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  • 1
    In: The Journal of Clinical Hypertension, Wiley, Vol. 14, No. 2 ( 2012-02), p. 85-91
    Abstract: The authors hypothesized that carvedilol controlled‐release plus lisinopril combination therapy (C+L) would increase endothelial function and decrease oxidative stress to a greater extent than hydrochlorothiazide plus lisinopril combination therapy (H+L) in obese patients with hypertension. Twenty‐five abdominally obese patients (aged 54.4±7.3 years; 14 women) with hypertension/prehypertension were enrolled in a 7‐month (two 3‐month treatment periods separated by a 1‐month washout), randomized, double‐blind, controlled, crossover clinical trial comparing C+L vs H+L. Endothelial function, measured by digital reactive hyperemic index (RHI), circulating oxidized low‐density lipoprotein (oxLDL), 8‐isoprostane, and asymmetric dimethylarginine (ADMA) were obtained at baseline, post‐period 1, post‐washout, and post‐period 2. Analyses were adjusted for baseline measurements by analysis of covariance, with robust variance estimation for confidence intervals and P values. C+L treatment compared to H+L treatment significantly improved RHI (0.74, 95% confidence interval, 0.31–1.19, P  =.001). This difference persisted after adjustment for the change in systolic blood pressure. No significant treatment differences were observed for oxLDL, 8‐isoprostane, or ADMA. These data provide evidence that independent of blood pressure–lowering, C+L therapy improves endothelial function to a greater extent than H+L therapy. Levels of oxidative stress were not significantly different between treatments, suggesting that other mechanisms may be responsible for the improvement in endothelial function.
    Type of Medium: Online Resource
    ISSN: 1524-6175 , 1751-7176
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2012
    detail.hit.zdb_id: 2058690-5
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  • 2
    In: Journal of Evaluation in Clinical Practice, Wiley, Vol. 14, No. 5 ( 2008-10), p. 854-860
    Abstract: Rationale, aims and objectives  Evidence suggests that educational outreach (‘academic detailing’) improves evidence‐based prescribing. We evaluated the impact of an academic detailing programme intended to increase new statin prescriptions. Methods  In a 2 × 2 factorial design we evaluated the effect of an academic detailing programme with/without telephonic care management for patients. Eligible patients were continuously enrolled Medicaid members at high risk for cardiovascular disease utilization who were not receiving statin medication in the 18 months prior to the intervention. All primary care prescribers assigned to these patients were randomized by clinic to academic detailing. Two trained nurses provided the detailing to prescribers, including specific discussion about the use of statins in this high‐risk patient population. Nurses left the prescribers with a summary of clinical practice guidelines, a one‐page detailing sheet and a list of patients under the care of the prescriber who were candidates for statins. The primary outcome was the incidence of a new statin prescription claim during the 6‐month intervention period and the subsequent 6 months. Logistic regression models were used to estimate main effects of the interventions and to adjust for potential confounding variables in the study. Results  Forty‐eight clinics were randomized, effectively randomizing a total of 284 patients and 128 prescribers. Among the 284 patients, 46 (16%) received a new statin claim during the evaluation period. Controlling for significant bivariate associations, the academic detailing intervention had no significant effect on new statin prescriptions compared with the control group (odds ratio = 0.8, 95% confidence interval: 0.4–1.6, P  = 0.5). Conclusion  Among this Medicaid population at high risk for cardiovascular events, an academic detailing programme to increase statin prescriptions was not effective. To assist others to learn from our failed effort, we identify and discuss critical elements in the design and implementation of the programme that could account for these results.
    Type of Medium: Online Resource
    ISSN: 1356-1294 , 1365-2753
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2008
    detail.hit.zdb_id: 2006772-0
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  • 3
    In: Academic Emergency Medicine, Wiley, Vol. 16, No. 5 ( 2009-05), p. 379-387
    Abstract: Objectives:  Even after acute coronary syndrome (ACS) is ruled out, observational studies have suggested that many patients with nonspecific chest pain have a high burden of cardiovascular risk factors (CRFs) and are at increased long‐term risk of ischemic heart disease (IHD)‐related mortality. The aim of this study was to evaluate the premise that evaluation in an observation unit for symptoms of possible ACS is a “teachable moment” with regard to modification of CRFs. Methods:  The authors conducted a baseline face‐to‐face interview and a 3‐month telephone interview of 83 adult patients with at least one modifiable CRF who presented with symptoms of possible ACS to an academic medical center. Existing questionnaires were adapted to measure Health Belief Model (HBM) constructs for IHD. Stage of change and self‐reported CRF‐related behaviors (diet, exercise, and smoking) were assessed using previously validated measures. The paired t‐test or signed rank test was used to compare baseline and 3‐month measures of health behavior within the analysis sample. Results:  Of the 83 study patients, 45 and 40% reported having received clinician advice regarding diet and physical activity during the observation unit encounter, respectively; 69% of current smokers received advice to quit smoking. Patients reported lower susceptibility to IHD (13.3 vs. 14.0, p = 0.06) and greater perceived benefit of healthy lifestyles (27.5 vs. 26.4, p = 0.0003) at 3‐month follow‐up compared to baseline. Patients also reported greater readiness to change and improved self‐reported behaviors at follow‐up (vs. baseline): decreased intake of saturated fat (10.1% vs. 10.5% of total calories, p = 0.005), increased fruit and vegetable intake (4.0 servings/day vs. 3.6 servings/day, p = 0.01), and fewer cigarettes (13 vs. 18, p = 0.002). Conclusions:  Observed changes in IHD health beliefs and CRF‐related behaviors during follow‐up support the idea that observation unit admission is a teachable moment. Patients with modifiable risk factors may benefit from systematic interventions to deliver CRF‐related counseling during observation unit evaluation.
