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  • 1
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    Online Resource
    miR ‐146b Protects the Perinatal Brain against Microglia‐Induced Hypomyelination
    Wiley ; 2022
    In:  Annals of Neurology Vol. 91, No. 1 ( 2022-01), p. 48-65
    Details
    In: Annals of Neurology, Wiley, Vol. 91, No. 1 ( 2022-01), p. 48-65
    Abstract: In the premature newborn, perinatal inflammation mediated by microglia contributes significantly to neurodevelopmental injuries including white matter injury (WMI). Brain inflammation alters development through neuroinflammatory processes mediated by activation of homeostatic microglia toward a pro‐inflammatory and neurotoxic phenotype. Investigating immune regulators of microglial activation is crucial to find effective strategies to prevent and treat WMI. Methods Ex vivo microglial cultures and a mouse model of WMI induced by perinatal inflammation (interleukin‐1‐beta [IL‐1β] and postnatal days 1–5) were used to uncover and elucidate the role of microRNA‐146b‐5p in microglial activation and WMI. Results A specific reduction in vivo in microglia of Dicer , a protein required for microRNAs maturation, reduces pro‐inflammatory activation of microglia and prevents hypomyelination in our model of WMI. Microglial miRNome analysis in the WMI model identified miRNA‐146b‐5p as a candidate modulator of microglial activation. Ex vivo microglial cell culture treated with the pro‐inflammatory stimulus lipopolysaccharide (LPS) led to overexpression of immunomodulatory miRNA‐146b‐5p but its drastic reduction in the microglial extracellular vesicles (EVs). To increase miRNA‐146b‐5p expression, we used a 3DNA nanocarrier to deliver synthetic miRNA‐146b‐5p specifically to microglia. Enhancing microglial miRNA‐146b‐5p overexpression significantly decreased LPS‐induced activation, downregulated IRAK1, and restored miRNA‐146b‐5p levels in EVs. In our WMI model, 3DNA miRNA‐146b‐5p treatment significantly prevented microglial activation, hypomyelination, and cognitive defect induced by perinatal inflammation. Interpretations These findings support that miRNA‐146b‐5p is a major regulator of microglia phenotype and could be targeted to reduce the incidence and the severity of perinatal brain injuries and their long‐term consequences. ANN NEUROL 2022;91:48–65
    Type of Medium: Online Resource
    ISSN: 0364-5134 , 1531-8249
    URL: Issue
    URL: Article
    DOI: 10.1002/ana.v91.1
    DOI: 10.1002/ana.26263
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2037912-2
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  • 2
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    P2‐439: Investigations on the anti‐Alzheimer's potential of calotropis procera in mice
    Wiley ; 2008
    In:  Alzheimer's & Dementia Vol. 4, No. 4S_Part_15 ( 2008-07)
    Details
    In: Alzheimer's & Dementia, Wiley, Vol. 4, No. 4S_Part_15 ( 2008-07)
    Type of Medium: Online Resource
    ISSN: 1552-5260 , 1552-5279
    URL: Article
    DOI: 10.1016/j.jalz.2008.05.1518
    Language: English
    Publisher: Wiley
    Publication Date: 2008
    detail.hit.zdb_id: 2201940-6
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  • 3
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    Advances in Metal Oxide‐based Nanocatalysts for Biodiesel Production: A Review
    Wiley ; 2023
    In:  ChemBioEng Reviews Vol. 10, No. 3 ( 2023-06), p. 258-271
    Details
    In: ChemBioEng Reviews, Wiley, Vol. 10, No. 3 ( 2023-06), p. 258-271
    Abstract: The demand for renewable fuels has risen as a result of increasing human population, urbanization, industrialization, and transport systems. Biodiesel production using metal oxide‐based heterogeneous catalysts is an efficient, sustainable, and environmentally friendly approach. Because of their recovery, reusability, and consistency, heterogeneous catalysts may be preferable to homogeneous catalysts. Since the last few decades, the metal oxides of alkali earth and transition metals and their composite materials have been used as nanocatalysts in the production of biodiesel fuel. Utilization of inorganic metal oxide nanoparticles (MONPs) and their composite materials in producing biodiesel has gained increased attention because of their advanced physical and chemical characteristics. In this review, the applicability of metal oxides and their nanocomposite‐based catalysts in biodiesel production, transesterification reactions with nanocatalytic systems, and the important parameters that affect these reactions are discussed.
