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  • 1
    Online Resource
    Online Resource
    Comparison of Drug Delivery Efficiency between Doxorubicin Intercalated in RNA Aptamer and One Encapsulated in RNA Aptamer‐Conjugated Liposome
    Wiley ; 2015
    In:  Bulletin of the Korean Chemical Society Vol. 36, No. 10 ( 2015-10), p. 2494-2500
    Details
    In: Bulletin of the Korean Chemical Society, Wiley, Vol. 36, No. 10 ( 2015-10), p. 2494-2500
    Abstract: Combination of drug delivery and specific targeting has the potential for treating cancers. To achieve this goal, specific ligands targeting cancer cells and bioconjugate vehicles for drug delivery are necessary. Liposomes constitute successful drug‐delivery materials because they can reduce toxicity and enhance the stability of drugs by encapsulation. Previously, we have developed an RNA aptamer‐conjugated liposome (named as aptamosome) that specifically targeted prostate cancer cells expressing prostate‐specific membrane antigen ( PSMA ). Using the aptamosome, the anticancer drug doxorubicin (Dox) was specifically and efficiently delivered to the prostate tumors. The PSMA ‐specific RNA aptamer by itself has been also recognized as tumor‐specific drug delivery material by intercalating Dox. In this study, we compared two different methods for Dox delivery toward PSMA ‐positive cancer cells, namely intercalation of Dox into the aptamer (Apt‐Dox), and encapsulation of Dox in the aptamosome (Apm‐Dox). We observed that the Apm‐Dox was superior to the Apt‐Dox in specificity and Dox delivery efficiency toward PSMA (+) cancer cells.
    Type of Medium: Online Resource
    ISSN: 1229-5949 , 1229-5949
    URL: Issue
    URL: Article
    DOI: 10.1002/bkcs.2015.36.issue-10
    DOI: 10.1002/bkcs.10480
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2056474-0
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  • 2
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    Stimulation of protein kinase C‐α suppresses colon cancer cell proliferation by down‐regulation of β‐catenin
    Wiley ; 2009
    In:  Journal of Cellular and Molecular Medicine Vol. 13, No. 8b ( 2009-08-02), p. 2171-2180
    Details
    In: Journal of Cellular and Molecular Medicine, Wiley, Vol. 13, No. 8b ( 2009-08-02), p. 2171-2180
    Abstract: We reported previously that protein kinase C‐α (PKC‐α) negatively regulates Wnt/β‐catenin signalling pathway. The current study explores the role of PKC‐α in the regulation of proliferation of colon cancer cells, which contain aberrant up‐regulation of intracellular β‐catenin. In colon tissue and cells, an inverse correlation was observed between the expression levels of PKC‐α and intracellular β‐catenin. Activation of PKC‐α inhibited β‐catenin response transcription by down‐regulation of intracellular β‐catenin and induced phosphorylation of the N‐terminal serine and threonine residues (Ser33/Ser37/Thr41) of β‐catenin, marking it for proteasomal degradation, in colon cancer cells. Pharmacological inhibition or depletion of PKC‐α‐abrogated PKC‐α‐mediated β‐catenin down‐regulation and phosphorylation in colon cancer cells. Notably, the Ser45 residue of β‐catenin was essential for PKC‐α‐induced β‐catenin down‐regulation in colon cancer cells. Moreover, PKC‐α activation repressed the expression of cyclin D1 and c‐myc , which are known β‐catenin target genes, and thus inhibited the growth of colon cancer cells. These findings suggest that PKC‐α negatively regulates colon cancer cell proliferation via β‐catenin phosphorylation/down‐regulation and may facilitate the development of new strategies to treatment of colon cancer.
