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  • 1
    Online Resource
    Online Resource
    An epidemic of bladder cancer: ten cases of bladder cancer in male Japanese workers exposed to ortho ‐toluidine
    Wiley ; 2018
    In:  Journal of Occupational Health Vol. 60, No. 4 ( 2018-07), p. 307-311
    Details
    In: Journal of Occupational Health, Wiley, Vol. 60, No. 4 ( 2018-07), p. 307-311
    Abstract: ortho ‐Toluidine (OT) was listed as a Group 1 carcinogen by the International Agency for Research on Cancer in 2012 based on epidemiological observations of workers co‐exposed to OT and aromatic amines. From 2014 to 2017, several cases of bladder cancer (BCa) secondary to occupational exposure, primarily to OT, were detected in Japan. Objective To describe 10 cases of BCa in male Japanese workers exposed primarily to OT at two plants that produce organic dye and pigment intermediates. Methods Details of the 10 cases were obtained from company records and through a questionnaire and interview. The surrogate level of exposure to each aromatic amine was calculated as the total job‐weight/month for each process for each job‐year. Results No quantitative exposure data were available. In most cases the surrogate level of exposure to OT was higher than to other amines. All 10 cases were exposed primarily to OT and co‐exposed to para toluidine, ortho ‐anisidine, aniline, 2,4‐xylidine or ortho chloroaniline. The age range at diagnosis was 41‐71 years (mean 56). The duration of OT exposure was 7‐28 years (mean 16.5) . Disease latency was 16‐28 years (mean 21.9) . Eight patients were smokers. The main symptom at diagnosis was hematuria (70%). Conclusions The characteristics of BCa cases were associated with a high surrogate level of OT exposure and a disease latency of more than 20 years from the initial OT exposure. The main route of OT exposure was likely through the skin. It is necessary to continue health examinations in these target groups.
    Type of Medium: Online Resource
    ISSN: 1341-9145 , 1348-9585
    URL: Article
    DOI: 10.1539/joh.2017-0220-OA
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 1340985-2
    detail.hit.zdb_id: 2075956-3
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  • 2
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    Online Resource
    The role of gut microbiota and diet in experimental autoimmune encephalitis and multiple sclerosis
    Wiley ; 2015
    In:  Clinical and Experimental Neuroimmunology Vol. 6, No. S1 ( 2015-12), p. 30-37
    Details
    In: Clinical and Experimental Neuroimmunology, Wiley, Vol. 6, No. S1 ( 2015-12), p. 30-37
    Abstract: The prevalence of multiple sclerosis has been increasing over the last few decades, especially in certain areas such as the Mediterranean regions and Japan. This increase may be attributed to a modified microbiota in accordance with the changes in food habits, although the precise cause remains unknown. To investigate the association between the microbiota and central nervous system inflammation, mice under germ‐free conditions and experimental autoimmune encephalomyelitis ( EAE ) has been widely used. For example, Th17 cells are induced by intestinal segmented filamentous bacteria and have been implicated in the pathogenesis of autoimmune diseases, including EAE . Certain groups of commensal bacteria and their metabolites, including short‐chain fatty acids, play significant roles in the induction of regulatory T cells in the intestine, which suppress autoimmune reaction. In this review, we introduce the current advances in this field, including our data on Pediococcus acidilactici and Candida kefyr in EAE , and discuss the potential of probiotics in terms of prophylactic or therapeutic treatment options for multiple sclerosis.
