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  • 1
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    Online Resource
    Restratification of survival prognosis of N1b papillary thyroid cancer by lateral lymph node ratio and largest lymph node size
    Wiley ; 2017
    In:  Cancer Medicine Vol. 6, No. 10 ( 2017-10), p. 2244-2251
    Details
    In: Cancer Medicine, Wiley, Vol. 6, No. 10 ( 2017-10), p. 2244-2251
    Abstract: The current 7th TNM staging stratifies N1b papillary thyroid cancer ( PTC ) patients without distant metastasis into either stage I or stage IV merely by an age threshold (45 years). To date, no studies have adequately quantified the mortality risk of PTC patients with N1b disease. We hypothesized that incorporating lymph node ( LN ) factors into the staging system would better predict cancer‐specific mortality ( CSM ). A total of 745 nonmetastatic PTC patients with N1b disease were enrolled. We identified factors related to LN s and cut‐points using Cox regression and time‐dependent ROC analysis. New prognostic groupings were derived based on minimal hazard differences for CSM among the groups stratified by LN risk and age, and prediction of CSM was assessed. Lateral lymph node ratio ( LNR ) and largest LN size were significant prognostic LN factors at cut‐points of 0.3 and 3 cm. Without LN risk (lateral LNR 〉 0.3 or largest LN size 〉 3 cm), stage IV patients had prognosis [adjusted HR 1.10 (98% CI 0.19–6.20); P  = 0.906] similar to stage I patients with LN risk. Patients were restratified into three prognostic groups: Group 1, 〈 45 years without LN risk; Group 2, 〈 45 years with LN risk or ≥45 years without LN risk; and Group 3, ≥45 with LN risk. This system had a lower log‐rank P ‐value ( 〈 0.001 vs. 0.002) and higher C ‐statistics (0.80 vs. 0.71) than the 7th TNM . New prognostic grouping using lateral LNR and largest LN size predicts CSM accurately and distinguishes N1b patients with different prognosis.
    Type of Medium: Online Resource
    ISSN: 2045-7634 , 2045-7634
    URL: Issue
    URL: Article
    DOI: 10.1002/cam4.2017.6.issue-10
    DOI: 10.1002/cam4.1160
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2659751-2
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  • 2
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    Delayed TSH recovery after dose adjustment during TSH ‐suppressive levothyroxine therapy of thyroid cancer
    Wiley ; 2017
    In:  Clinical Endocrinology Vol. 87, No. 3 ( 2017-09), p. 286-291
    Details
    In: Clinical Endocrinology, Wiley, Vol. 87, No. 3 ( 2017-09), p. 286-291
    Abstract: Delayed thyroid‐stimulating hormone ( TSH ) recovery during treatment of Graves’ disease is caused by long‐term excessive thyroid hormone, which results in downregulation of pituitary thyrotrophs. However, it is unknown whether delayed TSH recovery exists after levothyroxine ( LT 4) dose reduction in patients with differentiated thyroid cancer ( DTC ) after long‐term TSH suppression. Methods We retrospectively reviewed 97 DTC patients with LT 4 dose reduction after long‐term TSH suppression. TSH levels at baseline (point 1), 6 months (point 2) and 12‐18 months (point 3) after LT 4 dose reduction were compared. A delayed TSH recovery group whose TSH levels changed to upper target TSH category (2015 revised ATA guidelines) from point 2 to point 3 was identified, and risk factors were analysed. Results The median TSH level at point 3 was significantly higher than that of point 2 (0.17 vs 0.09 mIU/L; P 〈 .001). The delayed TSH recovery group (44.3%) showed increased body weight (60.84 vs 62.73 kg; P =.01), while normal response group did not. Greater reduction (%) in the LT 4 dose per weight [ HR 1.10, 95% CI (1.00‐1.22), P =.04] and higher BMI before thyroid surgery [1.19, 1.03‐1.38, P =.01] predicted the occurrence of delayed TSH recovery, while higher dose of LT 4 per weight after reduction showed preventive effect [ HR 0.01, 95% CI (0.00‐0.54); P =.02]. Conclusions Delayed TSH recovery was common during LT 4 dose reduction after long‐term TSH suppression for DTC management. Six months may not be enough for TSH recovery and to evaluate thyroid hormone status by serum TSH .