    Type of Medium: Online Resource
    ISSN: 1582-1838 , 1582-4934
    URL: Issue
    URL: Article
    DOI: 10.1111/jcmm.2009.13.issue-8b
    DOI: 10.1111/j.1582-4934.2008.00683.x
    Language: English
    Publisher: Wiley
    Publication Date: 2009
    detail.hit.zdb_id: 2076114-4
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  • 3
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    Initial clinical experience with BRAF V600E mutation analysis of core‐needle biopsy specimens from thyroid nodules
    Wiley ; 2016
    In:  Clinical Endocrinology Vol. 84, No. 4 ( 2016-04), p. 607-613
    Details
    In: Clinical Endocrinology, Wiley, Vol. 84, No. 4 ( 2016-04), p. 607-613
    Abstract: The accurate diagnosis of thyroid nodules is important for making management decisions. The purpose of this study was to evaluate the feasibility of core‐needle biopsy with BRAF V600E mutation analysis (CNB + BRAF V600E ) and to compare the clinical usefulness of CNB + BRAF V600E and fine‐needle aspiration with BRAF V600E mutation analysis (FNA + BRAF V600E ) in the diagnosis of thyroid malignancy. Design, patients and measurements The results of BRAF V600E mutation analyses of 820 nodules from 820 patients (153 men, 667 women; mean age, 51·1 years), who underwent CNB + BRAF V600E ( n  = 256) or FNA + BRAF V600E ( n  = 564) between January 2011 and March 2012 were retrospectively evaluated. The feasibility of CNB + BRAF V600E was assessed by comparing its rate of detection of BRAF V600E mutations and positive predictive value with those of FNA + BRAF V600E . The clinical usefulness of CNB + BRAF V600E was determined by comparing rates of inconclusive results, the additional value of BRAF V600E mutation analysis, diagnostic surgery and diagnostic performance with those of FNA + BRAF V600E . Results CNB + BRAF V600E and FNA + BRAF V600E had similar rates of BRAF V600E mutation detection (66·3% vs 64·4%, P  =   0·883) and positive predictive value (100·0% vs 96·6%, P  =   0·135). CNB + BRAF V600E had a significantly higher diagnostic accuracy rate (95·7% vs 85·9%, P  〈   0·001), and significantly lower rates of inconclusive results (8·2% vs 51·8%, P  〈   0·001), and diagnostic surgery (8·9% vs 22·3%, P  =   0·006), than FNA + BRAF V600E . Conclusions The greater diagnostic performance of CNB + BRAF V600E and its lower rate of inconclusive results than FNA + BRAF V600E suggest that CNB + BRAF V600E can reduce rates of preventable diagnostic surgery.
    Type of Medium: Online Resource
    ISSN: 0300-0664 , 1365-2265
    URL: Issue
    URL: Article
    DOI: 10.1111/cen.2016.84.issue-4
    DOI: 10.1111/cen.12866
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2004597-9
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  • 4
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    Online Resource
    Association between neck ultrasonographic findings and clinico‐pathological features in the follicular variant of papillary thyroid carcinoma
    Wiley ; 2015
    In:  Clinical Endocrinology Vol. 83, No. 6 ( 2015-12), p. 968-976
    Details
    In: Clinical Endocrinology, Wiley, Vol. 83, No. 6 ( 2015-12), p. 968-976
    Abstract: The follicular variant of papillary thyroid carcinoma ( FVPTC ) has multiple histological subtypes. Clinical outcomes of FVPTC are variable depending on the subtypes. This study evaluated the association of pre‐operative ultrasonographic ( US ) findings and clinico‐pathological features of FVPTC . Patients This retrospective study enrolled patients with FVPTC ( n  = 70), size‐matched classical variant of papillary thyroid carcinoma ( CPTC , n  = 328), follicular carcinoma ( n  = 85) and follicular adenoma ( FA , n  = 120). We defined the histological subtypes of FVPTC as infiltrative (I‐ FVPTC ; n  = 19) or encapsulated (E‐ FVPTC ; n  = 51) according to the presence of a fibrous capsule. Pre‐operative US was reviewed using a US scoring system and classified into low US score ( n  = 42) and high US score ( n  = 28). Results The median US score for FVPTC was lower than CPTC (2 vs 7, P  〈   0·001), but higher than FA (2 vs 0, P  〈   0·001). The median US score for I‐ FVPTC was significantly higher than E‐ FVPTC (4 vs 2, P  =   0·009). I‐ FVPTC was more likely to be diagnosed as a malignancy or suspicious for malignancy on cytology than E‐ FVPTC ( P  =   0·002). The cumulative risks of cervical lymph node ( LN ) or distant metastasis according to tumour size were significantly higher in I‐ FVPTC than E‐ FVPTC (all P  〈   0·001). The cumulative risks for cervical LN metastasis or capsular invasion according to tumour size were significantly higher in FVPTC with high US score than FVPTC with low US score ( P  =   0·005, P  〈   0·001, respectively). Conclusions Pre‐operative US findings of thyroid nodules were associated with not only histological subtypes, but also the clinical behaviour in FVPTC .