    Type of Medium: Online Resource
    ISSN: 2196-9744 , 2196-9744
    URL: Issue
    URL: Article
    DOI: 10.1002/cben.v10.3
    DOI: 10.1002/cben.202200019
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2754405-9
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  • 4
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    Genetic diversity varies with species traits and latitude in predatory soil arthropods (Myriapoda: Chilopoda)
    Wiley ; 2023
    In:  Global Ecology and Biogeography Vol. 32, No. 9 ( 2023-09), p. 1508-1521
    Details
    In: Global Ecology and Biogeography, Wiley, Vol. 32, No. 9 ( 2023-09), p. 1508-1521
    Abstract: To investigate the drivers of intra‐specific genetic diversity in centipedes, a group of ancient predatory soil arthropods. Location Asia, Australasia and Europe. Time Period Present. Major Taxa Studied Centipedes (Class: Chilopoda). Methods We assembled a database of 1245 mitochondrial cytochrome c oxidase subunit I sequences representing 128 centipede species from all five orders of Chilopoda. This sequence dataset was used to estimate genetic diversity for centipede species and compare its distribution with estimates from other arthropod groups. We studied the variation in centipede genetic diversity with species traits and biogeography using a beta regression framework, controlling for the effect of shared evolutionary history within a family. Results A wide variation in genetic diversity across centipede species (0–0.1713) falls towards the higher end of values among arthropods. Overall, 27.57% of the variation in mitochondrial COI genetic diversity in centipedes was explained by a combination of predictors related to life history and biogeography. Genetic diversity decreased with body size and latitudinal position of sampled localities, was greater in species showing maternal care and increased with geographic distance among conspecifics. Main Conclusions Centipedes fall towards the higher end of genetic diversity among arthropods, which may be related to their long evolutionary history and low dispersal ability. In centipedes, the negative association of body size with genetic diversity may be mediated by its influence on local abundance or the influence of ecological strategy on long‐term population history. Species with maternal care had higher genetic diversity, which goes against expectations and needs further scrutiny. Hemispheric differences in genetic diversity can be due to historic climatic stability and lower seasonality in the southern hemisphere. Overall, we find that despite the differences in mean genetic diversity among animals, similar processes related to life‐history strategy and biogeography are associated with the variation within them.
    Type of Medium: Online Resource
    ISSN: 1466-822X , 1466-8238
    URL: Issue
    URL: Article
    DOI: 10.1111/geb.v32.9
    DOI: 10.1111/geb.13709
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1479787-2
    detail.hit.zdb_id: 2021283-5
    SSG: 12
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  • 5
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    Predicting activities of daily living in people with dementia of Alzheimer’s type using neurocognitive measures : Neuropsychology/Early detection of cognitive decline with neuropsychological tests
    Wiley ; 2020
    In:  Alzheimer's & Dementia Vol. 16, No. S6 ( 2020-12)
    Details
    In: Alzheimer's & Dementia, Wiley, Vol. 16, No. S6 ( 2020-12)
    Abstract: Cognitive deterioration in neurodegenerative disorders like dementia of Alzheimer’s type affects the overall functioning of daily life activities of a person. Till date, numerous studies have shown correlation between performance on cognitive task and activities of daily living (ADL). Among all the cognitive domains attentional functioning has been the main focus in DAT as it has been the first cognitive domain to be affected. Method The present study has an attempt to associate the cognitive functions especially attentional functioning in predicting ADLs in people with DAT. The different ADLs which mainly categories into basic and instrumental ADL have been studied meta‐anatically in relation to its relationship with cognitive functioning in people with DAT. The keywords related with study have been selected and searched on different platforms like Google Scholar, Pubmed etc. The lack of research works in this field narrows the studies related with predictive value of cognitive ability. Result The study revealed that out of 11 studies, 7 were related to the assessment of cognitive functioning with ADLs. Out of which 4 were concerning about the cognitive domain related with ADLs whereas 3 studies have shown domains other than attention like visuospatial ability, immediate memory and executive functioning as a predictor to the ADLs in DAT. Conclusion The relevance of conducting the present study is the emerging life problems of elderly with cognitive impairment. The study suggests how the present approach can be applied to address research issues related with diagnosis and rehabilitation technique for people with DAT.
