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  • 1
    In: Journal of the American Ceramic Society, Wiley, Vol. 102, No. 11 ( 2019-11), p. 6837-6849
    Abstract: CuO‐doped (1–x)(Na 0.2 K 0.8 )NbO 3 ‐xBaZrO 3 ceramics (0.0 ≤ x ≤ 0.06) were densified at 960°C. The ceramic with x = 0 exhibited a large sprout‐shaped strain vs electric‐field ( S‐E ) curve and a double polarization vs electric‐field ( P‐E ) hysteresis curve, owing to the defect polarization ( P D ) developed between Cu 2+ ions at Nb 5+ sites and oxygen vacancies. The sizes of the S‐E and P‐E loops decreased with increasing x, owing to the decrease in the number of P D s. The ceramic with x = 0.04 displayed small S‐E and P‐E curves, indicating its small dielectric loss. It exhibited large strain (0.19% at 8.0 kV/mm) at room temperature, which was maintained at 200°C. A similar strain was observed after applying 10 6 cycles of an electric field (3.0 kV/mm). Hence, this specimen exhibited large strain with excellent thermal and fatigue properties. Moreover, the synthesized multilayer actuator using the ceramic with x = 0.04 showed excellent vibrational properties, making it promising for applications in multilayer piezoelectric actuators.
    Type of Medium: Online Resource
    ISSN: 0002-7820 , 1551-2916
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2008170-4
    detail.hit.zdb_id: 219232-9
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  • 2
    In: Journal of Hepato-Biliary-Pancreatic Sciences, Wiley, Vol. 26, No. 10 ( 2019-10), p. 459-466
    Abstract: Afferent loop obstruction ( ALO ) is a rare mechanical complication of pancreaticoduodenectomy ( PD ) and is associated with a high rate of morbidity and mortality. Methods Data from patients who underwent PD between May 2007 and July 2017 at a single large‐volume center were retrospectively reviewed. Results Of the 3,223 patients who underwent PD , 67 developed ALO . More patients in the laparoscopic PD ( LPD ) group had developed ALO due to internal herniation than did those in the ope n PD (OPD) group (46.2 vs. 4.7%, P 〈 0.001). Patients in the LPD group also showed earlier occurrence of ALO ( ALO occurrence within 60 days: 76.9 vs. 22.2%, P 〈 0.001) and more frequent requirement for surgical treatment (76.9 vs. 18.9%, P 〈 0.001) than did those in the OPD group. Conclusions The characteristics of ALO were significantly different between patients who had received LPD and OPD . The most common cause of ALO in the LPD group was internal herniation occurring in the early postoperative period. Internal herniation following LPD may be prevented by routine closure of mesocolic window and should be treated by emergency surgery if it occurs.
    Type of Medium: Online Resource
    ISSN: 1868-6974 , 1868-6982
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2536390-6
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  • 3
    Online Resource
    Online Resource
    Wiley ; 2005
    In:  Macromolecular Symposia Vol. 224, No. 1 ( 2005-04), p. 85-92
    In: Macromolecular Symposia, Wiley, Vol. 224, No. 1 ( 2005-04), p. 85-92
    Abstract: The ring‐opening polymerization of L ‐lactide initiated by 1‐dodecanol/stannous 2‐ethylhexanoate (DoOH/Sn(Oct) 2 ) was carried out in supercritical chlorodifluoromethane at various reaction times, pressures, and temperatures. The monomer conversion increased to ca 70 % on increasing the reaction time to 25 h. The molecular weight of the product also increased to ca 75,000 g/mol over the same period. Increasing the pressure resulted in an accelerated polymerization rate. The pressure‐induced increase in the rate of L ‐LA polymerization can be explained by the formation of chemical bonds in the transition state, which implies the production of a transition state with a lower partial molar volume than the reactants.
    Type of Medium: Online Resource
    ISSN: 1022-1360 , 1521-3900
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2005
    detail.hit.zdb_id: 2038549-3
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  • 4
    In: Journal of the American Ceramic Society, Wiley, Vol. 101, No. 9 ( 2018-09), p. 3997-4010
    Abstract: CuO‐added 0.96(Na 0.5 K 0.5 )(Nb 1‐ x S b x )O 3 ‐0.04SrTiO 3 ceramics sintered at the low temperature of 960°C for 10 hours showed dense microstructures and high relative densities. The specimens with 0.0 ≤  x  ≤ 0.04 had orthorhombic‐tetragonal polymorphic phase boundary ( PPB ) structure. Tetragonal‐pseudocubic PPB structure was observed in specimens with 0.05 ≤  x  ≤ 0.07, while the specimen with x  = 0.08 has a pseudocubic structure. The structural variation in the specimens is explained by the decreases in the orthorhombic‐tetragonal transition temperature and Curie temperature with the addition of Sb 5+ ions. The specimens with 0.05 ≤  x  ≤ 0.07, which have tetragonal‐pseudocubic PPB structure, had large electric field‐induced strains of 0.14%‐0.016%. Moreover, these specimens also showed increased d 33 values between 280 pC /N and 358 pC /N. In particular, the specimen with x  = 0.055 showed particularly enhanced piezoelectric properties: d 33 of 358 pC /N, k p of 0.45, and the electric field‐induced strain of 0.16% at 4.5 kV/mm.