    Type of Medium: Online Resource
    ISSN: 0300-0664 , 1365-2265
    URL: Issue
    URL: Article
    DOI: 10.1111/cen.2015.83.issue-6
    DOI: 10.1111/cen.12674
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2004597-9
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  • 5
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    Online Resource
    A cut‐off value of basal serum calcitonin for detecting macroscopic medullary thyroid carcinoma
    Wiley ; 2015
    In:  Clinical Endocrinology Vol. 82, No. 4 ( 2015-04), p. 598-603
    Details
    In: Clinical Endocrinology, Wiley, Vol. 82, No. 4 ( 2015-04), p. 598-603
    Abstract: Serum calcitonin ( CT ) level is used to detect medullary thyroid carcinoma ( MTC ), but the cut‐off level is unclear. We aimed at identifying the optimal cut‐off value of basal serum CT levels for detecting MTC . Design and patients We retrospectively enrolled patients with hypercalcitoninemia (≥2·9 pmol/l) who had undergone thyroid ultrasonography ( US ) and subsequent work‐up between 2001 and 2013 at A san M edical C enter. We divided patients into four groups: proven MTC (group 1, n  =   93), pathologically proven non‐ MTC after surgery (group 2, n  =   57), benign single nodule by cytology (group 3, n  =   68) and patients without nodules on US (group 4, n =  24). Measurement Basal serum CT levels were evaluated. Results The median CT level of group 1 (119·5 pmol/l) was significantly higher than those of other groups (4·0, 3·8 and 3·8 pmol/l, P  〈   0·001). When we adopted 19·0 pmol/l of CT level as a cut‐off value, the sensitivity, specificity, and positive and negative predictive values were 77·4%, 98·7%, 97·3% and 87·8%, respectively. When we compared 29·2 pmol/l (100 pg/ml) and 19·0 pmol/l (65 pg/ml) as cut‐off values, 19·0 pmol/l was more sensitive and accurate than 29·2 pmol/l. Factors associated with hypercalcitoninemia in non‐ MTC groups were autoimmune thyroiditis, chronic kidney disease, proton pump inhibitors and other malignancies. Serum CT levels tended to decrease spontaneously in non‐ MTC groups. Conclusion Basal serum CT levels higher than 19·0 pmol/l can be a useful cut‐off value for detecting macroscopic MTC , even though values below 19·0 pmol/l cannot exclude the presence of MTC like small volume MTC or premalignant C ‐cell hyperplasia.
    Type of Medium: Online Resource
    ISSN: 0300-0664 , 1365-2265
    URL: Issue
    URL: Article
    DOI: 10.1111/cen.2015.82.issue-4
    DOI: 10.1111/cen.12562
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2004597-9
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  • 6
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    Differentiating the location of cervical lymph node metastasis is very useful for estimating the risk of distant metastases in papillary thyroid carcinoma
    Wiley ; 2014
    In:  Clinical Endocrinology Vol. 81, No. 4 ( 2014-10), p. 593-599
    Details
    In: Clinical Endocrinology, Wiley, Vol. 81, No. 4 ( 2014-10), p. 593-599
    Abstract: A larger primary tumour size, greater numbers of cervical lymph node ( LN ) metastasis are associated with a higher risk of distant metastases in papillary thyroid carcinoma ( PTC ). However, the impact of the location of cervical LN metastasis on distant metastasis is controversial. The aim of this study was to evaluate the risk of distant metastases according to the tumour size and LN status in PTC patients, with special consideration of the LN metastasis pattern. Patients This retrospective cohort study reviewed 1700 classical PTC patients who underwent initial thyroid surgery at Asan Medical Center between 2000 and 2004. Results The cumulative risk of distant metastases was increased with the increase in tumour size and was significantly different according to the location of involved LNs by the tumour node metastasis (TNM) staging. The cumulative risk in pN 1b group showed the steepest increasing pattern with the increase in tumour size compared with pN 1a and pN 0/Nx group. When we analysed the cumulative risk of distant metastases according to the number of involved LNs, patients with more than 20 involved LNs also had the steepest increase in the risk of distant metastases with the increase in tumour size. However, only the location of involved LNs, not the number of involved LNs, was associated with distant metastases in multivariate analysis. Conclusions We confirm that the location of involved LN s categories based on the TNM staging system is more useful than the number of involved LN s categories for estimating the risk of distant metastasis in PTC . Differentiating N1a disease from N1b disease is important for the follow‐up and management of patients with PTC.