    Type of Medium: Online Resource
    ISSN: 1759-1961 , 1759-1961
    URL: Issue
    URL: Article
    DOI: 10.1111/cen3.2015.6.issue-S1
    DOI: 10.1111/cen3.12270
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2508135-4
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  • 3
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    Online Resource
    Outcomes after resection of occupational cholangiocarcinoma
    Wiley ; 2016
    In:  Journal of Hepato-Biliary-Pancreatic Sciences Vol. 23, No. 9 ( 2016-09), p. 556-564
    Details
    In: Journal of Hepato-Biliary-Pancreatic Sciences, Wiley, Vol. 23, No. 9 ( 2016-09), p. 556-564
    Abstract: Cholangiocarcinoma caused by exposure to 1,2‐dichloropropane and/or dichloromethane is recognized as occupational cholangiocarcinoma. The aim of this study was to investigate the outcomes after resection of occupational cholangiocarcinoma to establish a treatment strategy for this disease. Methods Clinicopathological findings and outcomes after surgical intervention in 20 patients with occupational cholangiocarcinoma were investigated. Results Of 20 the patients, curative resection was performed in 16 patients. Three patients underwent radiation at the stump of the bile ducts. Adjuvant chemotherapy was performed in 12 patients. Biliary intraepithelial neoplasia, intraductal papillary neoplasm of the bile duct, and/or chronic bile duct injury was detected in most subjects. Intraabdominal infection developed after surgery in nine patients. Cholangiocarcinoma recurred in 12 of the 20 patients. The recurrent tumors in five patients developed at a different part of the bile duct from the primary tumor and a second resection was performed in four of these five patients. Conclusions The incidence of postoperative complications including intraabdominal infection was high in patients with occupational cholangiocarcinoma. Multicentric recurrence occurred not infrequently after surgery because the bile ducts had a high potential for the development of carcinoma. The aggressive treatment including second resection for the multicentric recurrence appeared to be effective.
    Type of Medium: Online Resource
    ISSN: 1868-6974 , 1868-6982
    URL: Issue
    URL: Article
    DOI: 10.1002/jhbp.v23.9
    DOI: 10.1002/jhbp.373
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2536390-6
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  • 4
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    Online Resource
    Management of complicated diverticulitis of the colon
    Wiley ; 2018
    In:  Annals of Gastroenterological Surgery Vol. 2, No. 1 ( 2018-01), p. 22-27
    Details
    In: Annals of Gastroenterological Surgery, Wiley, Vol. 2, No. 1 ( 2018-01), p. 22-27
    Abstract: Diverticular disease of the colon occurs quite frequently in developed countries, and its prevalence has recently increased in Japan. The appearance of diverticulosis increases with age, although mostly remaining asymptomatic. Approximately 20% of cases require treatment. As the Western lifestyle and number of elderly people increase, the need for medical treatment also increases. Computed tomography (CT) is the gold standard for diagnosing diverticulitis. Complicated diverticulitis is classified by the size and range of abscess formation and the severity of the peritonitis. Each case should be classified based on clinical and computed tomography (CT) findings and then treated appropriately. Most patients with uncomplicated diverticulitis (stages 0–Ia) can be treated conservatively. Diverticulitis with a localized abscess (stages Ib–II) is generally resolved with conservative treatment. If the abscess is larger or conservative treatment fails, however, percutaneous drainage or surgery should be considered. Operative treatment is considered standard therapy for severe diverticulitis with perforation and generalized peritonitis (stages III–IV). Colonic diverticulitis treated conservatively frequently recurs. Elective surgery after recovery should be considered carefully and decisions made on a case‐by‐case basis. Because cases of colonic diverticulitis will undoubtedly increase in Japan, it is likely that we will be confronted with increasing numbers of treatment decisions. We therefore need to have a systematic strategy for treating the various stages of colonic diverticulitis appropriately. We herein review the management of complicated diverticulitis.