    Type of Medium: Online Resource
    ISSN: 1552-5260 , 1552-5279
    URL: Issue
    URL: Article
    DOI: 10.1002/alz.v16.S6
    DOI: 10.1002/alz.041379
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2201940-6
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  • 6
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    Effect of COVID‐19 in cognitive manifestations in people with dementia of Alzheimer’s type
    Wiley ; 2021
    In:  Alzheimer's & Dementia Vol. 17, No. S6 ( 2021-12)
    Details
    In: Alzheimer's & Dementia, Wiley, Vol. 17, No. S6 ( 2021-12)
    Abstract: The coronavirus disease 2019 (COVID‐19) has been spreading worldwide and affecting people of all the age groups. Recent studies are claiming that it causes brain fog state in patients. The elderly are more prevalent in this disorder because of higher medical comorbidities and resulting in cognitive impairments. Method The present study has taken 2 cases of dementia of Alzheimer’s disease patients with Covid 19 positive as experimental and 2 cases of Alzheimer’s disease patients with Covid 19 negative as control group. A video interview has been structured with few questions to assess their cognitive perspective on Covid 19. They have been matched on cognitive status using Hindi‐ mini Mental State Examination and Cognitive Failure questionnaire. After a period of two month they have been interviewed again to compare the changes. Result The findings of the present study revealed a differences in the scores of Cognitive Failure Questionnaire in experimental group as compared to control group. Conclusion The study showed that there was an effect of Covid 19 on cognitive status of cases of dementia of Alzheimer’s disease patients with Covid 19 positive as compared to dementia of Alzheimer’s disease patients with Covid 19 negative cases.
    Type of Medium: Online Resource
    ISSN: 1552-5260 , 1552-5279
    URL: Issue
    URL: Article
    DOI: 10.1002/alz.v17.S6
    DOI: 10.1002/alz.057408
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2201940-6
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  • 7
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    Comparing visuospatial construction ability of MoCA and MMSE in cognitive assessment of patients with dementia of Alzheimer’s type
    Wiley ; 2023
    In:  Alzheimer's & Dementia Vol. 19, No. S4 ( 2023-06)
    Details
    In: Alzheimer's & Dementia, Wiley, Vol. 19, No. S4 ( 2023-06)
    Abstract: The ability to see an object or picture as a set of parts and then to construct a replica of the original from these parts is known as visuospatial constructive cognition. Examples of visuospatial construction include drawing, buttoning shirts, constructing models, making a bed, and putting together furniture that arrives unassembled. Visuospatial construction is a central cognitive ability. At the same time, there are enormous individual differences among people in their ability to perform visuospatial constructive tasks. The MoCA had greater sensitivity than MMSE in detecting MCI versus HCs (; however, specificity was lower for the MoCA than MMSE. Method The present study has considered visuospatial construction ability in cognitive neuropsychological screening tool. The neuropsychological screening tool were Mini‐mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). The intersecting pentagons copy sub‐item was administered as part of the MMSE whereas there was cube figure to copy where subjects have to initially convert a two‐dimensional contour to a three‐dimensional cube. The sample consisted of 15 patients with mild Dementia of Alzheimer’s type. Result The result showed that both the MoCA and the MMSE were successful in differentiating between patients with and without cognitive domain deficits and cognitive impairment. The scores in visuospatial construction ability on MoCA and MMSE are different on visuospatial domain which on further analysis showed significant differences in cognitive performance. Conclusion The cognitive scores of mild Dementia of Alzheimer’s patient differs which showed the differences in the ability to complete a cognitive task as and thus revealed greater sensitivity of MoCA as compared to MMSE.
