: Journal of General and Family Medicine, Wiley, Vol. 19, No. 5 ( 2018-09), p. 160-165
    Abstract: We compared the quality of care for nursing‐ and healthcare‐associated pneumonia ( NHCAP ) and aspiration pneumonia provided by general physicians and pulmonologists. Methods Questionnaires were mailed to 2490 medical facilities across Japan. The questionnaire assessed participants’ implementation of microbiological investigations for NHCAP or aspiration pneumonia, as well as steps taken to prevent pneumonia recurrence (eg, use or discontinuation of drugs associated with swallowing and administration of pneumococcal polysaccharides). Survey results were statistically compared between the two groups using chi‐square tests. Results We received responses from 350 hospitals; of those, medical care for aspiration pneumonia was provided by pulmonologists at 190 hospitals and by general physicians at 79 hospitals. No significant differences were observed between the two groups of physicians for any of the items regarding proactive microbiological investigations or measures for preventing pneumonia recurrence. However, general physicians tended to be more proactive in conducting Gram's stains for sputum, sputum culture inspections, and blood culture tests. They also were more likely to implement measures for preventing pneumonia recurrence such as striving to increase patients’ consciousness levels, reducing medication doses, and discontinuing drugs that cause difficulty with swallowing (response rates of “is done in nearly all cases” were 73.4%, 88.6%, 36.7%, 35.4%, and 40.5%, respectively). Conclusions The quality of care provided by general physicians may be on par with pulmonologists in terms of proactive microbiological investigations and preventing pneumonia recurrence.
    Type of Medium: Online Resource
    ISSN: 2189-7948 , 2189-7948
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2886539-X
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