    Type of Medium: Online Resource
    ISSN: 0300-0664 , 1365-2265
    URL: Issue
    URL: Article
    DOI: 10.1111/cen.2017.87.issue-3
    DOI: 10.1111/cen.13344
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2004597-9
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  • 3
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    Analysis of the skin mycobiome in adult patients with atopic dermatitis
    Wiley ; 2018
    In:  Experimental Dermatology Vol. 27, No. 4 ( 2018-04), p. 366-373
    Details
    In: Experimental Dermatology, Wiley, Vol. 27, No. 4 ( 2018-04), p. 366-373
    Abstract: With the recent availability of culture‐independent sequencing methods, studies have been conducted to analyse skin micro‐organisms present in patients with atopic dermatitis ( AD ). However, the database on the skin fungal communities, “mycobiome,” has been relatively restrictive compared with the bacterial world. We aimed to comparatively analyse the overall skin mycobiome between patients with AD and healthy individuals in the Korean population. We analysed skin swab samples obtained from the antecubital fossae of 8 patients with AD and 8 healthy controls. Using sequencing method followed by direct DNA extraction and molecular PCR , taxonomic compositions of fungi at stepwise level ranks were analysed. The phylogenic marker used was internal transcribed spacer 2 regions of DNA . We observed the tendency of higher intra‐ and interpersonal taxonomic diversity at genus and species levels in AD samples. Non‐ Malassezia fungal diversity was also noticeable in the patient group compared with healthy controls. Malassezia globosa and Malassezia restricta were prevalent in all samples across both study groups, and some Malassezia species, including Malassezia sloofiae and Malassezia dermatis, characterized AD . Our data might provide a new insight into the mycobiome of adult AD , which contributes to building a systemic mycobiome database in AD .
    Type of Medium: Online Resource
    ISSN: 0906-6705 , 1600-0625
    URL: Issue
    URL: Article
    DOI: 10.1111/exd.2018.27.issue-4
    DOI: 10.1111/exd.13500
    RVK:
    XA 42446
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2026228-0
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  • 4
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    Three‐dimensional reconstruction of the luminal structure of human seminal vesicle
    Wiley ; 2020
    In:  Journal of Anatomy Vol. 237, No. 6 ( 2020-12), p. 1006-1014
    Details
    In: Journal of Anatomy, Wiley, Vol. 237, No. 6 ( 2020-12), p. 1006-1014
    Abstract: The seminal vesicles are the glands of male reproductive organs that produce the fluid and nutrient constituents of semen. It has been believed for a long time that the lumen of a seminal vesicle was a single‐coiled tubular structure with irregular diverticula. There are several previous reports on the symmetry, differences in morphological sizes and classification of the seminal vesicles. However, a three‐dimensional‐coiled tubular structure is difficult to understand using a classical anatomical methodology, and hence, three‐dimensional reconstruction is needed to understand the structure of the lumen. Thirty‐one seminal vesicles harvested from 21 formalin‐embalmed cadavers were investigated. The seminal vesicle along with the ampulla of the ductus deferens was separated, and the length and width of each seminal vesicle were measured. The vesicles were then embedded in coloured paraffin, and the resulting paraffin block was sectioned transversely and photographed at an interval of 500 μm, with the sectioned surfaces then utilized in three‐dimensional reconstruction performed by ‘Reconstruct’ software. The mean length and width of the seminal vesicles were 39.4 mm and 13.4 mm, respectively, and the right seminal vesicle was a little larger than the one on the left. The size differed from previous reports, while the luminal structure was similar to the classification of Aboul‐azm (Archives of Andrology, 3, 1979, 287–292) but differed from that of Pereira (AJR. American Journal of Roentgenology, 69, 1953, 361–379). The seminal vesicles typically comprised about 9 curls and had about 12 diverticula. The seminal vesicles resembled a skein of coral rather than comprising a single strand. These findings will help in improving the understanding of pathophysiologies of the seminal vesicles, such as recurrent inflammation of the gland.