    Type of Medium: Online Resource
    ISSN: 1552-5260 , 1552-5279
    URL: Issue
    URL: Article
    DOI: 10.1002/alz.v19.S4
    DOI: 10.1002/alz.065307
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2201940-6
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  • 8
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    Online Resource
    P1‐571: INTERACTION BETWEEN PHASIC ALERTING AND EXECUTIVE CONTROL IN PATIENTS WITH MCI AND PATIENTS WITH EARLY DEMENTIA OF THE ALZHEIMER'S TYPE
    Wiley ; 2018
    In:  Alzheimer's & Dementia Vol. 14, No. 7S_Part_10 ( 2018-07)
    Details
    In: Alzheimer's & Dementia, Wiley, Vol. 14, No. 7S_Part_10 ( 2018-07)
    Type of Medium: Online Resource
    ISSN: 1552-5260 , 1552-5279
    URL: Article
    DOI: 10.1016/j.jalz.2018.06.583
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2201940-6
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  • 9
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    Identification of Potent Antitubercular Secondary Metabolites from Kigelia africana: An In‐Silico Investigation
    Wiley ; 2023
    In:  ChemistrySelect Vol. 8, No. 37 ( 2023-10-06)
    Details
    In: ChemistrySelect, Wiley, Vol. 8, No. 37 ( 2023-10-06)
    Abstract: Ethyl‐acetate extract of heartwood of Kigelia africana Lam . affords tecomaquinone‐I ( 1 ), lapachol ( 2 ), dehydro‐α‐lapachone ( 3 ), cluytyl ferulate ( 4 ), kigelinone ( 5 ), D‐sesamin ( 6 ), paulownin ( 7 ), wodeshiol ( 8 ) and cycloolivil ( 9 ). Isolation of cycloolivil from this plant is being reported for the first time. The structures of these compounds were elucidated by advanced spectroscopic methods ( 1 H, 13 C NMR, IR & Mass spectrometry). Structure of cycloolivil ( 9 ) was confirmed by X‐ray crystallographic analysis. In order to study the anti‐tubercular activity and to develop new drugs from natural sources, molecular docking studies of isolated phytochemicals were performed for potential inhibitory action towards Type I polyketide synthase 13 (Pks13). For this purpose, isoniazid, and a co‐crystallized PDB ligand were used as reference drug. Tecomaquinone‐I exhibited best docking score (−12.4 kcal/mol) among all the tested compounds. Molecular simulation and QSAR study of tecomaquinone‐I favoured docking results. Hence, the present study suggests that tecomaquinone‐I exhibits potent anti‐tubercular activity.
    Type of Medium: Online Resource
    ISSN: 2365-6549 , 2365-6549
    URL: Issue
    URL: Article
    DOI: 10.1002/slct.v8.37
    DOI: 10.1002/slct.202302269
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2844262-3
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  • 10
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    Feasibility of exclusive enteral feeds from birth in VLBW infants 〉1200 g - an RCT
    Wiley ; 2013
    In:  Acta Paediatrica Vol. 102, No. 7 ( 2013-07), p. e299-e304
    Details
    In: Acta Paediatrica, Wiley, Vol. 102, No. 7 ( 2013-07), p. e299-e304
    Type of Medium: Online Resource
    ISSN: 0803-5253
    URL: Issue
    URL: Article
    DOI: 10.1111/apa.2013.102.issue-7
    DOI: 10.1111/apa.12254
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 1492629-5
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