    Type of Medium: Online Resource
    ISSN: 0002-7820 , 1551-2916
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2008170-4
    detail.hit.zdb_id: 219232-9
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  • 5
    Online Resource
    Online Resource
    Wiley ; 2004
    In:  Macromolecular Bioscience Vol. 4, No. 3 ( 2004-03-15), p. 340-345
    In: Macromolecular Bioscience, Wiley, Vol. 4, No. 3 ( 2004-03-15), p. 340-345
    Abstract: Summary: The ring‐opening polymerization of L ‐lactide initiated by stannous octoate was carried out in supercritical chlorodifluoromethane (scR22) at various reaction conditions (time and temperature) and reactant concentrations (initiator, monomer, and solvent). The monomer conversion increased to ca. 70% on increasing the reaction time to 1 h. The molecular weight of the poly( L ‐lactide) (PLLA) product also increased to ca. 160 000 g · mol −1 over the same period. Increasing reaction temperature from 90 to 130 °C resulted in increased monomer conversion and PLLA molecular weight. A series of polymerizations conducted at various 1‐dodecanol and stannous octoate concentrations suggested that stannous octoate does not act as an initiator by itself, and that the tin‐alkoxide formed from 1‐dodecanol and stannous octoate serves as the initiating species in scR22. While enhancements of the monomer conversion and PLLA molecular weight were observed with increasing monomer concentration, the chlorodifluoromethane concentration had the opposite on both. After the polymerization, PLLA microspheres were prepared in situ by using a continuous supercritical antisolvent process without residual organic solvent and monomer to yield highly purified microspheres for environmental and biomedical applications. Relation between monomer conversion (○) and poly( L ‐lactide) molecular weight (•). image Relation between monomer conversion (○) and poly( L ‐lactide) molecular weight (•).
    Type of Medium: Online Resource
    ISSN: 1616-5187 , 1616-5195
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2004
    detail.hit.zdb_id: 2039130-4
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    Wiley ; 2019
    In:  Biofuels, Bioproducts and Biorefining Vol. 13, No. 3 ( 2019-05)
    In: Biofuels, Bioproducts and Biorefining, Wiley, Vol. 13, No. 3 ( 2019-05)
    Abstract: The cover image is based on the Review Feasibility of unsaturated fatty acid feedstocks as green alternatives in bio‐oil refinery by Jong Yeol Jeon et al., DOI: 10.1002/bbb.1979 . Designed by Kyung Ha Hwang. image
    Type of Medium: Online Resource
    ISSN: 1932-104X , 1932-1031
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2381232-1
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  • 7
    In: Journal of the American Ceramic Society, Wiley, Vol. 101, No. 10 ( 2018-10), p. 4669-4676
    Abstract: Lead‐free 0.77(Bi 0.5 Na 0.5 )TiO 3 –0.23Sr(Ti 1− x Fe x )O 3 ( x  =   0, 0.04) ( BNT –23 STF x ) was prepared using a conventional solid‐state reaction route. The effects of Fe‐modification on the chemical homogeneity from a μm scale perspective, the core‐shell domains structures, and the ferroelectric properties were investigated. The chemical homogeneity was analyzed using energy dispersive X‐ray mapping in scanning transmission electron microscopy mode, and the field‐dependent behaviors of strain and polarization were obtained to determine the ferroelectric properties. Substituting Fe 3+ for Ti 4+ resulted in completely different electrical behavior and properties, despite similar XRD patterns and microstructures. The Fe‐substitution promoted the mobility of Sr 2+ ions in the BNT phase and, as a consequence, the chemical homogeneity increased and the core‐domains collapsed. Extending the ceramic processing, such as milling time and sintering time, affected domain distribution and compositional inhomogeneity, which led to a gradual transformation from ferroelectric to relaxor.
