In:
Clinical Transplantation, Wiley, Vol. 27, No. 5 ( 2013-09), p. 659-665
Abstract:
Cardiac denervation following transplantation has a variable effect on heart rate ( HR ), and the consequence of this is not known. We examined the impact of first‐year HR on five‐yr outcomes after heart transplant. Methods We evaluated 544 heart transplant recipients from 1994 to 2008. Patients were divided into groups by mean first‐year HR : group 1, HR 〈 90 (mean 85.0 ± 4.3); group 2, 90 ≤ HR 〈 110 (mean 97.8 ± 4.9); group 3, HR ≥ 110 (mean 111.5 ± 1.8). Endpoints included one‐yr freedom from treated rejection, five‐yr survival, five‐yr freedom from cardiac allograft vasculopathy ( CAV ), and five‐yr freedom from non‐fatal major adverse cardiac events ( NF ‐ MACE ). Results One‐yr freedom from treated rejection, five‐yr survival and freedom from CAV were not significantly different between groups. Five‐yr freedom from NF ‐ MACE was significantly lower in group 3 compared with group 2, 69% vs. 91%, p 〈 0.01, mainly due to higher prevalence of congestive heart failure ( CHF ) in group 3 over five yr. Conclusions Mean first‐year HR does not provide prognostic significance for one‐yr freedom from treated rejection, five‐yr survival or development of CAV five yr after heart transplant. These results suggest that HR post‐heart transplantation does not affect long‐term outcomes, but high first‐year HRs may be associated with new‐onset CHF .
Type of Medium:
Online Resource
ISSN:
0902-0063
,
1399-0012
DOI:
10.1111/ctr.2013.27.issue-5
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
2739458-X
detail.hit.zdb_id:
2004801-4
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