    Type of Medium: Online Resource
    ISSN: 0021-8782 , 1469-7580
    URL: Issue
    URL: Article
    DOI: 10.1111/joa.v237.6
    DOI: 10.1111/joa.13269
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 1474856-3
    SSG: 12
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  • 5
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    Lateral branches of the facial artery and its clinical implications
    Wiley ; 2022
    In:  Clinical Anatomy Vol. 35, No. 8 ( 2022-11), p. 1142-1146
    Details
    In: Clinical Anatomy, Wiley, Vol. 35, No. 8 ( 2022-11), p. 1142-1146
    Abstract: The facial artery is the main artery supplying blood to the face and is known to have facial branches of the inferior labial, superior labial, lateral nasal and angular arteries. These known major branches of facial artery run medially, however, there are sometimes branches of the facial artery heading laterally. The purpose of the present study was to investigate the lateral branches of the facial artery in face. We dissected facial branches of the facial artery in 74 cadaveric hemifaces. We investigated the presence of the lateral branches of the facial artery. Following parameters were investigated: lateral branch presence, the location of its origin, and the lateral branch diameter. Among the lateral branches, we evaluated the prevalence and diameter of the premasseteric branch. Lateral branches were observed in 48 of the 74 hemifaces (64.9%). The total number was 81 in the 48 hemifaces. The most common origin was between the inferior border of the mandible and inferior labial artery origin (42 of 81, 51.9%). The mean diameter of all lateral branches of the facial artery was 0.7 mm. Among the lateral branches, the premasseteric branches were present in 38 of 74 specimen (51.4%) and the mean diameter was 0.8 mm. The lateral branches of the facial artery may be registered in Terminologia Anatomica based on their prevalence. Accurate knowledge of the anatomy of the lateral branches of the facial artery is helpful for clinicians to avoid complications during facial procedures or maxillofacial surgeries.
    Type of Medium: Online Resource
    ISSN: 0897-3806 , 1098-2353
    URL: Issue
    URL: Article
    DOI: 10.1002/ca.v35.8
    DOI: 10.1002/ca.23932
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2004511-6
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  • 6
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    Comparison of calcitriol versus cholecalciferol therapy in addition to oral calcium after total thyroidectomy with central neck lymph node dissection: A prospective randomized study
    Wiley ; 2011
    In:  Head & Neck Vol. 33, No. 9 ( 2011-09), p. 1265-1271
    Details
    In: Head & Neck, Wiley, Vol. 33, No. 9 ( 2011-09), p. 1265-1271
    Type of Medium: Online Resource
    ISSN: 1043-3074
    URL: Issue
    URL: Article
    DOI: 10.1002/hed.v33.9
    DOI: 10.1002/hed.21619
    Language: English
    Publisher: Wiley
    Publication Date: 2011
    detail.hit.zdb_id: 2001440-5
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  • 7
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    The role of PET CT to evaluate the response to neoadjuvant chemotherapy in advanced breast cancer: Comparison with ultrasonography and magnetic resonance imaging
    Wiley ; 2010
    In:  Journal of Surgical Oncology Vol. 102, No. 5 ( 2010-10), p. 392-397
    Details
    In: Journal of Surgical Oncology, Wiley, Vol. 102, No. 5 ( 2010-10), p. 392-397
    Abstract: Recently PET is emerged as a method to estimate the response of neoadjuvant chemotherapy (NAC) in advanced breast cancer. This study is aimed to estimate the predictive role of PET CT and other imaging modalities (ultrasound, MRI) through NAC. Methods PET CT was acquired before and after NAC from 41 patients. Pathologic results were classified as pathological complete response (pCR) and non‐pCR. The results of clinical responses were assessed with imaging indexes ( postTx , postchemotherapy size or peak standardized uptake values (pSUV); delta , the size difference between treatment; RR , reduction rate of tumor size or pSUV), and they were compared with pathologic results. Results Seven patients (17.1%) showed pCR. As a result of comparison of the image index, all image indexes of MRI were predictive for pCR ( P   〈  0.05). In contrast, only delta and RR of US, RR of PET CT were significant. The area under curve of delta and RR in MRI were higher (0.91, 0.90) than US (0.83, 0.80) and PET CT (0.62, 0.72). The MRI is superior to the US or PET CT. Conclusions We have concluded that the MRI is better than PET CT for monitoring the effect of NAC in advanced breast cancer. J. Surg. Oncol. 2010;102:392–397. © 2009 Wiley‐Liss, Inc.
