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  • 1
    Online Resource
    Online Resource
    Personality profiles and health: Longitudinal evidence among Finnish adults
    Wiley ; 2012
    In:  Scandinavian Journal of Psychology Vol. 53, No. 6 ( 2012-12), p. 512-522
    Details
    In: Scandinavian Journal of Psychology, Wiley, Vol. 53, No. 6 ( 2012-12), p. 512-522
    Abstract: Kinnunen, M.‐L., Metsäpelto, R. L., Feldt, T., Kokko, K., Tolvanen, A., Kinnunen, U., Leppänen, E. & Pulkkinen, L. (2012). Personality profiles and health: Longitudinal evidence among Finnish adults. Scandinavian Journal of Psychology 53, 512–522. This study investigates the associations of longitudinal Big Five personality profiles with long‐term health in 304 adults (53% males). Personality traits (Neuroticism, Extraversion, Openness, Conscientiousness, Agreeableness) were assessed at ages 33, 42, and 50. Subjective (self‐rated health, symptoms, psychological distress) and objective (body mass index, waist‐to‐hip ratio, blood pressure, cholesterol, triglycerides) indicators of health were measured at ages 42 and 50. Five longitudinally stable personality profiles were extracted over 17 years by latent profile analysis. The levels of traits were the same in each profile at each age. Resilient individuals (N = 65; Neuroticism low, other traits high) had the best subjective health and Overcontrolled individuals (N = 40; Neuroticism high, other traits low) the poorest health over eight years. Reserved individuals (N = 25; high Conscientiousness, other traits low), Undercontrolled (N = 41; high Openness and Extraversion, low Conscientiousness), and Ordinary (N = 133; all traits scored medium) individuals were in the middle of these extremes in subjective health. No differences between the profiles were found in the objective indicators of health. Thus, overcontrol and resilience were most discriminative in terms of good health. Moreover, personality profiles revealed associations with health to be more nuanced than simply being composed of single traits. High Extraversion needed to be combined with high Conscientiousness (Resilients) in order to be associated with the best health; high Extraversion with low Conscientiousness (Undercontrolled) was associated with average health; and low Extraversion with high Neuroticism (Overcontrolled) was associated with the poorest health.
    Type of Medium: Online Resource
    ISSN: 0036-5564 , 1467-9450
    URL: Issue
    URL: Article
    DOI: 10.1111/sjop.2012.53.issue-6
    DOI: 10.1111/j.1467-9450.2012.00969.x
    RVK:
    CL 1000
    Language: English
    Publisher: Wiley
    Publication Date: 2012
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    detail.hit.zdb_id: 219197-0
    SSG: 5,2
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  • 2
    Online Resource
    Online Resource
    Laryngeal cancer in Finland: A 5‐year follow‐up study of 366 patients
    Wiley ; 2016
    In:  Head & Neck Vol. 38, No. 1 ( 2016-01), p. 36-43
    Details
    In: Head & Neck, Wiley, Vol. 38, No. 1 ( 2016-01), p. 36-43
    Abstract: The purpose of this study was to acquire nationwide data on the management and outcome of laryngeal squamous cell carcinoma (SCC) in Finnish university hospitals over a 5‐year posttreatment follow‐up. Methods All records of patients diagnosed and treated for primary laryngeal SCC during 2001 to 2005 were reviewed. Results Three hundred sixty‐six patients with laryngeal cancer were identified, 360 of whom had laryngeal SCC. Three hundred forty‐two patients with laryngeal SCC (95%) were treated with curative intent. Five‐year disease‐specific survival (DSS) for T1a, T1b, T2, T3, and T4 glottic SCC was 100%, 95%, 78%, 79%, and 53%, respectively. The corresponding figures for T1 to T4 supraglottic SCC were 68%, 54%, 72%, and 59%. Conclusion Results of this nationwide study give a general overview of the outcome of unselected patients treated with unified guidelines. Patients with T2 tumors, usually treated with radiotherapy (RT), had a worse prognosis than expected. This patient group warrants further investigation and possibly treatment intensification. © 2015 Wiley Periodicals, Inc. Head Neck 38: 36–43, 2016
    Type of Medium: Online Resource
    ISSN: 1043-3074 , 1097-0347
    URL: Issue
    URL: Article
    DOI: 10.1002/hed.v38.1
    DOI: 10.1002/hed.23834
    Language: English
    Publisher: Wiley
    Publication Date: 2016
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    detail.hit.zdb_id: 645165-2
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  • 3
    Online Resource
    Online Resource
    Retinal arterial macroaneurysms
    Wiley ; 2014
    In:  Acta Ophthalmologica Vol. 92, No. 2 ( 2014-03), p. 101-104
    Details
    In: Acta Ophthalmologica, Wiley, Vol. 92, No. 2 ( 2014-03), p. 101-104
    Abstract: Retinal arterial macroaneurysms are acquired saccular or fusiform dilatations of the large arterioles of the retina, usually within the first three orders of bifurcation. They are associated with systemic vascular conditions such as hypertension and arteriosclerotic disease occurring most commonly in elderly women. The primary reported symptom is a sudden loss of vision due to haemorrhage or oedema affecting the macula. Most of macroaneurysms regress without treatment and without causing decreased visual acuity. Poor visual outcome may occur secondary to foveal exudates and subfoveal haemorrhage.