    Type of Medium: Online Resource
    ISSN: 1069-6563 , 1553-2712
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2009
    detail.hit.zdb_id: 2029751-8
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  • 4
    In: Academic Emergency Medicine, Wiley, Vol. 24, No. 8 ( 2017-08), p. 968-982
    Abstract: Admission to the chest pain observation unit ( CPOU ) may be an advantageous time for patients to consider heart‐healthy lifestyle changes while undergoing diagnostic evaluation to rule out myocardial ischemia. The aim of this pragmatic trial was to assess the effectiveness of a multiple risk factor intervention in changing CPOU patients' health beliefs and readiness to change health behaviors. A secondary aim was to obtain preliminary estimates of the intervention's effect on diet, physical activity, and smoking. Methods We conducted a pilot randomized controlled trial of a moderate‐intensity counseling intervention that aimed to build motivation to change and problem‐solving skills in 140 adult patients with at least one modifiable cardiovascular risk factor ( CRF ) who were admitted to the CPOU of an academic emergency department ( ED ) with symptoms of possible acute coronary syndrome. Study patients were randomly assigned to full counseling (face‐to‐face cardiovascular risk assessment and personalized counseling on nutrition, physical activity, and smoking cessation in the ED , plus two telephone follow‐up sessions) or minimal counseling (brief instruction [ 〈 5 minutes] on benefits of modifying cardiovascular risk factors) by a cardiac rehabilitation specialist. We measured Health Belief Model constructs for ischemic heart disease, stage of change, and self‐reported CRF ‐related behaviors (diet, exercise, and smoking) during 6‐month follow‐up using previously validated measures. We used linear mixed models and logistic regression (with generalized estimating equations) to compare continuous and dichotomous behavioral outcomes across treatment arms, respectively. Results Approximately 20% more patients in the full counseling arm reported having received counseling on diet and physical activity during CPOU admission, compared to the minimal counseling arm; a similar proportion of patients in both counseling arms reported having received advice or assistance in quitting smoking. There were no significant differences between treatment arms for any cardiovascular health beliefs, readiness to change, or CRF ‐related behaviors during longitudinal follow‐up. In secondary analyses in both treatment arms combined, however, patients showed significant differences between follow‐up and baseline measurements: increases in the perceived benefits of improving CRF ‐related behaviors (27.7 vs. 26.6 on a scale from 7 to 35, p = 0.0001) and increased readiness to change dietary behavior and physical activity during follow‐up—intake of saturated fat (83% vs. 49%), readiness to change fruit and vegetable consumption (83% vs 56%), and readiness to perform regular exercise (34% vs. 14%) at 6 months and baseline, respectively (p 〈 0.0001 for all comparisons in both treatment arms combined). Conclusions A multiple risk factor intervention that focused on increasing motivation to change and problem‐solving skills did not significantly improve behavioral outcomes, compared to minimal counseling. Patients admitted to the CPOU demonstrated sustained changes in several cardiovascular health beliefs and risk‐related behaviors during follow‐up; this provides further evidence that the CPOU visit is a “teachable moment” for cardiovascular risk reduction. Future studies should evaluate the effectiveness of ED ‐initiated counseling interventions to engage patients in changing cardiovascular risk behaviors, in coordination with primary care.