    Type of Medium: Online Resource
    ISSN: 2475-0328 , 2475-0328
    URL: Issue
    URL: Article
    DOI: 10.1002/ags3.2018.2.issue-1
    DOI: 10.1002/ags3.12035
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2895706-4
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  • 5
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    Online Resource
    Dietary Yeasts Reduce Inflammation in Central Nerve System via Microflora
    Wiley ; 2015
    In:  Annals of Clinical and Translational Neurology Vol. 2, No. 1 ( 2015-01), p. 56-66
    Details
    In: Annals of Clinical and Translational Neurology, Wiley, Vol. 2, No. 1 ( 2015-01), p. 56-66
    Abstract: The intestinal microflora affects the pathogenesis of several autoimmune diseases by influencing immune system function. Some bacteria, such as lactic acid bacteria, have been reported to have beneficial effects on immune function. However, little is known about the effects of yeasts. Here, we aimed to investigate the effects of various dietary yeasts contained in fermented foods on experimental autoimmune encephalomyelitis ( EAE ), an animal model of multiple sclerosis ( MS ), and to elucidate the mechanisms underlying these effects. Methods The effects of eight yeasts selected from 18 types of yeasts contained in fermented foods were examined using an EAE model. Of these, Candida kefyr was investigated by analyzing the intestinal microflora and its effects on intestinal and systemic immune states. Results Administration of C. kefyr ameliorated the severity of EAE. Reduced numbers of Th17 cells, suppressed interleukin (IL)‐6 production by intestinal explants, and increased Tregs and CD103‐positive regulatory dendritic cells in mesenteric lymph nodes (MLNs) were observed. Analysis of 16s‐ rDNA from feces of C. kefyr ‐treated mice demonstrated increased Lactobacillales and decreased Bacteroides compared to control flora. Transfer of intestinal microbiota also resulted in decreased Bacteroides and ameliorated symptoms of EAE. Thus, oral administration of C. kefyr ameliorated EAE by altering the microflora, accompanied by increased Tregs and CD103‐positive regulatory dendritic cells in MLNs and decreased Th17 cells in the intestinal lamina propria. Interpretation Oral ingestion of C. kefyr may have beneficial effects on MS by modifying microflora. In addition, our findings also suggested the potential health benefits of dietary yeasts.
    Type of Medium: Online Resource
    ISSN: 2328-9503 , 2328-9503
    URL: Article
    DOI: 10.1002/acn3.153
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2740696-9
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  • 6
    Online Resource
    Online Resource
    Topics of the 29th European Committee for Treatment and Research in Multiple Sclerosis Congress in Copenhagen, Denmark, 2013
    Wiley ; 2013
    In:  Clinical and Experimental Neuroimmunology Vol. 4, No. 3 ( 2013-12), p. 354-357
    Details
    In: Clinical and Experimental Neuroimmunology, Wiley, Vol. 4, No. 3 ( 2013-12), p. 354-357
    Type of Medium: Online Resource
    ISSN: 1759-1961 , 1759-1961
    URL: Issue
    URL: Article
    DOI: 10.1111/cen3.2013.4.issue-3
    DOI: 10.1111/cen3.12075
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 2508135-4
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  • 7
    Online Resource
    Online Resource
    Roles of S ema4 A in multiple sclerosis and interferon‐β therapy efficacy
    Wiley ; 2013
    In:  Clinical and Experimental Neuroimmunology Vol. 4, No. 3 ( 2013-12), p. 274-282
    Details
    In: Clinical and Experimental Neuroimmunology, Wiley, Vol. 4, No. 3 ( 2013-12), p. 274-282
    Abstract: The early initiation of appropriate treatment is important for a better prognosis for patients with multiple sclerosis ( MS ). Although interferon ( IFN ‐β) has been the most prescribed therapy for MS , some patients are poor responders to this therapy. Therefore, finding biomarkers to predict treatment responsiveness is required. Some patients with MS have high serum S ema4 A and concurrently have characteristics of T h17‐skewing conditions, and do not respond well to IFN ‐β therapy. In the present review, we discuss S ema4 A and responsiveness to IFN ‐β therapy. In addition, we review biomarkers relevant to IFN ‐β therapy responsiveness.