    Type of Medium: Online Resource
    ISSN: 0300-0664 , 1365-2265
    URL: Issue
    URL: Article
    DOI: 10.1111/cen.2014.81.issue-4
    DOI: 10.1111/cen.12463
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2004597-9
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  • 7
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    Online Resource
    Site-specific cleavage of mutant ABL mRNA by DNAzyme is facilitated by peptide nucleic acid binding to RNA substrate
    Wiley ; 2012
    In:  FEBS Letters Vol. 586, No. 21 ( 2012-11-02), p. 3865-3869
    Details
    In: FEBS Letters, Wiley, Vol. 586, No. 21 ( 2012-11-02), p. 3865-3869
    Type of Medium: Online Resource
    ISSN: 0014-5793
    URL: Article
    DOI: 10.1016/j.febslet.2012.09.013
    RVK:
    WA 15000
    Language: English
    Publisher: Wiley
    Publication Date: 2012
    detail.hit.zdb_id: 1460391-3
    SSG: 12
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  • 8
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    The pharmaceutical potential of AR‐65, a novel Alzheimer’s disease drug targeting the immunoproteasome
    Wiley ; 2022
    In:  Alzheimer's & Dementia Vol. 18, No. S10 ( 2022-12)
    Details
    In: Alzheimer's & Dementia, Wiley, Vol. 18, No. S10 ( 2022-12)
    Abstract: Previously, we reported that inhibition of the immunoproteasome (iP), which is upregulated in reactive glial cells near amyloid‐β (Aβ) deposits in the brains of patients with Alzheimer’s disease (AD), leads to improved cognitive function in an AD mouse model of Aβ amyloidosis (Tg2576) via suppression of microglia‐mediated inflammation, independent of Aβ accumulation. Method Here, we investigated the pharmaceutical properties of our lead iP inhibitor (AR‐65), a macrocyclic peptide epoxyketone, selected based on in vitro and cellulo iP inhibitory activities and cell‐based anti‐inflammatory efficacy. Specifically, the metabolic stability of AR‐65 was assessed using pooled human liver microsomes. In addition, the flux rate of AR‐65 was measured to evaluate the permeability across Caco‐2 monolayers over‐expressing ABCB1 and ABCG2, two major efflux drug transporters present in the human brain. Result The macrocyclic AR‐65 displayed improved metabolic stability (6‐fold increased half‐life), permeability, and solubility (in an injectable pharmaceutical buffer system with no cyclodextrin) compared to the FDA‐approved linear peptide epoxyketone proteasome inhibitor, carfilzomib (Kyprolis®). Finally, pilot PK studies performed using ICR mice confirmed that AR‐65 is metabolically more stable than carfilzomib and can cross the blood‐brain barrier to inhibit the brain iP. Conclusion Taken together, the results suggest that AR‐65 may hold great potential to be further investigated in clinical settings.
    Type of Medium: Online Resource
    ISSN: 1552-5260 , 1552-5279
    URL: Issue
    URL: Article
    DOI: 10.1002/alz.v18.S10
    DOI: 10.1002/alz.064511
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2201940-6
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  • 9
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    Clinicopathologic review of 58 patients with biliary papillomatosis
    Wiley ; 2004
    In:  Cancer Vol. 100, No. 4 ( 2004-02-15), p. 783-793
    Details
    In: Cancer, Wiley, Vol. 100, No. 4 ( 2004-02-15), p. 783-793
    Type of Medium: Online Resource
    ISSN: 0008-543X , 1097-0142
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.1002/cncr.v100:4
    DOI: 10.1002/(ISSN)1097-0142
    DOI: 10.1002/cncr.20031
    Language: English
    Publisher: Wiley
    Publication Date: 2004
    detail.hit.zdb_id: 1479932-7
    detail.hit.zdb_id: 2599218-1
    detail.hit.zdb_id: 2594979-2
    detail.hit.zdb_id: 1429-1
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  • 10
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    Effects of social prescribing pilot project for the elderly in rural area of South Korea during COVID ‐19 pandemic
    Wiley ; 2021
    In:  Health Science Reports Vol. 4, No. 3 ( 2021-09)
    Details
    In: Health Science Reports, Wiley, Vol. 4, No. 3 ( 2021-09)
    Abstract: Older adults—classified as a high‐risk group—are highly likely to experience increased loneliness due to the implementation of various policies designed to prevent the spread of COVID‐19. Accordingly, this study aims to examine the effects of a pilot social prescribing project for elderly people in rural area of South Korea during the COVID‐19 pandemic. Methods Using the PRECEDE‐PROCEED model, the effectiveness of the pilot project was verified through pre‐ and post‐impact and outcome evaluation. Results According to the results of the impact evaluation, loneliness reduced significantly, while the social participation attitude score increased. Although the average score of self‐efficacy increased, it was not statistically significant. Moreover, it was found that self‐esteem increased significantly. In the outcome evaluation, depression reduced considerably. Conclusion To conclude, the pilot social prescribing project was effective in reducing depression and loneliness for the elderly in rural areas of Korea. It was also confirmed that there is potential to develop a new health promotion project that can improve the self‐esteem of the elderly, and expand their social activities. Second, the pilot project was carried out in an integrated manner by utilizing resources in communities with good accessibility. Therefore, it is expected to be used as a new “Integrated community care model” to improve the mental health of the elderly in rural areas. Third, during the COVID‐19 pandemic, the elderly tend to experience increasing feelings of depression, isolation, and loneliness due to “social distancing.” Therefore, it is expected that social prescribing programs for the elderly in rural areas would become a new alternative for relieve mental disorder of the seniors.
    Type of Medium: Online Resource
    ISSN: 2398-8835 , 2398-8835
    URL: Issue
    URL: Article
    DOI: 10.1002/hsr2.v4.3
    DOI: 10.1002/hsr2.320
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2927182-4
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