    Type of Medium: Online Resource
    ISSN: 1069-6563 , 1553-2712
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2029751-8
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  • 5
    In: Magnetic Resonance in Medicine, Wiley, Vol. 84, No. 4 ( 2020-10), p. 1844-1856
    Abstract: Hyperpolarized 15 N‐labeled molecules have been proposed as imaging agents for investigating tissue perfusion and pH. However, the sensitivity of direct 15 N detection is limited by the isotope's low gyromagnetic ratio. Sensitivity can be increased by transferring 15 N hyperpolarization to spin‐coupled protons provided that there is not significant polarization loss during transfer. However, complete polarization transfer would limit the temporal window for imaging to the order of the proton T 1 (2‐3 s). To exploit the long T 1 offered by storing polarization in 15 N and the higher sensitivity of 1 H detection, we have developed a pulse sequence for partial polarization transfer. Methods A polarization transfer pulse sequence was modified to allow partial polarization transfer, as is required for dynamic measurements, and that can be implemented with inhomogeneous B 1 fields, as is often the case in vivo. The sequence was demonstrated with dynamic spectroscopy and imaging measurements with [ 15 N 2 ]urea. Results When compared to direct 15 N detection, the sequence increased the signal‐to‐noise ratio (SNR) by a factor of 1.72 ± 0.25, where both experiments depleted ~20% of the hyperpolarization ( 〉 10‐fold when 100% of the hyperpolarization is used). Simulations with measured cross relaxation rates showed that this sequence gave up to a 50‐fold increase in urea proton polarization when compared to spontaneous polarization transfer via cross relaxation. Conclusion The sequence gave an SNR increase that was close to the theoretical limit and can give a significant SNR benefit when compared to direct 13 C detection of hyperpolarized [ 13 C]urea.
    Type of Medium: Online Resource
    ISSN: 0740-3194 , 1522-2594
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 1493786-4
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  • 6
    Online Resource
    Online Resource
    Wiley ; 1987
    In:  Environmental and Molecular Mutagenesis Vol. 10, No. 2 ( 1987), p. 197-203
    In: Environmental and Molecular Mutagenesis, Wiley, Vol. 10, No. 2 ( 1987), p. 197-203
    Type of Medium: Online Resource
    ISSN: 0893-6692 , 1098-2280
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 1987
    detail.hit.zdb_id: 1497682-1
    SSG: 12
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  • 7
    Online Resource
    Online Resource
    Wiley ; 1989
    In:  Environmental and Molecular Mutagenesis Vol. 13, No. 2 ( 1989-01), p. 97-99
    In: Environmental and Molecular Mutagenesis, Wiley, Vol. 13, No. 2 ( 1989-01), p. 97-99
    Abstract: The antitumor agent cisplatin was evaluated for genotoxicity in the somatic tissue of Drosophila melanogaster in combination with the nucleo‐philic compound sodium thiosulfate (STS). Third instar larvae transheterozygous for mwh and flr 3 were grown on media containing (1) water, (2) 200 mM STS, (3) 0.05 mM cisplatin in 200 mM STS, or (4) 0.05 mM cisplatin. Wings of surviving adults were scored for the presence of twin spots and both small and large single spots; 200 mM STS was nongenotoxic in the assay. Whereas 0.05 mM cisplatin significantly induced all three endpoints, 0.05 mM cisplatin in combination with 200 mM STS was found to have no genotoxic activity. Hence, STS possessed antimutagenic activity in the wing‐spot assay and completely inhibited cisplatin‐induced mutagenesis and mitotic recombination.
    Type of Medium: Online Resource
    ISSN: 0893-6692 , 1098-2280
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 1989
    detail.hit.zdb_id: 1497682-1
    SSG: 12
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  • 8
    Online Resource
    Online Resource
    Wiley ; 1993
    In:  Environmental and Molecular Mutagenesis Vol. 22, No. 1 ( 1993), p. 54-58
    In: Environmental and Molecular Mutagenesis, Wiley, Vol. 22, No. 1 ( 1993), p. 54-58
    Type of Medium: Online Resource
    ISSN: 0893-6692 , 1098-2280
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 1993
    detail.hit.zdb_id: 1497682-1
    SSG: 12
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  • 9
    Online Resource
    Online Resource
    Wiley ; 1998
    In:  Teratogenesis, Carcinogenesis, and Mutagenesis Vol. 18, No. 2 ( 1998), p. 93-100
    In: Teratogenesis, Carcinogenesis, and Mutagenesis, Wiley, Vol. 18, No. 2 ( 1998), p. 93-100
    Type of Medium: Online Resource
    ISSN: 0270-3211 , 1520-6866
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 1998
    detail.hit.zdb_id: 1474933-6
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  • 10
    In: Annals of Neurology, Wiley, Vol. 66, No. 2 ( 2009-08), p. 235-244
    Type of Medium: Online Resource
    ISSN: 0364-5134 , 1531-8249
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2009
    detail.hit.zdb_id: 2037912-2
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