In:
APMIS, Wiley, Vol. 125, No. 8 ( 2017-08), p. 699-707
Abstract:
Resectable pancreatic cancer has a high recurrence rate after curative surgery. Biomarkers are needed for distinguishing patients who may benefit from curative resection. In this study, we sought to analyze the prognostic value of p21‐activated kinase 1 ( PAK 1), p21‐activated kinase 4 ( PAK 4), human equilibrative nucleoside transporter 1 ( hENT 1), and thymidylate synthase ( TS ) in surgically resected pancreatic ductal adenocarcinomas. A total of 160 pancreatic cancer patients who underwent surgery with curative intent were retrospectively reviewed. Tissue microarrays were constructed and immunohistochemical stains were performed for PAK 1, PAK 4, hENT 1, and TS . The absence of PAK 4 expression in pancreatic adenocarcinomas was associated with poorer histologic differentiation (p 〈 0.001), shorter overall survival [hazard ratio ( HR ) = 2.86, 95% confidence interval ( CI ) 1.43–5.71; p = 0.003], and disease‐free survival ( HR = 2.29, 95% CI: 1.11–4.74; p = 0.025) on univariate analyses. In addition, more frequent venous invasion and lymph node metastases were seen in PAK 4‐negative tumors although not statistically significant. PAK 1, hENT 1, and TS expression status did not have significant influences on patient survival. In conclusion, PAK 4 of the markers tested in this study may be a potential prognostic biomarker for pancreatic adenocarcinomas.
Type of Medium:
Online Resource
ISSN:
0903-4641
,
1600-0463
DOI:
10.1111/apm.2017.125.issue-8
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2098213-6
SSG:
12
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