    Type of Medium: Online Resource
    ISSN: 1755-375X , 1755-3768
    URL: Issue
    URL: Article
    DOI: 10.1111/aos.2014.92.issue-2
    DOI: 10.1111/aos.12210
    Language: English
    Publisher: Wiley
    Publication Date: 2014
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    detail.hit.zdb_id: 2408333-1
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  • 4
    Online Resource
    Online Resource
    Tag SNP selection for Finnish individuals based on the CEPH Utah HapMap database
    Wiley ; 2006
    In:  Genetic Epidemiology Vol. 30, No. 2 ( 2006-02), p. 180-190
    Details
    In: Genetic Epidemiology, Wiley, Vol. 30, No. 2 ( 2006-02), p. 180-190
    Abstract: The pattern and nature of linkage disequilibrium in the human genome is being studied and catalogued as part of the International HapMap Project [:2003 Nature 426:789–796]. A key goal of the HapMap Project is to enable identification of tag single nucleotide polymorphisms (SNPs) that capture a substantial portion of common human genetic variability while requiring only a small fraction of SNPs to be genotyped [International HapMap Consortium, 2005: Nature 437:1299–1320]. In the current study, we examined the effectiveness of using the CEU HapMap database to select tag SNPs for a Finnish sample. We selected SNPs in a 17.9‐Mb region of chromosome 14 based on pairwise linkage disequilibrium (r 2 ) estimates from the HapMap CEU sample, and genotyped 956 of these SNPs in 1,425 Finnish individuals. An excess of SNPs showed significantly different allele frequencies between the HapMap CEU and the Finnish samples, consistent with population‐specific differences. However, we observed strong correlations between the two samples for estimates of allele frequencies, r 2 values, and haplotype frequencies. Our results demonstrate that the HapMap CEU samples provide an adequate basis for tag SNP selection in Finnish individuals, without the need to create a map specifically for the Finnish population, and suggest that the four‐population HapMap data will provide useful information for tag SNP selection beyond the specific populations from which they were sampled. Genet. Epidemiol . 2006. © 2005 Wiley‐Liss, Inc.
    Type of Medium: Online Resource
    ISSN: 0741-0395 , 1098-2272
    URL: Issue
    URL: Article
    DOI: 10.1002/gepi.v30:2
    DOI: 10.1002/gepi.20131
    Language: English
    Publisher: Wiley
    Publication Date: 2006
    detail.hit.zdb_id: 605785-8
    detail.hit.zdb_id: 1492643-X
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  • 5
    Online Resource
    Online Resource
    Type 1 diabetes linked PTPN22 gene polymorphism is associated with the frequency of circulating regulatory T cells
    Wiley ; 2020
    In:  European Journal of Immunology Vol. 50, No. 4 ( 2020-04), p. 581-588
    Details
    In: European Journal of Immunology, Wiley, Vol. 50, No. 4 ( 2020-04), p. 581-588
    Abstract: Dysfunction of FOXP3‐positive regulatory T cells (Tregs) likely plays a major role in the pathogenesis of multiple autoimmune diseases including type 1 diabetes (T1D). Whether genetic polymorphisms associated with the risk of autoimmune diseases affect Treg frequency or function is currently unclear. Here, we analysed the effect of T1D‐associated major HLA class II haplotypes and seven single nucleotide polymorphisms in six non‐HLA genes [ INS (rs689), PTPN22 (rs2476601), IL2RA (rs12722495 and rs2104286), PTPN2 (rs45450798), CTLA4 (rs3087243), and ERBB3 (rs2292239)] on peripheral blood Treg frequencies. These were determined by flow cytometry in 65 subjects who had progressed to T1D, 86 islet autoantibody‐positive at‐risk subjects, and 215 islet autoantibody‐negative healthy controls. The PTPN22 rs2476601 risk allele A was associated with an increase in total ( p = 6 × 10 −6 ) and naïve ( p = 4 × 10 −5 ) CD4+CD25+CD127lowFOXP3+ Treg frequencies. These findings were validated in a separate cohort comprising ten trios of healthy islet autoantibody‐negative children carrying each of the three PTPN22 rs2476601 genotypes AA, AG, and GG ( p = 0.005 for total and p = 0.03 for naïve Tregs, respectively). In conclusion, our analysis implicates the autoimmune PTPN22 rs2476601 risk allele A in controlling the frequency of Tregs in human peripheral blood.
    Type of Medium: Online Resource
    ISSN: 0014-2980 , 1521-4141
    URL: Issue
    URL: Article
    DOI: 10.1002/eji.v50.4
    DOI: 10.1002/eji.201948378
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 120108-6
    detail.hit.zdb_id: 1491907-2
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