    Type of Medium: Online Resource
    ISSN: 0022-4790 , 1096-9098
    URL: Issue
    URL: Article
    DOI: 10.1002/jso.v102:5
    DOI: 10.1002/jso.21424
    Language: English
    Publisher: Wiley
    Publication Date: 2010
    detail.hit.zdb_id: 1475314-5
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  • 8
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    Online Resource
    Robust Cognitive-Radio-Based OFDM Architecture with Adaptive Traffic Allocation in Time and Frequency
    Wiley ; 2008
    In:  ETRI Journal Vol. 30, No. 1 ( 2008-02-11), p. 21-32
    Details
    In: ETRI Journal, Wiley, Vol. 30, No. 1 ( 2008-02-11), p. 21-32
    Type of Medium: Online Resource
    ISSN: 1225-6463
    URL: Article
    DOI: 10.4218/etrij.08.0106.0253
    Language: English
    Publisher: Wiley
    Publication Date: 2008
    detail.hit.zdb_id: 2119239-X
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  • 9
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    Korean red ginseng induces extrinsic and intrinsic apoptotic pathways in MCF ‐7 breast cancer cells and MCF‐10A non‐malignant breast cells
    Wiley ; 2021
    In:  Journal of Obstetrics and Gynaecology Research Vol. 47, No. 8 ( 2021-08), p. 2758-2766
    Details
    In: Journal of Obstetrics and Gynaecology Research, Wiley, Vol. 47, No. 8 ( 2021-08), p. 2758-2766
    Abstract: Among non‐hormonal treatments, herbal products are frequently used by women. Korean red ginseng (KRG) is one of the popular herbal medicines. KRG could be one option for relieving menopausal symptoms. However, there are still concerns about the safety for long‐term use. In order to be used for alleviating menopausal symptoms, the safety of KRG on breast must be ensured. The purpose of this study was to investigate the effects of KRG on breast cells. Methods MCF‐7 and MCF‐10A cells were treated with different concentrations of KRG extracts for 48 h. Cell viability was evaluated by MTT assay, and apoptosis by flow cytometry. The expression of apoptosis‐related proteins was determined by western blot analysis and estrogen receptor (ER) affinity by ER binding assay. Results KRG extract inhibited growth and induced apoptosis of both MCF‐7 and MCF‐10A cells in dose‐dependent manner. KRG extract increased the expression of pro‐apoptotic proteins BAX, BAK, and BAD and decreased the expression of anti‐apoptotic proteins Bcl‐2 and Bcl‐XL in both cells. The expressions of Fas and FasL were increased in lower doses, but decreased in higher doses in both cells. Activities of caspase‐3, ‐8 and ‐9 increased in MCF‐10A, while caspase‐8 and ‐9 showed increase in MCF‐7. Competition of KRG to E 2 was significant in MCF‐7 as KRG dose increased, whereas ER binding was hardly shown in MCF‐10. Conclusion KRG induced apoptosis via extrinsic and intrinsic pathway in MCF‐7 breast cancer cells and MCF‐10A non‐malignant cells. KRG may be safely used with regard to breast cancer risk in postmenopausal women to reduce the vasomotor symptoms.
    Type of Medium: Online Resource
    ISSN: 1341-8076 , 1447-0756
    URL: Issue
    URL: Article
    DOI: 10.1111/jog.v47.8
    DOI: 10.1111/jog.14826
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2079101-X
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  • 10
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    Silent mating‐type information regulation 2 homolog 1 overexpression is an important strategy for the survival of adapted suspension tumor cells
    Wiley ; 2019
    In:  Cancer Science Vol. 110, No. 9 ( 2019-09), p. 2773-2782
    Details
    In: Cancer Science, Wiley, Vol. 110, No. 9 ( 2019-09), p. 2773-2782
    Abstract: Characterization of circulating tumor cells (CTC) is important to prevent death caused by the metastatic spread of cancer cells because CTC are associated with distal metastasis and poor prognosis of breast cancer. We have previously developed suspension cells (SC) using breast cancer cell lines and demonstrated their high metastatic potential. As survival of CTC is highly variable from a few hours to decades, herein we cultured SC for an extended time and named them adapted suspension cells (ASC). Silent mating‐type information regulation 2 homolog 1 (SIRT1) expression increased in ASC, which protected the cells from apoptosis. High SIRT1 expression was responsible for the suppression of nuclear factor kappa B (NF‐κB) activity and downregulation of reactive oxygen species (ROS) in ASC. As the inhibition of NF‐κB and ROS production in SIRT1‐depleted ASC contributed to the development of resistance to apoptotic cell death, maintenance of a low ROS level and NF‐κB activity in ASC is a crucial function of SIRT1. Thus, SIRT1 overexpression may play an important role in growth adaptation of SC because SIRT1 expression is increased in long‐term rather than in short‐term cultures.
    Type of Medium: Online Resource
    ISSN: 1347-9032 , 1349-7006
    URL: Issue
    URL: Article
    DOI: 10.1111/cas.v110.9
    DOI: 10.1111/cas.14147
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2115647-5
    detail.hit.zdb_id: 2111204-6
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