    Type of Medium: Online Resource
    ISSN: 1759-1961 , 1759-1961
    URL: Issue
    URL: Article
    DOI: 10.1111/cen3.2013.4.issue-3
    DOI: 10.1111/cen3.12070
    Language: English
    Publisher: Wiley
    Publication Date: 2013
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  • 8
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    Obesity and recurrence‐free survival in patients with hepatocellular carcinoma after achieving sustained virological response to interferon therapy for chronic hepatitis C
    Wiley ; 2018
    In:  Annals of Gastroenterological Surgery Vol. 2, No. 4 ( 2018-07), p. 319-326
    Details
    In: Annals of Gastroenterological Surgery, Wiley, Vol. 2, No. 4 ( 2018-07), p. 319-326
    Abstract: Some patients who achieve a sustained virological response (SVR) to interferon (IFN) treatment for chronic hepatitis C prior to hepatic resection for hepatocellular carcinoma (HCC) experience postoperative recurrence. This study investigated the relationship between obesity and postoperative HCC recurrence in SVR patients. Methods Fifty‐nine patients who had achieved SVR before hepatic resection were evaluated. Patients had a solitary tumor ≤5 cm in diameter or ≤3 lesions each ≤3 cm in size with no macroscopic vascular invasion (Milan criteria). Patient characteristics potentially associated with recurrence risk were investigated. Results Three‐, 5‐, and 7‐year recurrence‐free survival after surgery were 65%, 44%, and 41%, respectively. Univariate analysis showed that obesity ( P 〈 .01), hypertension ( P = .038), and non‐anatomical resection ( P = .022) were significantly associated with a lower recurrence‐free survival rate. In a multivariate analysis, obesity (hazard ratio, 2.8; 95% confidence interval [CI] 1.3‐6.1; P 〈 .01) and non‐anatomical resection (hazard ratio, 2.7; 95% CI 1.1‐6.2; P = .025) were independently associated with postoperative recurrence. Three‐, 5‐, and 7‐year overall survival rates after surgery were 100%, 80%, and 64% in obese patients and 100%, 92%, and 82% in non‐obese patients, respectively ( P = .014). However, other variables showed no significant difference in the overall survival rate. Conclusions Obesity and non‐anatomical resection were independent risk factors for HCC recurrence after hepatic resection and successful IFN therapy. Obesity is an important clinical problem to consider to improve postoperative outcomes in such patients.
    Type of Medium: Online Resource
    ISSN: 2475-0328 , 2475-0328
    URL: Issue
    URL: Article
    DOI: 10.1002/ags3.2018.2.issue-4
    DOI: 10.1002/ags3.12183
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2895706-4
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  • 9
    Online Resource
    Online Resource
    Reply to comment on: Dietary yeasts reduce inflammation in central nervous system via microflora
    Wiley ; 2015
    In:  Annals of Clinical and Translational Neurology Vol. 2, No. 11 ( 2015-11), p. 1040-1040
    Details
    In: Annals of Clinical and Translational Neurology, Wiley, Vol. 2, No. 11 ( 2015-11), p. 1040-1040
    Type of Medium: Online Resource
    ISSN: 2328-9503 , 2328-9503
    URL: Article
    DOI: 10.1002/acn3.258
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2740696-9
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  • 10
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    Effectiveness of psychological first aid in infectious disease pandemics: An overview of systematic reviews
    Wiley ; 2023
    In:  Psychiatry and Clinical Neurosciences Reports Vol. 2, No. 2 ( 2023-06)
    Details
    In: Psychiatry and Clinical Neurosciences Reports, Wiley, Vol. 2, No. 2 ( 2023-06)
    Abstract: There is insufficient research on the usefulness of psychological interventions, such as psychological first aid (PFA), during outbreaks. We searched for and critically appraised systematic reviews that examined the effectiveness of PFA during infectious disease outbreaks, such as the novel coronavirus disease (COVID‐19). Systematic reviews that examined the efficacy of PFA in the severe acute respiratory syndrome, Middle East respiratory syndrome coronavirus, Ebola virus disease, and COVID‐19 outbreaks were searched through PubMed on February 19, 2021. The three included systematic reviews were critically appraised and assessed using AMSTAR‐2. One review's overall confidence in its findings was evaluated as “high,” which suggested that PFA training had a favorable effect on healthcare personnel. Furthermore, the review also demonstrated that PFA was commonly used during outbreaks and could be delivered through multiple methods, such as a phone or video call. Although it was anticipated that PFA would improve subjective well‐being, reports showed no evidence of reduced depression or insomnia. Future studies should examine additional numbers of PFA recipients and conduct quasi‐experimental studies to better understand the effectiveness of PFA. Evidence on its effectiveness in infectious disease outbreaks is still lacking, along with research and evaluation methods. Quasi‐experimental studies, such as comparisons with other psychological interventions, are required to better understand the effectiveness of PFA.
    Type of Medium: Online Resource
    ISSN: 2769-2558 , 2769-2558
    URL: Issue
    URL: Article
    DOI: 10.1002/pcn5.v2.2
    DOI: 10.1002/pcn5.107
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 3118589-7
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