    Type of Medium: Online Resource
    ISSN: 0002-7820 , 1551-2916
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2008170-4
    detail.hit.zdb_id: 219232-9
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  • 8
    Online Resource
    Online Resource
    Wiley ; 2019
    In:  Biofuels, Bioproducts and Biorefining Vol. 13, No. 3 ( 2019-05), p. 690-722
    In: Biofuels, Bioproducts and Biorefining, Wiley, Vol. 13, No. 3 ( 2019-05), p. 690-722
    Abstract: Bio‐oil contains plant, animal, fish, and micro‐algae oil, and more than 200 million tons are produced annually. However, many edible and non‐edible bio‐oils are still under development, and their value and feasibility have yet to be determined. The vast majority of bio‐oils produced in the world have a very high unsaturated fatty acid content (70–98%), which could be used as a renewable, eco‐friendly alternative to petroleum. Hydrolysis (or transesterification) with ethylene metathesis technology converts unsaturated fatty acids to C 4 –C 30 oil fragments. These oil fragments are a sustainable chemical technology used in chemical industry platform technology and carbon dioxide abatement green chemical technology, and as a petrochemical substitute. These platform chemicals also have their own market but are used as raw materials for other products (polymers, surfactants, synthetic lubricants, plasticizers, other specialty chemicals, general purpose chemicals, biofuels, etc.). The biodegradability and biocompatibility of the polymeric materials made from the oil mean that it is also possible to develop diverse functional products with high added value such as toothpaste, dandruff treatment shampoo, and melanin pigment removal cosmetics, medical and shape memory polymer materials. According to the cradle‐to‐gate analysis for environmental impact and economics, the total carbon dioxide emission reduction per ton of soybean oil was estimated to be 1.5 kg kg −1 products. Moreover, the metathesis of soybean oil ($680/ton) with additional raw materials ($237.4) will generate a value that is 7.5 times higher at $6857. Due to the biodegradability and biocompatibility of the products made from bio‐oils, it is expected that various functional products with high added value will be developed and that industrial applicability will be greatly expanded in the near future. In addition, for the development of various derivatives, fusion and cooperative research in chemical fields such as catalytic engineering, organic chemistry, polymer chemistry, maintenance chemistry, and reaction engineering are essential. © 2019 Society of Chemical Industry and John Wiley & Sons, Ltd
    Type of Medium: Online Resource
    ISSN: 1932-104X , 1932-1031
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2381232-1
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  • 9
    In: Clinical and Translational Science, Wiley, Vol. 15, No. 12 ( 2022-12), p. 2938-2946
    Abstract: Anti‐angiogenic antibodies are widely used in the treatment of neovascular macular degeneration. Human antibody targeting C‐type lectin domain family 14 member A (CLEC14a) is potential therapeutic agents owing to its antiangiogenic activity. In the present study, we aimed to predict the human intraocular pharmacokinetic (PK) properties of an anti‐CLEC14a antibody. I‐125 labeled aflibercept and anti‐CLEC14a antibody were intravitreally injected into mice, rats, and rabbits. Single photon emission computed tomography/computed tomography imaging was performed, and the intraocular radioactivity concentration (%ID/ml) was obtained. The PK parameters in those three animal species were obtained by compartmental analysis. The PK parameters in humans were estimated by allometric scaling of the animal PK parameters with consideration of the hydrodynamic radius of the antibody. The mean half‐life values of intraocular I‐125‐labeled aflibercept in mice, rats, and rabbits were 1.13 days, 1.25 days, and 4.91 days, respectively, by analysis with a one‐compartment model. The predicted human half‐life of intraocular aflibercept was 5.75 days based on vitreal volume by allometric scaling. The half‐life values of intraocular I‐125‐labeled anti‐CLEC14a in mice, rats and rabbits were 1.05 days, 1.84 days, and 6.37 days, respectively, by analysis with a one‐compartment model. The predicted human half‐life of intraocular anti‐CLEC14a was 10.29 days based on vitreal volume. According to the hydrodynamic volume of the anti‐CLEC14a, the predicted human half‐life of intraocular anti‐CLEC14a was 9.81 days. The PK characteristics of the intraocular anti‐CLEC14a antibody were evaluated noninvasively in animals using I‐125 labeling, and the intraocular PK characteristics in humans were predicted using these animal data. This methodology can be applied for the development of new antiangiogenic antibodies to treat macular degeneration.
    Type of Medium: Online Resource
    ISSN: 1752-8054 , 1752-8062
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2433157-0
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  • 10
    In: Advanced Healthcare Materials, Wiley, Vol. 7, No. 4 ( 2018-02)
    Abstract: Immunotargeting ability of antibodies may show significant difference between in vitro and in vivo. To select antibody leads with high affinity and specificity, it is necessary to perform in vivo validation of antibody candidates following in vitro antibody screening. Herein, a robust in vivo validation of anti‐tetraspanin‐8 antibody candidates against human colon cancer using ratiometric quantification method is reported. The validation is performed on a single mouse and analyzed by multiplexed surface‐enhanced Raman scattering using ultrasensitive and near infrared (NIR)‐active surface‐enhanced resonance Raman scattering nanoprobes (NIR‐SERRS dots). The NIR‐SERRS dots are composed of NIR‐active labels and Au/Ag hollow‐shell assembled silica nanospheres. A 93% of NIR‐SERRS dots is detectable at a single‐particle level and signal intensity is 100‐fold stronger than that from nonresonant molecule‐labeled spherical Au NPs (80 nm). The result of SERRS‐based antibody validation is comparable to that of the conventional method using single‐photon‐emission computed tomography. The NIR‐SERRS‐based strategy is an alternate validation method which provides cost‐effective and accurate multiplexing measurements for antibody‐based drug development.
    Type of Medium: Online Resource
    ISSN: 2192-2640 , 2192-2659
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2645585-7
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